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Staphylococcus aureusStaphylococcusStaphylococcal InfectionsMethicillin-Resistant Staphylococcus aureusMethicillin ResistanceStaphylococcus epidermidisAnti-Bacterial AgentsStaphylococcus PhagesMicrobial Sensitivity TestsMethicillinCoagulaseStaphylococcal Protein AVancomycinBacterial ProteinsStaphylococcal Skin InfectionsOxacillinNoseLysostaphinBacteremiaCarrier StateCross InfectionExotoxinsBacterial ToxinsVancomycin ResistanceDNA, BacterialLeukocidinsDrug Resistance, BacterialPneumonia, StaphylococcalDaptomycinMupirocinGram-Positive BacteriaAnti-Infective AgentsPenicillin ResistanceEndocarditis, BacterialDrug Resistance, MicrobialOxazolidinonesElectrophoresis, Gel, Pulsed-FieldAcetamidesMastitis, BovineColony Count, MicrobialBiofilmsBacteriophage TypingAbscessStaphylococcal VaccinesCommunity-Acquired InfectionsBacterial Typing TechniquesNasal CavityStaphylococcus haemolyticusCulture MediaExfoliatinsBacteriaVirulence FactorsOsteomyelitisTeichoic AcidsEnterotoxinsTeicoplaninFusidic AcidBacteriological TechniquesGene Expression Regulation, BacterialGenes, BacterialSoft Tissue InfectionsPenicillinsCell WallPenicillin-Binding ProteinsGentamicinsSuperantigensNafcillinPeptidoglycanMolecular Sequence DataMicrobial ViabilityGram-Negative BacteriaHemolysin ProteinsCloxacillinBacteriolysisDrug Resistance, Multiple, BacterialBacterial AdhesionStaphylococcal Food PoisoningMolecular TypingWound InfectionPenicillinaseCiprofloxacinBacterial InfectionsMuramoylpentapeptide CarboxypeptidasePeptidyl TransferasesClindamycinCephalosporinsHexosyltransferasesAdhesins, BacterialMastitisDNA FingerprintingFluoroquinolonesEscherichia coliNasal MucosaStaphylococcus lugdunensisEnterococcusVirulenceVirginiamycinPolymerase Chain ReactionAnti-Infective Agents, LocalMolecular Epidemiology
StrainsIsolatesStreptococcusPatientsBloodstream infectionsBacteremiaBacteriaClostridiumAbstractBacteraemiaMethicillinClinicalPneumoniaColonization and infectionVirulenceInfective endocarditisBiofilm formationPathogensInvasiveResistanceSepsisIncidenceCatheter-Related InfectionsPseudomonasMajor pathogenAntibioticsPolymicrobialAbscessesMSSACoagulase-negative stapSoft tissue infectionSSTIsVitroMultidrugControl and Hospital EpidemiologyStaphylococcalViral InfectionsSkinPreventionEpidemiologyMorbiditySpeciesUrinaryNosocomialInfestationsStrainBacterial infectionMusculoskeletalIntensive careVancomycin
Strains21
  • Both community-associated and hospital-acquired infections with Staphylococcus aureus have increased in the past 20 years, and the rise in incidence has been accompanied by a rise in antibiotic-resistant strains-in particular, methicillin-resistant S aureus (MRSA) and, more recently, vancomycin-resistant strains. (medscape.com)
  • Rates of methicillin-resistant infections were extremely high (146-482/10,000 population), and most (98.2%) were caused by USA400 strains. (cdc.gov)
  • These CA-MRSA strains are causing infections in often young otherwise healthy persons with no traditional health care- associated risk factors ( 2 ), linked with increased illness severity and deaths ( 3 ), and now entering and being disseminated within health care facilities ( 4 ). (cdc.gov)
  • Effective S. aureus prevention strategies require a multifaceted approach that includes adherence to current CDC recommendations for preventing not only device- and procedure-associated infections, but also transmission of health care-prevalent strains. (cdc.gov)
  • A novel class of small amphipathic peptides with strong surfactant-like properties, the phenol soluble modulins, particularly PSMα as well as the leukocidin LukAB, are involved in phagosomal escape of the clinical S. aureus strains LAC, MW2 and 6850 in non-professional and professional phagocytes. (uni-wuerzburg.de)
  • This could be confirmed by an infection assay including S. aureus knockout mutants in psmα or lukAB which were significantly less cytotoxic, compared with those infected with escape-positive wild type strains. (uni-wuerzburg.de)
  • Pathogenic strains often promote infections by producing virulence factors such as potent protein toxins, and the expression of a cell-surface protein that binds and inactivates antibodies. (wikipedia.org)
  • S. aureus is one of the leading pathogens for deaths associated with antimicrobial resistance and the emergence of antibiotic-resistant strains, such as methicillin-resistant S. aureus (MRSA), is a worldwide problem in clinical medicine. (wikipedia.org)
  • Only a few strains of S. aureus are associated with infections in humans. (wikipedia.org)
