Influenza 1999 antibody lymphocyte subsets. Medical search. Frequent questions

The M2 (M2-Ad) had enhanced antibody responses that cross- ability of anti-M2 monoclonal antibody (MAb) to reduce reacted with human and avian M2 sequences and pro- viral replication ( 5 ) implicates M2, in particular M2e, as a duced T-cell responses. (cdc.gov)
DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization. (doximity.com)
Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145: II. (doximity.com)

M2 contains a small ectodomain ( 4 ), M2e, and then boosted with recombinant adenovirus expressing which makes it a target for antibody-based immunity. (cdc.gov)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
There are two main mechanisms in the adaptive immune system-humoral immunity and cellular immunity, which are mediated by antibodies and cells respectively. (frontiersin.org)
Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses. (rush.edu)
Our adaptive immunity, also called acquired immunity, is composed of lymphocyte cells that are triggered when a specific pathogen enters the body. (squareonepublishers.com)
The goal of vaccination is to induce immunity against pathogens and cancer cells by stimulating antigen-specific cytotoxic T lymphocytes (CTLs) or B cells. (biomedcentral.com)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)

Test vaccination with lation of strain-specific influenza vaccines. (cdc.gov)
This vaccination induced challenge infection, DNA vaccination with NP and M antibodies that cross-reacted with divergent M2 peptide achieved limited protection against an H5N1 virus strain from an H5N1 subtype. (cdc.gov)
Vaccination with M2, explored include peptide-carrier conjugates ( 6 ), bac- with key sequences represented, may provide broad pro- ulovirus-expressed M2 ( 7 ), fusion proteins ( 8,9 ), multiple tection against influenza A. antigenic peptides ( 10 ), and M DNA constructs that poten- tially express M2 ( 11,12 ). (cdc.gov)
and 5) minor changes to the recommendations about vaccination during pregnancy and vaccination of internationally adopted children, in accordance with new ACIP vaccine-specific recommendations for use of inactivated influenza vaccine and hepatitis B vaccine. (cdc.gov)
Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. (biomedcentral.com)
Aging is usually associated with reduced influenza virus-specific and influenza vaccine-specific antibody responses but some elderly individuals with higher pre-exposure antibody titers, due to a previous infection or vaccination, have less probability to get infected. (biomedcentral.com)
Although influenza vaccination represents the most effective way to prevent influenza infection, vaccines with greater immunogenicity are needed to improve the response of elderly individuals. (biomedcentral.com)
His work covers various topics, including B cell responses to viral infection and vaccination, human primary immunodeficiency, and biology of lymphocyte development and function and to elucidate etiology of immunological disorders. (stanford.edu)
and 5) the assessment of vaccine supply, timing of influenza vaccination, and prioritization of inactivated vaccine in shortage situations. (cdc.gov)
Influenza vaccination is the primary method for preventing influenza and its severe complications. (cdc.gov)
Vaccination is associated with reductions in influenza-related respiratory illness and physician visits among all age groups, hospitalization and death among persons at high risk, otitis media among children, and work absenteeism among adults ( 8--18 ). (cdc.gov)
The 'gold standard' method to assess humoral antibody responses fol owing vaccination is the neutralization assay. (who.int)

To induce CD8+ cytotoxic T lymphocytes (CTLs) along with neutralizing antibody and CD4+ T cell help, a live canarypox virus construct expressing gp120, transmembrane gp41, the gag and protease genes, and sequences containing CTL epitopes in nef and pol was given simultaneously with, or followed by, rgp120 SF2. (lookformedical.com)

DNA constructs that express conserved influenza A nucle- on conserved antigens provide broader protection. (cdc.gov)
Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)

Effector T cells activate B cells, so that B cells produce antibodies that recognize microorganisms. (biomedcentral.com)
B cells produce antibodies that specifically recognize pathogen- or cancer related molecules. (biomedcentral.com)

