Infectious diseases disease models animal. Medical search. Frequent questions

The mentors for the training program are 23 NIH-funded investigators at UC Davis, whose work uses animal models to better understand a broad range of viral and bacterial human pathogens. (ucdavis.edu)
Used models, tailored with patient flow and health economic data, to support decisions about outbreak control interventions and to prevent transmission of resistant pathogens. (cdc.gov)
Explored the role companion animals play in the transmission and persistence of human pathogens. (cdc.gov)
The main objectives of the interdisciplinary Department of Global Health are to study infectious diseases and tackle the emergence of new pathogens. (pasteur.fr)
This has led to a wide array of new insights into the infectious action of pathogens, ranging from toxoplasma gondii to mycobacterium tuberculosis . (corning.com)
It is unclear when, where and how novel pathogens such as human immunodeficiency virus (HIV), monkeypox and severe acute respiratory syndrome (SARS) will cross the barriers that separate their natural reservoirs from human populations and ignite the epidemic spread of novel infectious diseases. (nih.gov)
New pathogens are believed to emerge from animal reservoirs when ecological changes increase the pathogen's opportunities to enter the human population and to generate subsequent human-to-human transmission. (nih.gov)
Increased human-animal interactions lead to the emergence and spread of zoonotic pathogens, which cause about 75% of infectious diseases affecting human health. (phys.org)
It adapts established methods developed to study the planet's natural systems, including climate change, ocean circulation and forest growth, and applies them to parasites and pathogens that cause disease . (phys.org)
Predicting where, how and when people and animals are at risk from emerging pathogens-and the best ways to manage this-remains a significant challenge. (phys.org)
Despite incredible advances in the understanding of how infectious diseases are transmitted, the models these efforts are based on are relatively limited in scope, focusing on specific pathogens and often overlooking how pathogens interact within their hosts. (phys.org)
What we're proposing is a new approach to modeling infectious diseases that are circulating in nature, which would allow scientists to simulate the behavior of these pathogens in wildlife populations, how they respond to human activities and better determine the risk that they pose to people. (phys.org)
By identifying general rules for how food chains that include disease entities are structured, it should be possible to predict the types of pathogens that are present in any given ecosystem. (phys.org)
Mice models are essential tools to study the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against various human pathogens. (medgadget.com)
The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has enabled the research community to study the process of the way pathogens cause diseases, the role of specific host genes in controlling or promoting disease, and potential targets for prevention or identification of treatment for a variety of infectious agents. (medgadget.com)
Mice models are necessary for learning about infections from many human pathogens. (medgadget.com)
Infectious diseases resulting from pathogens that have jumped from one host species to another are known as zoonoses . (medicalnewstoday.com)
The work comes as a salutary reminder that we are constantly at risk of new emergence of zoonotic pathogens and that farmed animals, with which humans have greater contact than with wildlife, may act as the source for important pandemic viruses. (medicalnewstoday.com)
This resistance to antimicrobial medicines is happening in all parts of the world for a broad range of pathogens, with an increasing prevalence that threatens human and animal health. (who.int)
The disease in "Contagion" is modeled on the lethal Nipah virus, one of the most threatening new infectious pathogens to jump from animals to humans. (brandeis.edu)
Our investigators study all aspects of infectious disease ranging from the fundamental science of microbial pathogens to the clinical outcomes of the infections they cause. (imperial.ac.uk)
That's a potentially big problem: some marine pathogens can eventually infect humans, and - less directly but perhaps more problematically - they can serve as a reservoir for antibiotic resistance genes that are eventually transferred to human diseases. (anthropocenemagazine.org)
Novel and faster diagnostic methods for the identification of disease causing pathogens are under investigation, with a focus on detection of antibiotic resistance and determination of pathogenicity. (lu.se)

Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Courtesy of the Centers for Disease Control and Prevention (CDC), Rob Weyant. (medscape.com)
Post-COVID Conditions Interim Guidance for Healthcare Professionals The Centers for Disease Control and Prevention has provided interim guidance on the diagnosis and management of post-COVID conditions, which are often referred to as 'Long COVID. (medscape.com)
Stephen C. Guptill (U.S. Geological Survey, Reston, VA) reported that the U.S. Geological Survey is working with the Centers for Disease Control and Prevention (CDC) to learn the current geographic extent of WNV. (cdc.gov)

