Inflammation obesity. Medical search. Frequent questions

Obesity and diabetes lead to chronic inflammation beyond which an acute sensory stimulation no longer has any effect. (medicalnewstoday.com)
Shifting this balance by either reducing one or increasing the other could provide a new therapeutic approach to preventing and treating obesity and several obesity-related conditions," said Zhen Jiang, Ph.D., assistant professor in Sanford-Burnham's Diabetes and Obesity Research Center at Lake Nona, Orlando and senior author of the study. (medindia.net)
Scientists at the University of Illinois have developed new hybrids of purple corn containing different combinations of phytochemicals that may fight obesity, inflammation and diabetes, a new study in mice indicates. (news-medical.net)
The smaller phenols such as quercetin, luteolin and rutin - which are present in many plant foods - played key roles in reducing some of the obesity, inflammation and some markers of Type 2 diabetes, de Mejia said. (news-medical.net)
There is a global epidemic in obesity in adults and children, with obese people predisposed to develop diabetes, cardiovascular disease, and cancer. (sciencedaily.com)
The scientists then showed that modifications in the so-called immune checkpoint proteins of mice on a Western "high fat" diet were linked to dramatic reductions in the development of obesity and diabetes. (sciencedaily.com)
Prof. Fallon commented: "This new process of checkpoint regulation of cells in visceral fat of obese individuals advances our understanding of how the immune system controls diet-induced weight gain that can lead to conditions such as obesity and type 2 diabetes. (sciencedaily.com)
The study investigated inflammatory changes in patients with obesity, with or without type 2 diabetes, in collaboration with Dr Andy Hogan (Maynooth University), Profs. (sciencedaily.com)
1 The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research and Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA. (nih.gov)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
An interdisciplinary collaborative study published in MDPI suggests that the daily consumption of pecans may help to prevent obesity as well as reduce inflammation that leads to associated health issues such as diabetes and fatty liver disease. (worldhealth.net)
Moreover, the severity of hypothalamic inflammation and gliosis has been related to comorbid conditions, including glucose intolerance, insulin resistance, type 2 diabetes, and low testosterone levels in men, independent of elevated body adiposity. (nih.gov)
OBJECTIVE- Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown. (diabetesjournals.org)
RESEARCH DESIGN AND METHODS- We changed gut microbiota by means of antibiotic treatment to demonstrate, first, that changes in gut microbiota could be responsible for the control of metabolic endotoxemia, the low-grade inflammation, obesity, and type 2 diabetes and, second, to provide some mechanisms responsible for such effect. (diabetesjournals.org)
Environmental factors, such as a fat-enriched diet and a sedentary lifestyle, are the causes of the great prevalence of obesity and type 2 diabetes in the population ( 1 ). (diabetesjournals.org)
But now we have a secondary prevention trial of people with obesity who have established cardiovascular disease but do not have diabetes, and the drug reduces major adverse cardiovascular events. (medscape.com)
Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management (Contemporary Endocrinology) free ebook download. (freebookspot.eu)
Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. (freebookspot.eu)
Chronic inflammation occurs in diseases such as asthma, rheumatoid arthritis, and type 2 diabetes. (medicalnewstoday.com)
Trans fats may increase inflammatory markers and the risk of chronic inflammation, which can lead to diseases such as diabetes and cardiovascular disease. (medicalnewstoday.com)
is an self-employed risk element for systemic diseases including diabetes liver Cyclocytidine cirrhosis and chronic kidney disease (CKD) (Borgeson and Sharma 2013 Ix and Sharma 2010 Rate of metabolism is closely linked to the immune system and chronic non-resolving swelling is considered a driving pressure of obesity-related pathologies. (crispr-reagents.com)
A review of 4,103 patients found that obesity and its resultant inflammation, heart disease and diabetes are the most common conditions found in patients requiring hospitalization with COVID-19 ( Physician's Weekly , pre-print, April 14, 2020). (drmirkin.com)
During the 1957-1960 Asian flu and the 1968 Hong Kong flu, both obesity and diabetes were associated with a marked increase in prolonged illness and death ( Prev Med , 2013;56(2):118-123), even in those who were apparently healthy before they got the flu ( Influenza Other Respiratory Viruses , 2019;13:3-9). (drmirkin.com)
People who have high levels of leptin and low levels of adiponectin suffer from inflammation to cause diabetes (insulin insensitivity), infections (high white blood cell counts), and heart, liver and kidney damage ( Nat Rev Immunol , 2011;11(2):85-97). (drmirkin.com)
Skeletal muscle insulin resistance is a major characteristic of obesity and type 2 diabetes. (oregonstate.edu)
Overall, these results demonstrate IL-10 effects to attenuate obesity-mediated inflammation and improve insulin sensitivity in skeletal muscle, and our findings implicate a potential therapeutic role of anti-inflammatory cytokines in treating insulin resistance and type 2 diabetes. (oregonstate.edu)
It's important to note that obesity and Type-2 diabetes are two of the underlying conditions that increased infectious disease mortality during the COVID-19 crisis. (naturalnews.com)
But, the rise in the prevalence of obesity that's happened over the last 3 decades has made it clear that it's creating a burden of chronic disease ranging from cardiovascular disease to diabetes to many cancers, and really diseases, chronic diseases of virtually every organ system in the body so you can't really afford to think of it as a cosmetic condition. (ajmc.com)
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. (jci.org)
Chronic inflammation following prolonged signaling of cytokine receptors is a critical process in the pathogenesis of many inflammatory disorders, including autoimmunity, obesity, psoriasis, type 1 diabetes, endometriosis, preeclampsia and Alzheimer's disease. (lu.se)
ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
Replication studies identify several genetic variants in Arabs with obesity- linked diabetes. (who.int)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
Gaps exist in our information about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)