T-cell responses and protected against heterosubtypic influenza A subtypes. (cdc.gov)
The M gene of influenza A encodes 2 proteins, both specific antibody responses and protected against highly conserved: M1, the capsid protein, and M2, an ion challenge with lethal influenza. (cdc.gov)
Several studies have allowed the identification of B cell intrinsic defects accounting for sub-optimal antibody responses of elderly individuals. (biomedcentral.com)
These defects include 1) reduced class switch recombination, responsible for the generation of a secondary response of class switched antibodies, 2) reduced de novo somatic hypermutation of the antibody variable region, 3) reduced binding and neutralization capacity, as well as binding specificity, of the secreted antibodies, 4) increased epigenetic modifications that are associated with lower antibody responses, 5) increased frequencies of inflammatory B cell subsets, and 6) shorter telomeres. (biomedcentral.com)
A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. (lookformedical.com)

Cameroon from January 1999 to April 2001. (cdc.gov)

Changes in influenza viruses require regular reformu- turing in response to outbreaks. (cdc.gov)
Y tected against challenge with homologous or early development of influenza vaccines that are anti- heterosubtypic viruses, but even the heterosubtypic virus- genically matched to circulating strains poses extraor- es had an M2e sequence identical to the vaccine constructs dinary challenges. (cdc.gov)
Moreover, the need to immunize an entirely naive popula- sequence (M2e-con) ( 9,13 ), some influenza A viruses do tion would exacerbate problems with vaccine production not. (cdc.gov)
19 ). To modify the sequence to the widely shared M2e with influenza viruses in which M2e sequences differed sequence, full-length consensus M2 cDNA with Kozak substantially from those of the immunizing antigen. (cdc.gov)
The influenza viruses are the most common viral cause of pneumonia. (medscape.com)
Influenza viruses also can cause pandemics, during which rates of illness and death from influenza-related complications can increase worldwide. (cdc.gov)
Influenza viruses cause disease among all age groups ( 2--4 ). (cdc.gov)

I. Expression on dendritic cells and other subsets of mouse leukocytes. (doximity.com)
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (doximity.com)
Dendritic cells and their subsets, located at mucosal surfaces, are among the first immune cells to encounter disseminating pathogens. (biomedcentral.com)
Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. (cnrs.fr)
MHC-II molecules present antigenic peptides internalized by professional antigen presenting cells, such as macrophages, dendritic cells, or T lymphocytes. (biomedcentral.com)

Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)

Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. (prolekarniky.cz)
Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)

One hundred years after the 1918 influenza pandemic, we now face another pandemic with the severe acute respiratory syndrome-novel coronavirus-2 (SARS-CoV-2). (thieme-connect.com)
Examples of this exception are the elderly individuals infected during the 2009 pandemic season who made antibodies with broader epitope recognition and higher avidity than those made by younger individuals. (biomedcentral.com)

Benefits and risks are associated with using all immunobiologics (i.e., an antigenic substance or antibody-containing preparation). (cdc.gov)

A number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA + subjects and those with UCTD. (biomedcentral.com)

Aluminum adjuvant in vaccines induce the production of IgE antibodies, which can lead to an increase in allergies and sensitivities. (currenthealthscenario.com)

Centers for Disease Control and Prevention (CDC) estimated the overall cumulative hospitalization rate from influenza was 68 per 100,000 population across all age groups in the United States and 94 per 100,000 in 0 to 4 year age group. (thieme-connect.com)
Aims: We assessed the risk factors for influenza-associated hospitalization for severe acute respiratory infections (SARI) that occurred during the last 5 seasons. (bvsalud.org)

Their efficacy in patients with influenza viral pneumonia or severe influenza is unknown. (medscape.com)

Methods: We conducted a retrospective, analytical study among patients recruited in the ambulatory and hospital sites of the influenza sentinel surveillance system in Morocco between 2014 and 2019. (bvsalud.org)

He also co-authored a series of papers which utilized human plasmablasts after immunization to define the human immune response to influenza vaccine and generated human monoclonal antibodies from the blood. (wikipedia.org)
Exposure to hemophilus influenza B (HiB) immunization is associated with an increased risk of insulin dependent diabetes. (currenthealthscenario.com)
2003. Clustering of cases of insulin dependent diabetes (IDDM) occuring thre years after hemophilus influenza B (Hib) immunization support causal relationship between immunization and IDDM . (currenthealthscenario.com)
This report updates the 2004 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of influenza vaccine and antiviral agents (CDC. (cdc.gov)

