• vitro
  • Our previous research showed that in vitro human Tenon's fibroblast produced interferon β was responsible for preventing T cell apoptosis, suggesting that this interaction could contribute to the development of chronic inflammation. (bmj.com)
  • progression
  • As the use of natural product supplements by RA patients is increasing, this paper presents timely and useful information about the mechanism of action of promising herbal products that can inhibit the progression of inflammation and bone damage in the course of arthritis. (hindawi.com)
  • 2, 8 In addition, increased inflammation has been implicated in disease progression in the fibrosing conjunctival disease ocular cicatricial pemphigoid. (bmj.com)
  • Cancer
  • Notably, this obesity-inflammation-aromatase axis provides a plausible explanation for increased rates of post-menopausal, hormone receptor-positive breast cancer associated with obesity and hence may offer targets for interventions to attenuate risk or improve prognosis. (aacrjournals.org)
  • cells
  • Consistent with this, adoptive transfer of effector Th2 cells into naive mice followed by exposure to inhaled Ag induces features of asthma, including eosinophilic inflammation, mucus hypersecretion, and AHR ( 11 , 12 , 13 , 14 ), demonstrating that these cells are fully capable of producing the asthma phenotype. (jimmunol.org)
  • A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation. (wikipedia.org)
  • Both CD4 and CD8 IL-17 producing T cells have been shown to cause aTH1, causing tissue inflammation and resulting in severe GVHD. (wikipedia.org)
  • therapeutic
  • Furthermore, phenolic compounds might have a preventive and/or therapeutic utility in chronic inflammation such as IBD, and therefore, they should be further analyzed in in vivo studies to consolidate these findings. (unibas.ch)
  • Understanding how sunburn is resolved, will increase our understanding of skin inflammation and can facilitate the discovery of new therapeutic agents. (isrctn.com)
  • STAT6-mediated chemokine production in the lung is required for Th2 lymphocyte and eosinophil homing into the airways in allergic pulmonary inflammation, and thus is a potential therapeutic target in asthma. (jimmunol.org)
  • microglia
  • These mediators are important in the normal functions of microglia and their production is usually decreased once their task is complete. (wikipedia.org)
  • release
  • RU486 significantly blocked the effect of DEX, but no correlations were found between the inhibition of mediator release and the K d or receptor number. (hindawi.com)
  • response
  • Chronic inflammation may develop from failure of the immune system to deactivate itself during resolution of the wound healing response, and is recognised as a major risk factor for trabeculectomy failure. (bmj.com)
  • Although the response is initiated to protect the central nervous system from the infectious agent, the effect may be toxic and widespread inflammation as well as further migration of leukocytes through the blood-brain barrier. (wikipedia.org)
  • cases
  • In most cases, the airway inflammation characteristic of asthma results from an allergic-type reaction to an inhaled substance from the environment (allergic asthma). (jimmunol.org)