In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)
Our study also showed that Ucp2 deletion alleviates HFD-induced weight gain and adipose tissue inflammation by blocking adipocyte apoptosis, an event preceding the recruitment of macrophages and proinflammatory cytokine secretion. (bmbreports.org)

This study aimed to investigate alterations in KYN and microbiota-mediated indole routes of TRP metabolism in obese subjects relatively to non-obese controls and to determine their relationship with systemic inflammation. (frontiersin.org)
High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of systemic inflammation using enzyme-linked immunosorbent assay. (frontiersin.org)
These results indicate for the first time that KYN and indole TRP metabolic pathways are concomitantly altered in obese subjects and highlight their respective associations with obesity-related systemic inflammation. (frontiersin.org)
Systemic inflammation in obesity originates primarily from the adipose tissue, in which adipocytes and infiltrated immune cells accumulate and secrete inflammatory factors ( 2 - 5 ). (frontiersin.org)
Individuals with obesity may also be more sensitive to stress potentially leading to greater systemic inflammation (Agustí et al 2018). (nutritionalresourcesinc.com)
Whole grains including whole-wheat, oats, quinoa, brown rice, and barley may reduce systemic inflammation by reducing inflammatory markers throughout the body (Xu et al 2018). (nutritionalresourcesinc.com)
HsCRP is a protein made by the liver that is associated with increased systemic inflammation, and IL-6 promotes inflammation by allowing inflammatory proteins in the body to be expressed. (crohnscolitisprofessional.org)
Eagle explained that the blood biomarkers spiked at different times in the obese mTBI patients mainly because hsCRP is a marker of systemic inflammation, whereas IL-6 is more often associated with trauma. (crohnscolitisprofessional.org)
2013 In addition to the low-grade systemic swelling obesity is associated with significant adipose swelling (Donath et al. (crispr-reagents.com)
Here we explored the restorative potential of LXA4 in experimental obesity-induced systemic disease. (crispr-reagents.com)
We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. (jci.org)
Obese participants had elevated markers of systemic inflammation up to 6 months post-mTBI and higher symptomatology up to 1 year post-mTBI. (bmj.com)
Background: Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. (cdc.gov)
Also obesity may induce low-grade systemic inflammation. (cdc.gov)
Results: At week 12, the GMA-SS exposure induced pulmonary inflammation in both strains, without consistent changes in markers of systemic inflammation (CRP, MCP-1, IL-6 and TNFá). (cdc.gov)
The discovery of a form of low-grade systemic and chronic inflammation ("metaflammation"), linked to inducers (broadly termed "anthropogens") associated with modern man-made environments and lifestyles, suggests an underlying basis for chronic disease that could provide a 21st-century equivalent of the germ theory. (cdc.gov)

