Infiltrate plasma cells. Medical search. Frequent questions

There was a very dense inflammatory cell infiltrate consisting of lymphocytes and plasma cells (figure 2). (ispub.com)
The lamina propria of the mucosa is infiltrated by moderate numbers of lymphocytes and plasma cells. (avma.org)
The inflammation is composed primarily of lymphocytes and plasma cells. (nih.gov)
Intro IgG4-related disease (IgG4-RD) is a systemic disease seen as a cells infiltration of lymphocytes and plasma cells enriched for IgG4-manifestation and fibrosis arranged inside a storiform design. (estme.org)
infi ltrate in- borne infectious disease in the United States and Eu- cluded lymphocytes and plasma cells around the perivas- rope ( 1 , 2 ). (cdc.gov)
In between, we found mixed inflammatory infiltrate composed of neutrophils, lymphocytes and plasma cells ( Figure 2A and 2B ). (bvsalud.org)

It is characterized by myofibroblastic and fibroblastic spindle cells and an infiltrate of plasma cells, lymphocytes, and/eosinophils. (hindawi.com)
Histopathologic Findings The histologic sections of the biopsy showed an infiltrate composed predominantly of histiocytes with interspersed eosinophils, lymphocytes and rare plasma cells (Figure 3). (dentalcare.com)
Low power histologic image showing a diffuse infiltrate of histiocytes with admixed eosinophils. (dentalcare.com)
Eosinophils and focal multinucleated giant cells are present in the background. (dentalcare.com)
90% non-neoplastic cells, mainly T- and B-lymphocytes, plasma cells, macrophages, eosinophils and fibroblasts. (haematologica.org)
Biopsy of the hepatic lesion demonstrated a designated lymphoplasmacytic infiltrate admixed with eosinophils, followed by storiform fibrosis (Fig. (estme.org)
A, Liver organ biopsy showing designated lymphoplasmacytic infiltrate with admixed eosinophils and connected storiform fibrosis. (estme.org)

Histologically IMT is considered a benign lesion consisting of myofibroblastic spindle cells with a prominent inflammatory infiltrate composed of plasma cells and lymphocytes. (eurorad.org)

Exposure-dependent histopathological changes noted included eosinophilic granulomatous interstitial pneumonia, perivascular eosinophil infiltrates, bronchial-associated lymphoid tissue hyperplasia, and peribronchiolar plasma cell infiltrates. (cdc.gov)

Skin changes of chronic lym- perivascular infiltrate increased with lymphedema stage, phedema include thickening, nodular lesions, and pigmen- which suggested progressive chronic inflammation and tary changes (13,14). (cdc.gov)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
HS skin lesions were characterized by quantitative and qualitative dysfunction of type 2 conventional dendritic cells, relatively reduced regulatory T cells, an influx of memory B cells, and a plasma cell/plasmablast infiltrate predominantly in end-stage fibrotic skin. (jci.org)
We report a patient who developed specific lesions of sarcoidosis infiltrating some xanthelasmata 6 months after starting treatment with atezolizumab. (bvsalud.org)
At approximately 1 week, transition to early lesions is marked by the change to predominately lymphocytic infiltrates. (medscape.com)
With time, lesions become chronic and are characterized by the presence of plasma cells and B lymphocytes. (medscape.com)

Follow-up biopsies showed reductions in perivas- evidence of inflammatory infiltrate in lymphedematous cular mononuclear infiltrate in the superficial dermis (41% tissue (14,15). (cdc.gov)
HCV can also be detected in the peripheral blood, particularly in mononuclear cells. (medscape.com)
A biopsy specimen from the erosive lesion of the abdominal fold shows hyperplasia of the epidermis with a pleomorphic mononuclear perivascular infiltrate of the dermis (Figs. 3, 4). (cdlib.org)
Hyperplasia of the epidermis with a pleomorphic mononuclear perivascular infiltrate of the dermis (Fig. 3). (cdlib.org)

Histology of an ultrasound guided biopsy showed Kaposi's sarcoma infiltrating the head of gastrocnemius. (bmj.com)
Allograft biopsy showed IgG4+ plasma cells consistent with TIN from recurrence of IgG4-RD. He started on prednisone and rituximab with improvement of his creatinine to 1.2. (asn-online.org)