Such studies have led to the identification of a new innate lymphoid subset that produces the canonical type 2 cytokines IL-5, IL-9 and IL-13 in response to IL-25 and IL-33. (nature.com)

Molecular mimicry and ganglioside antibodies play an important role in the pathogenesis of some variants of Guillain-Barré syndrome (eg, acute motor axonal neuropathy). (medlink.com)

He was also involved in the development of mouse monoclonal antibodies directed against human tissues that are widely used as diagnostic reagents. (wikipedia.org)

However, a small subset of patients with XLA have normal protein expression. (medscape.com)
Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)

His contributions to immunology have focused on the molecular features of antibody variable regions, including key discoveries related to the antibody combining site and its relationship to antibody idiotypy and the hypervariable regions of antibody molecules. (wikipedia.org)

Primary influenza pneumonia manifests with persistent symptoms of cough, sore throat, headache, myalgia, and malaise for more than three to five days. (medscape.com)

volume = {171}, number = {1879-0542 (Electronic)}, pages = {5--14}, abstract = {Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)

Capra was an early leader in using human monoclonal antibodies from patients with lymphocytic malignancies helping to drive the field towards biopharmaceutical therapeutics, which now represents one of the largest segments of the pharmaceutical, diagnostic and research-based industries. (wikipedia.org)
He was among those who defined the subsets of human B lymphocytes. (wikipedia.org)
T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus. (rush.edu)
1999. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure. (cdc.gov)
We found that both antibodies recognized mouse RANK with high affinity, while RANK-02 and R12-31 recognized human RANK with high and lower affinities, respectively. (cnrs.fr)

He has co-authored/edited 2 books: The Antibody Enigma (1984) and Immunobiology 4th Edition (1999), co-edited seven volumes on The Antibodies with Maurizio Zanetti (1995-2002) and has served on the review and editorial boards of many journals. (wikipedia.org)

Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)

Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)

The most frequent adverse events were grade 1/2 injection site erythema, injection site reactions, fatigue, pyrexia, chills and influenza-like illness. (biomedcentral.com)

A total of 162 influenza-associated deaths in children have been reported so far this season. (thieme-connect.com)
Epidemics of influenza typically occur during the winter months in temperate regions and have been responsible for an average of approximately 36,000 deaths/year in the United States during 1990--1999 ( 1 ). (cdc.gov)

Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. (biomedcentral.com)
Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)

Capra is widely known for his studies of monoclonal antibodies. (wikipedia.org)

A previous paper revealed that the platelet number of patients with influenza virus-associated encephalopathy (IE) was correlated with the o. (researchgate.net)

however, in mild cases of XLA and in other antibody deficiencies, Ig levels must be carefully compared with age-related reference ranges. (medscape.com)
Determination of functional antibody levels as noted below is more appropriate in the rare case in which the total IgG level is indeterminate. (medscape.com)

1%) or absent expression of CD19+ lymphocytes with of normal-to-increased numbers of mature T lymphocytes. (medscape.com)

2 years, and persons of any age who have medical conditions that place them at increased risk for complications from influenza ( 2,5--7 ). (cdc.gov)

7. Younan P, Iampietro M, Bukreyev A. Disabling of lymphocyte immune response by Ebola virus. (prolekarniky.cz)

Background: Morocco is actively working towards expanding its influenza vaccine policy to cover high-risk groups, as recommended by the World Health Organization (WHO). (bvsalud.org)
and 3) persons who live with or care for persons at high risk (e.g., health-care workers and household contacts who have frequent contact with persons at high risk and who can transmit influenza to those persons at high risk). (cdc.gov)

A subset of positive samples was randomly selected in each epidemic year, the complete viral genome was sequenced, phylogenetic analysis was performed using the MEGA7 program and the genotypes were confirmed. (bvsalud.org)
Bilateral interstitial infiltrates in a 31-year-old patient with influenza pneumonia. (medscape.com)

These studies led to a single cell FACS-sorting based technology for the generation of monoclonal antibodies. (wikipedia.org)

Anatomy36

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Diseases14

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes44

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