The findings suggest that targeting the inflammatory factor involved may improve the early insulin response in people with obesity. (medicalnewstoday.com)
Prof. Spector agreed: "The authors' conclusions that cephalic insulin response, which causes insulin secretion before any food is consumed, such as when we see food or smell food, is inhibited in people with obesity due to chronic inflammation associated with obesity is likely to be part of the answer. (medicalnewstoday.com)
IL-1β […] signaling seems to be responsible for some of the vagus nerve stimulation that results in insulin secretion after sensory exposure to food, and a dysfunction in this signaling in people with obesity is likely impacting their cephalic insulin response," he added. (medicalnewstoday.com)
It will be interesting to investigate now how we can manipulate this checkpoint on specific cell populations of interest to help people with obesity. (sciencedaily.com)
This disappearing act could explain why some people with obesity seem to have a weakened sense of taste, which may compel them to eat more. (sciencenews.org)

We observed very important changes in molecules that reduced oxidative stress and inflammation in the insulin-resistant adipocytes,' Luna-Vital said. (news-medical.net)
This effect was correlated with reduced glucose intolerance, body weight gain, fat mass development, lower inflammation, oxidative stress, and macrophage infiltration marker mRNA expression in visceral adipose tissue. (diabetesjournals.org)
Evidence indicates that DPM exposure may cause respiratory symptoms via inflammation and oxidative stress (Ristovski et al. (cdc.gov)

This study highlights the complexity of our individual metabolic responses to food, and why understanding chronic low-grade inflammation over time is key in addressing obesity. (medicalnewstoday.com)
How do high neutrophil elastase levels increase inflammation and cause weight gain and other metabolic problems? (medindia.net)
Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. (nih.gov)
HsIL-6 and hsCRP were increased in obesity and were overall associated with TRP metabolic pathways alterations. (frontiersin.org)
Obesity is a metabolic disorder characterized by a chronic low-grade inflammatory state, as reflected in increased levels of circulating inflammatory markers, including pro-inflammatory cytokines and the acute phase protein C-reactive protein (CRP) ( 1 - 4 ). (frontiersin.org)
CONCLUSIONS- This new finding demonstrates that changes in gut microbiota controls metabolic endotoxemia, inflammation, and associated disorders by a mechanism that could increase intestinal permeability. (diabetesjournals.org)
We thought that inflammation leads to metabolic disease, but actually we need some localized inflammation to prevent metabolic disease. (conscienhealth.org)
Coconut oil supplements over a long period of time may have a major impact on the metabolic changes in diet that can lead to obesity. (medindia.net)

These investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM MHCII, escalates its progression. (nih.gov)
the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
Of these, only the macrophages associated with pyroptotic adipocyte deaths decreased after laparoscopic Roux-en-Y gastric bypass for obesity. (oulu.fi)
Our study suggests that Ucp2 deficiency may prevent diet-induced obesity by regulating adipocyte apoptosis. (bmbreports.org)
Click here to read Sargent's commentary and here to read the study of adipocyte inflammation. (conscienhealth.org)
Number 1 Lipoxins attenuated adipose swelling and shift adipose macrophage phenotype towards resolution system comprised of inflammatory MΦs and hypertrophic adipocytes where the second option resemble the adipocyte biology seen in obesity (Yoshizaki et al. (crispr-reagents.com)
Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulation in adipose tissue via Toll-like receptor 9 (TLR9), originally known as a sensor of exogenous DNA fragments. (tokushima-u.ac.jp)

Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models. (nih.gov)
Diet-induced obesity is closely related to macrophage infiltration and the secretion of pro-inflammatory cytokines. (bmbreports.org)
We have demonstrated that Ucp2 deletion dysregulates adipose tissue homeostasis under diet-induced obesity (DIO), but does not affect the browning of white adipose tissue (WAT). (bmbreports.org)

