BiopsySplenomegalyHepatosplenomegalyFeverProliferationInfectionChemotherapyPeripheral bloodAspirationTransplantationLeukemic infiltrationLiverCondition characterizedDiagnosisAbnormalitiesSyndromeExaminationInvolvementLymphomaLymphocytesTransplantsAnemiaAspirateSpleenSymptomsLaboratoryCellsSevereSecondaryBloodLesionsDiseaseDiagnosticPatients
Biopsy15
- A blood smear showed 10% hairy cells, and a bone marrow biopsy confirmed a diagnosis of hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, and tartrate-resistant acid phosphatase-positive cells. (cdc.gov)
- Bone marrow aspiration and biopsy showed hemophagocytosis and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, CD 103-positive, CD25-positive, CD11c-positive, and CD123-positive cells, leading to a diagnosis of hairy cell leukemia. (cdc.gov)
- If bone marrow aspiration is found to be impossible, imprints from the biopsy specimen should be obtained. (bmj.com)
- Ideally, reporting of trephine biopsy sections should be done by an individual who is competent in both histopathology and haematology, and who is able to make an appropriate assessment of both the bone marrow aspirate and the trephine biopsy sections. (bmj.com)
- Clinical details and the results of relevant laboratory tests including the blood count and blood film features must be known before a bone marrow biopsy is performed. (bmj.com)
- In general, patients who have a hypocellular bone marrow or bone marrow fibrosis are likely to need a trephine biopsy for adequate assessment. (bmj.com)
- Similarly, only a trephine biopsy shows the architecture of the bone marrow and permits the detection of an abnormal distribution of cells, bone marrow granulomas, and focal lymphoid infiltrates. (bmj.com)
- Unexplained pancytopenia and an unexplained leucoerythroblastic blood film are indications for a trephine biopsy because they are likely to indicate bone marrow infiltration or fibrosis. (bmj.com)
- Bone marrow biopsy is often the definitive test to diagnose Myelophthisic Anemia. (pathwaymedicine.org)
- The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. (haematologica.org)
- DENV-3 was detected in a premortem bone marrow biopsy in which erythrophagocytosis was evident. (cdc.gov)
- Laboratory investigations confirmed a Immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) was markedly elevated to more than 300 u/ml, colonoscopy was normal, Bone mass densitometry revealed osteopenia and hypercellular bone marrow on bone marrow biopsy. (nursingtermpapers.com)
- Upper gastrointestinal endoscopy showed a loss of folds in the second part of the duodenum and a biopsy from the second part of duodenum showed intraepithelial lymphocytes, flattening of duodenal mucosa, lymphoplasmacytic infiltration in lamina propria, and crypt hyperplasia (Marsh class 3). (nursingtermpapers.com)
- A bone marrow biopsy is the key to an early diagnosis. (ommegaonline.org)
- Bone marrow aspirate and biopsy studies revealed acute myeloid leukemia with 64% blasts. (juniperpublishers.com)
Splenomegaly5
- Secondary causes of pancytopenia as infections, splenomegaly and nutritional deficiencies where ruled out. (bvsalud.org)
- The present study includes seven unrelated Indian adult patients (age range: 20-40 years) having splenomegaly, with or without hepatomegaly, cytopenia and bone abnormality. (biomedcentral.com)
- There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
- More commonly, the splenomegaly is apparent in myelofibrosis or bone marrow failure, when the spleen becomes the primary organ of hematopoiesis. (cap.org)
- This disorder also causes pancytopenia and splenomegaly, but the age of onset is typically younger. (cap.org)
Hepatosplenomegaly3
- Leukemia should be suspected if persistent vague symptoms are accompanied by evidence of abnormal bleeding, bone pain, lymphadenopathy or hepatosplenomegaly. (aafp.org)
- Clinical case: 72-year-old man, hospitalized due to pancytopenia, with no history of hematological diseases, asymptomatic, without hepatosplenomegaly or bleeding. (bvsalud.org)
- Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that can be familial or acquired, and is characterized by persistent fever, pancytopenia, hepatosplenomegaly, and increased serum ferritin ( 2 ). (cdc.gov)
Fever4
- Seen mostly in children, multifocal unisystem LCH is characterized by fever, bone lesions and diffuse eruptions, usually on the scalp and in the ear canals. (wikipedia.org)
- Case-patient 1 was a 48-year-old man hospitalized in Paris with fever, asthenia, chills, and pancytopenia after returning from a 1-week visit to Thailand where he had been in flooded regions (Koh Samui and Koh Samet). (cdc.gov)
- However, shortly after hospital admission, the patient developed neuro‑psychiatric anomalies, fever and pancytopenia, and West‑Nile encephalitis was diagnosed. (spandidos-publications.com)
- Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. (biomedcentral.com)
Proliferation4
- Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. (wikipedia.org)
- Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem cells characterized by abnormal proliferation of myeloid blast cells in the bone marrow and blood, preventing them from further differentiating into the specialized cells of the bone marrow and thus causing pancytopenia. (dovepress.com)
- In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