This involves international monitoring of infectious diseases in association with the Institut Pasteur International Network and research on the animal reservoirs of antibiotic-resistant bacteria or viruses responsible for new outbreaks. (pasteur.fr)
We review the evidence for respiratory transmission of monkeypox virus (MPXV), examining key works from animal models, human outbreaks and case reports, and environmental studies. (researchgate.net)
Prior to the ongoing outbreak, Ebola virus disease (EVD) caused relatively small outbreaks (maximum outbreak size 425 in Gulu, Uganda) in isolated populations in central Africa. (nature.com)
These estimates can be used to parameterize transmission models to improve understanding of initial spread of EVD outbreaks and to inform surveillance and control guidelines. (nature.com)
Recent outbreaks of animal-borne emerging infectious diseases have likely been precipitated by a complex interplay of changing ecological, epidemiological and socio-economic factors. (nature.com)
Our modelling results match previously-observed outbreak patterns with high accuracy, and suggest further outbreaks could occur across most of West and Central Africa. (nature.com)
Ebola virus disease (EVD) was first identified in 1976, and since then there have been ~23 recognized outbreaks 12 , predominantly within central Africa. (nature.com)
Mechanistic, or process-based, models are ideal for capturing epidemiological characteristics of diseases and, importantly, testing how disease outbreaks might be impacted by intervention efforts 10 . (nature.com)
Finally, WNV surveillance data from CDC is being studied to determine the spatial and temporal relationships between disease outbreaks in birds and animals and human illness. (cdc.gov)
Somalia faced a triple threat of drought, impending famine and disease outbreaks. (who.int)
Ecological niche modeling for filoviruses: a risk map for Ebola and Marburg virus disease outbreaks in Uganda. (who.int)
Background: Lassa fever is a viral haemorrhagic illness responsible for disease outbreaks across West Africa. (folkhalsomyndigheten.se)

Collaborating with Cornell and Prof. Ben tenOever's Laboratory, and supported by Corning technologies, Chen aims to develop organoids using ultra-modern 3D cultures to advance our understanding of the disease mechanisms of COVID-19 and its links to diabetes and improved drug development, with the goal of more personalized medicine in the future. (corning.com)
Further, reports oriented towards the application of genetic analyses in oncological disease are not to be primarily targeted to the Immunogenetics unless they evolve in detail around the MHC (HLA) or other major immunogenetic systems and how those affect immune response and or therapy documented by real laboratory and/or clinical data, not solely bioinformatic analyses. (frontiersin.org)
Skilled in routine tissue sectioning in addition to histochemical and immunohistochemical staining techniques involving traditional laboratory animal models, Ms. Minai has become a technical expert in arthropod tissue processing supporting malaria, leishmaniasis, and tickborne. (nih.gov)
Indeed, virtually every major advance in medicine and surgery in this century has been made possible through the responsible use of laboratory animals. (nyu.edu)
A portable detection system can identify disease-causing bacteria far from the laboratory. (protomag.com)
This combination also seems to work against a broad spectrum of bacteria, and it's active against bacteria that form into a biofilm matrix-a sticky amalgam that can coat surfaces and be especially tricky to eliminate, explains Robin Patel , director of the Mayo Clinic's Infectious Diseases Research Laboratory in Rochester, Minn., the senior author of the new study. (protomag.com)
Laboratory Animal Science Professional 10(1) (January/February), 24-26. (awionline.org)
Laboratory Animal Science Professional 9(3) (May/June), 40-43. (awionline.org)
Laboratory Animals 55(6), 551-559. (awionline.org)
Laboratory Animals 54(4), 386-390. (awionline.org)
It's Okay to Cry - Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume V. Animal Welfare Institute, Washington, DC. (awionline.org)
This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. (awionline.org)
American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 597-598. (awionline.org)
T he proper care and use of laboratory animals in research, testing, teaching, and production ( animal use ) require scientific and professional judgment based on the animals' needs and their intended use. (nationalacademies.org)
The use of laboratory animals is governed by an interrelated, dynamic system of regulations, policies, guidelines, and procedures. (nationalacademies.org)
US Code, 42 USC § 289d) and the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS 2002). (nationalacademies.org)
The use of the Guide by non-US entities also presumes adherence to all regulations relevant to the humane care and use of laboratory animals applicable in those locations. (nationalacademies.org)
Supplemental information on various aspects of animal care and use is available in other publications prepared by the Institute for Laboratory Animal Research (ILAR) and other organizations ( Appendix A ). References in the Guide provide the reader with additional information that supports statements made in the Guide . (nationalacademies.org)
In the absence of published literature, some information in the Guide is derived from currently accepted practice standards in laboratory animal science (see Chapter 1 ). (nationalacademies.org)

