• We evaluated the presence of influenza A/B virus, human metapneumovirus, bocavirus, adenovirus, respiratory syncytial virus (RSV), and parainfluenza viruses in 105 SARS-CoV-2 positive dead patients, using polymerase chain reaction (PCR) and reverse transcription PCR tests. (nih.gov)
  • We found coinfection with influenza virus in 22.3%, RSV, and bocavirus in 9.7%, parainfluenza viruses in 3.9%, human metapneumovirus in 2.9%, and finally adenovirus in 1.9% of SARS-CoV-2 positive dead cases. (nih.gov)
  • Viruses that can be spread through the air include rhinoviruses, influenza and parainfluenza viruses, respiratory syncytial virus, and adenoviruses. (cdc.gov)
  • However, during periods of low influenza activity and outside of epidemics situations, the infection of other respiratory viruses e.g. rhinovirus, respiratory syncytial virus, parainfluenza and adenovirus can also present as Influenza-like Illness (ILI) which makes the clinical differentiation of influenza from other pathogens difficult. (who.int)
  • This revolutionary approach allows severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV) and human rhinovirus (HRV) to be detected in a single test. (pharmiweb.com)
  • 30 minutes sample-to-result in vitro diagnostic test, based on isothermal LAMP technology, intended for the extraction and qualitative detection of SARS-CoV-2 RNA as a single target and combined with the extraction and detection of Influenza A virus, Influenza B virus, human respiratory syncytial virus and human rhinovirus in a multiplex panel from a nasopharyngeal, nasal, throat, and buccal samples. (pharmiweb.com)
  • Bacterial pathogens that can cause ANI originating from humans include the group-A streptococci, Staphylococcus-aureus, and Mycobacterium- tuberculosis. (cdc.gov)
  • From an etiological classification perspective, the most common causative agents of pneumonia are bacteria (typical like Pneumococcus, H.Influenza and atypical like Legionella, Mycoplasma), viral (Influenza, Respiratory Syncytial Virus, Parainfluenza, and adenoviruses) and fungi (Histoplasma & Pneumocystis Carinii). (thehealthcareblog.com)
  • Currently circulating in humans are subtype A(H1N1) and A(H3N2) influenza viruses. (who.int)
  • The A(H1N1) is also written as A(H1N1)pdm09 as it caused the pandemic in 2009 and subsequently replaced the seasonal influenza A(H1N1) virus which had circulated prior to 2009. (who.int)
  • A(H1N2) variant viruses and one human case of infection with an influenza A(H3N2) variant virus were reported officially.3 One additional human case of infection with an influenza A(H1N1)v virus was detected. (who.int)
  • His research interests focus on pathogenesis and protective immunity in human respiratory viral infections, including respiratory syncytial virus (RSV), influenza and SARS-CoV-2. (imperial.ac.uk)
  • Targets in RSV, Influenza and Dengue viral infections have already been identified by ABIVAX and are being evaluated for further development under the partnership. (evotec.com)
  • Human metapneumovirus (HMPV or hMPV) is a negative-sense single-stranded RNA virus of the family Pneumoviridae and is closely related to the Avian metapneumovirus (AMPV) subgroup C. It was isolated for the first time in 2001 in the Netherlands by using the RAP-PCR (RNA arbitrarily primed PCR) technique for identification of unknown viruses growing in cultured cells. (wikipedia.org)
  • Human metapneumovirus was first discovered in 2001 in the Netherlands by Bernadette G. van den Hoogen and her colleagues. (wikipedia.org)
  • It was this close relationship to AMPV that gave rise to this new virus being named human metapneumovirus to reflect both its identity as a metapneumovirus and its use of humans as a host organism. (wikipedia.org)
  • Human metapneumovirus may cause mild upper respiratory tract infection (the common cold). (wikipedia.org)
  • Our findings highlight a high prevalence of coinfection with influenza A virus and the monopoly of coinfection with Human metapneumovirus in children. (nih.gov)
  • The virus is distributed worldwide and, in temperate regions, has a seasonal distribution generally following that of RSV and influenza virus during late winter and spring. (wikipedia.org)
  • In temperate regions, both influenza A and B cause winter epidemics, with sporadic cases and outbreaks occurring out of season. (who.int)
  • Epidemics of influenza typically occur during the winter months in temperate regions and have been responsible for an average of approximately 36,000 deaths/year in the United States during 1990--1999 ( 1 ). (cdc.gov)
