• Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). (prosci-inc.com)
  • C57BL/6 (B6), C57BL/10 (B10), and SJL mice showed markedly suppressed secondary anti-DNP responses when infected. (uky.edu)
  • The original genetic background used for the K18-hACE2 mice (C57Bl/6J) proved to be among the most susceptible, while the F1 crosses from a strain known as PWK were highly resistant to disease. (omniaeducation.com)
  • C3H/HeJ or C3H/HePas (susceptible), BALB/c (intermediate) and C57BL/6 (resistant) mice were infected with the CL or Colombian strain of Trypanosoma cruzi, and TNF activity was measured in the sera during the acute phase of the infection. (pasteur.fr)
  • Furthermore, the absolute amounts of Compact disc4+Compact disc25+ and Compact disc4+Compact disc25+FoxP3+ cells in spleens of infected BALB/c mice were greater than those from infected C57BL/6 mice (Figure 1E & F). the pathogenesis of experimental disease, their exact part remains questionable. (rawveronica.com)
  • We wanted to determine whether Tregs donate to specific phenotypic results in BALB/c and C57BL/6 mice and if just how they function regarding control of parasitemia and creation of disease-exacerbating proinflammatory cytokines. (rawveronica.com)
  • Strategy/Results BALB/c and C57BL/6 mice had been contaminated intraperitoneally (i.p) with 103 clone TC13 and both kinetics of Tregs development and intracellular cytokine information in the spleens and livers were monitored directly by movement cytometry. (rawveronica.com)
  • CFD1 As opposed to a transient and non significant upsurge in the percentages and total numbers of Compact disc4+Compact disc25+Foxp3+ T cells (Tregs) in C57BL/6 mouse spleens and livers, a substantial upsurge in the percentage and total amounts of Tregs was seen in spleens of contaminated BALB/c mice. (rawveronica.com)
  • Ablation or raising the amount of Compact disc25+ cells in the fairly resistant C57BL/6 mice by anti-CD25 mAb treatment or by adoptive transfer of Compact disc25+ T cells, respectively, ameliorates or exacerbates parasitemia and creation of proinflammatory cytokines. (rawveronica.com)
  • Summary Collectively, our outcomes display that regulatory T cells donate to susceptibility in experimental murine trypanosomiasis in both highly vulnerable BALB/c and fairly resistant C57BL/6 mice. (rawveronica.com)
  • Writer Overview BALB/c mice are susceptible even though C57BL/6 is relatively resistant to experimental disease highly. (rawveronica.com)
  • For instance, BALB/c mice are extremely susceptible as the C57BL/6 mice are fairly resistant to disease with as assessed by the capability to control parasitemia and success period [3], [4]. (rawveronica.com)
  • The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains of mice (e.g. (cdc.gov)
  • The suppressive effect of Toxoplasma infection on initiation of memory cells to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH) was drastically different among inbred strains of mice. (uky.edu)
  • In contrast, AMs from L. plantarum-primed mice challenged with virus ex vivo exhibited no differential susceptibility to rK2-PVM. (nih.gov)
  • Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice? (pasteur.fr)
  • Thus, sera collected from mice of strains differing in their susceptibility or resistance to Trypanosoma cruzi infection were checked for the presence and level of TNF alpha, a cytokine able to exert acute toxic effects. (pasteur.fr)
  • Likewise, different strains of inbred mice display varying amount of susceptibility to experimental disease. (rawveronica.com)
  • Susceptibility and permissiveness of a total of eleven cell lines, including six animal cell lines and five human cell lines for omicron BA.1.1 infection, were evaluated by infecting individual cell lines with omicron BA.1.1 isolate at a 0.1 multiplicity of infection. (bvsalud.org)
  • In mice primed and boosted with rMVA expressing the Wuhan S, neutralizing antibodies to Wuhan increased after one immunization with rMVA expressing Omicron S due to original antigenic sin, but substantial neutralizing antibody to Omicron required a second immunization. (bvsalud.org)
  • Immunogenicity of the other six proteins (SPELD, ETRAMP10.3, SIAP2, SPATR, HT, RPL3) was analyzed by immunization of inbred BALB/c and outbred CD-1 mice with viral-vectored (ChAd63 or ChAdOx1, MVA) vaccines, followed by challenge with chimeric sporozoites. (ox.ac.uk)