Biopsies show a granulomatous formation in combination with a localized infiltration of multi-nucleated giant cells, epithelioid histiocytes, and plasma cells. (karger.com)
Cutaneous biopsy from an infiltrated xanthelasma and from still yellow, no infiltrated xanthelasma showed differing proportions of foamy histiocytes and sarcoid granulomas. (bvsalud.org)
Histopathologically, the foamy histiocytes of xanthelasma seem to be replaced by or evolve to epithelioid cells to form sarcoid granulomas. (bvsalud.org)
Initially described in Japan, KFD was first reported almost simultaneously by Kikuchi and by Fujimoto and associates in 1972 as a lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. (medscape.com)

In‐depth molecular analysis of neoplastic melanocytes in whole tissue biopsies may be diluted by inflammatory infiltration, which may obscure gene signatures specific to neoplastic cells. (researchgate.net)
We hypothesize that a preexisting submucosal leiomyoma became colonized by neoplastic plasma cells with resultant expansion and protrusion of the leiomyoma through the cervical canal. (dtic.mil)

The neutrophil is also the predominant infiltrating cell type in suppurative inflammation , but the neutrophils are aggregated, and many of them are degenerate (suppurative exudate). (nih.gov)

Histologic sections revealed a brisk, mixed inflammatory infiltrate including numerous plasma cells within the superficial dermis to the mid-dermis. (ccjm.org)
With immunoelectron microscopy in pemphigus erythematosus, IgG and C3 deposits are localized to the epidermal cell membranes and the upper dermis. (medscape.com)
Many mature plasma cells associated with marked endothelial swelling within the dermis (Fig. 4). (cdlib.org)
A dense inflammatory-cell infiltrate is present in both papillary and reticular dermis (Fig. 3). (cdlib.org)

IgG4-positive plasma cells, "storiform"-like fibrosis and obliterative phlebitis are noted histologically. (aad.org)
Histologic evaluation demonstrates IgG4+ plasmacyte infiltrate, storiform fibrosis, and obliterative phlebitis. (asn-online.org)
On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)

The essential components include inflammatory cell infiltrate and hepatocellular injury with predominantly lobular involvement. (medscape.com)
Verrucous carcinoma is an uncommon but distinct variety of well differentiated squamous cell carcinoma first delineated by Ackerman in 1948 3 .The term verrucous carcinoma refers to those exophytic mucosal or cutaneous squamous tumors that are heaped above the epithelial surface with a papillary micronodular surface and pushing margins 4 .Predominantly being a squamous mucosal lession, verrucous carcinoma may also be found on cutaneous surfaces. (ispub.com)

It is characterized by a diffuse and intense infiltration of mature plasma cells in the subepithelial gingiva. (pathologyoutlines.com)
Recent studies on diffuse large B-cell lymphoma (DLBCL) revealed a previously unknown tumor-suppressive signaling axis involving SMAD1 as a downstream messenger of TGF-β. (haematologica.org)
D, Immunofluorescence on frozen cells displays diffuse granular staining from the glomerular cellar membrane (GBM) for IgG, diagnostic of MN. (estme.org)
The diagnosis was made by typical clinical findings (such as dyspnoea and dry cough) in association with the radiological finding of diffuse interstitial infiltrate. (bmj.com)

Leukemic myoblast differentiation into PDCs occurs as a result of sharing a common hematopoietic precursor to dendritic cells, monocytes, and myeloid cells. (news-medical.net)
Monocytes and plasma cells also may be present. (medscape.com)
It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)

Microscopically, there was a dense infiltration of mature plasma cells beneath the squamous epithelium, separated by thick collagen bundles. (pathologyoutlines.com)
The clinical manifestations of IgG4-RD are usually tumor-like masses or organ enlargement, which result from dense tissue infiltration by immune cells and expansion of the extra-cellular matrix. (msdmanuals.com)

Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma. (johnshopkins.edu)

There was infiltration of the masses by variable numbers of heterophils, lymphocytes, plasma cells, and macrophages. (vin.com)

In the tissue surrounding the exudate, there may be fibroblasts, fibrous connective tissue, and mixed inflammatory cells, depending on the chronicity of the lesion. (nih.gov)
The severity grade depends on the extent of the lesion in the esophagus and the density of the cellular infiltrate. (nih.gov)

