• An abnormal postcoital test result is observed in 10% of infertile couples. (medscape.com)
  • Males with Klinefelter's syndrome have an extra X chromosome, which causes abnormal development of the testicles. (ubbcluj.ro)
  • A review in 2013 came to the result that oligospermia and azoospermia are significantly associated with being overweight (odds ratio 1.1), obese (odds ratio 1.3) and morbidly obese (odds ratio 2.0), but the cause of this is unknown. (wikipedia.org)
  • Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)
  • Men with microdeletions affecting the Y chromosome, particularly in the AZFc (azoospermia factor c) region, can develop oligozoospermia via various mechanisms, depending on the specific deletion. (msdmanuals.com)
  • It is divided into roughly 60% Non-obstructive Azoospermia (NOA) cases and 40% Obstructive Azoospermia cases (OA).Non-Obstructive Azoospermia (NOA) is a medical disorder in which spermatogenesis fails and a man is unable to make sperm. (jananamfertility.com)
  • Non-Obstructive Azoospermia is a condition in which a male is unable to produce sperm. (jananamfertility.com)
  • In azoospermia, no sperm are present.To determine the causes and establish a treatment plan, additional investigations such hormone tests, chromosomal analysis (Karyotype and Yq microdeletions), and testicular ultrasonography are helpful. (jananamfertility.com)
  • There are many causes for oligospermia including: Pre-testicular factors refer to conditions that impede adequate support of the testes and include situations of poor hormonal support and poor general health including: Hypogonadism due to various causes Drugs, alcohol, smoking Strenuous riding (bicycle riding, horseback riding) Medications, including androgens. (wikipedia.org)
  • Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
  • Patients should be asked about a history of childhood illnesses such as testicular torsion , postpubertal mumps, developmental delay, and precocious puberty , as well as urinary tract infections, sexually transmitted diseases, and bladder neck surgery. (medscape.com)
  • A common single-nucleotide polymorphism of BRCA2 is associated with severe oligospermia. (wikipedia.org)
  • Increasingly, genetic abnormalities are being found in men with severe oligospermia. (wellinghomeopathy.com)
  • A team at Newcastle University has identified a genetic mechanism that causes severe male infertility Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. (ubbcluj.ro)
  • One of the most severe types of male infertility is this one. (jananamfertility.com)
  • These include conditions such as Klinefelter syndrome (47, XXY) and exchanges of genetic material in non-sex chromosomes and are detected by blood tests. (wellinghomeopathy.com)
  • The discussion of male infertility focuses on genetic factors impairing spermatogenesis and includes numerical chromosomal anomalies such as Klinefelter syndrome, structural chromosomal anomalies such as Y-chromosome microdeletions, certain single gene mutations, syndromic diseases, and epigenetic mutations. (ubbcluj.ro)
  • have congenital bilateral absence of the vas deferens, but the vasa deferentia may also be absent in men with mutations of CTFR that do not cause symptomatic cystic fibrosis. (msdmanuals.com)
  • Identification of novel homozygous missense and deletion mutations manifesting oligospermia infertility in Kashmiri population. (cdc.gov)
  • Mutations that occur during the reproduction process, when the DNA of both parents is replicated, can lead to infertility in males later in life. (ubbcluj.ro)
  • Background Genetic causes of male infertility are hypothesized to involve multiple types of mutations, from single gene defects to complex chromosome rearrangements. (ubbcluj.ro)
  • Another rare mechanism of infertility is destruction or inactivation of sperm by sperm antibodies, which are usually produced by the man. (msdmanuals.com)
  • Cervical problems: Cervical mucus can hinder the passage of sperm due to estrogen deficiency, infections , damage to the cervical glands or, rarely, due to the fact that the woman develops antibodies against the sperm. (hickeysolution.com)
  • Neisseria meningitidis causes invasive meningococcal diseases and has also been identified as a causative agent of sexually transmitted infections, including urethritis. (bvsalud.org)
  • Unencapsulated sequence type 11 meningococci containing the gonococcal aniA-norB locus and belonging to the United States N. meningitidis urethritis clade (US_NmUC) are causative agents of urethral infections in the United States, predominantly among men who have sex with men. (bvsalud.org)
