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  • Urinary tract infections (UTIs) may be treated with various oral antibiotics, most commonly trimethoprim and sulfamethoxazole, amoxicillin, or cefixime. (medscape.com)
  • Treatment for cat eye infections often involves the use of antibiotics, such as ciprofloxacin. (topdollsites.com)
  • Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection? (goettingen-research-online.de)
  • Background: Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. (goettingen-research-online.de)
  • Patients who had an early postoperative infection are managed with débridement, replacement of the polyethylene (PE) insert of the acetabular/tibial component, retention of the prosthesis, and IV administration of antibiotics for 6 weeks. (medscape.com)
  • Patients who have an acute hematogenous infection are also managed with débridement, replacement of the PE insert, retention of the prosthesis if it is not loose, and IV administration of antibiotics for 6 weeks. (medscape.com)
  • Conclusion: This study identified the main pathogens responsible for neonatal bacterial infections and their level of sensitivity to antibiotics. (scirp.org)
  • The consequence of this situation is an excessive diagnosis of neonatal infection and the over-prescription of antibiotics. (scirp.org)
  • Antibiotics like amoxicillin are medicines that treat bacterial infections. (healthline.com)
  • Severe infections may require injected or intravenous antibiotics. (healthline.com)
  • Healthcare professionals prescribe different antibiotics to treat conditions such as strep throat , bronchitis , and inner ear infections . (healthline.com)
  • Read on to learn more about the most common types of antibiotics and which infections they treat. (healthline.com)
  • Penicillin antibiotics are effective at killing Staphylococci and Streptococci infections. (healthline.com)
  • Tetracyclines are a group of antibiotics with anti-inflammatory properties that can treat several bacterial infections. (healthline.com)
  • The treatment of choice for urinary tract infections is antibiotics. (emedicinehealth.com)
  • Most courses last three to seven days, though if you have a kidney infection you may need to take antibiotics for up to two weeks. (emedicinehealth.com)
  • Ciprofloxacin belongs to a class of drugs called quinolone antibiotics . (webmd.com)
  • For patient education resources, see Infections Center , MRSA Infection (Methicillin-Resistant Staphylococcus aureus Infection) , Sepsis (Blood Infection) , Life-Threatening Skin Rashes , and Antibiotics . (medscape.com)
  • Treated bacterial infections with wide range of antibiotics. (rxshop.md)
  • Antibiotics are a class of medications that are used to treat infections. (rxshop.md)
  • But not all infections are treated with antibiotics. (rxshop.md)
  • Bacterial infections can develop in anyone and cannot be treated otherwise than with the use of antibiotics. (rxshop.md)
  • Let's take a look at when antibiotics are used and how to detect a bacterial infection. (rxshop.md)
  • Guidelines recommend alternatives to fluoroquinolone antibiotics to treat minor, uncomplicated infections. (cdc.gov)
  • Antibiotics are powerful medicines that fight certain infections and can save lives when used properly. (cdc.gov)
  • More-severe infections may require parenteral antibiotics. (medscape.com)
  • Ciprofloxacin, clindamycin, and amoxicillin were the most sensitive antibiotics, while vancomycin and chloramphenicol were the most resistant. (bvsalud.org)
  • This is a follow-up to HAN 401: CDC Recommendations for Diagnosing and Managing Shigella Strains with Possible Reduced Susceptibility to Ciprofloxacin . (cdc.gov)
  • Decreased susceptibility to ciprofloxacin was found in 103 (20.9%) of 492 isolates. (cdc.gov)
  • Nontyphoidal Salmonella enterica (NTS) isolates produce a common food-related infection that causes mild and self-limiting diarrhea and, occasionally, a potentially fatal invasive disease with bacteremia and endovascular infection ( 1 ). (cdc.gov)
  • Isolates were stored in glycerol broth at −70°C and later subcultured for determination of MICs to ciprofloxacin and nalidixic acid by using the agar dilution and the Etest strip methods. (cdc.gov)