  • In some studies of hospitalizations and emergency room visits, HMPV is nearly as common and as severe as influenza in older adults. (wikipedia.org)
  • During previous severe acute respiratory syndrome (SARS) pandemic in 2003, researchers found that the patients with fever, cough, or sore throat had a 5% influenza virus-positive rate. (nih.gov)
  • Thus, we evaluated the coinfection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses in dead patients in North Khorasan. (nih.gov)
  • Their efficacy in patients with influenza viral pneumonia or severe influenza is unknown. (medscape.com)
  • Seasonal influenza is characterized by a sudden onset of fever, cough (usually dry), headache, muscle and joint pain, severe malaise (feeling unwell), sore throat, and a runny nose. (who.int)
  • But influenza can cause severe illness or death, especially in people at high risk. (who.int)
  • Worldwide, these annual epidemics are estimated to result in about 3 to 5 million cases of severe illness, and about 290 000 to 650 000 respiratory deaths. (who.int)
  • Influenza vaccination is the primary method for preventing influenza and its severe complications. (cdc.gov)
  • It is the second most common cause after respiratory syncytial virus (RSV) of lower respiratory infection in young children. (wikipedia.org)
  • Genotyping based on sequences of the F and G genes showed that subtype B was associated with increased cough duration and increased general respiratory systems compared to HMPV-A. hMPV is estimated to have a 3-6 day incubation period and is often most active during the later winter and spring seasons in temperate climates, overlapping with the RSV and influenza seasons and possibly allowing for repeated infection. (wikipedia.org)
  • He is an expert in human infection challenge studies and leads a group that uses infection and vaccination of volunteers as well as patient-centred research to investigate systemic and mucosal immunity against these infections. (imperial.ac.uk)
  • Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
  • Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)
  • Seasonal influenza is an acute respiratory infection caused by influenza viruses which circulate in all parts of the world. (who.int)
  • It is intended to aid in triage of COVID-19, influenza type A, influenza type B, RSV and HRV, in samples from people regardless of gender or age, with or without signs and symptoms suggestive of infection. (pharmiweb.com)
  • Since the last risk assessment on 21 May 2021, one new laboratory-confirmed human case of influenza A(H5N6) virus infection was reported from China to WHO on 30 May 2021. (who.int)
  • 1. What is the likelihood that additional human cases of infection with avian influenza A(H5) viruses will occur? (who.int)
  • Good quality serological investigations may be useful in differentiating infection from contamination in these cases and allow for better assessment of the risk of human infection. (who.int)
  • There are 4 types of seasonal influenza viruses, types A, B, C and D. Influenza A and B viruses are the most common and cause seasonal epidemics of disease globally (1). (who.int)
  • The effects of seasonal influenza epidemics in developing countries are not fully known, but research estimates that 99% of deaths in children under 5 years of age with influenza-related lower respiratory tract infections are found in developing countries (2). (who.int)
  • Proper collection, storage and transport of respiratory specimens is the essential first step for laboratory detection of influenza virus infections. (who.int)
  • Laboratory confirmation of influenza virus from throat, nasal and nasopharyngeal secretions or tracheal aspirate or washings is commonly performed using direct antigen detection, virus isolation, or detection of influenza-specific RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). (who.int)
  • The detection of influenza A(H5) virus in nasopharyngeal/oropharyngeal samples collected from individuals in close contact with infected poultry or other birds, whether the individuals are symptomatic or not, is not unexpected. (who.int)
  • In the last months of 2019, an outbreak of fatal respiratory disease started in Wuhan, China, and quickly spread to other parts of the world. (nih.gov)
