• Staphylococcus
  • Preliminary research shows healthy pores are only colonized by P. acnes, while unhealthy ones universally include the nonpore-resident Staphylococcus epidermidis, amongst other bacterial contaminants. (wikipedia.org)
  • Whether this is a root causality, just opportunistic and a side effect, or a more complex pathological duality between P. acnes and this particular Staphylococcus species is not known. (wikipedia.org)
  • clinical
  • Acne vulgaris is a clinical diagnosis. (medscape.com)
  • In vitro experiments have suggested that some fatty acids including lauric acid could be a useful component in a treatment for acne, but no clinical trials have yet been conducted to evaluate this potential benefit in humans. (wikipedia.org)
  • Nadifloxacin in addition to determine a therapeutic antibacterial action, can have a sebostatic and anti-inflammatory action, thus contributing to the improvement of the clinical condition of the patient. (wikipedia.org)
  • In a 2013 multicenter, randomized clinical study with a total of 184 Japanese patients with moderate to severe acne, adapalene 0.1% gel plus nadifloxacin 1% cream (combination therapy) showed a significant efficacy in decrement of inflammatory papulopustular lesions. (wikipedia.org)
  • In a clinical study in 253 people showed a 60% reduction of inflammatory acne by week 12 on average. (wikipedia.org)
  • AOBiome started its Phase 2 clinical trial for adult acne in 2015. (wikipedia.org)
  • therapies
  • There is no evidence that it is more effective in acne that is resistant to other therapies, or that the effects last longer. (cochrane.org)
  • There is moderate evidence for the efficacy of blue and blue-red light therapies in treating mild acne, but most studies are of low quality. (wikipedia.org)
  • They have since performed in-vitro studies, in-vivo studies, and two human studies in acne vulgaris, the results of which have led the company to now additionally explore systemic therapies for conditions such as hypertension. (wikipedia.org)
  • antimicrobial
  • Azerizin is claimed to be a proprietary blend of the natural ingredients nicotinamide, azelaic acid, quercetin and curcumin that purportedly combine the anti-inflammatory and antimicrobial properties, along with inhibiting effects on sebum production. (wikipedia.org)
  • efficacy
  • However, for acne vulgaris, several recent double blind studies have shown consistently superior efficacy for tazarotene and roughly equal tolerability for both treatments. (wikipedia.org)
  • Most often treatment of hyperpigmentation caused by melanin overproduction (such as melasma, acne scarring, liver spots) includes the use of topical depigmenting agents, which vary in their efficacy and safety, as well as in prescription rules. (wikipedia.org)
  • minocycline
  • In summary, there is no evidence to support the first-line use of minocycline in the treatment of acne. (cochrane.org)
  • All of the trials showed that, on average, people treated with minocycline experienced an improvement in their acne. (cochrane.org)
  • The only conclusion that we could make was that people treated with minocycline for acne are at a significantly greater risk of developing an autoimmune (lupus-like) syndrome than those given tetracycline or no treatment. (cochrane.org)
  • To assess new evidence on the effects of minocycline for acne vulgaris. (cochrane.org)
  • psoriasis
  • This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). (wikipedia.org)
  • Tazarotene is most commonly used topically to treat acne, psoriasis (a skin disease in which red, scaly patches form on some areas of the body), and to reduce skin wrinkling and liver spots. (wikipedia.org)
  • One common use of the term is associated with the treatment of skin disorders, chiefly psoriasis, acne vulgaris, eczema and neonatal jaundice. (wikipedia.org)
  • Due to the hyperproliferative action against epidermal cells, S1P has been considered as an active pharmaceutical ingredient for hyperproliferative skin diseases, in particular, psoriasis vulgaris and acne vulgaris. (wikipedia.org)
  • treatments
  • Its use has lessened due to safety concerns (including potentially irreversible pigmentation ), a relatively high cost, and no evidence of any greater benefit than other acne treatments. (cochrane.org)
  • Despite the wide variety of available topical and systemic acne treatments, treatment for acne remains far from optimal. (jcadonline.com)
  • Disease
  • 2002. Acne Vulgaris: A Disease of Western Civilization, Colorado State University. (scribd.com)