  • bacterial pink eye) is a bacterial infection of the eye which causes inflammation or swelling of the conjunctiva, Neofloxin D eye drops is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following microorganisms:Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, Streptococcus pneumoniae and others. (pharmacily.com)
  • The Centers for Disease Control and Prevention (CDC) continues to identify an increasing number of Shigella isolates that test within the susceptible range for the fluoroquinolone antibiotic ciprofloxacin (minimum inhibitory concentration [MIC] values of 0.12-1 μg/mL), but harbor one or more resistance mechanisms. (cdc.gov)
  • CDC has also identified an increasing number of Shigella isolates with azithromycin MICs that exceed the epidemiological cutoff value (ECV), and is requesting reports of any possible treatment failures occurring among patients with Shigella infections treated with azithromycin (see below). (cdc.gov)
  • Consider consulting an infectious disease specialist to identify other treatment options, because some Shigella isolates with susceptible ciprofloxacin MICs may harbor one or more quinolone resistance mechanisms. (cdc.gov)
  • Molecular data indicate that most Shigella isolates with ciprofloxacin MICs in the noted range harbor at least one quinolone resistance mechanism. (cdc.gov)
  • Shigella isolates without a quinolone resistance mechanism typically have a ciprofloxacin MIC of ≤0.015 μg/mL. (cdc.gov)
  • Clinical and Laboratory Standards Institute (CLSI) criteria categorize Shigella isolates with a ciprofloxacin MIC of ≤1 μg/mL as susceptible to ciprofloxacin. (cdc.gov)
  • Occurrence of single-point gyrA mutations among ciprofloxacin-susceptible Escherichia coli isolates causing urinary tract infections in Latin America. (jmilabs.com)
  • In this study, we investigated the presence of plasmid-mediated quinolone resistance (PMQR) genes among 101 ciprofloxacin-resistant urinary Escherichia coli isolates and searched for mutations in the quinolone-resistance-determining regions (QRDRs) of the DNA gyrase and topoisomerase IV genes in PMQR-carrying isolates. (scielo.br)
  • Therefore, in this study, we investigated the presence of the qnrA , qnrB , qnrS and aac(6-)-Ib-cr genes in a sample of ciprofloxacin-resistant E. coli isolates from women with CA-UTIs. (scielo.br)
  • None of the isolates was resistant to ciprofloxacin, sparfloxacin, ceftriaxone or moxifloxacin, while 71.1% were resistant to co-trimoxazole, 62.2% to gentamicin, 56.6% to ampicillin and 35.5% to nalidixic acid. (who.int)
  • Some other current infection-localizing radiopharmaceuticals, including polyclonal and monoclonal antibodies, also localize in inflammatory areas but do not have a significant advantage over WBC scanning in terms of specificity for bacterial infection ( 3 , 4 ). (snmjournals.org)
  • Bacterial infection is the primary concern. (betasciencepress-publishing.com)
  • It was conducted in the neonatal care unit of CHUD-Borgou and focused on 203 newborns who were admitted for suspected bacterial infection. (scirp.org)
  • The study involved all newborns admitted for suspected bacterial infection if their parents gave their verbal informed consent. (scirp.org)
  • For treating bacterial infection. (peacehealth.org)
  • DCS is associated with ciprofloxacin treatment failures in patients with typhoid fever ( 4 ) and probably with invasive NTS infection, although the clinical significance of DCS in NTS has not been widely explored ( 5 - 7 ). (cdc.gov)
  • It can also be used to treat some sexually transmitted infections (STIs), some forms of infectious diarrhea, and typhoid fever. (medbroadcast.com)
  • To prevent infection, people traveling to areas where typhoid fever is common should be vaccinated and, when there, should avoid certain foods and not drink unbottled water. (msdmanuals.com)
  • Alternative Regimens Amoxicillin 500 mg plus clavulanic acid 125 mg orally 3 times a day for 7 days, or Ciprofloxacin 500 mg orally 2 times a day for 3 days. (cdc.gov)
  • Therefore the watch-list monitoring obligation for the three substances or groups of substances that had been on the list since 2018, namely metaflumizone, amoxicillin and ciprofloxacin, ceased in 2022. (janusinfo.se)
  • Antimicrobial drug therapy, often with the fluoroquinolone ciprofloxacin, is required for treating invasive NTS infections and severe diarrhea in immunocompromised patients. (cdc.gov)
