• Most commonly, clinically relevant viral encephalitis affects children, young adults, or elderly patients, but the spectrum of involvement depends on the specific viral agent, host immune status, and genetic and environmental factors. (medscape.com)
  • however, most CNS viral infections involve the meninges to a greater or lesser extent, leading to aseptic meningitis or causing mild meningoencephalitis rather than pure encephalitis. (medscape.com)
  • In addition to acute viral encephalitis, other less established and more unusual manifestations of viral infections include progressive neurologic disorders, such as postinfectious encephalomyelitis (such as may occur after measles or Nipah virus encephalitis) and conditions such as postpoliomyelitis syndrome, which has been considered by some to be as a persistent manifestation of poliovirus infection. (medscape.com)
  • Acute - the most common diseases caused by acute viral infections are encephalitis, flaccid paralysis, aseptic meningitis, post infectious and encephalomyelitis. (wikipedia.org)
  • A wide variety of neurological symptoms are now reported in neurological complications that accompany the viral infection, including cerebrovascular disease, encephalopathy and encephalitis, seizures, movement disorders, neuropsychiatric disorders, myopathy, cranial and peripheral neuropathies ( 3 , 4 ). (spandidos-publications.com)
  • The investigation of patients with suspected central nervous system infections or inflammatory diseases of the central nervous system e.g. viral encephalitis, bacterial meningitis, neurosyphilis, sarcoid and lupus. (ouh.nhs.uk)
  • In this study, we present a protocol to use an immunocompetent outbred ICR (Institute of Cancer Research) mouse for investigating the induction of central nervous system (CNS) infection with DENV, followed by the progression of acute viral encephalitis-like disease. (tmu.edu.tw)
  • The use of corticosteroids as an adjunctive therapy for viral encephalitis is controversial and currently being evaluated in a large clinical trial. (medscape.com)
  • Because specific therapy for encephalitis is limited and because potentially serious sequelae (or death) may result from HSE, early treatment with acyclovir should be started as soon as possible in all patients with suspected viral encephalitis, pending the results of diagnostic studies. (medscape.com)
  • Neurological manifestations of Dengue usually result from multisystem dysfunction which may be secondary to vascular leak or it can be due to direct virus invasion (dengue encephalitis) or an immunological phenomenon which is triggered by dengue infection (demyelinating disorders). (bvsalud.org)
  • An accelerated model of human immunodeficiency virus central nervous system disease was developed in which more than 90% of infected macaques develop typical simian immunodeficiency virus (SIV) encephalitis with neuronal dysfunction by postinoculation (pi) day 84. (eurekamag.com)
  • Low levels of peripheral blood NK lytic activity at pi day 10, elevated cerebrospinal fluid (CSF) monocyte chemoattractant protein-1 after 28 days, and high CSF viral RNA after 42 days predicted SIV encephalitis. (eurekamag.com)
  • This model is ideal to track the viral, cellular, and immunologic changes in the brain during acute and asymptomatic infection and during viral recrudescence and SIV encephalitis. (eurekamag.com)
  • Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition. (ctsicn.org)
  • JEV is the primary cause for viral Encephalitis in a large number of countries in the Asian continent. (byjus.com)
  • Individuals of any age maybe affected by the disease, but most of the adult population in the countries where Japanese Encephalitis is endemic have a natural immunity after the childhood infection. (byjus.com)
  • WHO has made recommendations for inclusion of the JEV vaccine in the national immunisation schedule of all the areas that recognise Japanese Encephalitis as a public health issue in order to control and prevent the disease. (byjus.com)
  • The government of Uttar Pradesh has recently launched a huge door to door campaign DASTAK, to prevent Acute Encephalitis Syndrome (AES) and Japanese Encephalitis (JE) to make sure that the disease is eradicated from the state at the earliest. (byjus.com)
  • The disease can progress to inflammation of the brain (encephalitis) and is often accompanied by seizures. (byjus.com)
  • Japanese Encephalitis is a viral infection that affects parts of the central nervous system, including the brain and spinal cord. (byjus.com)
  • Tick-borne encephalitis (TBE) is a human viral infectious disease involving the central nervous system, and occurring in many parts of Europe and Asia. (europa.eu)
  • The second phase involves the neurological system with symptoms of meningitis (inflammation of the membrane that surrounds the brain and spinal cord) and/or encephalitis (inflammation of the brain). (europa.eu)
  • Tickborne encephalitis (TBE) is a viral infectious disease that attacks the central nervous system and can result in long-term neurological symptoms, and even death. (europa.eu)
  • Other flaviviral infections include dengue, Japanese encephalitis, and tick-borne encephalitis. (medscape.com)
  • citation needed] Most forms of aseptic meningitis are viral in origin, though neoplastic and Lyme disease meningitis are also aseptic. (wikipedia.org)
  • Viral Meningitis Viral meningitis is inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused. (msdmanuals.com)
  • Here, we have performed a prospective nationwide genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 ( DCTN4 ), retinoic acid early transcript 1E ( RAET1E ), and V-akt murine thymoma viral oncogene homolog 3 ( AKT3 ) to be associated with unfavourable outcome in patients with pneumococcal meningitis. (biomedcentral.com)
  • Bacterial meningitis is a severe infection of the central nervous system, which is caused by Streptococcus pneumoniae in 70 % of cases [ 1 ]. (biomedcentral.com)
  • Viruses cause a variety of diseases in animals, including humans, ranging from the common cold to potentially fatal illnesses like meningitis (Figure 1). (lumenlearning.com)
  • [ 6 ] Meningitis typically affects both ears, whereas otogenic infections typically cause unilateral symptoms. (medscape.com)
  • This phase is followed by an asymptomatic interval lasting seven (range 1-33) days that precedes the second phase, when the central nervous system is involved (meningitis, meningoencephalitis, myelitis, paralysis, radiculitis). (europa.eu)
  • The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network Health Advisory about an outbreak of suspected fungal meningitis among U.S. patients hospitalized in Texas after undergoing cosmetic procedures under epidural anesthesia in the city of Matamoros, state of Tamaulipas, Mexico. (cdc.gov)
  • Multiple pathogens can cause healthcare-associated fungal meningitis, and infections may involve multiple pathogens at once. (cdc.gov)