Those mice were also protected against inflammation, insulin resistance, and fatty liver. (medindia.net)
Normal mice on a high-fat diet were also protected against inflammation, insulin resistance, and fatty liver when they were given a chemical compound that inhibits neutrophil elastase. (medindia.net)
To examine the impact of anthocyanins on obesity-induced inflammation, then-graduate student and first author of the study Qiaozhi Zhang combined fat cells - called adipocytes - from mice with large immune cells called macrophages. (news-medical.net)
HFD-fed MHCII(-/-) mice developed less adipose inflammation and insulin resistance than did wild-type mice, despite developing similar adiposity. (nih.gov)
To study the role of Ucp2 in adipose tissue, we have examined HFD-induced obesity and β3 adrenergic stimulation in Ucp2 KO mice. (bmbreports.org)
In the new study, the researchers fed mice a fast food-like diet rich in fat for four weeks, which is known to cause microglia to expand in number and to trigger local inflammation within the MBH. (sciencedaily.com)
To learn whether the multiplying microglia are a cause of overeating and obesity in these mice, rather than a result of their weight gain, Koliwad's team at UCSF depleted the number of microglia in the MBH of mice on the fatty diet by giving them an experimental drug, called PLX5622, which is made by Plexxikon Inc., a Berkeley, California-based biotech company. (sciencedaily.com)
They found that even in mice fed a healthy, low-fat diet, forcing microglia-induced inflammation in the hypothalamus caused mice to eat 33 percent more food and expend 12 percent less energy, leading to a four-fold (400 percent) increase in weight gain compared to untreated mice on the same healthy diet. (sciencedaily.com)
When challenged with a high-fat diet, mice that received β1-/- bone marrow displayed enhanced adipose tissue macrophage inflammation and liver insulin resistance compared with animals that received WT bone marrow. (edu.au)
Here, we examined the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (M). After 16 weeks of a high-fat diet (HFD), M mice became markedly obese but showed improved insulin action compared to that of wild-type mice, which was largely due to increased glucose metabolism and reduced inflammation in skeletal muscle. (oregonstate.edu)
Since leptin regulates inflammation, the beneficial effects of interleukin-10 (IL-10) were further examined in leptin-deficient ob/ob mice. (oregonstate.edu)
Muscle-specific overexpression of IL-10 in ob/ob mice (MCK-IL10) did not affect spontaneous obesity, but MCK-IL10 mice showed increased glucose turnover compared to that in ob/ob mice. (oregonstate.edu)
Fat-fed Tlr9−/− mice demonstrated reduced macrophage accumulation and inflammation in adipose tissue and better insulin sensitivity compared with wild-type mice, whereas bone marrow reconstitution with wild-type bone marrow restored the attenuation of insulin resistance observed in fat-fed Tlr9−/− mice. (tokushima-u.ac.jp)

International Journal of Obesity (2019), Bd. (uni-tuebingen.de)

A new research study shows pecans may help prevent obesity and reduce inflammation. (worldhealth.net)
Nuts and seeds like walnuts, flax seeds, pumpkin seeds, and peanuts contain omega-3 fatty acids, which have been shown to reduce inflammation by reducing the substances and molecules within the body that spark inflammation (Calder 2010). (nutritionalresourcesinc.com)
Our hope is to build our research program to find treatments that reduce inflammation and improve overall health for obese patients after sustaining an mTBI," said Eagle. (crohnscolitisprofessional.org)

The imbalance between neutrophil elastase and its inhibitor, α1-antitrypsin, is likely an important contributing factor in the development of obesity, inflammation, and other health problems. (medindia.net)
A differential response in the development of obesity complications exists depending on WAT depot distribution. (springer.com)
In this review, we aim to describe the relationships and discussed sequence of events associated with hypoxia, ECM remodeling and inflammation in the development of obesity and associated complications. (springer.com)

Scientists have just identified how specific immune cells can work together in fat to cause inflammation that leads to weight gain and obesity. (sciencedaily.com)
Red and processed meats are high in saturated fats , which can cause inflammation in fat tissue. (medicalnewstoday.com)
High levels of leptin turn on your immune system to cause inflammation, and reduce levels of adiponectin, a hormone that reduces inflammation. (drmirkin.com)

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an imbalance between an enzyme called neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. (medindia.net)
However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
While the impact of maternal obesity on immune function of mother and child is relatively unknown, animal models reveal that obesity and/or high-fat feeding during pregnancy have detrimental effects on the development of the pancreas, liver, and the central and peripheral nervous systems. (swan.ac.uk)
Increased inflammation is also associated with asthma, atherosclerosis, heart disease, non-alcoholic fatty liver disease, and cancer ( 1 ). (lluniversity.com)