  • Staphylococcus aureusis considered one of the most critical human pathogens worldwide, and its levels of methicillin resistance have increased even in strains isolated from people without nosocomial risk factors. (una.py)
  • MRSA strains have the ability to be resistant to most β-lactam antibiotics, but also to a wide range of other antimicrobials, making infections difficult to manage and very costly to treat. (biomedcentral.com)
  • In this study, we analysed the antimicrobial susceptibility patterns of biofilm-producing S. aureus strains isolated from diabetic foot infections. (biomedcentral.com)
  • The emergence of MDR S. aureus strains in the community setting has major implications in disease management. (uthscsa.edu)
  • Conclusions: These findings highlight the high prevalence and epidemiological factors associated with MDR S. aureus strains in the community setting and demonstrate the utility of next-generation sequencing to potentially quicken antimicrobial resistance detection and surveillance for targeted interventions. (uthscsa.edu)
  • The burden of infection with antimicrobial resistant strains of pathogens involves increased risk of mortality, increased hospital stay, and related attributable costs compared to infection with antimicrobial susceptible pathogens [ 4 ]. (biomedcentral.com)
  • MRSA results from infection with bacterial strains that have acquired resistance to particular antibiotics. (medicalnewstoday.com)
  • 8. Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? (koreamed.org)
  • It's worth noting that methicillin-resistant Staphylococcus aureus (MRSA) is tougher to treat than most strains of S. aureus . (healthline.com)
  • Three Staphylococcus aureus strains (303, 18Z and TG), exhibiting various patterns of survival within abscesses, were significantly more sensitive to the bactericidal activity of oleic acid during the log phase of growth than at other stages of the growth cycle. (microbiologyresearch.org)
  • However, all three S. aureus strains exhibited significant increases in membrane fluidity during the log phase of growth, but upon entering the stationary phase membrane fluidity again decreased. (microbiologyresearch.org)
  • Health facilities in the state should institute effective antimicrobial stewardship, intensify surveillance and screening of Staphylococcus aureus for MRSA strains to guard against dissemination of multidrug resistant strains in both hospital and community settings because of the clinical implications. (who.int)
Isolates12
  • LL-37 susceptibility among S. aureus isolates causing uncomplicated and complicated BSI was investigated. (scirp.org)
  • S. McNicholaswhj, H. Humphreys and D. Hughes, "Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37," Open Journal of Medical Microbiology , Vol. 3 No. 1, 2013, pp. 80-83. (scirp.org)
  • S. McNicholas, A. C. Shore, D. C. Coleman, H. Humphreys and D. F. Hughes, "DNA Microarray Genotyping and Virulence and Antimicrobial Resistance Gene Profiling of Methicillin-Resistant Staphylococcus aureus Bloodstream Isolates from Renal Patients," Journal of Clinical Microbiology, Vol. 49, No. 12, 2011, pp. 4349-4351. (scirp.org)
  • In vitro, AB-SA01 killed 94.5% of 401 clinical Staphylococcus aureus isolates, including methicillin-resistant and vancomycin-intermediate ones for a total of 95% of the 205 known multidrug-resistant isolates. (pacb.com)
  • Objectives: To use whole-genome sequences to describe the diversity and distribution of resistance mechanisms among community-associated S. aureus isolates. (uthscsa.edu)
  • Methods: S. aureus isolates from skin and soft tissue infections (SSTIs) and nasal colonization were collected from patients within 10 primary care clinics from 2007 to 2015. (uthscsa.edu)
  • The Illumina Miseq platform was used to determine the genome sequences for 144 S. aureus isolates. (uthscsa.edu)
  • Results: Approximately one-third of S. aureus isolates in the South Texas primary care setting were MDR. (uthscsa.edu)
  • A total of 79 S. aureus isolates were recovered from 54(57.4%) of patients. (biomedcentral.com)
  • Fifty-four (68.4%) of the isolates were methicillin resistant S. aureus (MRSA). (biomedcentral.com)
  • S. aureus isolates from patients in TASH exhibited resistance to majority of antimicrobials commonly employed for the treatment of staphylococcal infections which calls for urgent need of prudent use of antimicrobials and the need for implementation of effective infection control practices to hamper spread of MDR S. aureus . (biomedcentral.com)
  • Several current aspects related to the virulence of S. aureus and CoNS are discussed, including isolates of different origins, phenotypic and genotypic techniques for the detection of these toxins, and the gene regulation mechanism involved in the expression of these toxins. (novapublishers.com)