  • Meningitis is the leading infectious syndrome that affects the central nervous system, and most cases are caused by viral infections, mainly enterovirus. (bvsalud.org)
  • enterovirus, cerebrospinal fluid, viral meningitis. (bvsalud.org)
  • Viral meningitis can occur in people of all present nonspecific symptoms, such as headache, ages, but it is more common in children5,6. (bvsalud.org)
  • viral meningitis are caused by enterovirus. (bvsalud.org)
  • It is noteworthy that the initial clinical infections can present high morbidity and low presentations of viral meningitis and bacterial mortality rates. (bvsalud.org)
  • Treatment consists of supportive care and efforts to prevent secondary infections, control symptoms of vomiting, seizures and more. (akc.org)
  • If the animal survives the symptoms, it is hoped that the dog's immune system will have a chance to fight it off. (akc.org)
  • Early in the disease, leukemia may cause nonspecific symptoms similar to those of a viral infection. (aafp.org)
  • Furthermore, as shown in Table 2 , the presenting signs and symptoms are often nonspecific and mimic those of common childhood conditions such as viral infections. (aafp.org)
  • For example, the disease gets worse after viral infections, and bacterial infections cause an increase in MS symptoms. (sciencedaily.com)
  • Giving the formerly germ-free mice a dose of one species of segmented filamentous bacteria induced Th17 not only in the gut but in the central nervous system and brain -- and caused the formerly healthy mice to become ill with MS-like symptoms. (sciencedaily.com)
  • Most people have mild or no symptoms, but some people develop a severe infection that affects the central nervous system. (msdmanuals.com)
  • Most (4 out of 5) people with West Nile virus infection have no symptoms. (msdmanuals.com)
  • Neurological manifestations were among the last identified, as initial attention focused on the severe acute respiratory syndrome (SARS) and digestive symptoms, with the virus appearing, initially, to spare the nervous system. (spandidos-publications.com)
  • The wide variety of symptoms found under this disease classification is said to be due to the distemper virus' lowering of the overall immune system which in turn allows for secondary opportunistic infections that produce the diverse clinical symptoms. (dogsnaturallymagazine.com)
  • Due to the vast array of clinical symptoms produced by this disease, an experienced veterinary homeopath should be consulted immediately to determine the most appropriate remedy. (dogsnaturallymagazine.com)
  • Live viral vaccines are designed in the laboratory to cause few symptoms in recipients while giving them protective immunity against future infections. (lumenlearning.com)
  • The cohort included 114 patients with confirmed COVID-19 infection by polymerase chain reaction test, six people with probable infection diagnosed from chest x-rays or CT scans, and five people with possible infection whose symptoms were consistent with disease, but diagnostic tests were either negative or not done. (medpagetoday.com)
  • [ 2 ] Auditory and vestibular symptoms develop in approximately 25% of patients with herpes oticus, in addition to the facial paralysis and vesicular rash that characterize the disease. (medscape.com)
  • EV outbreaks are common and normally cause nothing more severe than cold-like symptoms or the rash-producing hand, foot and mouth disease. (neurosciencenews.com)
  • They wanted to know how someone could get neurologic symptoms with no virus detectable in their central nervous system," said Michael Wilson, MD, associate professor of neurology, member of the UCSF Weill Institute for Neurosciences, and senior author of the new study. (neurosciencenews.com)
  • If we could detect something specific to a virus in in the spinal fluid of AFM patients, we would feel more secure claiming that the neurologic symptoms of the disease are virally mediated. (neurosciencenews.com)
  • Initial symptoms resemble a common cold, but as the disease progresses, it can lead to neurological issues, seizures, and even death. (petzmaster.com)
  • Rabies is almost always fatal once symptoms appear, making vaccination against the disease a legal requirement in many regions. (petzmaster.com)
  • People suffering for years from the effects of Lyme Disease see reversal of their symptoms. (andreacandee.com)
  • I HAVE FELT no symptoms of Lyme Disease since working with Andrea. (andreacandee.com)
  • Only 20% of people with Zika virus infection show symptoms, which include mild fever, skin rash and conjunctivitis. (who.int)
  • Of these 42 confirmed cases, 26 had reported symptoms consistent with Zika virus infection. (who.int)
  • Zika virus infection further compounds the challenges as the majority of infected people do not display any symptoms and the population has no immunity to this new virus. (who.int)
  • A severe and contagious disease caused by a virus that attacks the respiratory, gastrointestinal (GI), and nervous systems of dogs, raccoons, skunks, and other animals, distemper spreads through airborne exposure (through sneezing or coughing) from an infected animal. (akc.org)
  • Canine coronavirus usually affects dogs' gastrointestinal systems, though it can also cause respiratory infections. (akc.org)
  • Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (mdpi.com)
  • Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
  • However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). (mdpi.com)
  • The coronavirus disease 2019 (COVID-19) pandemic constitutes a persistent threat caused by the novel single-stranded RNA β coronavirus, severe acute respiratory syndrome 2 virus (SARS-CoV-2). (spandidos-publications.com)
  • Dengue virus (DENV), an arthropod-borne virus transmitted by mosquitoes, may cause the severe disease known as dengue hemorrhagic fever, which is characterized by lethal complications due to plasma leakage, ascites, pleural effusion, respiratory distress, severe bleeding, and organ impairment. (tmu.edu.tw)
  • GSK -3888550A is under clinical development by GSK and currently in Phase III for Respiratory Syncytial Virus (RSV) Infections. (pharmaceutical-technology.com)
  • According to GlobalData, Phase III drugs for Respiratory Syncytial Virus (RSV) Infections does not have sufficient historical data to build an indication benchmark PTSR for Phase III. (pharmaceutical-technology.com)
  • GSK -3888550A is under development for the prevention of respiratory syncytial virus infections. (pharmaceutical-technology.com)
  • Distemper is a viral disease that affects various body systems, including the respiratory, gastrointestinal, and nervous systems. (petzmaster.com)
  • The causes and frequency of acute paralysis and respiratory failure with West Nile virus (WNV) infection are incompletely understood. (cdc.gov)