  • Taking ciprofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. (medlineplus.gov)
  • Ciprofloxacin can cause severe allergic reactions, including anaphylaxis, a life-threatening reaction. (onlinegenericmedicine.com)
  • GI infections are caused by viral and bacterial pathogens, but the minority that are most severe and for which causative agents are found are typically bacterial. (nih.gov)
  • These patients often have more severe disease, prolonged shedding, and recurrent infections. (cdc.gov)
  • Pseudomonas aeruginosa and Staphylococcus aureus causes severe infections, especially in nosocomial environments. (sasm.org.za)
  • In this case, these infections are moderate to severe and have not improved with other treatments. (healthline.com)
  • it has been associated with furunculosis and severe bone and joint infections. (medscape.com)
  • In more severe cases of shigellosis, and for people with weak immune systems, doctors may prescribe an antibiotic to treat the infection. (clevelandclinic.org)
  • Severe or partially responding infections may necessitate hospitalization and parenteral antimicrobial administration, along with surgical intervention. (medscape.com)
  • The lower susceptibility was associated with ciprofloxacin treatment failures and with particular serovars and phage types often acquired during foreign travel. (cdc.gov)
  • Resistance to nalidixic acid is often used as a marker for DCS, although the validity of this assumption has been debated ( 3 ), and some have suggested that the ciprofloxacin disk susceptibility zone size breakpoints should be changed to detect such strains ( 2 ). (cdc.gov)
  • The serovar, phage type, and susceptibility of each isolate were confirmed by the Laboratory for Gastrointestinal Pathogens, Health Protection Agency Centre for Infections, Colindale, London. (cdc.gov)
  • Currently, clinical laboratories have limited ability to differentiate the ciprofloxacin MIC values within the reduced susceptibility range, ≤1 μg/mL. (cdc.gov)
  • Condition of patient, severity of infection, and susceptibility of microorganism determine proper dose and route of administration. (medscape.com)
  • Indicated for adults and pediatric patients aged 3 months or older for complicated intra-abdominal infections (cIAIs) in combination with metronidazole and for complicated urinary tract infections (cUTIs) including pyelonephritis caused by certain susceptible Gram-negative microorganisms, including Escherichia coli . (medscape.com)
  • The most common cause of a urinary tract infection (UTI) is the bacterium Escherichia coli ( E. coli ), which is typically found in the colon. (emedicinehealth.com)
  • Escherichia coli was the most frequently isolated organism (41.5%), and it was highly susceptible to chloram- phenicol, ciprofloxacin, ceftizoxime and amikacin. (who.int)
  • Ciprofloxacin may increase the risk of developing Clostridium difficile-associated diarrhea, a potentially life-threatening infection. (onlinegenericmedicine.com)
  • The source of these recurrent infections is the same as for any simple cystitis. (nih.gov)
  • Pivmecillinam achieved success in patients with A. urinae cystitis and ciprofloxacin in patients with pyelonephritis. (lu.se)
  • Scientists have been trying to determine how to better identify cases for targeted use of ciprofloxacin therapy, reducing the need to use the injectable antibiotic ceftriaxone and decreasing the risk of resistance to that drug. (uclahealth.org)
  • Each white, oval, film-coated tablet, imprinted with 'R' on one side and '127' on the other, contains ciprofloxacin (as the hydrochloride) 500 mg. (medbroadcast.com)
  • Pill with imprint WW929 is White, Capsule-shape and has been identified as Ciprofloxacin Hydrochloride 750 mg. (drugs.com)
  • Orthopedic infections, such as septic arthritis, prosthetic joint infections, and osteomyelitis, are often challenging to diagnose and manage. (medscape.com)
  • This article provides an overview of diagnosis and management of septic arthritis, prosthetic joint infections, and osteomyelitis. (medscape.com)
  • Hypersensitivity to quinolones: (Ciprofloxacin) is contraindicated in persons with a history of hypersensitivity to (Ciprofloxacin), any member of the quinolone class of antimicrobial agents, or any of the product components. (pharmacily.com)