- chronic myeloid leukemia (cml) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of philadelphia (ph) chromosome. (liverpool.ac.uk)
Infection4
- Bone marrow: Pancytopenia with superadded infection usually implies a poor prognosis. (wikipedia.org)
- After returning to her home in Texas, she was initially diagnosed with West Nile virus (WNV) infection, developed pancytopenia, liver failure, and disseminated intravascular coagulopathy, and died. (cdc.gov)
- These patients are unable to control EBV infection and have infiltration of tissues by EBV positive T, NK, or less often B cells. (frontiersin.org)
- Among bone marrows studied a case of T-LL developed pancytopenia, during chemotherapy showed giant pronormoblast (Parvovirus infection). (ijmpo.org)
Chemotherapy1
- The goal of treatment is to find a match for a bone marrow transplant, but when not available chemotherapy is used to achieve a remission. (knowmedge.com)
Peripheral blood7
- Background: Acute myeloid leukemia (AML) is characterized by the presence of ≥ 20% myeloblasts in peripheral blood or bone marrow, as well as specific cytogenetic alterations. (bvsalud.org)
- Flow cytometry revealed pancytopenia without blasts in peripheral blood. (bvsalud.org)
- Diagnosis required 20% blast cells (immature WBCs) in the peripheral blood or bone marrow. (knowmedge.com)
- An interesting aspect of marrow replacement in Myelophthisic Anemia is the egress of blood cell progenitors, such as erythroblasts and myeloblasts, into the peripheral blood. (pathwaymedicine.org)
- Examination of peripheral blood smear and bone marrow is diagnostic. (msdmanuals.com)
- Aplastic Anemia" = tri-lineage peripheral blood cytopenia due to reduced or absent production of hematopoietic cells without cellular infiltration . (pedemmorsels.com)
- Therapy resulted in a decrease in tumor burden and improved survival, while human HSPC remained in the peripheral blood and bone marrow, suggesting they were protected from killing. (acir.org)
Aspiration1
- A bone marrow aspiration should be performed as part of the same procedure. (bmj.com)
Transplantation3
- Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. (scielo.org)
- Bad - Bone marrow transplantation. (medicowesome.com)
- Celiac disease Development in cases of acute leukemia after allogeneic bone marrow transplantation (BMT) from Human leukocyte antigen identical siblings who suffered from celiac disease [11,12]. (nursingtermpapers.com)
Leukemic infiltration1
- symptoms of extramedullary leukemic infiltration are present in only about 5% of patients (often as skin manifestations). (msdmanuals.com)
Liver6
- They may have chronic fatigue, hepatomegaly (with or without abnormal liver function test findings), bone pain, or pathologic fractures and may bruise easily because of thrombocytopenia. (medscape.com)
- Erythroblastic infiltration into the liver and hemophagocytosis in the spleen were found at autopsy. (elsevierpure.com)
- Beyond the liver and lung, and differently from other types of cancers, a not usual site of CRC metastases is the bone. (encyclopedia.pub)
- Abdominal ultrasound revealed diffuse fatty infiltration of the liver. (cdc.gov)
- The pathognomonic characteristic of HPS is the activation of well-differentiated macrophages, phagocyting erythrocytes, leukocytes and platelets in bone marrow, lymph nodes, spleen, liver and other organs, which can infiltrate almost anybody district and may account for many of its systemic features [ 3 ]. (biomedcentral.com)
- While erythrocytes in the fetus are initially produced in the yolk sac then the liver, the bone marrow eventually becomes the main site of production. (lecturio.com)
Condition characterized2
- This typically results in pancytopenia, a condition characterized by a reduction in the number of red and white blood cells, as well as platelets. (pathwaymedicine.org)
- Aplastic anemia (AA) is a hematologic condition characterized by bone marrow hypoplasia or aplasia resulting in pancytopenia. (haematologica.org)
Diagnosis2
- The diagnosis of Myelophthisic Anemia involves a combination of clinical evaluation, blood tests, and bone marrow examination. (pathwaymedicine.org)
- A laboratory diagnosis revealed pancytopenia, hypertriglyceridemia, and hyperferritinemia. (biomedcentral.com)
Abnormalities3
- AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. (dovepress.com)
- 4-6 They are caused by direct neoplastic cell infiltration or indirect complications secondary to hematologic abnormalities (thrombocytopenia, anemia and hyperviscosity state). (dovepress.com)
- In addition to changes in the skull, bone abnormalities can also be seen in the long bones, vertebrae, and pelvis. (passmed.uk)
Syndrome2
- Conclusions: AML that is presented as pancytopenia should be considered in the evaluation of marrow failure syndrome. (bvsalud.org)
- Therapy-related PEL with hemophagocytic syndrome and hepatic infiltration of PEL has never been reported. (elsevierpure.com)
Examination2
- He underwent a bone marrow (BM) examination for pancytopenia during the first outpatient department visit, which revealed an increased number of erythroid precursors with dysmegakaryopoiesis suggesting the possibility of Myelodysplastic syndromes (MDS). (bvsalud.org)
- However, a routine blood examination showed pancytopenia. (ommegaonline.org)
Involvement3