  • However, the frequency of acute paralysis in WNV neuroinvasive disease remains unknown, and the clinical features of WNV-associated respiratory weakness have not been characterized. (cdc.gov)
  • A CDC clinical team began providing consultations § to U.S. clinicians caring for patients with mpox, developing guidance and other online clinical resources for health care providers, and issuing health alerts ¶ when emerging clinical concerns (e.g., severe infections in patients with advanced HIV infection) were detected. (cdc.gov)
  • Many dogs can overcome the mild form of the disease, but the severe form can kill. (akc.org)
  • The treatment aims helping the patient overcome the infection and at relieving severe clinical signs. (byjus.com)
  • however, in approximately 1% of cases, systemic infection leads to involvement of the central nervous system, resulting in severe paralysis and possibly even death. (who.int)
  • The European subtype is associated with milder disease, with 20-30% of patients experiencing the second phase, mortality rates of 0.5-2%, and severe neurological sequelae in up to 10% of patients. (europa.eu)
  • People with compromised immune systems may suffer more severe, even fatal, consequences. (snapcats.org)
  • However, some people require medical attention because the diarrhea is severe or the infection is affecting other organs. (snapcats.org)
  • Its presentation can range from asymptomatic illness to acute-onset viral hepatitis and hemorrhagic fever. (medscape.com)
  • It was estimated that 75% (attack rate) of the island's inhabitants were infected with ZIKV resulting in 18% symptomatic and 82% asymptomatic infections. (cdc.gov)
  • Additionally, numerous asymptomatic persons, particularly pregnant women are tested for ZIKV infection and will meet laboratory criteria for infection. (cdc.gov)
  • Because asymptomatic infection might be epidemiologically significant, revisions to the interim surveillance case definitions are proposed to include ZIKV infections without disease. (cdc.gov)
  • Basic principles of vaccinology as well as different vaccination strategies to prevent disease and the spread of infections are discussed. (uu.se)
  • Before vaccination, rabies was always a death sentence, and hundreds of thousands died annually of this terrible disease. (wayoflife.org)
  • At the heart of the debate stand a few courageous physicians whose independent, multi-disciplinary approach to investigating the possible biological mechanisms of vaccine-induced autism is serving as a counterweight to the steadfast denials by infectious disease specialists and government health officials defending current mass vaccination policies. (nvic.org)
  • The incidence of autism, like that of learning disabilities, attention deficit hyperactivity disorder (ADHD), asthma, diabetes, arthritis, chronic fatigue syndrome, inflammatory bowel disease and other autoimmune and neurological disorders, has risen dramatically in the U.S. and other technologically advanced countries, while high vaccination rates have caused the incidence of childhood infectious diseases to fall just as dramatically in these countries. (nvic.org)
  • Third, are there any concerns for autoimmune development with either infection or vaccination with SARS-CoV-2? (frontiersin.org)
  • Vaccination suppresses the immune system for several days, increasing the puppy's risk of developing disease. (dogsnaturallymagazine.com)
  • Parvovirus is a common disease that appeared throughout the developed world in the 1970's as a direct result of vaccination. (dogsnaturallymagazine.com)
  • While we do have limited numbers of effective antiviral drugs, such as those used to treat HIV and influenza, the primary method of controlling viral disease is by vaccination, which is intended to prevent outbreaks by building immunity to a virus or virus family (Figure 2). (lumenlearning.com)
  • Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
  • Vaccination is the primary method of prevention, and early intervention is crucial in managing the disease effectively. (petzmaster.com)
  • Keeping your dog's rabies vaccination up to date not only protects them but also helps prevent the spread of this deadly disease to other animals and humans. (petzmaster.com)
  • Awareness about the disease will be created by initiating sanitation drive, ensuring vaccination and early treatment to the disease, through mass media communication etc. (byjus.com)
  • Distempter Combination vaccination contains a variety of different viral disease protections including distemper virus, adenovirus type 2, parainfluenza, parvovirus, and sometimes others as well. (stjamesanimalhospital.com)
  • 1 Widespread vaccination and education efforts, along with vigilant surveillance of the disease have resulted in near eradication of poliomyelitis worldwide. (who.int)
  • Once a region achieves polio-free status (defined by the WHO as three years with zero indigenous poliovirus cases) 1 polio vaccination coverage is recommended to be maintained at more than 95% to ensure against cases of wild poliovirus infection and potential epidemic. (who.int)
  • Thus, it is critical for regional and national health departments to accurately monitor the performance of established vaccination systems (measured as the percentage of vaccination coverage in a particular population). (who.int)
  • Serological results should be interpreted according to previous exposure to other flaviviral infections and the flavivirus vaccination status. (europa.eu)
  • While acute viral diseases come on quickly, chronic viral conditions have long incubation periods inside the body. (wikipedia.org)
  • Having less HIV in the body gives the immune system a chance to recover and fight off infections and cancers. (wikipedia.org)
  • Even though there is still some HIV in the body, the immune system is strong enough to fight off infections and cancers. (wikipedia.org)
  • If left untreated, HIV will attack the immune system and eventually progress to AIDS. (wikipedia.org)
  • The life cycle, structure and biology of pathogens are discussed, but also their interaction with the host organism's immune system and methods to prevent disease and spread. (uu.se)
  • As we gained an appreciation for how profoundly the gut microbiota can affect the immune system, we decided to ask if symbiotic bacteria are the missing variable in these mice with MS," he says. (sciencedaily.com)
  • In prior studies, these bacteria had been shown to lead to intestinal inflammation and, more intriguingly, to induce in the gut the appearance of a particular immune-system cell known as Th17. (sciencedaily.com)
  • Th17 cells are a type of T helper cell -- cells that help activate and direct other immune system cells. (sciencedaily.com)
  • In fact, everything was the same except for the presence of those otherwise benign bacteria, which are clearly playing a role in shaping the immune system," Mazmanian says. (sciencedaily.com)
