Lymph nodesIdiopathicMediastinal fibrosisAutoimmune pancreatitisCholangitisSalivary glandsStoriform fibrosisDensePulmonary fibrosisTissueFoamy histiocytesKidneysIgG4-Related DiseaseNeurological manifestationsHistiocytesLymphocytesBoneThyroid glandSystemicOrbitalOrgansFibrosclerosisFibrousDiseasePancreasInvolvementSyndromesSymptomsAbdominalSpineLikelihoodObstructionAbsenceDiseasesUltrasoundHttpsExposureBloodLevels
Lymph nodes1
- Autotransplanted mouse model of endometriosis showed lenvatinib treatment abrogated the increased lymphatic vessels development in the endometriotic lesion, enlarged retroperitoneal lymph nodes, and immune cells infiltration, indicating that blocking VEGF-C signaling can reduce local chronic inflammation and concomitantly endometriosis development. (endometriosistreatmentreport.com)
Idiopathic2
- This uncommon idiopathic syndrome is characterized by fibrosis involving multiple organ systems. (medscape.com)
- IgG4-RD likely accounts for most cases of idiopathic retroperitoneal fibrosis. (msdmanuals.com)
Mediastinal fibrosis1
- type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)
Autoimmune pancreatitis1
- Finally, IgG4-related disease must be investigated in patients with SS presenting with sclerosing cholangitis, especially when autoimmune pancreatitis or retroperitoneal fibrosis are also present. (xiahepublishing.com)
Cholangitis2
- Sclerosing Cholangitis Sclerosing cholangitis refers to chronic cholestatic syndromes characterized by patchy inflammation, fibrosis, and strictures of the intrahepatic and extrahepatic bile ducts. (msdmanuals.com)
- IgG4-related sclerosing cholangitis (IgG4-SC) is characterized by elevation of serum IgG4 levels, and dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall. (biomedcentral.com)
Salivary glands1
- It typically affects the pancreas, the salivary glands, and the retroperitoneal space. (hindawi.com)
Storiform fibrosis2
- On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)
- Common features of IgG4-related disorders include tumor-like swelling of involved organs, lymphoplasmacytic infiltration enriched in IgG4-positive plasma cells, and variable degree of storiform fibrosis. (basicmedicalkey.com)
Dense2
- Riedel thyroiditis, or Riedel's thyroiditis (RT), is a rare, chronic inflammatory disease of the thyroid gland characterized by a dense fibrosis that replaces normal thyroid parenchyma. (medscape.com)
- The clinical manifestations of IgG4-RD are usually tumor-like masses or organ enlargement, which result from dense tissue infiltration by immune cells and expansion of the extra-cellular matrix. (msdmanuals.com)
Pulmonary fibrosis1
Tissue6
- Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory disorder associated with fibrosis and abundant tissue lymphoplasmacytic infiltrations. (hindawi.com)
- This can include kidney, skin, brain and lung involvement, and less frequently retroorbital tissue, pituitary gland and heart involvement is observed. (wikipedia.org)
- Tissue samples show xanthomatous or xanthogranulomatous infiltration by lipid-laden or foamy histiocytes, and are usually surrounded by fibrosis. (wikipedia.org)
- 1 It is associated with tissue infiltration by foamy histiocytes. (bmj.com)
- IgG4-related disease ( IgG4-RD ), formerly known as IgG4-related systemic disease , is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4 -secreting plasma cells , various degrees of fibrosis (scarring) and a usually prompt response to oral steroids . (mdwiki.org)
- They demonstrate various contrast enhancement patterns including early peripheral enhancement because of vascular tissue ( Figure 1 ), delayed central enhancement of the fibrotic components, heterogenous, homogenous and absent enhancement. (sajr.org.za)
Foamy histiocytes1
- In 1994, after three years of progressive neurological dysfunction, diagnosis of Erdheim-Chester disease was made by analysis of biopsies of the femur bones, showing infiltration with foamy histiocytes lacking Birbeck granules and S-100 protein, and with few lymphocytes. (bmj.com)
Kidneys1
- Abdominal echography and CT showed "fat kidneys" with perirenal infiltration. (bmj.com)
IgG4-Related Disease1
- The authors used various nomenclatures to describe conditions related to the presence of IgG4 until 2010 in Kanazawa, where it was unified as an "IgG4-related disease" with the consensus that it can affect various organs, including the thyroid and the eye with its adnexa and extraocular muscles [ 4 ]. (hindawi.com)
Neurological manifestations3
- Although neurological manifestations and changes in brain volumes have been described in Erdheim-Chester disease (ECD), it remains unknown whether ECD may be associated with psychiatric symptoms and cognitive dysfunctions. (bvsalud.org)
- This contrasts with previous reports, which describe rare neurological manifestations and the failure of different therapeutic approaches. (bmj.com)
- Neurological manifestations are less frequent. (bmj.com)
Histiocytes1
- The disease involves an infiltration of lipid-laden macrophages, multinucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones. (wikipedia.org)
Lymphocytes1
- However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
Bone7
- in 1996 reported the following symptoms in order of frequency of occurrence: Bone pain Retroperitoneal fibrosis Diabetes insipidus Exophthalmos Xanthomas Neurological and central nervous system involvement Dyspnea caused by interlobular septal and pleural thickening Kidney failure Hypopituitarism Liver failure Radiologic osteosclerosis and histology are the main diagnostic features. (wikipedia.org)
- The most frequent systemic manifestations are bone lesions. (bmj.com)