D: Prominent endothelial cell swelling. (wjgnet.com)
Higher magnification reveals a pleomorphic perivascular infiltrate with many mature plasma cells in association with marked endothelial swelling (Fig. 4). (cdlib.org)
Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
We investigated eight patients with acute GVHD and ten with chronic GVHD for signs of endothelial injury and microvessel loss by measurement of von Willebrand factor (vWF) in plasma and blood vessel density in biopsy samples taken from lesional skin. (nih.gov)
Inflammation and endothelial injury were assessed in selected samples by immunostaining for CD8 T cells, activated cytotoxic T lymphocytes, and vascular endothelial cells. (nih.gov)
Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
Host endothelial cells are a target of alloreactive donor cytotoxic T lymphocytes. (nih.gov)

Therapeutically, glucocorticoids alone or in combination with B-cell depletion with rituximab induces prompt clinical response to IgG4-RD (1). (aad.org)
He underwent a renal biopsy demonstrating interstitial infiltrate with IgG4+ plasma cells consistent with TIN and was diagnosed with IgG4-RD. (asn-online.org)
T h cells stimulate B cells to produce IgG4 and collectively release inflammatory cytokines. (asn-online.org)
An immunohistochemical stain for IgG4 demonstrated abundant IgG4+ plasma cells inside the infiltrate (up to 60 per high-power field) (Fig. (estme.org)
B, An immunohistochemical stain for IgG4 displays abundant IgG4-positive plasma cells inside the infiltrate in the liver organ. (estme.org)

The tumour is composed of an admixture of spindle-shaped and ovoid cells with a prominent inflammatory infiltrate (figures 2-3). (dermnetnz.org)

In both cases the accompanying plasmacytic infiltrate was interpreted as reactive and not malignant. (arizona.edu)
He had been diagnosed with primary syphilis 9 months prior to presentation, with a reactive plasma reagin titer of 1:64, and had been treated with intramuscular penicillin G benzathine 2.4 million units. (ccjm.org)
The substantial amount of reactive cells in HL is supposed to be the net effect of a complex signaling network of cytokines and chemokines secreted by either the HRS cells or nonneoplastic cells. (haematologica.org)

Endoscopic biopsy from the pancreatic mass was adverse for malignancy but exposed a lymphoplasmacytic infiltrate with abundant IgG4+ plasma cells (not really quantified exactly), connected with gentle tissue eosinophilia. (estme.org)

This signaling cascade was shown to be recurrently inactivated in DLBCL, mainly by hypermethylation of five promoter regions surrounding the SMAD1 transcription start site, which finally generates a significant growth advantage for lymphoma cells. (haematologica.org)

The adenocarcinoma in both cases infiltrated into the underlying submucosa and muscularis externa. (vin.com)

1998). Airway bronchial-associated lymphoid tissue hyperplasia, and peribron- responses have been induced after inhalation challenge with chiolar plasma cell infiltrates. (cdc.gov)

A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)

In acute inflammation , the predominant infiltrating cell is the neutrophil, though fewer macrophages and lymphocytes may also be present. (nih.gov)

E ) xCell Scores indicating predicted enrichment of different cell populations in whole-tissue RNA-Seq data from lesional HS (L) and healthy (H) skin. (jci.org)

Previously, IMT was also described as inflammatory pseudotumor, plasma cell granuloma, and inflammatory myofibrohistiocytic proliferation. (hindawi.com)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Microscopically, the mass was comprised of a well-circumscribed proliferation of smooth muscle diffusely effaced and expanded by a population of CD138,lambda light chain-restricted plasma cells. (dtic.mil)
RESULTS: cSCCs conserving epithelial traits exhibited strong activation of EGFR signaling, which promoted tumor cell proliferation, in contrast to mesenchymal-like cSCCs. (bvsalud.org)
A subset of initially responding tumors acquired resistance after long-term treatment, which was induced by the bypass from EGFR to FGFR signaling to allow tumor cell proliferation and survival upon gefitinib treatment. (bvsalud.org)
In these circumstances, the hormones estrogen and progesterone are found at high levels, causing dilatation and proliferation of gingival microvasculature, as well as destruction of mast cells with release of vasoactive substances, which results in the worsening of pre-existing inflammatory conditions, such as gingivitis 1,4,7 . (bvsalud.org)

The tumour cells stain strongly with vimentin and variably with smooth muscle markers. (dermnetnz.org)

Granulomatous inflammation is another form of chronic inflammation, but this diagnosis requires the presence of a significant number of aggregated, large, activated macrophages, epithelioid macrophages, or multinucleated giant cells. (nih.gov)