  • Conservative estimates are that about 500,000 Americans are autistic but that number is growing daily, with new evidence that perhaps as many as 1 in 150 children are suffering from autism spectrum disorder that can include a range of neurological, behavior and immune system dysfunction. (nvic.org)
  • The refusal two decades ago by vaccine manufacturers, government health agencies and medical organizations to seriously investigate reports of vaccine-associated brain injury and immune system dysfunction, including autistic behaviors, is reaping tragic consequences today. (nvic.org)
  • HIV infection causes prolonged and excessive activation of the immune system. (catie.ca)
  • As cells of the immune system interact with many organ systems, prolonged activation of the immune system causes many cells in the body to release chemical messengers that incite inflammation. (catie.ca)
  • These and other cells of the immune system, such as macrophages, have receptors for vitamin D. Also, these cells can convert vitamin D 2 into vitamin D 3 . (catie.ca)
  • Other cells of the immune system, such as dendritic cells, whose function is to help amplify the immune response, can also have some of their functions weakened by vitamin D. (catie.ca)
  • Overview of the Immune System The immune system is designed to defend the body against foreign or dangerous invaders. (msdmanuals.com)
  • The main mechanism of Guillain‑Barré syndrome is probably post‑viral dysregulation of the immune system generated by SARS‑CoV‑2. (spandidos-publications.com)
  • The adaptive immune system contains two major arms. (what-when-how.com)
  • The immune response consists of an initial magnification phase, which can either be deleterious as in autoimmune disease or beneficial as in vaccinations, and a later downregulatory phase to return the immune system to homeostasis. (nature.com)
  • They help your immune system recognise an intruder and tell immune cells to attack. (clicksold.com)
  • Interferons are a family of substances naturally made by our immune system (CML).Interferon-alpha is a man-made drug that acts like the substance our immune system naturally produces. (clicksold.com)
  • Boosting the immune system naturally can allow your body to fight off infectious agents without having to rely on ill-advised drugs later in life. (clicksold.com)
  • How do interferons work within the immune system? (clicksold.com)
  • By helping the immune system to stop the virus from multiplying. (clicksold.com)
  • Lab studies show interferons … Interferons are important for fighting viruses in the body, regulating reproduction of cells, and regulating the immune system. (clicksold.com)
  • Hyper immune immunoglobulin has been used for prophylaxis of measles, herpes zoster virus, HSV-2, vaccine, rabies, and some other infections in high-risk groups. (wikipedia.org)
  • The success of the polio vaccine paved the way for the routine dispensation of childhood vaccines against measles, mumps, rubella, chickenpox, and other diseases. (lumenlearning.com)
  • Other viruses, such as those that cause the childhood diseases measles, mumps, and rubella, mutate so infrequently that the same vaccine is used year after year. (lumenlearning.com)
  • For example, poliomyelitis, smallpox, measles and influenza are well recognized diseases in which viral vaccines have proven effective. (justia.com)
  • However, three of the proteins that appear to play an important role in the induction of the anti-viral state have been intensively studied. (clicksold.com)
  • Currently, there is no vaccine to prevent the disease or any specific anti-viral treatment available. (who.int)
  • Infectious canine hepatitis is a highly contagious viral infection that affects the liver, kidneys, spleen, lungs, and the eyes of the affected dog. (akc.org)
  • It affects all aspects of a dog's health eventually attacking the central nervous system causing spasm, seizures and paralysis. (dogsnaturallymagazine.com)
  • Canine parvovirus is a highly contagious and potentially deadly disease that primarily affects puppies and unvaccinated dogs. (petzmaster.com)
  • The disease mostly affects children. (byjus.com)
  • Poliomyelitis is a contagious viral disease, which mainly affects children below five years of age. (who.int)
  • Organ ischemia, which primarily affects the kidneys and central nervous system, leads to altered mental status and/or signs of volume overload. (medscape.com)
  • DETAILED DISEASE AND PREVENTION INFORMATION Simultaneous Administration of Vaccines Simultaneous administration of most inactivated vaccines has not resulted in impaired antibody responses or increased rates of adverse reactions. (cdc.gov)
  • If IG needs to be administered because of imminent exposure to disease, live virus vaccines may be administered simultaneously with IG recognizing that vaccine-induced immunity may be compromised. (cdc.gov)
  • Disease Specific Menu Cholera Cholera is an acute intestinal infection caused by VIBRIO CHOLERA O-group I. The current vaccines have shown a 50% effectiveness in reducing clinical illness for 3-6 months after administration, with the greatest effectiveness in the first 2 months. (cdc.gov)
  • Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
  • There are no vaccines to prevent West Nile virus infection in humans, but people can reduce the risk of transmission by taking steps to prevent mosquito bites. (msdmanuals.com)
  • For those who wish to vaccinate less and decrease the risk of vaccine related diseases, it's important to understand what vaccines are available for your dog and the risks and benefits of each. (dogsnaturallymagazine.com)
  • Like many modified live vaccines, the distemper vaccine has been known to create the disease it was intended to prevent. (dogsnaturallymagazine.com)
  • These diseases can be treated by antiviral drugs or by vaccines, but some viruses, such as HIV, are capable of both avoiding the immune response and mutating to become resistant to antiviral drugs. (lumenlearning.com)
  • The killed viral vaccines and subunit viruses are both incapable of causing disease. (lumenlearning.com)
  • Polio was one disease that represented a milestone in the use of vaccines. (lumenlearning.com)
  • The danger of using live vaccines, which are usually more effective than killed vaccines, is the low but significant danger that these viruses will revert to their disease-causing form by back mutations . (lumenlearning.com)
  • Live vaccines are usually made by attenuating (weakening) the "wild-type" (disease-causing) virus by growing it in the laboratory in tissues or at temperatures different from what the virus is accustomed to in the host. (lumenlearning.com)
  • In some cases, vaccines can be used to treat an active viral infection. (lumenlearning.com)
  • Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
  • DC vaccines have been developed for cancer and infectious diseases. (jci.org)
  • At present, the control of virus infections is primarily achieved by means of immunization vaccines. (justia.com)
