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OvalbuminInflammationOviductsInflammation MediatorsMice, Inbred C57BLDisease Models, AnimalBronchoalveolar Lavage FluidBronchial HyperreactivityLungMice, Inbred BALB CCytokinesAllergensRespiratory HypersensitivityChickensAsthmaImmunoglobulin EPneumoniaEosinophilsHypersensitivityMice, KnockoutCOUP Transcription Factor IAnti-Inflammatory AgentsAntigensTh2 CellsTumor Necrosis Factor-alphaInterleukin-6NeutrophilsNeurogenic InflammationMacrophagesCells, CulturedRNA, MessengerCOUP Transcription Factor IICOUP Transcription FactorsBiological MarkersConalbuminLipopolysaccharidesMethacholine ChlorideC-Reactive ProteinInterleukin-5Rats, Inbred BNMice, TransgenicImmunizationOvomucinDermatitisColitisImmunoglobulin GSignal TransductionPulmonary EosinophiliaGene Expression RegulationAirway RemodelingEosinophiliaNF-kappa BChemokinesGoblet CellsInterleukin-13Enzyme-Linked Immunosorbent AssayLeukocytesT-LymphocytesEdemaTime FactorsCarrageenanInterferon-gammaInterleukin-1betaInterleukin-4Respiratory SystemImmune ToleranceGuinea PigsLeukocyte CountHypersensitivity, DelayedFreund's AdjuvantMucusBronchiIntestinal MucosaChronic DiseaseDendritic CellsEgg WhiteAdjuvants, ImmunologicSpleenPassive Cutaneous AnaphylaxisPeroxidaseNeutrophil InfiltrationCD4-Positive T-LymphocytesFood HypersensitivityChemokine CCL2DiethylstilbestrolAnaphylaxisImmunohistochemistryBronchoconstrictor AgentsAnti-Inflammatory Agents, Non-SteroidalOxidative StressReverse Transcriptase Polymerase Chain ReactionMast CellsInterleukin-8Arthritis, ExperimentalAirway ResistanceBronchoconstrictionRats, Sprague-DawleyInterleukin-10SkinLymphocyte Activation
HyperresponsivenessMice were sensitizedPulmonary inflammationAsthmaDemonstrated that airway inflammationMurineAsthmaticLung inflammation modelBALBAntigen-induced airwaySkin Inflammation in MiceGuinea pigsEosinophilic inflammationAllergenSensitizationInhibit inflammationAcuteAssessment of inflammationSignificantlyMaturationTransgenicBronchoalveolar lavageLungsHistopathologicalCytokinesAntitumorAngiogenesisMediatorsExposureEdemaAbstractExhibitHyperreactivityInflammatory cellsVivoSuppressExtractInhalationProtectiveSeverityResultsSecretionTreatment
Hyperresponsiveness6
  • INTRODUCTION: Several studies have shown the importance of Rho-kinase in the modulation of smooth muscle contraction, airway hyperresponsiveness and inflammation. (usp.br)
  • METHODS: We evaluated the effects of chronic treatment with Y-27632, a highly selective Rho-kinase inhibitor, on airway hyperresponsiveness, oxidative stress activation, extracellular matrix remodeling, eosinophilic inflammation and cytokines expression in an animal model of chronic airway inflammation. (usp.br)
  • However, it remains unclear whether myricetin alleviates airway hyperresponsiveness (AHR), airway inflammation, and oxidative stress in asthma. (bvsalud.org)
  • Amish dust extracts, however, were able to significantly inhibit ovalbumin-induced airway hyperresponsiveness, bronchoalveolar lavage eosinophilia , and serum ovalbumin-specific IgE. (medscape.com)
  • Genetically engineered mice with targeted nmMLCK deletion (nmMLCK -/- ) exhibited significant reductions in lung inflammation and airway hyperresponsiveness. (northwestern.edu)
  • The relationship between inflammation, remodeling changes, and airway hyperresponsiveness (AHR) were examined. (monash.edu)
Mice were sensitized2
  • Female BALB/c mice were sensitized and challenged with ovalbumin (OVA), and administered different doses of mulberroside F via intraperitoneal injection. (bvsalud.org)
  • These mice were sensitized to exhibit ovalbumin-mediated allergic inflammation. (northwestern.edu)
Pulmonary inflammation3
  • Furthermore, in the context of respiratory research, local expertise include a large number of animal models including bleomycin-induced pulmonary inflammation and fibrosis, endotoxin- and ventilation- induced acute lung injury, ovalbumin-induced pulmonary allergic inflammation, as well as KRAS-driven or chemically-induced lung cancer. (ersnet.org)
  • RESULTS: Control mice exposed to inhaled OVA showed no evidence of pulmonary inflammation, indices of remodeling, or airway hyper-reactivity. (ox.ac.uk)
  • The goal of this study was to investigate the impact of multiple exposomal factors (genetics, lifestyle factors, environmental/occupational exposures) on pulmonary inflammation and corresponding alterations in local/systemic immune parameters. (cdc.gov)
Asthma14
  • Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. (ersjournals.com)
  • Airway inflammation is a central feature of bronchial asthma. (ersjournals.com)
  • Inhaled corticosteroids suppress airway inflammation, which is responsible for asthma-associated changes of the airway vasculature. (ersjournals.com)
  • Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5. (jci.org)
  • In the present study, we investigated the possible protective effect of cinnamic acid (CA) on ovalbumin-induced asthma in a mouse model. (edu.iq)
  • Study the Anti-Asthmatic Activity of Guggulsterone in Ovalbumin-Induced Asthma in Rat. (edu.iq)