Most chapters are devoted to a specific biological agent or toxin and supply interesting historical information as well as descriptions about the pathogenesis in humans and in animal models. (cdc.gov)
Here, we utilise our pre-clinical models to conduct a detailed gene-targeted investigation to understand and systematically dissect the pathways underlying SARS-CoV-2 pathogenesis. (edu.au)
My research focuses on companion animal virology and immunology with a view to understanding disease pathogenesis, correlates of immunity to infection and the development of novel approaches to the diagnosis, prevention and treatment of viral diseases. (gla.ac.uk)
and provides complete microscopic tissue evaluation utilizing a wide array of diagnostic, molecular, and special studies to support spontaneous and experimental disease pathogenesis research primarily involving significant and/or emerging public health threats. (nih.gov)
Mice with xenografted human immune systems have been used to study the pathogenesis of various infectious agents, including Plasmodium falciparum (malaria), Mycobacterium tuberculosis, dengue virus, and influenza virus. (medgadget.com)
Mice models are an essential resource for studying the mechanisms underlying infectious disease pathogenesis and as platforms for testing potential vaccines and therapies. (medgadget.com)

While the precise mechanisms leading to acute disease are still not fully understood, the cumulative damage of infection is now giving rise to a second pandemic of its long-term effects. (edu.au)
This information, along with data on ZDV efficacy in preventing perinatal transmission (3) and evidence that PEP prevented or ameliorated retroviral infection in some studies in animals (4), prompted a Public Health Service (PHS) interagency working group *, with expert consultation (5), in June 1996 to issue provisional recommendations for PEP for HCWs after occupational HIV exposure (6). (cdc.gov)
At the start of an infectious disease outbreak, it is critical to understand the transmission dynamics of the pathogen and to determine those at highest risk for infection or severe outcomes in the population(s) affected 28 , 29 . (nature.com)
These models have been beneficial for studying HIV, including analyzing viral and host factors that promote viral replication, HIV interactions with the host's immune response, and as platforms for testing therapeutic approaches to control or cure HIV infection. (medgadget.com)
Over the past century, advances in the development of vaccines, antibiotics/antivirals, and infection control measures have significantly reduced the public health burden of infectious diseases. (medgadget.com)
The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)
Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)

The Research Centre for Emerging and Reemerging Infectious Diseases is part of the Pasteur Institute of Iran. (wikipedia.org)
Teams in the department are also working closely with national and international organizations such as Santé Publique France (SpF), the European Centre for Disease Prevention and Control (ECDC), the World Health Organisation (WHO), and the World Organisation for Animal health (OIE). (pasteur.fr)
It is in human tissue that we will find the answers to these diseases' - Dr John Xuereb, Director, Cambridge Brain Bank & Wolfson Imaging Centre. (safermedicines.org)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers interested in solving practical health problems using multidisciplinary approaches and in a One Health framework. (sfu.ca)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers with backgrounds in microbiology, molecular biology, computer science, cognitive science, statistics, public health, and genomics. (sfu.ca)

ABSTRACT Zoonoses constitute more than 60% of all known infectious diseases and 75% of emerging infectious diseases. (who.int)

NICEATM and NC3Rs are partnering with the National Institute of Allergy and Infectious Diseases, the U.S. Army Combat Capabilities Development Command Chemical Biological Center, and NCATS to direct the MPS for COVID Research (MPSCoRe) working group. (nih.gov)

I am a wildlife ecologist and field veterinarian, most recently working on modelling the impact of canine distemper (CDV) on wild tiger populations to understand the contribution of domestic and wild carnivores to the CDV reservoir. (gla.ac.uk)