  • Clinical clues to the presence of DCS in S. enterica infections could guide early empirical prescription of antimicrobial drug therapy. (cdc.gov)
  • The medical records of patients with bacteremia were retrieved and reviewed to establish whether ciprofloxacin had been used for therapy and the clinical outcome. (cdc.gov)
  • Biochemical, radiologic, and microbiologic data and clinical outcomes also contributed, along with the results from scintigraphic techniques, in determining the presence or absence of infection. (snmjournals.org)
  • Tsukayama et al based their treatment of infections after total hip arthroplasty (THA) on the clinical presentation-that is, positive intraoperative cultures, early postoperative infection, acute hematogenous infection, or late chronic infection. (medscape.com)
  • 2-3 week study with 4 clinic visits to Evaluate the Clinical Equivalence of Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Suspension (Par) Compared to CIPRODEX (ciprofloxacin 0.3%/dexamethasone 0.1%) Sterile Otic Suspension (Alcon) ear drops for male and female children ages 6 months - 12 years. (centerwatch.com)
  • This study aimed to investigate the epidemiological, clinical and bacteriological aspects of neonatal bacterial infections and their outcomes in the neonatal care unit of the Borgou Regional University Teaching Hospital (CHUD-Borgou). (scirp.org)
  • The aim of this research work was to investigate the epidemiological, clinical and etiological aspects of neonatal bacterial infections and their outcomes. (scirp.org)
  • Treatment Successful treatment cures infection, resolves clinical symptoms, and prevents transmission to others. (cdc.gov)
  • In research published in the peer-reviewed journal Clinical Infectious Diseases, a UCLA-led team found that of 106 subjects the test identified as having a strain of gonorrhea called wild-type gyrA serine, all were cured with a single dose of oral ciprofloxacin. (uclahealth.org)
  • The duration of therapy for P multocida infections has not been well established and can be tailored to clinical response. (medscape.com)
  • Initially, clinical findings lead to the suspicion of infection. (medscape.com)
  • Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. (medscape.com)
  • The extended release form of ciprofloxacin is used to treat bladder and kidney infections. (medbroadcast.com)
  • Urinary tract infections are infections that involve the bladder (most common) or the kidneys. (emedicinehealth.com)
  • Functional defects, like overactive bladder and urinary incontinence, tend to lead to recurrent infections. (nih.gov)
  • Older men can often develop urinary tract infections due to outflow obstruction or neurogenic bladder resulting in urinary stasis and an increased risk of recurrent infection. (nih.gov)
  • In this study, we evaluated the efficacy of infecton scintigraphy for detecting chronic bone and joint infections. (snmjournals.org)
  • Taking this improved specificity into consideration, our goal was to determine the efficacy of infecton imaging in the detection of chronic orthopedic infections. (snmjournals.org)
  • Reserve use of ciprofloxacin for patients with no alternative treatment options for an acute exacerbation of chronic bronchitis or acute sinusitis. (drugs.com)
  • Populations that have been reported to have increased rates of S aureus colonization include persons with type 1 diabetes, intravenous drug users, asthmatic patients, the elderly, persons who require hemodialysis or peritoneal dialysis, persons with rheumatoid arthritis, those with chronic sinusitis, and persons with human immunodeficiency virus (HIV) infection. (medscape.com)
  • It is recognized as one of the most important causes of both acute and chronic cases of community-acquired and hospital-associated infections including urinary tract infections, blood stream infections, soft tissue infections and 2 pneumonia. (who.int)
  • People who are at risk for more dangerous infections (such as people with chronic bowel diseases, kidney disease, cancer, diabetes, or HIV) should talk to their provider before traveling. (medlineplus.gov)
  • Ciprofloxacin has a very high chronic toxicity. (janusinfo.se)
  • A few infected people develop chronic infection of the gallbladder or urinary tract. (msdmanuals.com)