  • All human infections caused by a new influenza subtype are required to be reported under the International Health Regulations (IHR, 2005).4 This includes any influenza A virus that has demonstrated the capacity to infect a human and its haemagglutinin gene (or protein) is not a mutated form of those, i.e. (who.int)
  • Human infections with viruses of animal origin are expected at the human-animal interface wherever these viruses circulate in animals. (who.int)
  • there are promising vaccines against respiratory syncytial virus, tuberculosis, and vaccines for all strains of influenza are in the pipeline. (bailliegifford.com)
  • Primary influenza pneumonia manifests with persistent symptoms of cough, sore throat, headache, myalgia, and malaise for more than three to five days. (medscape.com)
  • these techniques included the randomly primed PCR technique which obtained the limited sequence data needed to reveal a clear relationship between this new virus and the avian pneumovirus. (wikipedia.org)
  • 2. What is the likelihood of human-to-human transmission of avian influenza A(H5) viruses? (who.int)
  • hMPV was first detected in the respiratory secretions of 28 young children in the Netherlands and had initially stood out from other common respiratory viruses because the testing methods van den Hoogen et al. (wikipedia.org)
  • and 5) the assessment of vaccine supply, timing of influenza vaccination, and prioritization of inactivated vaccine in shortage situations. (cdc.gov)
  • Vaccination is associated with reductions in influenza-related respiratory illness and physician visits among all age groups, hospitalization and death among persons at high risk, otitis media among children, and work absenteeism among adults ( 8--18 ). (cdc.gov)
  • Influenza D viruses primarily affect cattle and are not known to infect or cause illness in people. (who.int)
  • Influenza viruses also can cause pandemics, during which rates of illness and death from influenza-related complications can increase worldwide. (cdc.gov)
  • HMPV is associated with 5% to 40% of respiratory tract infections in hospitalized and outpatient children. (wikipedia.org)
  • Influenza C virus is detected less frequently and usually causes mild infections, thus does not present public health importance. (who.int)
  • Even though small clusters of A(H5) virus infections have been reported previously including those involving healthcare workers, current epidemiological and virological evidence suggests that influenza A(H5) viruses have not acquired the ability of sustained transmission among humans, thus the likelihood is low. (who.int)
  • A significant number of viruses, bacteria, and fungi can spread by way of airborne mechanisms in hospitals. (cdc.gov)
  • The work encompasses early phase clinical vaccine trials as well as fundamental studies of human immunity, which together enhance our understanding of how respiratory viral illnesses may be prevented and accelerate the development of better vaccines. (imperial.ac.uk)
  • This report updates the 2004 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of influenza vaccine and antiviral agents (CDC. (cdc.gov)
  • This finding made us think that the wide range of symptoms and also relatively high prevalence of death in our patients may be due to the coinfection with other viruses. (nih.gov)
  • The symptoms may worsen with time, and new respiratory signs and symptoms, such as dyspnea and cyanosis, appear. (medscape.com)
  • Treatment focuses on relieving symptoms of influenza such as fever. (who.int)
  • ABX464, ABIVAX's lead candidate in Phase II clinical trials, is based on this mode of action and is the first drug candidate ever shown to reduce HIV reservoirs in humans (http://programme.ias2017.org/Abstract/Abstract/5650). (evotec.com)
  • Stored clinical samples that were positive for other respiratory viruses were tested to evaluate cross-reactivity. (mdpi.com)
  • Rapid influenza diagnostic tests (RIDTs) are used in clinical settings, but they have lower sensitivity compared to RT-PCR methods and their reliability depends largely on the conditions under which they are used. (who.int)
  • In tropical regions such as the Eastern Mediterranean Region, the circulation of influenza viruses ranges from a seasonal peak from October to May to sporadic cases throughout the year. (who.int)
  • On completion of his specialist training, he was awarded an MRC Clinician Scientist fellowship and furthered his research by working with Rafi Ahmed's group at Emory University, examining antibody, B cell and T cell responses to influenza and varicella zoster virus vaccines. (imperial.ac.uk)