  • Acne is the most common skin disease of adolescence, and in most cases it clears spontaneously. (cochrane.org)
  • P. acnes can be found in bronchoalveolar lavage of approximately 70% of patients with sarcoidosis and is associated with disease activity, but it can be also found in 23% of controls. (wikipedia.org)
  • Acne vulgaris is the disease most commonly associated with P. acnes infection. (wikipedia.org)
  • In 2015, acne was estimated to affect 633 million people globally, making it the 8th most common disease worldwide. (wikipedia.org)
  • commonly
  • Although commonly thought to primarily affect teenagers, adolescents comprised only 36.5 percent of acne patients while adults comprised 61.9 percent. (jcadonline.com)
  • Antibiotics are commonly used to treat infections caused by P. acnes. (wikipedia.org)
  • Acne commonly occurs in adolescence and affects an estimated 80-90% of teenagers in the Western world. (wikipedia.org)
  • lesion
  • Outcome measures used in the trials included lesion counts, acne grades/severity scores, doctors' and participants' global assessments, adverse effects , and dropout rates. (cochrane.org)
  • The healing of an acne lesion includes three successive phases . (jle.com)
  • Systemic
  • Systemic symptoms often accompany acne fulminans. (cancertherapyadvisor.com)
  • Systemic symptoms are most often absent in acne vulgaris. (medscape.com)
  • In addition, prescription acne medications, such as systemic antibiotics and retinoids, can cause adverse effects (AEs) that occasionally pose significant health risks to the patient,, and the long-term use of systemic antibiotics can be a significant factor in bacterial resistance. (jcadonline.com)
  • rosacea
  • Azerizin was developed at Elorac for use as an adjunct in the management of acne vulgaris and rosacea. (wikipedia.org)
  • Acne inversa (L. invertō, "upside down") and acne rosacea (rosa, "rose-colored" + -āceus, "forming") are not true forms of acne and respectively refer to the skin conditions hidradenitis suppurativa (HS) and rosacea. (wikipedia.org)
  • infection
  • Although antibiotics have been used for decades to treat acne vulgaris, acne is not a traditional infection. (aafp.org)
  • P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections e.g., surgery, post-neurosurgical infection, joint prostheses, shunts and prosthetic heart valves. (wikipedia.org)
  • Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory response - the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. (wikipedia.org)
  • scars
  • Expression of innate immunity markers in non-affected and inflammatory skin of patients prone to scars and not prone to scars. (jle.com)
  • B) Thesame markers were significantly differently expressed in the inflammatory skin (papules) of the same patients prone to scars and not prone to scars. (jle.com)
  • Expression of metalloproteinases and their regulators in non-affected and inflammatory skins of patients prone to scars and not prone to scars. (jle.com)
  • Difference of the profile of innate immunity of uninvolved epidermis between acne patients prone to scars or not. (jle.com)
  • The expression of TLR-4 and at a lesser level TLR-2 are higher in acne patients developing scars. (jle.com)
  • The ratio of cytokines IL-2/ IL-10 is decreased in acne patients developing scars linked both to a decrease of IL-2 and an increase of IL-10. (jle.com)
  • Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for approximately 75% of all acne scars). (wikipedia.org)
  • reduction
  • The Wall Street Journal describes that "Although the company knew when it began work on treating acne that nitric oxide has a beneficial effect on hypertension, it didn't expect to see such a strong reduction of blood pressure in the [acne] study. (wikipedia.org)
  • treat
  • Consequently, some authors argued that it should not be used to treat relatively harmless diseases like acne vulgaris, risking the development of quinolone resistances. (wikipedia.org)
  • The gel is used on the skin to treat light to medium acne vulgaris in people 12 years and older. (wikipedia.org)
  • antibiotics
  • Although it is often claimed that the more expensive once-daily slow-release preparation is a more attractive option to teenagers with acne, the evidence in this review does not show it to be any better or safer compared to other oral antibiotics that have to be taken more frequently. (cochrane.org)
  • Antibiotics and retinoids are available in formulations that are applied to the skin and taken by mouth for the treatment of acne. (wikipedia.org)