Drug-resistant bacteria can circulate in populations of human beings and animals, through food, water and the environment, and transmission is influenced by trade, travel and both human and animal migration. (who.int)
A long-term study of two populations found extraordinarily high levels of disease, which is likely related to high levels of pesticides and other pollutants in their bodies - a sign of ecosystem-wide problems, and also a warning that people in the region may also be at risk. (anthropocenemagazine.org)
Farm animal populations as models for infectious diseases of humans. (bvsalud.org)
The majority of infections result from interactions between the animal reservoir and human populations, although secondary transmission between humans can occur, particularly in hospital settings. (folkhalsomyndigheten.se)
This life-threatening disease mostly affects poor rural populations, causing significant harm. (who.int)

With the emergence of new infectious diseases, the animal model has become a vital tool for studying disease mechanisms and developing therapeutics. (medgadget.com)
I want to talk to someone about my research proposal (basic research, neural mechanisms, or disease mechanisms). (nih.gov)
Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
Immunoregulatory mechanisms of dietary compounds during infectious diseases. (frontiersin.org)
During sepsis, these host defence systems become pathologically augmented and deregulated and we develop experimental models to delineate cellular and molecular mechanisms involved. (lu.se)

Resistance that develops in one organism or location can also spread rapidly and unpredictably, through for instance exchange of genetic material between different bacteria, and can affect antibiotic treatment of a wide range of infections and diseases. (who.int)
It is futile to study infections in animals that do not contract them in any similar way. (safermedicines.org)
Models suggest that an individual requires more than 150 lifetime infections to develop the blinding complications of trachoma. (who.int)

The program seeks to train talented graduate students to conduct studies of human infectious diseases using animal models and novel biological methods that are evolving from the revolutions in genomics and bioinformatics. (ucdavis.edu)
HLA traveled a long distance from initially being regarded as a transplant antigen to becoming a molecule of interest in the 21st century for the development of novel diagnostics and therapeutics in the treatment of human diseases, vaccine design, pharmacogenetics, and genomics. (frontiersin.org)
On another floor is Paradigm Therapeutics, which plans to extend the genomics-driven research on the central nervous system and metabolic diseases that it does at its UK home in Cambridge. (newscientist.com)

As an Honorary Consultant in Infectious Diseases, my research focuses on the epidemiology of influenza and other respiratory viruses in the UK and sub-Saharan Africa including COVID-19. (gla.ac.uk)

Some currently-available drugs as well as approaches undergoing testing in pre-clinical models of radiation injury have shown great promise as mitigators/treatments, improving survival and enhancing other indicators such as levels of immune and other blood cells. (nih.gov)
Under the agreement, Navacims - a precision nanomedicine discovered by Santamaria that is designed to trigger a naturally occurring regulatory mechanism in the immune system to protect against autoimmune disease - will be developed and commercialized. (ucalgary.ca)
Later, using animals, scientists found that it was the immune system that was responsible for the rejection phenomenon. (nyu.edu)
Most were infected or afflicted by virulent fungi, bacteria and viruses, a disease profile that suggests profound disturbances in their immune systems. (anthropocenemagazine.org)
Modulation of immune responses by dietary components in inflammatory bowel disease, celiac disease, diabetes and obesity. (frontiersin.org)
Computational modeling of the modulation of immune responses by dietary components, natural products and oral drugs. (frontiersin.org)

The global Coronavirus Disease (COVID-19) pandemic caused by the SARS-CoV-2 virus has raised many urgent questions about the transmission of this disease, including the possible roles of aerosols containing SARS-CoV-2. (cdc.gov)
Research by the aerosol science community is needed to learn more about whether SARS-CoV-2 can spread by infectious aerosols and about the effectiveness of different protective measures. (cdc.gov)
The virus also had the ability to infect ferrets, which researchers often use to model human influenza, and to transmit from animal to animal via tiny airborne droplets called aerosols. (medicalnewstoday.com)

The NITD is plugging into the country's strengths in infectious disease research by concentrating on developing new treatments for dengue fever and tuberculosis. (newscientist.com)
A novel use of bacteria could blunt the spread of dengue and other mosquito-borne diseases. (protomag.com)
Dengue is a mosquito-borne viral disease that has rapidly spread in all regions of WHO in recent years. (who.int)