Streptococcus3
Patients38
  • Moreover, MRSA infection declines were much larger among patients not carrying MRSA at the time of admission than among those who were. (cdc.gov)
  • Staphylococcus aureus Infections in Pediatric Oncology Patients: High Rates of Antimicrobial Resistance, Antiseptic Tolerance and Complications. (medscape.com)
  • ESKD patients on dialysis are at increased risk for Staphylococcus aureus bloodstream infections, but racial, ethnic, and socioeconomic disparities associated with this outcome are not well described. (medscape.com)
  • Among seven EIP sites, the S. aureus bloodstream infection rate during 2017-2020 was 100 times higher among hemodialysis patients (4,248 of 100,000 person-years) than among adults not on hemodialysis (42 of 100,000 person-years). (medscape.com)
  • Unadjusted S. aureus bloodstream infection rates were highest among non-Hispanic Black or African American (Black) and Hispanic or Latino (Hispanic) hemodialysis patients. (medscape.com)
  • Infections are a leading cause of morbidity and mortality in hemodialysis patients. (medscape.com)
  • [ 11 ] Higher rates of invasive S. aureus infections have been observed in dialysis patients compared with nondialysis patients. (medscape.com)
  • These patients were matched with an on-going study of patients with well-characterized MRSA infection (2005-10). (emory.edu)
  • Patients with 25(OH)D determinations without an MRSA infection served as controls. (emory.edu)
  • A total of 6405 patients with 25(OH)D determinations were included in the analyses, of which 401 (6.3%) experienced an MRSA infection during the study period. (emory.edu)
  • Testing a cohort of 82 patients with S. aureus musculoskeletal infections (MSKI) and 30 healthy individuals enabled discrimination of individual patient responses to different S. aureus antigens , with statistical significance between osteomyelitis patients and controls obtained overall for four individual antigens (IsdA, IsdB, Gmd, and SCIN). (bvsalud.org)
  • The measure takes into account risk factors that may impact the number of infections at a facility, including facility size, the types of patients treated and kinds of procedures performed. (massgeneral.org)
  • Each year, around 500,000 hospital patients in the United States contract a staphylococcal infection, chiefly by S. aureus. (wikipedia.org)
  • Prior to the 1940s, S. aureus infections were fatal in the majority of patients. (wikipedia.org)
  • We focus on (recurrent) UTI due to (particularly) resistant micro-organisms (BRMO), UTI in patients after renal transplantation, the role of the microbioma and complications of antibiotic therapy such as Clostridioides difficile infections. (lumc.nl)
  • Innovative strategies like antimicrobial peptides and bacteriophages are urgently needed to improve outcome for patients with these complex infections. (lumc.nl)
  • Objectives: Patients with Staphylococcus aureus bacteraemia (SAB) at risk for infective endocarditis (IE) need to be identified because they should undergo echocardiography. (lu.se)
  • Lindner AK, Hommes F, Nikolai O, Martinez GE, Gürer B, Krüger R, Leistner R, Nurjadi D, Mockenhaupt FP, Zanger P. Imported Panton-valentine leucocidin (PVL)-positive Staphylococcus aureus skin infections: patients' perspective on quality of life and quality of medical care. (charite.de)
  • Most patients with wound infections are managed in the community. (medscape.com)
  • Patients with increased risk of colonisation with Methicillin-resistant Staphylococcus aureus (MRSA) are screened before admission to hospitals in Norway. (tidsskriftet.no)
  • Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. (biomedcentral.com)
  • Wound and corresponding nasal swabs from patients with surgical site infection from general surgery ward ( n = 14), orthopedic ward ( n = 21) and those with otitis media ( n = 59) from Ear Nose and Throat (ENT) ward were cultured for S. aureus isolation according to standard procedures from December 2013 to June 2014. (biomedcentral.com)
  • Staphylococcus aureus bloodstream infections (bacteremia) in pediatric patients (1 to 17 years of age). (nih.gov)
  • The book is divided into eight chapters, with a presentation of the genus Staphylococcus , current classification, general characteristics of these bacteria and the clinical significance of coagulase-negative staphylococci (CoNS), which are often classified as mere blood culture contaminants, but are the etiological agents most commonly associated with neonatal infections and peritonitis in patients undergoing peritoneal dialysis. (novapublishers.com)
  • Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital. (cdc.gov)
  • Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. (cdc.gov)
  • Comparison of Oligon catheters and chlorhexidine-impregnated sponges with standard multilumen central venous catheters for prevention of associated colonization and infections in intensive care unit patients: a multicenter, randomized, controlled study. (cdc.gov)
  • us type 336 infections in at-risk patients. (infectioncontroltoday.com)
  • Patients at the highest risk for S. aureus infections include dialysis patients, patients undergoing certain types of invasive surgery, patients in intensive care or shock-trauma units, patients receiving cancer chemotherapy or other immune suppressive treatments, and patients in long-term care facilities. (infectioncontroltoday.com)
  • compromised patients face an elevated risk of contracting Staph infections. (infectioncontroltoday.com)
  • in approximately 2 million patients who contract these infections each year. (infectioncontroltoday.com)
  • Approximately 31 percent of patients with low platelet counts died from the infection, compared to less than 6 percent of patients with platelets above the threshold. (news-medical.net)
  • Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
  • Patients with complicated infections, including suspected necrotizing fasciitis and gangrene, require empiric polymicrobial antibiotic coverage, inpatient treatment, and surgical consultation for debridement. (aafp.org)
  • This study was conducted to investigate the prevalence of methicillin resistance Staphylococcus aureus among patients in two health facilities in Akwa Ibom State, Nigeria. (who.int)
  • This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)
  • SNAP is a multicentre, pragmatic, multi-arm, open-label adaptive platform trial which aims to identify the effects of a range of clinical interventions on patients with Staphylococcus aureus Bacteraemia (SAB) in order to improve clinical outcomes. (who.int)
  • Results A total of 1989 cases of colonization and 544 MRSA invasive infections occurred under standard precautions per 10,000 patients. (medscape.com)
Bloodstream infections8
  • Areas with higher poverty levels, crowding, and lower education levels accounted for disproportionately higher proportions of hemodialysis-associated S. aureus bloodstream infections. (medscape.com)
  • Health care providers and public health professionals should prioritize prevention and optimized treatment of ESKD, identify and address barriers to lower-risk vascular access placement, and implement established best practices to prevent bloodstream infections. (medscape.com)
  • MRSA can cause serious bloodstream infections and is often spread through direct contact with an infection or contaminated hands. (massgeneral.org)
  • Bloodstream infections caused by Pseudomonas aeruginosa, Candida albicans , or multidrug resistant Enterococcus faecium is associated with increased mortality. (atsu.edu)
  • An educational intervention to prevent catheter-associated bloodstream infections in a non-teeaching community medical center. (cdc.gov)
  • A multicenter intervention to prevent catheter-associated bloodstream infections. (cdc.gov)
  • Higuera F, Rosenthal VD, Duarte P, Ruiz J, Franco G, Safdar N. The effect of process control on the incidence of central venous catheter-associated bloodstream infections and mortality in intensive care units in Mexico. (cdc.gov)
  • Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit. (cdc.gov)
Bacteremia4
Bacteria19
Clostridium1
Abstract1
  • ABSTRACT Urinary tract infection (UTI) is a common problem in pregnant woman. (who.int)
Bacteraemia1
Methicillin35
Clinical4
  • Our research focuses on promoting good use of antibiotics through clinical and epidemiological research on the treatment of infections. (lumc.nl)
  • This research is closely connected with our clinical and epidemiological research regarding biofilm-associated infections, e.g. prosthetic joint infection and fracture-related infection ( www.protheseinfectie.nl ). (lumc.nl)
  • Simple infections are usually monomicrobial and present with localized clinical findings. (aafp.org)
  • resistant S. aureus (VRSA) in clinical samples The study was approved by the Health Ethics impacted negatively on the efficacy of vancomycin Committee of the State Ministry of Health and the 6 leading to treatment failures. (who.int)
Pneumonia4
  • Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. (uni-koeln.de)
  • Two reports are scheduled for revision, namely, those on prevention of intravascular infections, and prevention of nosocomial pneumonia. (cdc.gov)