The American Gastroenterological Association has released new guidelines recommending prescription medication along with lifestyle changes to treat obesity. (healthline.com)
Here are some of her recommendations when considering medication to treat obesity. (healthline.com)
Neurons within a region at the base of the brain known as the hypothalamus, which plays a crucial role in eating, have long been a target for the development of drugs to treat obesity. (sciencedaily.com)
Is It Time for Cardiologists to Treat Obesity? (medscape.com)

In this review, we aim to describe two hypotheses trying to explain the sequence of events linking fibrosis, inflammation and obesity complications. (springer.com)
Obesity rates in the United States have increased over the past 20 years from 30% to nearly 42%, leading to health complications, according to the study authors. (healthline.com)
Obese people suffer increased risk for complications from infections because obesity leads to an overactive immune system called inflammation (Adv Nutr. (drmirkin.com)

In this thesis, two behaviorally distinct macrophage pools are identified in subcutaneous adipose tissue of subjects with obesity. (oulu.fi)
In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)

People with overweight and obesity have an excessive inflammatory response which impairs insulin secretion. (medicalnewstoday.com)
However, in people with overweight or obesity, an excessive inflammatory response during the cephalic phase can impair this insulin secretion. (medicalnewstoday.com)
In addition to the temporal and contractile association with the inflammatory response, our data suggest inflammation occurs in response to myocyte cellular damage regardless of mode of damage e.g. contractile or chemically induced. (gla.ac.uk)
In this type of inflammation, our immune systems initiate an inflammatory response even though there is no virus or injury to protect against. (lluniversity.com)
The study is the first to investigate if obesity impacts the relationship between recovery time, symptoms and increased inflammatory response in mTBI patients. (crohnscolitisprofessional.org)
However, no research had been conducted examining the way that obesity could possibly mediate the inflammatory response and mTBI symptoms in humans. (crohnscolitisprofessional.org)
Obesity and mild traumatic brain injury (mTBI) are associated with inflammation, but little is known about whether obesity moderates the relationship between mTBI and inflammatory response. (bmj.com)

Cross-sectional findings are augmented by a small number of prospective studies suggesting that a greater degree of hypothalamic inflammation and gliosis may predict adiposity gain and worsening insulin sensitivity in susceptible individuals. (nih.gov)
Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity. (jci.org)

In the Western countries, cutoff points of 25 and 30 kg/m2 are used for describing overweight and obesity. (benthamscience.com)

The fight against the obesity epidemic cannot wait two years. (medindia.net)
Obesity is a worldwide epidemic that affects half a billion people. (freebookspot.eu)
Obesity is a well-described epidemic in Westernized cultures. (jci.org)

This review summarizes and synthesizes available translational data to better understand the applicability of preclinical findings to human obesity and its comorbidities. (nih.gov)

Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. (frontiersin.org)

Their work pinpoints new avenues to exploit the regulation of that inflammation in fat tissue, thereby suggesting new ways to manage obesity [Wednesday 9th March 2022]. (sciencedaily.com)

Additionally, changes in the gut microbiota composition and permeability that have been highly documented in obesity ( 6 - 9 ), were also found to play a role in obesity-related inflammation ( 10 , 11 ). (frontiersin.org)
In conclusion, existing human studies corroborate a large preclinical literature demonstrating that hypothalamic neuroinflammatory responses play a role in obesity pathogenesis. (nih.gov)

Additionally, the researchers noted that the anti-inflammatory properties of the pecans were observed to reduce levels of low-grade inflammation that can lead to chronic inflammation and the development of a range of diseases. (worldhealth.net)
In addition, excessive sugar consumption may increase inflammatory markers in children and lead to chronic inflammation, according to a 2018 study . (medicalnewstoday.com)

In conclusion, the prevalence of obesity is increasing at an alarming rate in many parts of the world. (benthamscience.com)

Other studies show that obesity (body mass index or BMI greater than 30) is a major risk factor for dying from COVID-19 ( Lancet , April 1, 2020), and the more you weigh, the more likely you are to need to be put on a ventilator which markedly increases your chance of dying ( Obesity , April 9, 2020). (drmirkin.com)