- Clinical details and the results of relevant laboratory tests including the blood count and blood film features must be known before a bone marrow biopsy is performed. (bmj.com)
- Suspected bone marrow fibrosis. (bmj.com)
- In general, patients who have a hypocellular bone marrow or bone marrow fibrosis are likely to need a trephine biopsy for adequate assessment. (bmj.com)
- Unexplained pancytopenia and an unexplained leucoerythroblastic blood film are indications for a trephine biopsy because they are likely to indicate bone marrow infiltration or fibrosis. (bmj.com)
- without infiltration of bone marrow. (controllab.com)
Thyroid gland1
- Characteristic features of GD with elevated IgG4 levels include lower echogenicity of the thyroid gland on ultrasound examination, peripheral blood eosinophilia, higher prevalence of orbitopathy, and better response to antithyroid drugs with a tendency to develop hypothyroidism when compared to patients with GD and normal levels of IgG4. (hindawi.com)
Systemic1
- Some experts have traditionally believed that RT is not primarily a thyroid disease but rather that it is a manifestation of the systemic disorder multifocal fibrosclerosis. (medscape.com)
Orbital1
- Intracranial manifestations are rare and the usual localisations are the retro-orbital space and hypothalamic involvement with neurogenic diabetes insipidus. (bmj.com)
Organs3
- However, it might also involve multiple other organs, including the orbit and the thyroid. (hindawi.com)
- However, IgG4-RD can involve the vast majority of organs, including the thyroid and the orbit [ 2 , 8 , 9 ]. (hindawi.com)
- IgG4-RD has a wide range of manifestations that vary by which organs are involved and that are unified by their histopathologic findings and response to treatment. (msdmanuals.com)
Fibrosclerosis1
- Additionally, one third of published RT cases have demonstrated at least 1 manifestation of extracervical fibrosclerosis. (medscape.com)
Fibrous1
- 4 Differential diagnosis includes desmoid tumour and solitary fibrous tumour. (sajr.org.za)
Disease5
- Typical signs of GO accompanied by increased concentration of IgG4 include younger age at diagnosis, and more severe course of the disease with a higher Clinical Activity Score (CAS). (hindawi.com)
- RT may be but 1 manifestation of this multifocal disease. (medscape.com)
- PBC-related SS patients may have a broad spectrum of abnormalities of the liver, including having no clinical or analytical data suggestive of liver disease. (xiahepublishing.com)
- Treatment must be individualized, taking the clinical problem in its entirety into account, including the impact of the disease and the effect of its treatment on quality of life. (blogspot.com)
- Data from this registry may be used to generate descriptive statistics on demographics, and clinical characteristics, including co-morbidities, treatment patterns and adverse outcomes (resulting from treatment or disease), as well as patients' quality of life measurements. (umn.edu)
Pancreas1
- Chronic Pancreatitis Chronic pancreatitis is persistent inflammation of the pancreas that results in permanent structural damage with fibrosis and ductal strictures, followed by a decline in exocrine and endocrine. (msdmanuals.com)
Involvement1
- Liver involvement was one of the first extraglandular manifestations to be reported in patients with primary Sjögren syndrome (SS). (xiahepublishing.com)
Syndromes1
- The simultaneous manifestation of all three syndromes suggests causal interrelationships. (biomedcentral.com)
Symptoms1
- 1 Although xerophthalmia and xerostomia are the most frequent sicca symptoms, nearly 30% of patients present with extraglandular manifestations, and 5% may develop a hematological neoplasia. (xiahepublishing.com)
Abdominal1
- of either the thoracic or abdominal aorta, which is distinguished from retroperitoneal fibrosis by the presence of circumferential mural aortic wall thickening or enhancement on imaging studies. (msdmanuals.com)
Spine1
- By creating this registry, a more complete picture of degenerative spine disorders - including treatment practices - will be established, by collecting information about the health status of patients across several hospitals in several countries. (umn.edu)
Likelihood1
- There is also a greater likelihood of detection of infiltration by non-haemopoietic neoplasms. (bmj.com)
Obstruction1
- Renal dysfunction sometimes occurs, and is attributed to ureteral obstruction and renal artery stenosis by histiocytic infiltration. (bvsalud.org)
Absence1
- He noted the presence of chronic inflammation with fibrosis and the absence of malignancy on microscopic examination. (medscape.com)
Diseases1
- CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)
Ultrasound1
- We detail current diagnostic tools, including advanced transvaginal ultrasound, magnetic resonance imaging, and surgical diagnostic tools such as cystourethroscopy. (endometriosistreatmentreport.com)
Https1
- Aug 9, 2014 · - If you use this textbook as a bibliographic reference, please include https://openstax.org/details/books/american-government in your citation. (clickzengage.com)
Exposure1
- Common risk factors in the development of uterine leiomyoma include African-American race, early menarche , prenatal exposure to diethylstilbestrol , having one or more pregnancies extending beyond 20 weeks, obesity , significant consumption of beef and other red meats, hypertension , family history , and alcohol consumption. (wikidoc.org)
Blood1
- Additional plays include Confederates Pipeline Sunset Baby Blood at the Root and Follow Me to Nellie's. (avalyb.best)
Levels1
- 4] These infiltrates ultimately lead to fibrosis and elevated serum levels of IgG4. (medscape.com)