  • In both neutropenic and immunocompetent mouse models of acute pneumonia, AB-SA01 reduced lung S. aureus populations equivalently to vancomycin. (pacb.com)
  • It is recognized as one of the most important causes of both acute and chronic cases of community-acquired and hospital-associated infections including urinary tract infections, blood stream infections, soft tissue infections and 2 pneumonia. (who.int)
Colonization and infection1
  • In an in vivo rabbit model, subtherapeutic (15-mg/kg) and therapeutic (30- or 45-mg/kg) doses of telavancin were demonstrated to be noninferior and superior to vancomycin (20 mg/kg), respectively, for preventing subcutaneous implant colonization and infection by Staphylococcus aureus. (nih.gov)
Virulence7
  • We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
  • AB-SA01 contains three naturally occurring, obligately lytic myoviruses related to Staphylococcus phage K. AB-SA01 component phages have been sequenced and contain no identifiable bacterial virulence or antibiotic resistance genes. (pacb.com)
  • The physiopathology of diabetic foot infections (DFI) is complex, but its severity and prevalence are a consequence of host-related disorders and pathogens-factors, as virulence and antibiotic resistance traits [ 1 ]. (biomedcentral.com)
  • Several structural and secreted virulence factors play a role in S. aureus infections, which are multifactorial and depend on bacterial adherence and biofilm formation. (biomedcentral.com)
  • If Staphylococcus (S.) aureus carries the PVL toxin (PVL= Panton Valentine leukocidin), its virulence is considerably increased. (charite.de)
  • The ability of S. aureus to invade the host immune system through various virulence factors and its rapid acquisition of multi-drug resistance phenotype, makes it one of the most notorious organism among gram positive bacterial pathogens [ 3 ]. (biomedcentral.com)
  • The book also focuses on the identification of CoNS, virulence factors responsible for the symptoms and severity of infections caused by Staphylococcus spp. (novapublishers.com)
Infective endocarditis1
Biofilm formation1
Pathogens5
  • Further, we aim to develop innovative treatment strategies for infections with multi-resistant pathogens. (lumc.nl)
  • Promising strategies including bacteriophages and antimicrobial peptides are being tested for their efficacy against biofilm associated infections caused by different pathogens. (lumc.nl)
  • Tests of nasopharyngeal specimens for specific pathogens are helpful when targeted therapy depends on the results (eg, group A streptococcal infection, gonococcus, pertussis). (medscape.com)
  • Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. (biomedcentral.com)
  • An infection is the invasion of tissues by pathogens , their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. (wikipedia.org)
Invasive4
  • This study investigated the post invasive events upon S. aureus infection. (uni-wuerzburg.de)
  • Obtain the MRSA typing that caused invasive infections in children by using the automated multi-locus variable number of tandem repeats (MLVA) analysis technique. (una.py)
  • In 2008, about 86% of all invasive MRSA infections in the U.S. were healthcare-associated. (medicalnewstoday.com)
  • Sepsis due to H. influenzae was very common however since the introduction of the Hib vaccine, invasive H. influenzae infections have virtually disappeared. (atsu.edu)
Resistance8
  • Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. (nature.com)
  • Antimicrobial peptides (AMPs) and bacteriophages may offer a solution for treatment of drug-resistant infections in this era of antimicrobial resistance. (lumc.nl)
  • Furthermore, S. aureus populations are able to acquire and lose antimicrobial resistance genes. (uthscsa.edu)
  • It is important that clinicians recognize the changing resistance patterns and epidemiology of Staphylococcus spp. (wustl.edu)
  • Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. (biomedcentral.com)
  • MRSA is a common and potentially serious infection that has developed resistance to several types of antibiotics. (medicalnewstoday.com)
  • Effect of capsulation on the resistance of Staphylococcus aureus to the bactericidal lipids produced in abscesses. (microbiologyresearch.org)
  • Correlation of carotenoid production, decreased membrane fluidity, and resistance to oleic acid killing in Staphylococcus aureus 18Z. (microbiologyresearch.org)
Sepsis4
  • 1. recite the most likely causes of sepsis based on the knowledge of the initial site of infection and where these organisms usually come from (sources of infection). (atsu.edu)