Another condition that may be associated with both obesity and inflammation is rheumatoid arthritis or RA. (nutritionalresourcesinc.com)
It is well known that chronic inflammation is a cause of autoimmune diseases including rheumatoid arthritis, celiac disease and inflammatory bowel disease. (lluniversity.com)

This finding helps validate the team's conclusions about neutrophil elastase's role in inflammation and metabolism and also suggests that a medicinal drug could someday be developed to target this enzyme. (medindia.net)
A growing body of evidence indicates that inflammation is associated with alterations in the metabolism of tryptophan (TRP) ( 12 , 13 ), an essential amino acid and biochemical precursor of serotonin (5-HT), kynurenine (KYN) and indoles ( 14 ). (frontiersin.org)
Alterations in TRP metabolism in obese subjects may also arise from the gut microbiota, which has been shown to be disrupted both at compositional and functional levels in obesity ( 20 - 22 ). (frontiersin.org)
However, it is still unclear if adipocytes from other depots, such as intramuscular adipocytes, also emerging in the context of obesity and aging ( 6 ) can influence skeletal muscle metabolism, function, and mass. (diabetesjournals.org)
However, there was a clear contraction and time dependent transcriptional wave, with overrepresentation of genes associated with inflammation and cellular damage/apoptosis, and down-regulation of pathways concerning cellular metabolism. (gla.ac.uk)
Many of these changes relate to regulation of energy balance and metabolism but there is a growing appreciation of the impact of maternal obesity on inflammatory responses in many tissues of both mother and child. (swan.ac.uk)

The two disease states have been proposed to play off each other where obesity leads to inflammation and inflammation leads to symptoms that may trigger greater weight gain. (nutritionalresourcesinc.com)
HealthWise products can be of great assistance for those struggling with inflammation seen in conditions like RA and its associated signs and symptoms. (nutritionalresourcesinc.com)
Although many factors are involved in inflammation, certain foods may either increase or decrease the symptoms. (medicalnewstoday.com)
Many foods may worsen the symptoms of inflammation. (medicalnewstoday.com)
The objective was to assess the role of obesity in recovery of symptoms, functional outcome and inflammatory blood biomarkers after mTBI. (bmj.com)
For more than 2,000 years, classical inflammation has been recognized by the symptoms identified by the Roman physician Aurelius Celsus as pain ( dolor ), redness ( rubor ), heat ( calor ), and swelling ( tumor ), with the more recent addition of loss of function ( torpor ). (cdc.gov)

Prolonged fasting also activates genes that suppress inflammation and reduces inflammatory immune cells. (naturalnews.com)
Many things contribute to obesity, including your genes, your eating patterns, and how much activity you get. (webmd.com)
Addictive genes and the relationship to obesity and inflammation. (bvsalud.org)

Diet and nutritional habits represent the main contributors to obesity-related alterations in the gut microbiota given their major role in shaping intestinal bacteria environment. (frontiersin.org)

Conclusions Obesity is associated with higher symptomatology at 6 and 12 months and higher concentrations of blood inflammatory markers throughout recovery following mTBI. (bmj.com)
conclusions:="" inflammation="" demonstrated="" by="" fdg="" pet="" correlates="" endoscopic="" findings="" symptomatology="" gerd. (who.int)

Excess weight and obesity relate to multiple comorbidities, lost quality of life and mortality and cause major burden to healthcare and society. (oulu.fi)
The comorbidities related to obesity are increasingly viewed as a result of low-grade inflammation characterizing the state of excess adiposity. (oulu.fi)
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. (medindia.net)
From these experiments we can confidently say that the inflammatory activation of microglia is not only necessary for high-fat diets to induce obesity, but also sufficient on its own to drive the hypothalamus to alter its regulation of energy balance, leading to excess weight gain," said Thaler, who was a co-senior author on the new paper. (sciencedaily.com)
Doctors define obesity as a chronic (long-lasting) disease that results when have you have excess body fat that puts your health at risk. (webmd.com)
In this review, we discuss potential mechanisms by which brief nutrient excess and obesity lead to insulin resistance and propose that these mechanisms of action are different but interrelated. (jci.org)