  • If you experience any of the following symptoms of tendon rupture, stop taking ciprofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. (medlineplus.gov)
  • Eighty otherwise healthy women aged 18 to 85 years, presenting with at least one of the main UTI symptoms dysuria and frequency and without any complicating factors, were randomly assigned to receive either ibuprofen 3 x 400 mg oral or ciprofloxacin 2 x 250 mg (+1 placebo) oral, both for three days. (goettingen-research-online.de)
  • During Days 0 and 9, 12/36 (33%) of patients in the ibuprofen-group received secondary antibiotic treatment due to ongoing or worsening symptoms, compared to 6/33 (18%) in the ciprofloxacin-group (non significant). (goettingen-research-online.de)
  • What are the symptoms of Shigella infection? (clevelandclinic.org)
  • Your provider may diagnose you with Shigella infection on the basis of your symptoms. (clevelandclinic.org)
  • Clinicians should carefully monitor patients with Shigella infections who require fluoroquinolone treatment and report any possible treatment failures. (cdc.gov)
  • CDC is particularly concerned about people who are at high risk for multidrug-resistant Shigella infections and are more likely to require antibiotic treatment, such as men who have sex with men, patients who are homeless, and immunocompromised patients. (cdc.gov)
  • Shigella infection, also called shigellosis, is a condition that affects your digestive system. (clevelandclinic.org)
  • What is Shigella infection? (clevelandclinic.org)
  • Shigella infection, a type of food poisoning, may also be called bacillary dysentery. (clevelandclinic.org)
  • Who does Shigella infection affect? (clevelandclinic.org)
  • How common is Shigella infection? (clevelandclinic.org)
  • Fifty-six sites with suspected bone or joint infection were examined with 99m Tc-WBC and infecton scans in 51 patients. (snmjournals.org)
  • Infecton results for vertebral infections were the most notable findings in this study, despite the limited number of patients with this condition. (snmjournals.org)
  • Results: Seventy-nine patients were analyzed (ibuprofen n = 40, ciprofloxacin n = 39). (goettingen-research-online.de)
  • On Day 4, 21/36 (58.3%) of patients in the ibuprofen-group were symptom-free versus 17/33 (51.5%) in the ciprofloxacin-group. (goettingen-research-online.de)
  • Reserve use of ciprofloxacin for patients with no alternative treatment options for an uncomplicated UTI. (drugs.com)
  • Infections are common in critically ill patients and often contribute to the severity of their condition. (betasciencepress-publishing.com)
  • Chancroid has been well established as a co-factor for HIV transmission and a high rate of HIV infection among patients with chancroid has been reported in the United States and in other countries. (cdc.gov)
  • All three regimens are effective for the treatment of chancroid among patients without HIV infection. (cdc.gov)
  • Summarize the management considerations for patients with recurrent urinary tract infections. (nih.gov)
  • Explain the importance of improving care coordination among the interprofessional team to enhance the delivery of care for patients affected by recurrent urinary tract infections. (nih.gov)
  • This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)
  • Ciprofloxacin was used to treat gonorrhea until 2007, when the Centers for Disease Control and Prevention stopped recommending its use after gonococcal infections developed resistance to the drug. (uclahealth.org)
  • This damage may occur soon after you begin taking ciprofloxacin. (medlineplus.gov)
  • This can occur after the first dose of ciprofloxacin. (medlineplus.gov)
  • As with other antibiotic preparations, sometimes additional infections may occur caused by organisms which are not affected by Ciprofloxacin. (pharmacily.com)
  • Some side effects of ciprofloxacin may occur that usually do not need medical attention . (drugs.com)
  • While sexually transmitted infections are mostly transmitted through sexual intercourse, transmission can occur also from mother to child during pregnancy and childbirth, and through blood products or tissue transfer, as well as occasionally through other non-sexual means. (who.int)