  • Despite this, many genetic causes of male infertility remain unknown, even though it is recognised that rates of genetic abnormalities are likely to be increased among men requiring ART. (ubbcluj.ro)
  • Detection of certain genetic causes of male infertility allows couples to be informed about the potential to transmit genetic abnormalities that may affect the health of offspring. (ubbcluj.ro)
  • Evaluation of TUBB8 gene alterations in infertile women with oocyte maturation and cleavage arrest referred to Royan Institute. (cdc.gov)
  • We previously identified TBC1D21 as a sterility-related RabGAP gene from infertile men. (ubbcluj.ro)
  • For many decades sperm concentrations of less than 20 million sperm/ml were considered low or oligospermic, recently, however, the WHO reassessed sperm criteria and established a lower reference point, less than 15 million sperm/ml, consistent with the 5th percentile for fertile men. (wikipedia.org)
  • Reference ranges for sperm counts are defined in fertile (not infertile) men. (wellinghomeopathy.com)
  • In cases of sole male-factor infertility, the female partner is fertile, and has properly functioning ovaries, fallopian tubes, and uterus. (givelegacy.com)
  • Female-factor infertility would be the opposite - a case in which the male partner was fertile, but the female partner had a condition that affected their ability to conceive or carry a pregnancy. (givelegacy.com)
  • Many men conceive without trouble having low sperm counts. (wellinghomeopathy.com)
  • One study found that the male children of men who used intracytoplasmic sperm injection (ICSI) to conceive were significantly more likely to experience poor semen quality parameters - including lower sperm concentration , sperm count , and motility - compared to male children who were naturally conceived. (givelegacy.com)
  • Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population. (cdc.gov)
  • Recently, several recurrent X-chromosome microdeletions (located in subtelomeric region of the long arm) were reported to be associated with male infertility in Spanish and Italian males. (ubbcluj.ro)
  • A number of factors may be involved in the genesis of this condition, including age, infectious agents ( such as Chlamydia trachomatis), Y chromosome microdeletions, mitochondrial changes, environmental pollutants, and "subtle" hormonal changes. (wikipedia.org)
  • The initial evaluation of the male patient should be rapid, noninvasive, and cost-effective, as nearly 70% of conditions that cause infertility in men can be diagnosed with history, physical examination, and hormonal and semen analysis alone. (medscape.com)
  • In 2% of men, low sperm counts may be due to hormonal imbalance from prolactinoma. (wellinghomeopathy.com)
  • An estimated 15% of couples meet this criterion and are considered infertile, with approximately 35% due to female factors alone, 30% due to male factors alone, 20% due to a combination of female and male factors, and 15% unexplained. (medscape.com)
  • When couples are infertile, the man should always be evaluated for sperm disorders. (msdmanuals.com)
  • Author summary Male sterility affects one in seven couples, and around half of these are the result of male factor disorders. (ubbcluj.ro)
  • Many causes of genetic male infertility can be overcome with assisted reproductive technology (ART) , or fertility treatments. (givelegacy.com)
  • In a number of situations direct medical or surgical intervention can improve the sperm concentration, examples are use of FSH in men with pituitary hypogonadism, antibiotics in case of infections, or operative corrections of a hydrocele, varicocele, or vas deferens obstruction. (wikipedia.org)
  • Causes of male infertility - UpToDate Causes of male infertility Endocrine and systemic disorders (hypogonadotropic hypogonadism) Congenital disorders Congenital GnRH deficiency (Kallmann syndrome) Iron overload syndromes Multiorgan genetic disorders (Prader-Willi syndrome, Laurence-Moon-Biedl syndrome, familial cerebellar ataxia) Low sperm count (oligospermia) A malfunctioning immune system. (ubbcluj.ro)
  • Experts estimate about one-third of infertility cases are male-factor infertility, one-third are female-factor infertility, and the final third involve factors related to both partners, or are unexplained. (givelegacy.com)
  • Male Infertility Causes - More than 90% of male infertility cases are due to low sperm counts, poor sperm quality, or both. (ubbcluj.ro)