  • The 'classical' ovalbumin challenge model of asthma in mice. (edu.iq)
  • These results suggested that myricetin could effectively improve asthma symptoms, mainly through blocking Th2-cell activation, which reduced oxidative stress, AHR, and airway inflammation. (bvsalud.org)
  • To investigate the suspicion that the house dust was in itself the immune-modifying agent, the investigators compared the effects of Amish vs Hutterite house dust in a classic ovalbumin mouse model of allergic asthma . (medscape.com)
  • gene code, MYLK) is a multifunctional enzyme involved in isoform-specific nonmuscle (nm) and smooth muscle contraction, inflammation, and vascular permeability, processes directly relevant to asthma pathobiology. (northwestern.edu)
  • Researchers are investigating the benefits of lifestyle changes and alternative asthma treatments, including the ability of bromelain to inhibit inflammation. (todayspractitioner.com)
  • CONCLUSIONS: Innate epithelial-derived mediators are sufficient to drive airway hyper-reactivity and remodeling in response to environmental insults in the absence of overt Th2-type inflammation in a model of noneosinophilic, noninflammed types of asthma. (ox.ac.uk)
  • Our aim was to investigate the effects of intranasal application of S1P on antigen-induced airway inflammation in a mouse model of allergic bronchial asthma. (openrespiratorymedicinejournal.com)
  • Although the relationship between allergic inflammation and lung carcinogenesis is not clearly defined, several reports suggest an increased incidence of lung cancer in patients with asthma. (upatras.gr)
Demonstrated that airway inflammation1
  • Recently, a study demonstrated that airway inflammation in ovalbumin-induced mice was ameliorated through the inhibition of TLR4/NF- κ B signaling [ 14 ]. (hindawi.com)
Murine1
Asthmatic6
  • Ambient particulate matter (PM), a component of air pollution, exacerbates airway inflammation and hyper-reactivity in asthmatic patients. (cdc.gov)
  • Here, we investigated whether myricetin attenuated AHR, airway inflammation, and eosinophil infiltration in lungs of asthmatic mice. (bvsalud.org)
  • Mulberroside F is isolated from the leaves and roots of Morus alba L. Here, we investigated whether mulberroside F could alleviate airway inflammation and eosinophil infiltration in the lungs of asthmatic mice. (bvsalud.org)
  • Conversely, mice with overexpressed nmMLCK in endothelium (nmMLCK ec/ec ) exhibited elevated susceptibility and severity in asthmatic inflammation. (northwestern.edu)
  • In addition, reduction of nmMLCK expression in pulmonary endothelium by small interfering RNA results in reduced asthmatic inflammation in wild-type mice. (northwestern.edu)
  • These pathophysiological assessments demonstrate the positive contribution of nmMLCK to asthmatic inflammation, and a clear correlation of the level of nmMLCK with the degree of experimental allergic inflammation. (northwestern.edu)
Lung inflammation model2
BALB3
  • Surprisingly, Th1 cells did not attenuate Th2 cell-induced airway hyperreactivity and inflammation in either SCID mice or in OVA-immunized immunocompetent BALB/c mice, but rather caused severe airway inflammation. (jci.org)
  • The aim of this study was to assess how exposure to fine PM collected from Sacramento, CA, shapes the allergic airway immune response in BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA). (cdc.gov)
  • Male BALB/c mice were actively sensitized with ovalbumin antigen, and were repeatedly challenged with aerosolized antigen. (openrespiratorymedicinejournal.com)
Antigen-induced airway1
Skin Inflammation in Mice1
Guinea pigs1
  • Guinea pigs were submitted to seven ovalbumin or saline exposures (twice a week for four weeks). (usp.br)
Eosinophilic inflammation1
  • Pulmonary eosinophilic inflammation was not evident, and there was no change in serum IgE or IgG1 levels. (ox.ac.uk)
Allergen2
  • Particulate matter (PM), a component of air pollution, has been shown to enhance allergen-mediated airway hypersensitivity and inflammation. (cdc.gov)
  • 4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
Sensitization2
  • Total cell count, tissue TNF- α, IL -33, and serum IgE increased considerably after sensitization to ovalbumin (OVA), while GSH levels decreased significantly. (edu.iq)
  • Animals were exposed to intranasal ovalbumin (OVA) without systemic sensitization. (ox.ac.uk)
Inhibit inflammation1
  • In diabetes mellitus, Ficus formosana has been reported to ameliorate blood sugar levels and inhibit inflammation through its polyphenol and flavonoid contents. (bvsalud.org)
Acute2
  • We examined the sequence of events in remodeling using three commonly used mouse models of allergic airways disease in which mice are exposed to nebulized ovalbumin for four consecutive days (acute), seven consecutive days (subacute), or three times a week for 6 wk (chronic). (monash.edu)
  • The acute and subacute models exhibited marked airway inflammation, whereas the chronic model had very modest inflammation. (monash.edu)
Assessment of inflammation2