I study the transmission dynamics of bovine tuberculosis, a disease of cattle caused by Mycobacterium bovis . (gla.ac.uk)
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae. (who.int)

Adam Linder is an Senior Lecturer and senior consultant in Infectious Diseases at Lund University Hospital, Lund, Sweden. (lu.se)

Such lethal diseases were not hard to imagine considering the poor hygiene and lack of knowledge about the root of transmission, prevention and effective treatment of that time. (wikipedia.org)
The goal of the draft global action plan is to ensure, for as long as possible, continuity of successful treatment and prevention of infectious diseases with effective and safe medicines that are quality-assured, used in a responsible way, and accessible to all who need them. (who.int)
With this approach, the main goal of ensuring treatment and prevention of infectious diseases with effective and safe medicines is achievable. (who.int)
d Chinese Center for Disease Control and Prevention, Beijing, China. (who.int)

Interestingly, the vast majority of studies exploring the gradient have focused on free-living organisms, ignoring parasitic and infectious disease (PID) species. (plos.org)
The draft global action plan covers antibiotic resistance in most detail but also refers, where appropriate, to existing action plans for viral, parasitic and bacterial diseases, including HIV/AIDS, malaria and tuberculosis.1 Many of the actions proposed in this plan are equally applicable to antifungal resistance. (who.int)
Onchocerciasis - or "river blindness" - is a parasitic disease caused by the filarial worm Onchocerca volvulus transmitted by repeated bites of infected blackflies (Simulium spp. (who.int)

The book is exceptionally well written and furnishes a wealth of information from world-renowned scientists who spearheaded infectious disease research at the United States Army Research Institute of Infectious Diseases. (cdc.gov)
Biodefense: Research Methodology and Animal Models will certainly benefit scientists designing aerobiology studies or those exploring the infectious agents and toxins discussed in this book. (cdc.gov)
Training emphasizes rigorous scientific research, oral and written scientific communication, and interaction with a broad range of scientists interested in animal models of human infectious diseases. (ucdavis.edu)
Published May 17 in Nature Ecology and Evolution , Smithsonian scientists and partners provide a framework for a new approach to modeling infectious diseases. (phys.org)
While scientists and global health organizations are putting a lot of effort into studying the diversity of disease-causing organisms, existing models do not link this diversity to their roles within ecosystems . (phys.org)
The basis of this rejection phenomenon was uncovered early in the century by scientists who tested transplantation in animal experiments. (nyu.edu)
Mini gut models give scientists a front row seat to some of the most puzzling pathogen behaviors. (protomag.com)
One of our key objectives as a Department is to inspire the next generation of infectious disease scientists, which includes developing the careers of our postdoctoral Fellows. (imperial.ac.uk)

To investigate animal reservoirs of monkeypox virus in Nigeria, we sampled 240 rodents during 2018-2019. (researchgate.net)
Birds are often reservoirs for arboviruses, which are transmitted by mosquitoes to horses, other domestic animals, and humans. (msdmanuals.com)
These viruses may spread to humans from nonhuman reservoirs, but most arboviral diseases are not transmissible by humans, perhaps because the typical viremia is inadequate to infect the arthropod vector. (msdmanuals.com)
HAT transmission requires the interaction of humans, tsetse flies and parasite reservoirs (humans, and domestic and wild animals). (who.int)

New CDC Center Forecasting the Next Outbreak Modeling now allows CDC to identify and react quickly to emerging infectious disease threats. (medscape.com)
Hit Pandemic Show Is Fantastical but Not Baseless As a culture, we don't seem to be tiring of outbreak fiction, but a new series has something new to add to the genre, according to infectious disease expert Dr Paul Auwaerter. (medscape.com)
Our knowledge gaps and the need for improved forecasting of zoonotic disease risk were starkly illustrated by the 2013-2016 Ebola outbreak, which was unprecedented in terms of size, financial cost, and geographical location 10 , 11 . (nature.com)