  • Millions of viral sexually transmitted infections also occur annually, attributable mainly to HIV, human herpesviruses, human papillomaviruses and hepatitis B virus. (who.int)
  • However, at times, the infection could also occur because of other microorganisms, like Chlamydia or Mycoplasma. (home-remedies-for-you.com)
  • Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
  • Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)
  • Penicillin-resistant strains have been isolated only from respiratory tract infections. (medscape.com)
  • Ciprofloxacin should only be used to treat bacterial infections and is not effective against viral infections like the common cold or flu. (onlinegenericmedicine.com)
  • The most significant differences are that Intestinal Infections Due to Other Organisms (008) and Ill-Defined Intestinal Infections (009) in ICD-9 were replaced by Other Bacterial Intestinal Infections (A04), Other Bacterial Foodborne Intoxications (A05), and Viral and Other Specified Intestinal Infections (A08) in ICD-10. (nih.gov)
  • Quantitative plasma human immunodeficiency virus type 1 (HIV-1) ribonucleic acid (RNA) viral load is used clinically as a predictor of progression of HIV-1 infection. (annals.edu.sg)
  • The thing is that there are different types of infections: viral, fungal, and bacterial. (rxshop.md)
  • In the United States of America, the prevalence of the viral infection among 14-49-year-olds is 19%, and throughout the world, seropositivity rates are uniformly higher in women than in men and increase with age. (who.int)
  • The burden is greatest in the developing world, but industrialized nations can also be expected to experience an increased burden of disease because of the prevalence of non-curable viral infections, trends in sexual behaviour and increased travel. (who.int)
  • Conclusions: Co-administration of ciprofloxacin with riluzole increases the systemic levels of riluzole and thereby the oral pharmacokinetic properties of riluzole while co-administration of grapefruit juice with riluzole has no significant effect. (researchgate.net)
  • [ 1 ] Community-associated skin and soft-tissue infections (SSTIs) are most commonly caused by staphylococci or streptococci. (medscape.com)
  • Milder soft-tissue infections usually require 7-10 days of oral therapy. (medscape.com)
  • It is used in adults and in children aged 6 months and older to treat Otitis media (infection of the middle Eye & Ear) with draining Eye & Ear tubes (tympanostomy tubes) of bacterial origin. (pharmacily.com)
  • Infecton scanning was further compared with WBC scanning in humans with various types of infections and showed improved specificity over WBC scans ( 11 - 13 ). (snmjournals.org)
  • To Treat different types of infections. (rxshop.md)
  • Most were antimicrobial agents, such as ciprofloxacin, or they affected GI motility, such as promethazine. (nih.gov)
  • By electrospinning Ciprofloxacin into a nanofiber scaffold consisting of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO), the antibiotic was released within 2 h, killing 99% of P. aeruginosa and 91% of a methicillin-resistant strain of S. aureus in a biofilm. (sasm.org.za)
  • In the United States, most community-associated methicillin-resistant S aureus (CA-MRSA) infections have been caused by the USA300 epidemic clone. (medscape.com)
  • 5 infections caused by S. aureus . (who.int)
  • Unfortunately, the suspected cases of ear, wound and urinary tract report of emergence of vancomycin intermediate infections at both tertiary (UUTH) and secondary sensitive S. aureus (VISA) and vancomycin (GHIA) healthcare facilities in Akwa Ibom State. (who.int)
  • Conclusions: Our results support the assumption of non-inferiority of ibuprofen compared to ciprofloxacin for treatment of symptomatic uncomplicated UTI, but need confirmation by further trials. (goettingen-research-online.de)
  • Orthopedic infections can be devastating to the patient and are associated with significant costs. (medscape.com)
  • 1.2 Why invest in prevention and control of sexually transmitted infections now? (who.int)
  • Given social, demographic and migratory trends, the population at risk for sexually transmitted infections will continue to grow dramatically. (who.int)
  • Neofloxin D Eye & Ear drops … Ciprofloxacin+Dexamethasone. (pharmacily.com)
  • Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. (medlineplus.gov)