  • In general, however, viral vaccines have had only a moderate success in animal prophylaxis. (justia.com)
  • Though the disease has no cure, there are safe and effective vaccines available for prevention of the disease. (byjus.com)
  • Most viruses that enter can be opportunistic and accidental pathogens, but some like herpes viruses and rabies virus have evolved in time to enter the nervous system efficiently, by exploiting the neuronal cell biology. (wikipedia.org)
  • Rabies is a viral disease that infects the central nervous system (brain and spinal cord) of mammals. (in.gov)
  • Rabies in skunks has been restricted to counties in far south-central Indiana, where rabies in skunks continues to be transmitted at a very low level. (in.gov)
  • In the case of rabies, a fatal neurological disease transmitted via the saliva of rabies virus-infected animals, the progression of the disease from the time of the animal bite to the time it enters the central nervous system may be 2 weeks or longer. (lumenlearning.com)
  • The central nervous system of mammals, such as dogs and humans, is affected by the viral disease rabies. (petzmaster.com)
  • Rabies is a viral organism that ultimately causes death in 100% of patients due to brain and other nerve tissue infection. (stjamesanimalhospital.com)
  • However, most of these signs can also be indicative of other diseases like distemper or lead poisoning. (wayoflife.org)
  • Distemper is a rare but serious viral disease that dogs are still considered at risk from in many developed countries. (dogsnaturallymagazine.com)
  • Canine distemper is a serious disease and, when treated conventionally, 50% of dogs with distemper will die. (dogsnaturallymagazine.com)
  • Distemper is a relatively rare disease. (dogsnaturallymagazine.com)
  • The distemper vaccine has been strongly linked to joint disease and arthritis - two increasingly common chronic diseases in dogs. (dogsnaturallymagazine.com)
  • The risk of Vaccine Induced Autoimmune Disease is greater than the risk of distemper. (dogsnaturallymagazine.com)
  • Being a canine form of Feline Viral Enteritis, it is thought that the virus 'jumped' through dogs coming in contact with vaccinated cat's infectious stool, or mutated during the production of the distemper vaccine which was cultivated on infected cats kidneys, (very similar reports have been made regarding the polio vaccine in humans). (dogsnaturallymagazine.com)
  • An unusual CNS involvement leading to microcephaly due to infection of pregnant women by Zika virus has also been recently reported and highlights the constant need to look for new types of neurological manifestations of viral infections in humans. (medscape.com)
  • As the virus infection rate increases in birds it is more likely to be transmitted by an infected mosquito that bites horses and humans. (texasthoroughbred.com)
  • This family of retroviruses has been receiving a lot of attention from scientists in recent decades for causing serious diseases in humans, such as AIDS ( 3 ). (scielo.sa.cr)
  • Viruses can cause dozens of ailments in humans, ranging from mild illnesses to serious diseases. (lumenlearning.com)
  • Back mutations occur when the vaccine undergoes mutations in the host such that it readapts to the host and can again cause disease, which can then be spread to other humans in an epidemic. (lumenlearning.com)
  • as well as disruption of the hormone system in wildlife and humans. (campaign-whale.org)
  • The researchers created molecular libraries consisting of nearly 500,000 small chunks of every protein found in the over 3,000 viruses known to infect vertebrates (including humans), as well as those that infect mosquitoes and ticks (an effort to rule out disease transmission through their bites). (neurosciencenews.com)
  • Both humans and animals may acquire the bacterial infection known as leptospirosis. (petzmaster.com)
  • While most feline infectious diseases affect only cats, and most human infectious diseases affect only humans, it is important to be aware that some of these diseases-called zoonotic diseases-can be transmitted between cats and people. (snapcats.org)
  • Zika virus disease is caused by a RNA flavivirus transmitted to humans by the Aedes mosquito, the same type of mosquito that transmits dengue, chikungunya and yellow fever. (who.int)
  • This disease of the liver is caused by a virus that is unrelated to the human form of hepatitis. (akc.org)
  • Chronic - the most common diseases caused by chronic viral infections are subacute-sclerosing panencephalitis, progressive multifocal leukoencephalopathy, retrovirus disease and spongiform encephalopathies. (wikipedia.org)
  • Clinically relevant involvement of the central nervous system (CNS) by viruses is an uncommon event, considering the overwhelming number of individuals affected by the different human viral infections. (medscape.com)
  • We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid (CSF) samples from patients with acute CNS infection who were enrolled from Vietnam hospitals during 2012-2016. (cdc.gov)
  • However, the distribution of CNS infection pathogens is geographically dependent and has been shaped by the emergence of novel viruses. (cdc.gov)
  • However, in resource-limited settings like Southeast Asia and Vietnam, a limited number of mNGS studies examining known and unknown viruses in cerebrospinal fluid (CSF) samples from patients with CNS infections have been conducted, even though in this tropical region of the world, novel viruses are likely to emerge (P. Zhou et al. (cdc.gov)
  • The CNS viral diseases are caused by viruses that attack the CNS. (wikipedia.org)
  • Development of new therapies has been hindered by the lack of appropriate animal model systems for some important viruses and also because of the difficulty in conducting human clinical trials for diseases that are rare. (wikipedia.org)
  • These attenuated viruses thus still cause infection, but they do not grow very well, allowing the immune response to develop in time to prevent major disease. (lumenlearning.com)
  • Bacteria or viruses can cause acute inflammation of the labyrinth in conjunction with either local or systemic infections. (medscape.com)
  • There is a growing body of information that viruses play a vital role in a broad range of diseases, some of which represent the most serious of man's ills. (justia.com)
  • Arthritis, juvenile arthritis, diabetes, Hodgkin's disease and various immunological diseases and degenerative diseases of the central nervous system have been linked to viruses as the causative agents. (justia.com)
  • One approach to the control of virus-related diseases and, particularly to the spread of such virus diseases, has been to search for medicinal agents or chemotherapeutic agents which are capable of inhibiting the growth of viruses, thereby preventing the spread of disease as well as preventing further damage to cells and tissues of the animal host which have not as yet been infected. (justia.com)