The accumulation in adipose tissue of macrophages in an inflammatory state is a hallmark of obesity-induced insulin resistance. (edu.au)
Here, we reveal a role for AMPK β1 in protecting macrophages from inflammation under high lipid exposure. (edu.au)
β1-/- macrophages displayed increased levels of diacylglycerol and markers of inflammation, effects that were reproduced in WT macrophages by inhibiting fatty acid oxidation and, conversely, prevented by pharmacological activation of AMPK β1-containing complexes. (edu.au)

A major limitations on the study design in our particularly in central obesity, which is health issue in the Arab world is the ris- exclusion criteria. (who.int)
Is Physical Activity Associated With the Tethering and Migration of Pro-inflammatory Monocytes in White European and South Asian Males With and Without Central Obesity. (who.int)

Furthermore, in humans, plasma ssDNA level was significantly higher in patients with computed tomography-determined visceral obesity and was associated with homeostasis model assessment of insulin resistance (HOMA-IR), which is the index of insulin resistance. (tokushima-u.ac.jp)
Prolonged fasting also forces the body to breakdown visceral fat, which is linked to inflammation and insulin resistance. (naturalnews.com)
obesity="" markers="" both="" visceral="" general="" are="" independent="" determinants="" inflammation. (who.int)

In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)
The consistent elevated levels of pro-inflammatory cytokines have been seen in obesity, leading to the chronic condition of low-grade inflammation (Gregor & Hotamisligil 2011). (nutritionalresourcesinc.com)
Obesity-related chronic inflammation prevents your immune system from producing cells and cytokines to kill invading viruses ( Environ Toxicol Pharmacol , 2015;40(3):924-930). (drmirkin.com)

There are two general types of inflammation: acute and chronic. (lluniversity.com)
Acute inflammation occurs after physical injury or infection. (lluniversity.com)
Acute inflammation is a normal and beneficial response to injury or illness, while chronic inflammation has many harmful effects. (lluniversity.com)
Acute inflammation is a quick response from the body to injury or infection, which increases blood flow to the affected area. (medicalnewstoday.com)
White blood cells help rebuild damaged tissue, and acute inflammation generally stops when the wound heals. (medicalnewstoday.com)

Inflammation occurs when the immune system responds to an irritant within the body. (nutritionalresourcesinc.com)
Chronic inflammation is essentially caused by a malfunction of the immune system. (lluniversity.com)

We expect to define a novel mechanism that obesity mediates the development of postmenopausal breast via inflammation-driven Wnt signaling. (umass.edu)
We aimed to determine if inflammation mediates the associations between obesity and hearing ability in mid-childhood and mid- life . (bvsalud.org)

However, the mechanisms involved in the relationship between obesity and breast cancer are still not fully understood. (umass.edu)
Similarly, animal studies have explored the relationship between obesity and brain injury recovery. (crohnscolitisprofessional.org)

Dr Paul Froomes in Melbourne, Australia, is doing a clinical trial in humans for obesity. (curezone.com)
But the new study suggests that brain-resident immune cells called microglia could also be targets for obesity treatments that might avoid many side effects of the obesity drugs currently in clinical use. (sciencedaily.com)
Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (benthamscience.com)

In the present study, we have investigated the role of Ucp2 against high-fat diet (HFD)-induced obesity in epididymal white adipose tissue (eWAT) and browning of inguinal white adipose tissue (iWAT). (bmbreports.org)

In fact, those with RA and obesity often have greater difficulty with movement and joint function and experience increased pain sooner than people with RA who have a healthier weight (Baker et al 2018). (nutritionalresourcesinc.com)
A diet high in sugar may affect chronic inflammation by increasing inflammatory markers in the blood, according to a 2018 systematic review of several studies. (medicalnewstoday.com)
Another 2018 article suggests that fructose might cause cell inflammation. (medicalnewstoday.com)

Since HDL particles carry the "good cholesterol" and are highly anti-atherogenic particles, the lowering of plasma HDL levels in obesity, is of particular concern. (benthamscience.com)

How has bias and stigma among the general public affected the treatment of obesity? (ajmc.com)