  • 4. recite the major sites of infection that can lead to sepsis. (atsu.edu)
  • Pediatric septicemia - S. pneumoniae, Neisseria meningitidis , or S. aureus usually causes sepsis in the child. (atsu.edu)
  • Laboratory testing may be required to confirm an uncertain diagnosis, evaluate for deep infections or sepsis, determine the need for inpatient care, and evaluate and treat comorbidities. (aafp.org)
Incidence5
  • The significance of nasal carriage of Staphylococcus aureus and the incidence of postoperative wound infection. (medscape.com)
  • Incidence rates and relative risks for MRSA infections or colonisation were calculated for children adopted from abroad and for other children. (tidsskriftet.no)
  • An increased incidence of these infections in a herd warrants reassessment of the teat dip product used in the dairy and application methods. (cornell.edu)
  • The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. (cdc.gov)
  • Eggimann P, Harbarth S, Constantin MN, Touveneau S, Chevrolet JC, Pittet D. Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care. (cdc.gov)
Catheter-Related Infections5
Pseudomonas1
  • Chronic suppurative otitis media is often associated with MRSA, Pseudomonas and Staphyloccoi infection. (greenmedinfo.com)
Major pathogen1
Antibiotics11
  • Antibiotics are chosen based on whether they are likely to be effective against the strain causing the infection. (merckmanuals.com)
  • Though generally harmless, Staph occasionally causes infections that are treated with antibiotics. (massgeneral.org)
  • Results demonstrate that very high concentrations of the most used antibiotics in treating diabetic foot infections (DFI) are required to inhibit S. aureus biofilms in vitro, which may explain why monotherapy with these agents frequently fails to eradicate biofilm infections. (biomedcentral.com)
  • The use of antibiotics was a milestone in the effort to prevent wound infection. (medscape.com)
  • Antibiotics for dirty wounds are part of the treatment because infection is established already. (medscape.com)
  • Qualities of prophylactic antibiotics include efficacy against predicted bacterial microorganisms most likely to cause infection (see Table 3 below), good tissue penetration to reach wound involved, cost effectiveness, and minimal disturbance to intrinsic body flora (eg, gut). (medscape.com)
  • Specific medications used to treat infections include antibiotics , antivirals , antifungals , antiprotozoals , [3] and antihelminthics . (wikipedia.org)
  • [12] Distinguishing the two is important, since viral infections cannot be cured by antibiotics whereas bacterial infections can. (wikipedia.org)
  • More severe infections may require oral antibiotics. (healthline.com)
  • In severe cases, especially if the infection is acquired during a hospital stay, treatment may take longer and require antibiotics through an IV. (healthline.com)
  • Many cases of a staph infection in your ear are treatable with antibiotics. (healthline.com)
Polymicrobial1
  • In contrast, complicated infections can be mono- or polymicrobial and may present with systemic inflammatory response syndrome. (aafp.org)
Abscesses7
MSSA4
  • In this study, active surveillance was undertaken in 3 remote northern communities to assess the prevalence and effects of MRSA and MSSA infections. (cdc.gov)
  • Over the 2-year study period, rates of MRSA and MSSA infections in the 3 communities ranged from 146-482/10,000 and 112-329/10,000 population, respectively. (cdc.gov)
  • Overall, the highest quarterly rates of MRSA and MSSA infections were observed at site C, with 738/10,000 and 610/10,000 population, respectively. (cdc.gov)
  • 0.001), whereas MSSA infections showed no significant decline. (cdc.gov)
Coagulase-negative stap1
  • Coagulase-negative staphylococci can colonize the surface of catheters and produce an extracellular polysaccharide that leads to the formation of biofilms which potentiate their pathogenicity. (novapublishers.com)
Soft tissue infection1
  • Subject Characteristics (cases with skin and soft tissue infection and controls) . (emory.edu)
SSTIs3
  • SSTIs), urinary tract infections, upper respiratory tract infections, and lower respiratory tract infections, were identified as S. aureus . (cdc.gov)
  • Individuals with MDR S. aureus SSTIs were more likely to be African American and obese. (uthscsa.edu)
  • Skin and soft tissue infections (SSTIs) account for more than 14 million physician office visits each year in the United States, as well as emergency department visits and hospitalizations. (aafp.org)
Vitro3
  • We conclude that, despite peritoneal mast cells being activated by S. aureus in vitro, they do not influence the in vivo manifestations of intraperitoneal S. aureus infection. (uni-koeln.de)
  • Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study. (greenmedinfo.com)
  • In vitro and in vivo antimicrobial activity of Cymbopogon citratus against Staphylococcus spp. (greenmedinfo.com)
Multidrug1
  • Multidrug-Resistant Gram-Negative Infections: Bringing Back the Old. (llu.edu)
Control and Hospital Epidemiology1
  • Infection Control and Hospital Epidemiology, 2011;32(1): 97-98. (llu.edu)
Staphylococcal5
  • Furthermore, Myr confers a significant degree of protection against staphylococcal infection in the Galleria mellonella model. (nature.com)
  • Pääkkönen M, Kallio PE, Kallio MJ, Peltola H. Management of Osteoarticular Infections Caused by Staphylococcus aureus Is Similar to That of Other Etiologies: Analysis of 199 Staphylococcal Bone and Joint Infections. (medscape.com)
  • Up to 50,000 deaths each year in the U.S. are linked to staphylococcal infection. (wikipedia.org)
  • Mobile genetic elements that are common in S. aureus include bacteriophages, pathogenicity islands, plasmids, transposons, and staphylococcal cassette chromosomes. (wikipedia.org)
  • Fennel honey, propolis and bee venom significantly improve the immune response of rats to staphylococcal infection. (greenmedinfo.com)
Viral Infections3
  • As bacterial and viral infections can both cause the same kinds of symptoms, it can be difficult to distinguish which is the cause of a specific infection. (wikipedia.org)
  • In general, viral infections are systemic. (wikipedia.org)
  • Ear infections are often caused from contagious bacterial or viral infections, like the cold or flu. (healthline.com)
Skin14
  • Comparative Effectiveness of Antibiotic Treatment Strategies for Pediatric Skin and Soft-Tissue Infections. (medscape.com)
  • Aboriginal people at HNELHD emergency departments appear to represent a greater proportion of people with skin infections with CA-MRSA than non-Aboriginal people. (who.int)
  • The company was concerned because several workers had previously reported MRSA skin infections, and management wanted to determine if these infections were related to workplace exposures. (cdc.gov)
  • Staphylococcus aureus (Staph) is a common bacterium that is present in the nose or on the skin of about one quarter of healthy adults at any given time. (massgeneral.org)
  • Staphylococcus aureus is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. (wikipedia.org)
  • An estimated 21% to 30% of the human population are long-term carriers of S. aureus, which can be found as part of the normal skin microbiota, in the nostrils, and as a normal inhabitant of the lower reproductive tract of females. (wikipedia.org)
  • StaphTrav ( www.staphtrav.eu ) is a network of 12 centers in 7 European countries investigating the introduction of S. aureus with characteristics such as MRSA and PVL toxin in intercontinental travelers with pus-filled skin infections. (charite.de)
  • Leistner R, Hanitsch LG, Krüger R, Lindner AK, Stegemann MS, Nurjadi D. Skin Infections Due to Panton-Valentine Leukocidin-Producing S. Aureus. (charite.de)
  • Staphylococcus aureus is a normal flora associated with skin, skin glands and mucous membrane of almost all warm blooded animals and about 30% of the human population is colonized by S. aureus [ 1 ]. (biomedcentral.com)
  • and dermatophytes , a group of organisms causing infection of skin and other superficial structures in humans. (wikipedia.org)
  • See related handout on skin and soft tissue infections , written by the authors of this article. (aafp.org)
  • Skin and soft tissue infections result from microbial invasion of the skin and its supporting structures. (aafp.org)
  • Simple infections confined to the skin and underlying superficial soft tissues generally respond well to outpatient management. (aafp.org)
  • Effect of antimicrobial stewardship program guidance on the management of uncomplicated skin and soft tissue infections in hospitalized adults. (llu.edu)
Prevention13
  • These findings offer important insights informing S. aureus prevention strategy. (cdc.gov)
  • Effective prevention strategies require a multifaceted approach, including efforts to prevent transmission of MRSA as well as efforts directed at infection prevention. (cdc.gov)
  • Hospital Infections Program NOTE: Guidelines for Prevention of Intravascular Device-Related Infections is currently being updated Draft version was pubished for comment in the Federal Register on 9/27/95. (cdc.gov)
  • The 'CDC Guidelines for the Prevention and Control of Nosocomial Infections' is a set of 7 reports on different aspects of hospital infection control. (cdc.gov)
