Arthritis, RheumatoidInflammasomesArthritisDisease SusceptibilityGenotypeCaspase 1Genetic Predisposition to DiseaseArthritis, ExperimentalInterleukin-1betaArthritis, InfectiousSynovial MembraneArthritis, JuvenileAntirheumatic AgentsPolymorphism, Single NucleotidePolymorphism, GeneticSynovial FluidAllelesRheumatoid FactorCarrier ProteinsArthritis, PsoriaticJointsHaplotypesGene FrequencyGeneticsCase-Control StudiesArthritis, ReactiveGenetic VariationHLA-DRB1 ChainsGenome-Wide Association StudyInterleukin-18Immunity, InnateSynovitisOsteoarthritisHLA-DR AntigensInflammationMethotrexateAutoantibodiesLinkage DisequilibriumPhenotypeMice, Inbred C57BLGenetic MarkersGenetics, PopulationMacrophagesSeverity of Illness IndexAutoimmune DiseasesGenetic LinkageChromosome MappingBlood SedimentationTumor Necrosis Factor-alphaMice, KnockoutMice, Inbred DBALupus Erythematosus, SystemicSulfasalazineMolecular Sequence DataRheumatoid NoduleMutationCells, CulturedImmunoglobulin GMetacarpophalangeal JointReceptors, Purinergic P2X7Gold Sodium ThiomalateDisease Models, AnimalPeptides, CyclicHLA-DQ AntigensMicrobial Sensitivity TestsPolymerase Chain ReactionArthrographyModels, GeneticSpondylitis, AnkylosingCytokinesRheumatologySignal TransductionGenome, HumanCytoskeletal ProteinsNod2 Signaling Adaptor ProteinRheumatic DiseasesEpistasis, GeneticRisk FactorsWrist JointGenetic Association StudiesGenetic LociHLA-DR4 AntigenSequence Analysis, DNAHLA-DQ beta-ChainsCohort StudiesTreatment OutcomeAntibodies, MonoclonalCrohn DiseaseQuantitative Trait LociHLA-DR3 AntigenCARD Signaling Adaptor ProteinsArthritis, GoutyMicrosatellite RepeatsFinger JointHLA AntigensApoptosis Regulatory ProteinsGenetic TestingEnzyme-Linked Immunosorbent AssayCollagen Type IIBiological Markers