  • Certain infections caused by large viruses, such as lymphogranuloma venereum, psittacosis and trachoma have been successfully treated using antibiotics and sulfa drugs. (justia.com)
  • The normal function of interferon, as a protein naturally produced by the body, is to fight viruses and other infections and diseases. (clicksold.com)
  • Interferons help other cells resist the infection of viruses. (clicksold.com)
  • They are major infectious syndrome in the central nervous single-stranded RNA viruses belonging to the system. (bvsalud.org)
  • The Flavivirus genus is composed of more than 70 arthropod-transmitted viruses, of which 30 are known to cause human disease. (medscape.com)
  • The question was, if this organism is inducing Th17 cells in the gut, will it be able to do so in the brain and central nervous system? (sciencedaily.com)
  • Some researchers think that prolonged inflammation seen in HIV infection likely plays a role in the apparent accelerated aging of the brain, bone, cardiovascular, kidney and other organ-systems. (catie.ca)
  • With multiple sclerosis (MS), inflammation in the central nervous system-the brain and spinal cord-occurs. (catie.ca)
  • Most people with West Nile virus infection do not need treatment, but those who develop infections in their brain or spinal cord require close monitoring and supportive treatment, such a mechanical ventilation. (msdmanuals.com)
  • infection of the tissues that line the brain and spinal cord), or weakness and paralysis. (msdmanuals.com)
  • People whose central nervous system was affected often have long-lasting adverse effects on their brain and nerves. (msdmanuals.com)
  • The central nervous system includes the brain and spinal cord. (medlineplus.gov)
  • The available data continue to support microbial seeding and entrapment as a means for antimicrobial protection and consequent amyloidosis in the brain following HSV1 infection. (alzforum.org)
  • By pi day 56, viral recrudescence in the brain was detected in 2 of 6 infected macaques. (eurekamag.com)
  • A structural component of brain cells, tau has also been linked to Alzheimer's and Parkinson's diseases. (medlineplus.gov)
  • Liveborn infant with congenital microcephaly, or intracranial calcifications, or structural brain or eye abnormalities, or other congenital central nervous system-related abnormalities not explained by another etiology. (cdc.gov)
  • Viral infections can cause congenital and acquired hearing loss. (medscape.com)
  • Due to the rapidly evolving epidemic of Zika virus infection, the Council of State and Territorial Epidemiologists (CSTE) Executive Board developed an interim position statement to establish standardized case definitions for Zika virus disease and ZIKV congenital infection dated February 26, 2016, and to add these conditions to the Nationally Notifiable Diseases List. (cdc.gov)
  • Public health jurisdictions are encouraged to evaluate, report, and monitor identified ZIKV infections, particularly in pregnant women, that don't meet the clinical criteria of the confirmed and probable congenital and non-congenital disease case classifications. (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Therefore, to find evidence of the missing virus, Wilson and his collaborators - researchers at the Chan Zuckerberg Biohub, the Centers for Disease Control and Prevention, the California Department of Public Health, the University of Colorado, Boston Children's Hospital and the University of Ottawa - used an enhanced version of a virus-hunting tool called VirScan, first developed at Harvard Medical School in the laboratory of Stephen J. Elledge, PhD. (neurosciencenews.com)
  • The highly communicable nature of poliovirus and existence of an effective vaccine led to the launch of the Global Polio Eradication Initiative by the World Health Organization (WHO), Rotary International, the US Centers for Disease Control and Prevention, and the United Nations Children's Fund in 1988. (who.int)
  • The Centers for Disease Control and Prevention, Atlanta, and the European Centre for Disease Control and Prevention,Stockholm, and other national public health agencies have also issued travel warnings, which include recommendations that pregnant women consider postponing travel to any area with ongoing Zika virus transmission. (who.int)
  • 2,947 cases were reported to the US Centers for Disease Control and Prevention (CDC) that included 621 neuroinvasive cases and 63 deaths. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Interferons are produced in response to penetration of animal cells by viral (or synthetic) nucleic acid and then leave the infected cell to confer resistance on other cells of the organism. (clicksold.com)
  • The Jasper County horse exhibited classic clinical signs of neurological disease. (texasthoroughbred.com)
  • It is the leading cause of viral neurological disease. (byjus.com)
  • WNV is a viral disease that normally cycles between wild birds and mosquitoes. (texasthoroughbred.com)
  • It is impossible to keep mosquitoes away from you or your animal but you can be proactive by vaccinating against this potentially deadly disease. (texasthoroughbred.com)
  • West Nile virus infection is a viral disease spread primarily from mosquitoes to people. (msdmanuals.com)
  • European Journal of Clinical Microbiology and Infectious Diseases. (lu.se)
  • The course is divided into three parts: mycology (3 credits), parasitology (4 credits) and clinical microbiology and infectious diseases (8 credits). (uu.se)
  • The course section on clinical microbiology and infectious diseases discusses the most important viral, bacterial, fungal and parasitic infections that occur in human medicine. (uu.se)
  • But Mazmanian -- whose laboratory examines the relationships between gut microbes, both harmful and helpful, and the immune systems of their mammalian hosts -- had a hunch that intestinal bacteria were the key. (sciencedaily.com)
  • The company also offers over-the-counter (OTC) products for pain relief, oral health, nutrition, skin health and gastro-intestinal diseases. (researchandmarkets.com)
  • Some feline intestinal parasites, including roundworms and hookworms, can also cause disease in people. (snapcats.org)
  • Knowledge of this interaction is important in understanding viral spread, tropism, and pathogenesis. (medscape.com)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • Neurologic manifestations may be the result of virus neurotropism which can reach the central nervous system (CNS) through cranial nerves and olfactory pathways or via circulation, while damage to the peripheral nervous system (PNS) is likely the result of a parainfective autoimmune reaction ( 3 , 5 ). (spandidos-publications.com)
  • Dengue is a common viral infection worldwide, though its neurological manifestations are infrequent (2%-11% in recent years) and can be varied as the Dengue virus per se is a non-neurotropic virus. (bvsalud.org)