- This primary bone involvement helps to differentiate eosinophilic granuloma from other forms of Langerhans Cell Histiocytosis (Letterer-Siwe or Hand-Schüller-Christian variant). (wikipedia.org)
- It can reveal the presence of infiltrating lesions and the extent of marrow involvement. (pathwaymedicine.org)
- Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (lookformedical.com)
Lymphoma1
- Marrow infiltration was confirmed in 11 of 38 BM samples taken for staging/investigation of lymphoma/leukaemia. (bmj.com)
Lymphocytes3
- It is associated with ineffective but increased response and infiltration of active lymphocytes and histiocytes in various organs. (apjhs.com)
- The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. (frontiersin.org)
- Other authors, particularly when defining severe CAEBV disease, require both an elevated level of EBV in the blood as well as infiltration of tissues by EBV-positive lymphocytes ( 16 ). (frontiersin.org)
Transplants2
- His illness and the grueling treatment, including two bone marrow transplants (BMT) from his son, did not lessen his commitment to reporting on the NBA. (knowmedge.com)
- 4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
Anemia7
- Anemia can be due to a number of factors and does not necessarily imply bone marrow infiltration. (wikipedia.org)
- Infiltration of the bone marrow by blast cells results in pancytopenia (anemia, neutropenia, and thrombocytopenia) and the so-called B symptoms of night sweats, decreased appetite, and weight loss. (knowmedge.com)
- Myelophthisic Anemia is a complex medical condition that affects the bone marrow's ability to produce blood cells. (pathwaymedicine.org)
- It refers to anemia caused by the physical infiltration of the bone marrow by an external, space-occupying lesion. (pathwaymedicine.org)
- In the context of Myelophthisic Anemia, these cancers infiltrate the bone marrow, leading to its compromised function. (pathwaymedicine.org)
- These diseases can infiltrate the bone marrow, leading to Myelophthisic Anemia. (pathwaymedicine.org)
- Acquired aplastic anemia (AA) is a rare heterogeneous disease characterized by pancytopenia and hypoplastic bone marrow. (pedemmorsels.com)
Aspirate1
- Bone marrow aspirate showed infiltration by 45% of myeloblasts and myelodysplasia. (bvsalud.org)
Spleen2
- Many of the morphological changes characteristic of primary myelofibrosis typically seen in the bone marrow are also seen in the spleen. (cap.org)
- Another feature typical of primary myelofibrosis-intravascular hematopoiesis-seen in the marrow can be seen within the spleen. (cap.org)
Symptoms2
- Symptoms range from isolated bone lesions to multisystem disease. (wikipedia.org)
- Classically the disease is manifested by symptoms of diarrhea, flatulence and malabsorption, however, it is also associated with variable systemic manifestations, including metabolic bone disease, diabetes, thyroid dysfunction and lympho-proliferative malignancies [2]. (nursingtermpapers.com)
Laboratory1
- A 62-year-old man initially presented with the incidental finding of pancytopenia on routine laboratory tests. (juniperpublishers.com)
Cells5
- Progressive infiltration of Gaucher cells in the bone marrow may lead to thinning of the cortex, pathologic fractures, bone pain, bony infarcts, and osteopenia. (medscape.com)
- The bone marrow is a crucial component in our body responsible for producing blood cells. (pathwaymedicine.org)
- These malignancies, when metastasized to the bone marrow, can physically replace native marrow cells, leading to a reduction in the marrow's ability to produce blood cells. (pathwaymedicine.org)
- In these conditions, the bone marrow produces an increased number of red blood cells, leading to expansion of the bone marrow cavity and compression of the surrounding bone. (passmed.uk)
- Therefore, even though CD45 CAR T cells (CAR45) would target leukemias and lymphomas, they would be limited by fratricide, and would result in pancytopenia due to on-target/off-tumor toxicity. (acir.org)
Severe1
- This appearance is most frequently observed in conditions that cause bone marrow expansion, such as severe anaemia, thalassemia, and sickle cell disease. (passmed.uk)
Secondary1
- Here, we described a case of AML that presented with pancytopenia as the only manifestation in a secondary care center. (bvsalud.org)
Blood2
- Need to study bone structure or bone marrow blood vessels. (bmj.com)
- The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Lesions1
- The triad of diabetes insipidus, exophthalmos, and lytic bone lesions is known as the Hand-Schüller-Christian triad. (wikipedia.org)
Disease1
- Bone: The most-frequently seen symptom in both unifocal and multifocal disease is painful bone swelling. (wikipedia.org)
Diagnostic2
- Diagnostic utility of bone marrow sampling in HIV positive patients. (bmj.com)
- OBJECTIVE: To evaluate the diagnostic utility of bone marrow (BM) sampling in HIV positive patients. (bmj.com)
Patients2
- As pegylated liposomal formulation: In combination with bortezomib for the treatment of progressive cases in patients who have undergone or are unsuitable for a bone marrow transplant and who have received at least 1 prior therapy: 30 mg/m 2 on day 4 of the bortezomib 3 week regimen given via infusion over 60 minutes immediately after bortezomib infusion. (azurewebsites.net)
- The results of bone marrow puncture of the patients showed haemophagocytosis. (ommegaonline.org)