  • We have analyzed the potential of DNA vaccines expressing genetically detoxified derivatives of pneumolysin (pneumolysoids) against pneumococcal infections, and compared this with immunization using recombinant protein. (ox.ac.uk)
  • Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans, was isolated from healthy humans and its protective effect against IFV infection in a murine model shown. (nih.gov)
  • Infections occur in humans who have been fed upon by infected nymphal or adult ticks. (cdc.gov)
  • Although cross-reactivity of murine CD8+ T cells does not directly translate to humans, the molecular interactions involved in triggering T cell responses are the same in mouse and man. (ox.ac.uk)
  • DNA vaccines based on genetically detoxified derivatives of pneumolysin fail to protect mice against challenge with Streptococcus pneumoniae. (ox.ac.uk)
  • In order to track virus-target cell interactions during acute infection in vivo, we developed rK2-PVM, bacterial artificial chromosome-based recombinant PVM strain J3666 that incorporates the fluorescent tag monomeric Katushka 2 (mKATE2). (nih.gov)
  • CD11c(+) sialic acid-binding immunoglobulin-like lectin F(+)) in vivo and likewise detect mKATE2(+) DCs in mediastinal lymph nodes from infected mice. (nih.gov)
  • We have developed a fully functional recombinant PVM strain with a fluorescent reporter protein (rK2-PVM) that permits us to track infection of target cells in vivo. (nih.gov)
  • We show here that Lactobacillus administration also limits infection of leukocytes in vivo and results in diminished release of infectious virions from alveolar macrophages. (nih.gov)
  • However, influenza A virus (IAV) infection releases virulent pneumococci from biofilms in vitro and in vivo. (lu.se)
  • In vivo R12-31 agonist activity was demonstrated by its ability to induce the formation of intestinal villous microfold cells in mice. (cnrs.fr)
  • Conflicting reports identified opposing effects of IFITM3 on SARS-CoV-2 infection of cells, and its impact on viral pathogenesis in vivo remains unclear. (emory.edu)
  • Our results establish IFITM3 KO mice as a new animal model for studying severe SARS-CoV-2 infection and overall demonstrate that IFITM3 is protective in SARS-CoV-2 infections in vivo. (emory.edu)
  • This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in vivo stimulation. (ox.ac.uk)
  • With rK2-PVM, we demonstrate infection of leukocytes in the lung, notably, dendritic cells and alveolar macrophages. (nih.gov)
  • Alveolar macrophages undergo productive infection and release infectious virions. (nih.gov)
  • Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. (unicatt.it)
  • In vitro studies using a primary antisheep erythrocytes (SRBC) antibody response system demonstrated that the activation of plastic-adherent suppressor cells by Toxoplasma infection, in which suppressor macrophages have been proved to be the responsible cells for the suppressive activity, was controlled by both H-2-linked and -nonlinked genes. (uky.edu)
  • However, TNF activity could be measured in serum of all strains, following LPS infection, indicating that the infection was able to prime macrophages of infected mice to secrete TNF alpha. (pasteur.fr)
  • To determine how the profile of NK receptor expression changes in murine CD8(+) T cells as they respond to intracellular pathogens, we used class I tetramer reagents to directly examine Ag-specific T cells during lymphocytic choriomeningitis virus and Listeria monocytogenes infections. (duke.edu)
  • We employed recombinant MVAs (rMVAs) expressing modified S of several SARS-CoV-2 strains and compared their ability to neutralize variants, bind S proteins and protect K18-hACE2 mice against SARS-CoV-2 challenge when administered intramuscularly or intranasally. (bvsalud.org)
  • To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. (ox.ac.uk)
  • For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P. berghei sporozoites were created that express the P. falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter. (ox.ac.uk)
  • All fourteen chimeric parasites produced sporozoites but sporozoites of eight lines failed to establish a liver infection, indicating a negative impact of these P. falciparum proteins on sporozoite infectivity. (ox.ac.uk)
  • Of the six proteins only SPELD immunized mice showed partial protection. (ox.ac.uk)
  • We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. (umassmed.edu)
  • CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) are also involved in the mechanism of immune regulation against Plasmodium infection. (omicsonline.org)