A study looking at the relationship between dietary fats and inflammation found that consumption of tran-fats led to higher levels of markers of inflammation, compared with carbohydrate consumption ( 4 ). (lluniversity.com)

The findings suggested that different levels and chemical compositions of these phenolic compounds might prevent obesity or improve the insulin profile of people who are obese, Luna-Vital said. (news-medical.net)

A link between obesity and chronic inflammation in fat tissues has been suggested in many recent studies. (medindia.net)
This type of inflammation may cause tissues to become red, painful, warm or swollen. (lluniversity.com)

Further investigation of the myometrial and maternal peripheral response to uterine contractions in-vitro and in-vivo was also made with particular reference to the role of inflammation and myocyte damage. (gla.ac.uk)
To confirm the limits of our understanding, Jennifer Sargent summarizes new research that describes a role for healthy inflammation to regulate adipocytes. (conscienhealth.org)
In recent years, scientists have come a long way in elucidating the role that inflammation plays in our health and disease states. (lluniversity.com)
As scientists learn more about chronic inflammation, they are discovering that it plays a role in numerous diseases. (lluniversity.com)
Inflammation may play an important mediating role in the modest hearing reductions associated with obesity , particularly in children . (bvsalud.org)
The role of obesity has been studied in patients with more severe brain injuries, but little is known about its effect on milder brain injuries. (crohnscolitisprofessional.org)
Role of chronic inflammation in adipose tissue in the pathophysiology of obesity]. (elsevierpure.com)
The role of inflammation in obesity-related pathologies is well established. (crispr-reagents.com)

Paired with a new study on the subject, his commentary provides a good summary of the pathways that trigger inflammation after a meal. (conscienhealth.org)
Causal mediation analysis decomposed a 'total effect' ( obesity on hearing status) into 'indirect' effect via a mediator (eg GlycA, hsCRP ) and 'direct' effect via other pathways, adjusting for age, sex and socioeconomic position. (bvsalud.org)

In obese patients undergoing weight-loss surgery, higher blood levels of inflammation are associated with poor weight loss post-surgery. (medindia.net)

Even as some of the major global firms signed up for the British government's anti-obesity drive, many have criticized the campaign as it does not include the popular fast-food chains. (medindia.net)
Intake of anti-obesity drug liraglutide, resulted in better brain activity and in-turn finer associative learning in obese individuals. (medindia.net)
Anti-obesity potential of a tropical plant emerges as a promising solution to address the global surge in obesity-related lifestyle diseases. (medindia.net)
Synthetic anti-obesity drugs show side effects and variable effectiveness. (mdpi.com)
Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2011). (benthamscience.com)
The use of anti-obesity drug has become increasingly common in the last 30 years. (benthamscience.com)
Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (benthamscience.com)

The general stigma and bias circulating obesity hinders the ability to improve the patient's health, explained Ted Kyle, RPh, MBA, principal at ConscienHealth. (ajmc.com)

Maternal obesity may be one such insult. (swan.ac.uk)

Obesity: Is the sight or smell of food enough to trigger inflammation in the brain? (medicalnewstoday.com)

Anatomy33

Organisms10

Diseases60

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology6

Phenomena and Processes53

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care28

Geographicals1

Diabetes37

Adipose tissue inflammation3

Systemic16

People with obesity5

Oxidative stress3

Metabolic8

Adipocyte7

Diet-induced3

Mice13

20191

Reduce inflammation3

Development of obesity3

Cause inflammation3

Liver4

Treat obesity4

Complications3

Macrophage2

Inflammatory response7

Insulin sensitivity2

Overweight and obesity1

Epidemic3

Human obesity1

Chronic low-grade inflammation1

20221

Play a role in obesity2

Lead to chronic inflammation2

Prevalence1

20201

Rheumatoid arthritis2

Metabolism6

Symptoms6

Genes3

Microbiota1

Symptomatology2

Excess6

Macrophages3

Central obesity2

Visceral3

Cytokines3

Acute5

Immune system2

Mediates2

Relationship between obesity2

Clinical3

White adipos1

20183

Levels in obesity1

Treatment of Obesity1

Markers of inflammation1

Findings1

Tissues2

Role8

Pathways2

Obese patients1

Anti-obesity7

ConscienHealth1

Maternal obesity1

Trigger inflammation1