A major limitation of adoptive immunotherapy is the availability of T cells specific for both terminally differentiated tumor cells and their clonogenic precursors. (johnshopkins.edu)
Furthermore, activated MILs target both the terminally differentiated CD138 + plasma cells and the myeloma precursor as shown by profound inhibition in a tumor clonogenic assay. (johnshopkins.edu)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
TGF-β unfolds its immunosuppressive impact by stimulating tumor-infiltrating T-lymphocytes (TIL) to differentiate into anergic, tumor-promoting, regulatory T cells (Treg). (haematologica.org)
3 Interestingly and still poorly understood, the HRS cells themselves seem to remain unaffected by the tumor-suppressive properties of TGF-β. (haematologica.org)
This led us to hypothesize that the absence of SMAD1 expression in HRS cells may mechanistically be linked to their resistance to the tumor-suppressive effects of TGF-β. (haematologica.org)

Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)

The medical records of 13 patients diagnosed pathologically with IMT, inflammatory pseudotumor, or plasma cell granuloma of the paranasal sinus and nasopharynx in the Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital from 2006 to 2017 were reviewed. (hindawi.com)
Some of these tumours were labelled 'pseudotumours' or ' plasma cell granuloma ' in the past. (dermnetnz.org)

EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)

Endobronchial ultrasound-guided transbronchial needle aspiration of a mediastinal lymphadenopathy showed epithelioid cell granulomas. (bvsalud.org)

Numerous intestinal epithelial cells lining villi contain coccidial organisms representing various life stages, including meronts (Me) containing 8 to 12 merozoites, microgametocytes (Mi), macrogametocytes (Ma), and oocysts (O). Labels appear immediately to the right of the corresponding life stage. (avma.org)
Direct immunofluorescence microscopy performed on epithelial biopsy specimen obtained from a patient with pemphigus vulgaris detects immunoglobulin G deposits at the epithelial cell surfaces. (medscape.com)

PDCs are a class of specialized dendritic cells that play a role in immunomodulatory functions and antigen presentation. (news-medical.net)

Histologically, all cases were characterized by discrete to confluent, polypoid, adenomatous masses of hyperplastic mucosal epithelium that formed papilliferous projections and glandular structures lined by pseudostratified epithelium and hyperplastic goblet cells overlying a fibrous connective tissue stroma. (vin.com)

In both analysis types, all PDCs showed partial to moderate expression of the cell marker CD34 indicating premature PDCs. (news-medical.net)

It accounts for 5% of all intraoral squamous cell carcinomas 5 . (ispub.com)
PURPOSE: Recurrent and/or metastatic unresectable cutaneous squamous cell carcinomas (cSCCs) are treated with chemotherapy or radiotherapy, but have poor clinical responses. (bvsalud.org)

IBD is considered to represent a heterogenous disorder which is reflected in the variable nature of the inflammatory infiltrate, and the variable clinical manifestations and progress of the disease. (vin.com)

in NLPHL, 11/14 (79%) cases displayed abundant SMAD1-expressing TIL, including TIL involved in rosetting around LP cells ( Online Supplementary Figure S1 ). (haematologica.org)

The detection of monoclonal immunoglobulins ( antibodies ) confirm the presence of a monoclonal plasma cell proliferative disorder. (dermnetnz.org)

BPDCNs commonly infiltrate the skin and bone marrow, disseminate, and display an aggressive phenotype. (news-medical.net)
The group analyzed seven MN patients who presented with PDC proliferations comprising 5-26% of that blood cell or bone marrow. (news-medical.net)

Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
In the presence of water (sweat, saliva, tears), the liquid or gas slowly hydrolyzes to hydrochloric acid, which can irritate and damage cells. (cdc.gov)

The other type of inflammation is a slow accumulation of T-cells and B-cells in the absence of major blood brain barrier damage in the connective tissue spaces of the brain, such as the meninges and the large perivascular Virchow Robin spaces, where they may form aggregates or in most severe cases structures in part resembling tertiary lymph follicles. (frontiersin.org)

It is suggested that CD8 + T-lymphocytes remain in the brain and spinal cord as tissue resident cells, which may focally propagate neuroinflammation, when they re-encounter their cognate antigen. (frontiersin.org)
Key open questions in MS research are the identification of the target antigen recognized by tissue resident CD8 + T-cells and B-cells and the molecular nature of the soluble inflammatory mediators, which may trigger tissue damage. (frontiersin.org)

Nasopharyngeal secretions were examined for viruses by indirect immunofluorescence and cell culture. (scielo.br)

Anatomy41

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Phenomena and Processes37

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Lymphocytes and plasma cells6

Eosinophils7

Inflammatory infiltrate composed1

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Lesions7

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