  • To diagnose West Nile virus infection, doctors do a spinal tap or blood tests to check for the antibodies to the virus. (msdmanuals.com)
  • When there's an infection in the spinal cord, antibody-making immune cells travel there and make more antibodies. (neurosciencenews.com)
  • They then exposed these molecular libraries to spinal fluid obtained from 42 children with AFM and, as a control, 58 who were diagnosed with other neurological diseases. (neurosciencenews.com)
  • Any chunks of viral protein cross-reacting with any antibodies present in the spinal fluid would provide evidence for a viral infection in the central nervous system. (neurosciencenews.com)
  • Medical care should be devoted to appropriate management of the airway, bladder function, fluid and electrolyte balance, nutrition, prevention of bedsores, secondary pulmonary infection, and hyperpyrexia. (medscape.com)
  • Novel 3,6-bis basic ketone derivatives of acenaphthene, their preparation and use for the prevention and inhibition of viral infections are disclosed. (justia.com)
  • Heretofore, only a limited number of virus infections such as smallpox, Asian influenza and herpes keratistis have been susceptible to prevention by chemical antiviral agents. (justia.com)
  • Tick prevention measures, including regular tick checks and the use of appropriate preventive products, are essential in reducing the risk of Lyme disease. (petzmaster.com)
  • Our results expanded knowledge about the clinical burden of enterovirus in Vietnam and underscore the challenges of identifying a plausible viral pathogen in CSF of patients with CNS infections. (cdc.gov)
  • infection by the same pathogen. (what-when-how.com)
  • responses to infection by a pathogen. (what-when-how.com)
  • HIV is grouped into the genus Lentivirus (lentus, from Latin) due to the slow course of infection and thus disease, with a long latency period, persistent viral replication and central nervous system involvement ( 1 ). (scielo.sa.cr)
  • Mass immunization campaigns in the 1950s (killed vaccine) and 1960s (live vaccine) significantly reduced the incidence of the disease, which caused muscle paralysis in children and generated a great amount of fear in the general population when regional epidemics occurred. (lumenlearning.com)
  • Thirty-two patients with developing paralysis and acute WNV infection were identified. (cdc.gov)
  • Acute paralysis associated with West Nile virus (WNV) infection ( 1 - 8 ) has been attributed to Guillain-Barré syndrome ( 3 ), a poliomyelitislike syndrome ( 2 , 4 - 6 , 8 ), and a generalized myeloradiculitis ( 1 , 7 ). (cdc.gov)
  • This article is a general overview of the most common viral encephalitides and provides details about general workup and treatment for these important conditions. (medscape.com)
  • This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
  • GBS is a group of autoimmune diseases with acute/subacute evolution characterized by progressive and ascending motor deficit in the limbs, often with sensory, cranial nerve involvement ( 4 , 6 ). (spandidos-publications.com)
  • Treatment of human autoimmune diseases must take into consideration the dynamic nature of both the magnification and downregulatory phases of the immune response. (nature.com)
  • For example, neuroblastoma, retinoblastoma and Wilms' tumor most commonly occur in children between birth and four years of age, whereas osteosarcoma, Ewing's sarcoma and Hodgkin's disease tend to occur in children more than 10 years of age. (aafp.org)
  • Human infection with WNV is known to occur in the United States. (texasthoroughbred.com)
  • Transmission of a zoonotic disease can potentially occur when a person comes into direct contact with secretions or excretions-such as saliva or feces-from an infected cat. (snapcats.org)
  • Cat-scratch disease can occur when a person is bitten or scratched by an infected cat. (snapcats.org)
  • mental health problems, including substance-use disorders, are associated with increased risk of HIV infection and AIDS and interfere with their treatment, and conversely some mental disorders occur as a direct result of HIV infection. (who.int)
  • More than 100 known pathogens can cause CNS infections ( 1 ). (cdc.gov)
  • Of horses that recover from the disease, up to 40 percent may exhibit neurological signs for six months or more after the initial diagnosis. (texasthoroughbred.com)
  • Several neurological complications affecting the central and peripheral nervous system were described secondary to COVID‑19 infection such as hyposmia, headache, nausea, impaired consciousness, psychosis, neurocognitive syndromes and even cerebrovascular accidents. (spandidos-publications.com)
  • viral replication and microglial activation were suppressed at pi day 21. (eurekamag.com)
  • First, does cross-reactivity play a role in the multi-system disorders associated with SARS-CoV-2 infection? (frontiersin.org)
  • Here we present two cases of dengue fever associated demyelinating disorders in two pediatric patients aptly depicting the two spectra of the disease. (bvsalud.org)
  • On 1 February 2016, WHO announced that the recent cluster of neurological disorders and neonatal malformations reported in the Americas region constitute a Public Health Emergency of International Concern (PHEIC) and called for a global response to the spread of Zika virus disease. (who.int)
  • Several studies, including those conducted in African countries with high prevalence of HIV, have shown a positive association between HIV and alcohol consumption, with a prevalence of HIV infection among people with alcohol-use disorders higher than in the general population. (who.int)
  • Rubella and cytomegalovirus are the best-recognized viral causes of prenatal hearing loss. (medscape.com)
  • Existing and emerging viral CNS infections are major sources of human morbidity and mortality. (wikipedia.org)
  • Human Immunodeficiency Virus Infection (HIV) is treated by using a combination of medications to fight against the HIV infection in the body. (wikipedia.org)
  • Before the 2022 outbreak, CDC experts in poxviruses and associated MCMs had evaluated efficacy data from animal models and reports of MCM use for a few human cases of related OPXV infections (e.g., vaccinia virus and cowpox virus). (cdc.gov)
  • Most human infections come from stray dogs, cats, and bats. (wayoflife.org)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • Bourgade K, Garneau H, Giroux G, Le Page AY, Bocti C, Dupuis G, Frost EH, Fülöp T Jr . β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1 . (alzforum.org)
  • They maintained that until there was ample evidence of the virus invading the human nervous system, the link between EVs and AFM remained unproven. (neurosciencenews.com)
  • Human studies strongly suggest that epitope spreading has a role in ongoing disease, although epitope spreading is very difficult to verify in human disease. (nature.com)