  • The complete set of 'CDC Guidelines for the Prevention and Control of Nosocomial Infections' is publication No. PB86-133022. (cdc.gov)
  • The Guideline for Prevention of Catheter-associated Urinary Tract Infections (published in 1981) is PB84-923402. (cdc.gov)
  • The Guideline for Prevention of Intravascular Infections (published in 1981) is PB84-923403. (cdc.gov)
  • Further study is necessary to investigate this association in other populations and to determine if optimization of 25(OH)D levels could potentially be useful for prevention or treatment of MRSA infection. (emory.edu)
  • The CDC/STRIVE curriculum was developed by national infection prevention experts led by the Health Research & Educational Trust (HRET) for CDC. (cdc.gov)
  • Courses address both the technical and foundational elements of healthcare-associated infection (HAI) prevention. (cdc.gov)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. (cdc.gov)
  • The role and responsibility of executive-level oversight in infection prevention is growing. (infectioncontroltoday.com)
Epidemiology1
  • The epidemiology of MRSA infections is discussed highlights the importance of understanding why specific clones predominated in different regions in order to develop more effective control strategies and to choose more appropriate antimicrobial therapy. (novapublishers.com)
Morbidity3
  • Staphylococcus aureus is an important cause of health care-associated infections and accounts for significant morbidity and mortality. (cdc.gov)
  • Staphylococcus aureus is among the most common causes of health care-associated infections and accounts for significant morbidity and mortality. (cdc.gov)
  • Foot infections are a major cause of morbidity in people with diabetes and the most common cause of diabetes-related hospitalization and lower extremity amputation. (biomedcentral.com)
Species4
  • There is a great deal of genetic variation within the S. aureus species. (wikipedia.org)
  • It has been proposed that one possible reason for the great deal of heterogeneity within the species could be due to its reliance on heterogeneous infections. (wikipedia.org)
  • citation needed] Another notable evolutionary process within the S. aureus species is its co-evolution with its human hosts. (wikipedia.org)
  • Staphylococcus aureus is by far the most frequent species isolated from these infections. (biomedcentral.com)
Urinary3
  • Five reports are current or updated, namely, those on catheter-associated urinary tract and surgical wound infections, isolation precautions in hospitals, infection control in hospital personnel, and handwashing and hospital environmental control. (cdc.gov)
  • Urinary tract infection (UTI) is one of the most common bacterial infections, and the most common reason for antibiotic prescriptions. (lumc.nl)
  • Unfortunately, the suspected cases of ear, wound and urinary tract report of emergence of vancomycin intermediate infections at both tertiary (UUTH) and secondary sensitive S. aureus (VISA) and vancomycin (GHIA) healthcare facilities in Akwa Ibom State. (who.int)
Nosocomial2
  • Community-associated MRSA clones have emerged as an increasingly important subset of Staphyloccocus aureus and MRSA can no longer be considered as solely a nosocomial pathogen. (wustl.edu)
  • S. aureus is reported to be the most common cause of nosocomial infections and is particularly responsible for majority of surgical site infections [ 5 ]. (biomedcentral.com)
Infestations1
  • Diseases caused by helminths are sometimes termed infestations, but are sometimes called infections. (wikipedia.org)
Strain2
  • S. aureus strain COL (GenBank accession no. (cdc.gov)
  • Infections with a PVL strain are frequently described in travelers returning to their home countries. (charite.de)
Bacterial infection3
  • Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperitoneal bacterial infection we here studied the global effects of S. aureus on mast cell gene expression. (uni-koeln.de)
  • This is in contrast to previous studies in which an impact of mast cells on bacterial infection has been proposed based on the use of mice whose mast cell deficiency is a consequence of defective c-Kit signalling. (uni-koeln.de)
  • Your cat can give you this bacterial infection with a scratch, bite, or if she licks an open wound. (medicinenet.com)
Musculoskeletal1
Intensive care1
  • Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. (cdc.gov)
Vancomycin1
  • Although vancomycin has long been considered a first-line therapy for serious MRSA infections, multiple concerns with this agent have opened the door for existing and investigational agents demonstrating efficacy in this role. (wustl.edu)