I am interested in the applications of modelling techniques to conservation and management, particularly in modelling species occurrence, population dynamics and biotic interactions. (gla.ac.uk)
Moreover, our understanding of human diseases and the existence of complete data sets provide an incomparable opportunity to explore the existence of a relationship between PID species richness and latitude, and to identify the determining factors of this latitudinal gradient. (plos.org)
Ultimately, virtually all new drugs and treatments must be tested on animals serving as surrogates for us as well as their own or other species of animals. (nyu.edu)
They found that when transplantation was performed between animals of different species or between genetically different animals of the same species, the transplants were quickly rejected. (nyu.edu)
In other species, this type of prolonged smoldering inflammation is associated with cancer, autoimmune disease, cardiovascular disease and increased vulnerability to infectious disease," says Greg Bossart, chief veterinary officer at the Georgia Aquarium and part of the research team. (anthropocenemagazine.org)
A map defining areas of environmental suitability for zoonotic transmission of Lassa fever was generated using an ensemble boosted regression trees (BRT) species distribution modelling framework. (folkhalsomyndigheten.se)
The leishmaniases are a group of diseases caused by protozoan parasites from more than 20 Leishmania species. (who.int)
The efficacy of therapeutic interventions for zoonotic diseases is deemed to be comparable across species with scientifically valid results originating from a range of animal experiments. (who.int)

The agreement is for treatments for celiac disease, inflammatory bowel disease, and autoimmune liver diseases. (ucalgary.ca)

My research focuses on transmission of Streptococcus agalactiae in networks of humans and animals. (gla.ac.uk)
Leptospirosis is an infectious disease of humans and animals that is caused by pathogenic spirochetes of the genus Leptospira . (medscape.com)

The studies use both in vitro cellular models of bacterial communities (biofilms) to characterise the phenotype of disease-causing bacteria. (lu.se)

Lung and airway organoids are of interest for both drug and vaccine development and are valuable tools for studying infectivity in human respiratory diseases, particularly for challenging viral diseases like COVID-19. (corning.com)
However, there has been an increase in contagious viral diseases over the years. (medgadget.com)

Researchers say this new model will require expertise and collaboration across fields such as veterinary and human medicine, disease ecology, biodiversity conservation, biotechnology and anthropology. (phys.org)

clarification needed] One year after World War I and despite the persistent problems caused by casualties and infectious diseases in the country resulting from war, the Iranian government decided to renew its relationship with France to promote medical sciences and research concerning different types of endemic infectious diseases. (wikipedia.org)
Trends in the underlying drivers of EVD risk suggest a 1.75 to 3.2-fold increase in the endemic rate of animal-human viral spill-overs in Africa by 2070, given current modes of healthcare intervention. (nature.com)

We constructed a set of mathematical models to describe the trade-off between learning and feeding, and aim to link the theoretical results with activity of grey seals in Scotland. (gla.ac.uk)
I am interested in mathematical modelling of infectious diseases. (gla.ac.uk)

The threat of deadly zoonoses, diseases transmitted from animals to humans, isn't confined to medical thrillers. (brandeis.edu)
One downside is that mechanistic models of zoonoses often do not incorporate spatially heterogeneous ecological and environmental information, such as the environmental differences leading to variation in host suitability 25 . (nature.com)
The Sixth Annual Conference on New and Reemerging Infectious Diseases was hosted April 24–25, 2003, by the Center for Zoonoses Research and the College of Veterinary Medicine, University of Illinois at Urbana-Champaign (UIUC). (cdc.gov)

The results, reviewed in the journal Diseases of Aquatic Organisms , were troubling. (anthropocenemagazine.org)
Diseases of Aquatic Organisms , 2017. (anthropocenemagazine.org)
When a local or systemic disease process or concomitant use of medications alters this overall pattern, atypical organisms begin to predominate and some normal organisms with a benign nature, such as Candida albicans, become pathogenic. (medscape.com)
Periodontal disease permits organisms to enter deep systemic tissues, such as the carotid atheroma. (medscape.com)

Existing models are limited in their ability to predict disease emergence, since they rarely consider the dynamics of the hosts and ecosystems from which pandemics emerge. (phys.org)

