• PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. (lookformedical.com)
  • the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells. (wikipedia.org)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • For sialyl-Lewisx to bind to E-selectin it can be part of either an N-linked or O-linked glycan attached to cell surface glycoproteins such as PSGL-1, CD43 or CD44. (wikipedia.org)
  • Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
  • Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • [ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. (lookformedical.com)
  • expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. (wikipedia.org)
  • In this study, we explored whether FGFR1 acted a therapeutic target in human T-cell acute lymphoblastic leukemia (T-ALL) and the molecular mechanisms underlying T-ALL cell resistance to FGFR1 inhibitors. (bvsalud.org)
  • Sialyl-Lewisx allows a sperm cell to recognize and fertilize an egg cell. (wikipedia.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Reed-Sternberg cells display a characteristic pattern of Sialyl-Lewisx (CD15) positivity, with membranous staining combined with staining of the Golgi apparatus. (wikipedia.org)
  • Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. (wikipedia.org)
  • The presence of these cells is diagnostic of Hodgkin's lymphoma. (wikipedia.org)
  • Resting T- and B-lymphocytes lack its expression and are induced to strongly express sialyl Lewis X upon activation. (wikipedia.org)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • TMED2 increased cisplatin resistance in breast cancer cells in vitro via promoting ubiquitination of Kelch-like ECH-associated protein 1 (KEAP1), relieving inhibition of KEAP1 on nuclear factor erythroid 2-related factor 2 (Nrf2), and increasing expression of downstream drug resistance related genes, such as heme oxygenase 1 (HO-1) and NAD (P) H quinone oxidoreductase 1 (NQO1). (bvsalud.org)
  • Defective synthesis of the sialyl Lewis X antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). (wikipedia.org)
  • When a patient presents with neck lymphadenopathy and risk factors for a head and neck cancer, a fine-needle aspiration is usually advised as the initial diagnostic step, followed by excisional biopsy if squamous cell histology is excluded. (medscape.com)
  • Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are present on the cell surface. (wikipedia.org)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • In immunodeficient mice and in mice with transplanted human haematopoietic stem cells, the subcutaneous IL-6-adsorbing hydrogel largely suppressed CAR-T-cell-induced CRS, substantially improving the animals' survival and alleviating their levels of fever, hypotension and weight loss relative to the administration of free IL-6 antibodies. (bvsalud.org)
  • It is known to play a vital role in cell-to-cell recognition processes. (wikipedia.org)
  • When a patient presents with neck lymphadenopathy and risk factors for a head and neck cancer, a fine-needle aspiration is usually advised as the initial diagnostic step, followed by excisional biopsy if squamous cell histology is excluded. (medscape.com)
  • Methods: Here, we show through high-dimensional deep phenotyping using mass cytometry (CyTOF), next generation RNA sequencing and multispectral immunofluorescence imaging (VECTRA Polaris) that key differences exist in the B cell repertoire between tumor and circulation in paired specimens from lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). (bvsalud.org)
  • Mixed cellularity Hodgkin lymphoma showing both mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells (hematoxylin and eosin, original magnification x200). (medscape.com)
  • Low magnification of adenomatoid tumor showing cords of cells in parallel and haphazard orientation. (medscape.com)
  • Medium magnification showing cords of bland cells with abundant pink cytoplasm and focal vacuolization. (medscape.com)
  • To identify and find the transcriptional features of clonal plasma cells in POEMS syndrome (POEMS clones), single-cell RNA sequencing was performed on patient-derived bone marrow plasma cells. (bvsalud.org)
  • These cells have weakly acidophil and markedly vacuolated cytoplasm, without prominent nucleoli and little to no mitotic activity. (medscape.com)
  • POEMS clones were identified in 5 out of 10 patients, and the proportions of POEMS clones in the plasma cells were markedly smaller than that of other plasma cell malignancies such as multiple myeloma and MGUS. (bvsalud.org)
  • [ 4 ] Adenomatoid tumors typically have no distinct growth pattern. (medscape.com)
  • POEMS syndrome is a rare monoclonal plasma cell disorder with unique symptoms distinct from other plasma cell neoplasms. (bvsalud.org)
  • Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
  • Malignant C40367 Acinic Cell Breast Carcinoma A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation. (nih.gov)
  • The transcriptional features of POEMS clones differed from those of other plasma cell diseases, and representative MM-related oncogenes were not upregulated in POEMS clones. (bvsalud.org)
  • Acinic Cell Carcinoma A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
  • Reed-Sternberg cells display a characteristic pattern of Sialyl-Lewisx (CD15) positivity, with membranous staining combined with staining of the Golgi apparatus. (wikipedia.org)
  • Diffuse Large B-Cell Lymphoma with Expression of Full-Length Anaplastic Lymphoma Kinase A usually aggressive large B-cell lymphoma characterized by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. (nih.gov)
  • Morphological and immunohistochemical features were analyzed to examine the infiltration pattern, clonality, and IgG and IgG4 expression of plasma cells in these lymphadenopathies, and to summarize the differential diagnoses of plasma cell infiltration in common lymphadenopathies. (bvsalud.org)
  • Introduction: B cells, which have long been thought to be minor players in the development of anti-tumor responses, have been implicated as key players in lung cancer pathogenesis and response to checkpoint blockade in patients with lung cancer. (bvsalud.org)