  • Over the past 40 years, we have identified 80 plus new viruses, but managed to develop only three vaccines against these new viruses. (bailliegifford.com)
  • We have had a pretty good understanding of the mature infectious particle at a level where we can make specific predictions about the local chemical interactions between the protein subunits in the virus," said Rebecca Craven, professor of microbiology and immunology and at Penn State University and one of the study's authors. (sciencedaily.com)
  • Collection of appropriate respiratory samples and the application of a laboratory diagnostic test is required to establish a definitive diagnosis. (who.int)
  • These highly specialised methods provide a unique opportunity to examine correlates and mechanisms of protection and disease severity in human beings. (imperial.ac.uk)
  • Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)
  • Influenza viruses cause disease among all age groups ( 2--4 ). (cdc.gov)
  • GII.4 currently causes the majority of norovirus disease in humans. (itbusinessnet.com)
  • Fasciolosis caused by Fasciola hepatica is a disease of zoonotic importance that is common worldwide and can cause serious problems in farm animals, some wild animals and humans. (bvsalud.org)
  • The majority of cases of human influenza are clinically diagnosed. (who.int)
  • With that knowledge we can try to understand the precise molecular mechanisms of virus maturation and help to elucidate how drugs can be designed to interfere with that. (sciencedaily.com)
  • Now an atomic model of the immature retrovirus RSV has been constructed by researchers in order to understand and block the virus. (sciencedaily.com)
  • Over a period of two years, researchers have been performing calculations and simulations in order to reveal the structural features of the virus. (sciencedaily.com)
  • Environmental samples from these stalls tested positive for influenza A(H5N6) viruses. (who.int)
  • With that being said, it has been determined that the first step of the hMPV replication cycle is attachment to the host cell, specifically the epithelial cells of the respiratory tract, using the G protein. (wikipedia.org)
  • however, because recombinant viruses that lack the G protein have still been able to replicate in vitro and in vivo, it seems that attachment via the G protein is not required for rest of the replication cycle. (wikipedia.org)
  • The viruses that are released from infected cells are initially in an immature state and are composed of an RNA genome surrounded by a coat of protein. (sciencedaily.com)
  • According to Boon Chong Goh, a graduate student in physics at Illinois and lead author on the study, a six-helix bundle domain located on the inside surface of the immature protein shell could be a key to understanding and blocking the virus. (sciencedaily.com)
  • Serologic studies have shown that by the age of five, virtually all children worldwide have been exposed to the virus. (wikipedia.org)
  • A number of studies have examined the structure of the Rous sarcoma virus (RSV), which affects birds and provides a good model for other retroviruses, but none have been able to provide a high-resolution look at the immature stage of the virus. (sciencedaily.com)
  • But the field was really lacking similar high-resolution knowledge about the immature virus. (sciencedaily.com)
  • From a simple respiratory swab with minimal handling, high quality nucleic acids are extracted and provide results equivalent to gold standard laboratory-based PCR, outside of the lab environment at the point-of-need. (pharmiweb.com)
  • and 3) persons who live with or care for persons at high risk (e.g., health-care workers and household contacts who have frequent contact with persons at high risk and who can transmit influenza to those persons at high risk). (cdc.gov)
  • 2 years, and persons of any age who have medical conditions that place them at increased risk for complications from influenza ( 2,5--7 ). (cdc.gov)
  • Two, AI can do things that humans can't do - like telling you the exact time it would take you to go from point A to point B (i.e. (thehealthcareblog.com)
  • This pathogen can live for a very long time, possibly a lifetime, within the bodies of humans and other animals. (bvsalud.org)
  • Cytoplasmic inclusions usually are present in cells infected with a ribonucleic acid (RNA) virus. (medscape.com)