Even the most sophisticated non-animal methodologies cannot mimic the complicated interactions among cells, tissues and organs that occur in living beings. (nyu.edu)
Conclusions: These maps act as a spatial guide for future surveillance activities to better characterise the geo- graphical distribution of the disease and understand the anthropological, virological and zoological interactions necessary for viral transmission. (folkhalsomyndigheten.se)

We need to be vigilant about other infectious disease threats even as COVID is going on because viruses have no interest in whether we're already having another pandemic. (medicalnewstoday.com)

My group investigates the links between human papillomavirus (HPV) infectious lifecyle & epithelial differentiation and how HPV-associated tumour progression is achieved. (gla.ac.uk)
Discover how Dr. Hans Clevers from the Hubrecth Organoid Technology (HUB), located in Utrecth, The Netherlands, successfully expanded adult stem cell-derived organoids in genetically stable form and ultimately, was able to generate in vitro models of any epithelial disease from any patient. (corning.com)

Crimean-Congo haemorrhagic fever was reported in Afghanistan and Pakistan, and the United Arab Emirates reported travel-associated Legionnaire's disease during the first quarter of 2017. (who.int)

and finally, toxin- and superantigen-induced diseases caused by botulinum toxins, ricin, and staphylococcal and streptococcal bacteria. (cdc.gov)
With the new version, general "episystem" models, the paper's authors outline a framework for integrating disease agents (including parasites, viruses and bacteria) into these models. (phys.org)
Resistant bacteria can be found in food animals and food products destined for consumption by humans. (who.int)
When tested in the lab, bacteria in the Indian River dolphins also demonstrated high levels of antibiotic resistance, likely the result of exposure to antibiotics released farmed animal waste and human sewage. (anthropocenemagazine.org)

Our modelling framework can be used to target interventions designed to reduce epidemic risk for many zoonotic diseases. (nature.com)

The Department of Infectious Disease's mission is to apply excellent science and develop new approaches to address the unmet clinical needs for the control of infectious disease, both here in the UK and internationally. (imperial.ac.uk)

This reference will equip researchers with pertinent information regarding current animal models, so that future work will not repeat experiments already performed, while at the same time minimizing the number of animals projected for future biodefense studies. (cdc.gov)
The advancement of 3D cell culture disease modeling has allowed researchers to study viral and cellular science more realistically than ever before. (corning.com)
Researchers are working to develop disease-fighting therapies based on the interaction of the microbiome. (ucalgary.ca)

Our existing knowledge of SARS-CoV-2 driven disease predominantly relies on correlative or in vitro studies, and it is yet unclear which pathways are causative of severe inflammation in vivo . (edu.au)
Its research activities range from basic science to clinical studies, with an overall approach including human, animal and environmental health (One Health approach). (pasteur.fr)
Since 2016, Ms. Nagata has provided critical technical support to research studies requiring development, troubleshooting, and optimization of routine and special stains for immunohistochemistry, immunofluorescence, and in-situ hybridization on a wide host of animal tissues. (nih.gov)
Aside from coronavirus studies, mice models are considered the best small animal models for hepatitis B virus (HBV), hepatitis C virus (HCV), Zika virus, and cytomegalovirus (CMV). (medgadget.com)
Mice models have been widely used for various viral studies due to their small size, low cost, ease of use, and high reproducibility. (medgadget.com)
NAMs for chemical hazard assessment are often evaluated in comparison to animal studies. (nih.gov)
Ethical obligations limit the number of animals used in experiments as well as reduce repetition of studies. (who.int)

Habitat loss, rapid population growth and global travel are creating a perfect storm for lethal viruses to spill over from animals to people. (brandeis.edu)

In the midst of a devastating global pandemic of wildlife origin and with future spillovers imminent as humans continue to come into closer contact with wildlife, infectious-disease models that consider the full ecological and anthropological contexts of disease transmission are critical to the health of all life. (phys.org)

Several systemic diseases, such as diabetes mellitus, may increase the prevalence, incidence, or severity of gingivitis and periodontitis. (medscape.com)

2020. Use of high frequency jet ventilation as a refinement for imaging macaques with respiratory disease. (awionline.org)