  • The initial step in the evaluation of an infertile male is to obtain a thorough medical and urologic history. (medscape.com)
  • See also Diagnostic evaluation of the infertile male: A committee opinion , from the Practice Committee of the American Society for Reproductive Medicine. (msdmanuals.com)
  • Thus, an appropriate male evaluation may allow the couple to better understand the basis of their infertility and to obtain genetic counseling when appropriate. (ubbcluj.ro)
  • So while other male fertility factors like age , diet, lifestyle , and hormones may be common, genetics is sometimes a factor or even the sole cause of male-factor infertility. (givelegacy.com)
  • While many cases of male-factor infertility can be treated with simple lifestyle interventions, in some cases, the cause is deeper - your genes. (givelegacy.com)
  • A history of neurological diseases, diabetes, and pulmonary infections should be elicited. (medscape.com)
  • hence, the term is used as a synonym of recurrent Definition and causes of infertility Santiago Brugo-Olmedo1, Claudio Chillik, Susana Kopelman CEGYR, Center for Gynecology and Reproduction Studies, Viamonte 1438, Capital Federal (1055), Argentina Infertility in Men and Women Mary Goodman March 15, 2006 Infertility in Males Although men with Cystic Fibrosis still may have a great sex life, the majority of them are infertile. (ubbcluj.ro)
  • Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
  • Men with mild oligospermia (semen concentration of 15 million to 20 million sperm/ml) were studied for an association of sperm DNA damage with life style factors. (wikipedia.org)
  • Possible core outcomes will be identified by undertaking a systematic review of randomized controlled trials evaluating potential treatments for male factor infertility. (bvsalud.org)
  • Analysis of copy number variation in AZF region of Y chromosome in patients with spermatogenic failure]. (cdc.gov)
  • Male-factor infertility and genetics: Is male infertility inherited? (givelegacy.com)
  • There are a few known, but rare genetic conditions that affect male fertility or cause male-factor infertility. (givelegacy.com)
  • Genetics may contribute to anywhere from 15-60% of male-factor infertility. (givelegacy.com)
  • What is male-factor infertility? (givelegacy.com)
  • Male-factor infertility refers to difficulty conceiving that's primarily caused by issues with the sperm's inability to fertilize the egg. (givelegacy.com)
  • A number of conditions could contribute to male-factor infertility, including low sperm count or poor sperm motility . (givelegacy.com)
  • One sign that male-factor infertility may involve genetics: There is some evidence that men who are infertile are more likely to have sons who are infertile, as well. (givelegacy.com)
  • Since ICSI is a treatment that helps overcome male-factor fertility issues, such as oligospermia (low sperm count), it's possible that those same male fertility issues may be genetically passed down to male offspring. (givelegacy.com)
  • In most cases of oligospermia including its idiopathic form there is no direct medical or surgical intervention agreed to be effective. (wikipedia.org)
  • Am. Diagnosing male infertility problems usually involves: General physical examination and medical history. (ubbcluj.ro)
  • These may include complex issues, such as variation in outcome measures and outcome reporting bias, as well as failure to consider the perspectives of men and their partners with lived experience of fertility problems. (bvsalud.org)
  • Approximately 9% of men in the US have reported seeking advice, testing, or treatment for infertility . (givelegacy.com)
  • Conditions of the male that affect fertility are still generally underdiagnosed and undertreated. (medscape.com)
  • However, data indicate that daily ejaculation does not reduce the sperm count in men unless there is a problem. (msdmanuals.com)
  • The use of carnitine showed some promise in a controlled trial in selected cases of male infertility improving sperm quality and further studies are needed. (wikipedia.org)
  • This has a general effect on health and in some cases it can have a direct impact on male fertility. (hickeysolution.com)
  • The consistent use of hot tubs or baths, recreational drugs such as alcohol, cocaine, marijuana or tobacco, and fevers from flu's or other infections can all lower sperm counts in otherwise healthy men. (wellinghomeopathy.com)
  • Precocious puberty, defined as the onset of puberty before age 9 years in males, may be the sign of a serious underlying endocrinologic disorder. (medscape.com)