  • Several human studies have observed epitope spreading in beta cell-specific humoral responses from birth to disease onset in offspring of diabetic parents. (nature.com)
  • Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments. (nature.com)
  • Approximately two-thirds of human TBE virus infections are non-symptomatic. (europa.eu)
  • Human infection can be prevented by wearing gloves and washing hands thoroughly after cleaning litter boxes (especially if used by a cat with diarrhea). (snapcats.org)
  • Anti-parasite medications for kittens and annual fecal exams for adult cats can reduce environmental contamination and the risk of human infection. (snapcats.org)
  • Before 2007, there had been only 14 human ZIKV disease cases documented. (cdc.gov)
  • Scientists have identified over 30 disease fighting proteins produced by interferons. (clicksold.com)
  • Interferons (IFNα, IFNβ, and IFNγ) are proteins that help to fight infections and diseases. (clicksold.com)
  • Interferons block viral reproduction in healthy cells through the production of antiviral proteins. (clicksold.com)
  • The technology could help quickly detect viral or bacterial infections during major outbreaks. (medlineplus.gov)
  • The clinical characteristics and disease evolution seem to be similar to those observed in Guillain‑Barré syndrome secondary to other etiologies. (spandidos-publications.com)
  • Chest radiography is used to evaluate the extent of pulmonary edema, to reveal secondary bacterial pulmonary infections, and to aid in ventilator management if intubation is required. (medscape.com)
  • Salmonellosis , another common bacterial disease, can cause diarrhea, fever, and stomach pain beginning one to three days after infection. (snapcats.org)
  • Yellow fever is a mosquito-borne disease that is endemic to tropical South America and Sub-Saharan Africa (see the image below). (medscape.com)
  • Yellow fever is one of many causes of viral hemorrhagic fever . (medscape.com)
  • All three virus studies support an antiviral activity for Aβ that involves viral agglutination. (alzforum.org)
  • Worldwide, ≈50% of patients with CNS infections have no etiology identified ( 1 , 5 , 6 ). (cdc.gov)
  • For more information on TVMDL's equine neurologic disease testing, visit tvmdl.tamu.edu , or contact the agency headquarters at 1.888.646.5623. (texasthoroughbred.com)
  • Approach to the patient with neurologic disease. (medlineplus.gov)
  • Virus infections usually begin in the peripheral tissues, and can invade the mammalian system by spreading into the peripheral nervous system and more rarely the CNS. (wikipedia.org)
  • Monkeypox (mpox) is a disease caused by infection with Monkeypox virus (MPXV), an Orthopoxvirus (OPXV) in the same genus as Variola virus , which causes smallpox. (cdc.gov)
  • A scratch from a rabid animal could transmit the disease because there might be a virus on its nails. (in.gov)
  • La microbiología forense es un área científica que ha surgido con la necesidad de investigar los delitos biológicos, como en el caso de la transmisión intencional del virus de la inmunodeficiencia humana (VIH). (scielo.sa.cr)
  • "If the disease is noticed in the early stages, use of the potentised virus by itself may achieve spectacular results" (Macleod). (dogsnaturallymagazine.com)
  • Vaccinations are designed to boost immunity to a virus to prevent infection. (lumenlearning.com)
  • Adaptations to these new cells or temperatures induce mutations in the genomes of the virus, allowing it to grow better in the laboratory while inhibiting its ability to cause disease when reintroduced into conditions found in the host. (lumenlearning.com)
  • The concept behind this is that by giving the vaccine, immunity is boosted without adding more disease-causing virus. (lumenlearning.com)
  • This is enough time to vaccinate an individual who suspects that they have been bitten by a rabid animal, and their boosted immune response is sufficient to prevent the virus from entering nervous tissue. (lumenlearning.com)
  • Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
  • The cause of this disorder is reactivation of a latent varicella-zoster virus infection occurring years after the primary infection. (medscape.com)
  • Sulfonamides and antibiotics which have revolutionized the treatment of bacterial infections have substantially no effect upon virus infections. (justia.com)
  • Thus, it can be seen that there is a need for new chemotherapeutic agents which are effective against a broad range of virus diseases, and which at the same time, are non-toxic to the host. (justia.com)
  • These compounds are effective against a wide spectrum of virus infections and are useful in both the therapeutic and prophylactic treatment of such infections. (justia.com)
  • Studies in two models of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalitogenic virus-induced demyelinating disease (TMEV-IDD) have shown conclusively that epitope spreading plays a pathological role in ongoing disease and that blocking this process by inducing tolerance to spread myelin epitopes or blocking costimulation of T cells (necessary for epitope spreading) blocks (EAE) or inhibits (TMEV-IDD) ongoing clinical disease. (nature.com)
  • Figure 2: Hierarchical pattern of intramolecular and intermolecular epitope spreading in PLP 139-151 -induced relapsing EAE and Theiler's virus-induced demyelinating disease (TMEV-IDD). (nature.com)
  • Interferons represent a family of cytokines, which is of central importance in the innate immune response to virus infections. (clicksold.com)
  • This system is designed to block the spread of virus infection in the body, sometimes at the expense of accelerating the death of the infected cells. (clicksold.com)
  • A preceding viral infection was reported in 88% of these cases and retrospective analysis demonstrated that all 42 cases had serological tests suggesting prior dengue and Zika virus infections. (who.int)
  • Prior to 2007, Zika virus infection had not been documented outside Asia or Africa. (who.int)
  • As of April 2016, over 60 countries in the Americas, the Pacific Islands, South-east Asia and Africa have reported local transmission of Zika virus disease. (who.int)
  • As of May 2016, no countries of the Region have reported importation of Zika virus disease or autochthonous transmission. (who.int)
  • Some of these countries that are at risk for Zika virus infection are also either experiencing, or recovering from, complex emergencies, have fragile health systems, weak disease surveillance systems, poor response capacities, and a suboptimal level of public health preparedness. (who.int)
  • Learn how clinical and public health laboratories collaborate with healthcare teams to provide the testing required to diagnose and treat hospital patients under investigation (PUI) for Ebola virus disease. (cdc.gov)