  • The endpoints of this basic protocol include the assessment of inflammation via cells recovered from broncho-alveolar lavage (BAL), histopathological analysis, gene expression profiles, and protein quantification of inflammatory markers. (cdc.gov)
  • Additionally, the intraepidermal and sciatic nerve sections were examined, along with an assessment of inflammation- and pain response-related mRNA expression in the paws of the mice. (bvsalud.org)
Significantly1
  • Mice in the OVA + PM/OVA group displayed significantly increased airway inflammation compared to OVA/OVA animals. (cdc.gov)
Maturation2
  • FURIN was required for the normal production of the bioactive TGF-β1 cytokine, but it inhibited the maturation of the inflammation-provoking TACE and Caspase-1 enzymes. (oncotarget.com)
  • The study found that a specific mix (five species) of probiotic supplement accelerated the maturation of the microbiome into a term-like state and reduced intestinal inflammation in extremely preterm infants. (arrietalab.com)
Transgenic1
  • Th1, Th2, and Th0 lines were generated from ovalbumin (OVA)-specific T-cell receptor (TCR) transgenic mice and transferred into lymphocyte-deficient, OVA-treated severe combined immunodeficiency (SCID) mice. (jci.org)
Bronchoalveolar lavage2
Lungs3
  • Therefore, deregulation of miRNAs was assessed in whole lungs from mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI). (edu.au)
  • HDAC-2 function is impaired by oxidative stress in a PI3Kδ dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD patients. (biomedcentral.com)
  • We aimed at determining the functional impact of allergic inflammation on chemical carcinogenesis in the lungs of mice. (upatras.gr)
Histopathological1
  • Histopathological grading indicated that OVA + PM/OVA treatment induced significant inflammation compared to OVA/OVA. (cdc.gov)
Cytokines1
  • During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Antitumor1
  • Hyperforin is a type of bicyclic tetraketone with four isoprenoid chains extracted from Hypericum perforatum L. that has multiple biological activities such as anti‑diabetes, antitumor and anti‑inflammation. (spandidos-publications.com)
Angiogenesis1
  • Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
Mediators1
  • Inflammation is central in COPD development and the release of inflammatory mediators and destructive enzymes by inflammatory cells implicated in the progressive destruction of the lung in COPD [ 6 ]. (hindawi.com)
Exposure2
  • Surprisingly, we found that a very short period of exposure to ovalbumin was sufficient to elicit early changes of remodeling. (monash.edu)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
Edema1
  • In traditional Korean medicine (TKM), TF is used for improving eye trouble, as well as liver and kidney disorders, cutaneous pruritus, edema, inflammation, and tracheitis in skin diseases [ 13 ]. (hindawi.com)
Abstract1
Exhibit2
  • Cnp −/− mice exhibit early low-grade inflammation of white matter tracts and blood-brain barrier disruption. (nature.com)
  • Brazilian green propolis, a beeswax product, has been shown to exhibit multiple actions on inflammation and tissue repair. (blogspot.com)
Hyperreactivity1
  • OVA-specific Th2 and Th0 cells induced significant airway hyperreactivity and inflammation. (jci.org)
Inflammatory cells1
  • 1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues. (hindawi.com)
Vivo1
Suppress1
  • Corticosteroids are the most effective drugs to suppress airway inflammation, mainly by downregulation of pro-inflammatory proteins 22 , 23 . (ersjournals.com)
Extract2
  • The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation. (hindawi.com)
  • In this study, we investigated the effects of TF extract on skin inflammation in an AD animal model and also investigated the mechanism responsible for the effects of TF extract in AD on the modulation of calcium channels and the activation of mast cells. (hindawi.com)
Inhalation1
  • 2016). Thus, mice lacking B cells had less TFH cells and an increase Tedalinab in TRM cells, explaining why B cell deficient mice had increased airway inflammation when challenged with HDM inhalation long after the priming period (Hondowicz et al. (icem2012.org)
Protective2
Severity1
  • The main treatment for AD is skin hydration with emollients and suppression of cutaneous inflammation using topical steroids to reduce the number and severity of flares [ 1 ]. (hindawi.com)
Results2
  • This further results in decreased inflammation as measured by reduced MMP-9 levels in the tear fluid and decreased ocular surface damage as measured by corneal and conjunctival staining during the supplementation. (springer.com)
  • In summary, the present results revealed that hyperforin suppressed IL‑13‑induced nasal epithelial cell inflammation and barrier damage by targeting BCL6/p38 MAPK/CCL11, which may provide promising therapeutic targets for AR. (spandidos-publications.com)
Secretion1
  • Dry eye syndrome (DES) is a multifactorial disease of the ocular surface associated with reduced tear secretion, increased osmolarity of the tears and inflammation that may lead to ocular surface damage. (springer.com)
Treatment1