Tumor Necrosis Factor-alphaReceptors, Tumor Necrosis FactorInflammationReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IICytokinesInterleukin-1LipopolysaccharidesInterleukin-6Cells, CulturedNF-kappa BNecrosisRNA, MessengerInterferon-gammaMacrophagesMice, Inbred C57BLCell LineMonocytesSignal TransductionLymphotoxin-alphaRecombinant ProteinsInflammation MediatorsApoptosisMice, Inbred BALB CGene Expression RegulationDisease Models, AnimalAntibodies, MonoclonalArthritis, RheumatoidTumor Necrosis FactorsMice, KnockoutInterleukin-8Interleukin-10Gene ExpressionTransforming Growth Factor alphaDose-Response Relationship, DrugReverse Transcriptase Polymerase Chain ReactionTime FactorsInterleukin-1betaMolecular Sequence DataMacrophage ActivationAntigens, CDSynovial MembraneAntirheumatic AgentsTumor Necrosis Factor Decoy ReceptorsUp-RegulationNeutrophilsBase SequenceEnzyme-Linked Immunosorbent AssayAnti-Inflammatory AgentsCell Line, TumorLeukocytes, MononuclearTransfectionTumor Cells, CulturedMembrane GlycoproteinsFlow CytometryEndotoxinsT-LymphocytesLungMacrophages, PeritonealBlotting, WesternImmunohistochemistryDown-RegulationI-kappa B ProteinsCell SurvivalFibroblastsDrug SynergismCell DivisionEnzyme ActivationIntercellular Adhesion Molecule-1Endothelium, VascularTranscription, GeneticPromoter Regions, GeneticNitric OxideBiological MarkersLiverPentoxifyllineI-kappa B KinaseMice, Inbred C3HImmunoglobulin GTranscription Factor RelAInterleukin-12TNF Receptor-Associated Factor 2Receptors, Cell SurfacePhosphorylationInterleukinsGranulocyte-Macrophage Colony-Stimulating FactorKineticsRats, Sprague-DawleyAntigens, CD14Tumor Markers, BiologicalSpleenArthritis, ExperimentalDendritic CellsLymphocyte ActivationMice, TransgenicNitric Oxide Synthase Type IITumor Necrosis Factor Receptor-Associated Peptides and Proteinsp38 Mitogen-Activated Protein KinasesPolymerase Chain ReactionAntibodies