COVID-19 was a global pandemic of profound complexity, from seemingly asymptomatic cases to severe and life-threatening disease. (edu.au)
The emergence of the COVID-19 pandemic in 2019 has prompted animal models to study its pathology and develop an effective treatment. (medgadget.com)
Even more nerve-racking, many of the reported Nipah cases spread from person to person - an unsettling reminder of just how easily viruses carried by animals can adapt to human hosts - creating the potential for a pandemic. (brandeis.edu)

Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
3D modeling is more predictive of biological systems, making in vitro results more easily translated to human patients. (corning.com)
Information from these analyses will guide the creation of predictive models of disease risk. (cdc.gov)

It clearly and concisely provides extensive details about the animal models, both past and present, that have been used to investigate a selected number of disease processes caused by exposure to plausible biological threat agents. (cdc.gov)
The decision to recommend HIV postexposure prophylaxis must take into account the nature of the exposure (e.g., needlestick or potentially infectious fluid that comes in contact with a mucous membrane) and the amount of blood or body fluid involved in the exposure. (cdc.gov)
Transmission between humans occurs through exposure to infectious bodily fluids, typically from close contact with infectious individuals when caring for EVD patients (e.g., sharing of contaminated needles, family home care, insufficient protective measures among health care workers in health care settings 6 , 24 , 25 ) or with fatal EVD patients in preparation for burial 19 , 20 . (nature.com)
Available data indicate that more than three quarters of cases (59/77, 76%) had recent exposure to animals. (who.int)

The pathway to the $1-billion deal began in Santamaria's childhood, requiring him to overcome formidable challenges along the way, long before his research into autoimmune disease gained traction and attracted investor attention. (ucalgary.ca)

Biodefense: Research Methodology and Animal Models, edited by James R. Swearengen, is a timely and invaluable reference for those performing animal experimentation to develop medical countermeasures and diagnostics against infectious agents and toxins identified as potential biological weapons. (cdc.gov)
Organoid cell culture has transformed cell-based assays in drug discovery and basic biology by conferring physiologic relevance to in vitro cell-based biological models. (corning.com)
Future of biomedical, agricultural and biological systems research using domesticated animals. (usda.gov)

3D models better represent the physical and biochemical environments that viruses encounter in vivo . (corning.com)
Ebola Reston is unique among the five Ebola viruses in that it is not known to cause disease in humans 10 and Ebola Tai Forest has only been reported in 1 human case 11 . (nature.com)

Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, is caused by a zoonotic virus first discovered in 1976 in remote villages of Democratic Republic of Congo (DRC, formerly Zaire) and Sudan 1 - 4 . (nature.com)
Here, we develop modelling methods that capture elements of each of these factors, to predict the risk of Ebola virus disease (EVD) across time and space. (nature.com)

Guernier V, Hochberg ME, Guégan J-F (2004) Ecology Drives the Worldwide Distribution of Human Diseases. (plos.org)

This work involves production of monoclonal antibodies, cloning of P. carinii genes (in collaboration with Dr. C.G. Haidaris and Dr. P.J. Haidaris, Departments of Microbiology and Immunology and of Medicine), and extensive use of animal models of P. carinii pneumonia. (rochester.edu)
The recent advances in bioinformatics, systems biology and computational modeling provide an opportunity for systems level, mechanistic understanding of nutritional immunology processes. (frontiersin.org)

Here, we developed unique pre-clinical in vivo models that reproduce aspects of mild, severe and fatal COVID-19. (edu.au)
Interestingly, even long after the virus is cleared, animals still display pronounced lung inflammation, heart abnormalities and cognitive impairment, collective hallmarks of Long COVID. (edu.au)
This article presents information on human lung tissue modeling as a platform for studying COVID-19. (corning.com)

The animal reservoir is very important in T. b. rhodesiense and less so in T. b. gambiense, although it could explain the long-term endemicity in some foci despite control interventions. (who.int)
A compre- interventions providing evidence of a tain comparable levels of information hensive literature review by Taylor et treatment effect, either benefit or harm, from fewer animals or to obtain more al. (who.int)

Geographic information systems in conjunction with fine resolution satellite data and spatial statistics are also useful to investigate the distribution of other diseases, for example, schistosomiasis (Julie A. Clennon, UIUC, Urbana). (cdc.gov)
Schistosomiasis is a disease of poverty that leads to chronic ill-health. (who.int)

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