  • Following Bacille Calmette Guerin or Plasmodium yoelli infection, however, M phi recruited to liver and spleen hybridize strongly to the lysozyme probe. (ox.ac.uk)
  • Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
  • The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5. (prosci-inc.com)
  • The rK2-PVM pathogen promotes lethal infection in BALB/c mice and elicits characteristic cytokine production and leukocyte recruitment to the lung parenchyma. (nih.gov)
  • An outlier was WSB, which had high early IFN-1 expression but also high early virus burden in the lung, and clearance was delayed in a manner similar to mice with low IFN-1 expression. (omniaeducation.com)
  • KO mice have higher lung viral titers and increases in inflammatory cytokine levels, immune cell infiltration, and histopathology. (emory.edu)
  • Mechanistically, we observe disseminated viral antigen staining throughout the lung and pulmonary vasculature in KO mice, as well as increased heart infection, indicating that IFITM3 constrains dissemination of SARS-CoV-2. (emory.edu)
  • Here, we characterize a mouse model of SARS-CoV-2 infection and find that early CCR2 signaling restricts the viral burden in the lung. (emory.edu)
  • We find that a recently developed mouse-adapted SARS-CoV-2 (MA-SARSCoV- 2) strain as well as the emerging B.1.351 variant trigger an inflammatory response in the lung characterized by the expression of proinflammatory cytokines and interferon- stimulated genes. (emory.edu)
  • Using intravital antibody labeling, we demonstrate that MASARS- CoV-2 infection leads to increases in circulating monocytes and an influx of CD451 cells into the lung parenchyma that is dominated by monocyte-derived cells. (emory.edu)
  • Parenchymal monocyte-derived cells appear to play a protective role against MA-SARS-CoV-2, as mice lacking CCR2 showed higher viral loads in the lungs, increased lung viral dissemination, and elevated inflammatory cytokine responses. (emory.edu)
  • SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imperative to explore ways of enhancing protection. (bvsalud.org)
  • Nevertheless, monovalent vaccines with S mismatched to the challenge virus still protected against severe disease and reduced the amounts of virus and subgenomic RNAs in the lungs and nasal turbinates, though not as well as vaccines with matched S. Passive transfer of Wuhan immune serum with Omicron S binding but undetectable neutralizing activity reduced infection of the l-ungs by Omicron suggesting additional effector functions. (bvsalud.org)
  • This study determined the immune correlates induced by serial dilutions of rAd vaccines delivered intramuscularly (IM) and intranasally (IN) to mice and rats. (mdpi.com)
  • Results suggest that white-tailed deer harbor a variant strain not associated with human infection, but contrary to published reports, white-tailed deer are not a reservoir for strains that cause human disease. (cdc.gov)
  • Serum from mouse orally ingested with tissue cyst forming strain (Me49) of Toxoplasma gondii was assayed by Western blot and immunofluorescene assay (IFA) to establish early responses in antigenicity of the parasite in mouse model of foodborne toxoplasmosis. (koreamed.org)
  • Normally, the skin color of the mice from which the host blastocysts are derived is different from that of the strain used to produce the embryonic stem cells. (wikipedia.org)
  • Scholars@Duke publication: Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. (duke.edu)
  • These NK cell receptors are also expressed by certain memory phenotype CD8(+) T cells, and in some cases are up-regulated in T cells responding to viral infection. (duke.edu)
  • If the response is delayed, viral replication and spread can proceed unchecked during the early stages of infection. (omniaeducation.com)
  • These studies have identified a potential CCR2-monocyte axis that is critical for promoting viral control and restricting inflammation within the respiratory tract during SARS-CoV-2 infection. (emory.edu)
  • Although LLC MK-2 cells showed an increased TCID50 titer at the second infection, the viral load did not show much difference in both infections. (bvsalud.org)
  • In response to the pandemic, a mouse model was quickly re-derived that allowed SARS-CoV-2 infection through humanized angiotensin-converting enzyme 2 (hACE2) receptors. (omniaeducation.com)
  • T cells provide protection to infection by cytokine-mediated mechanisms or through production of antibodies. (omicsonline.org)
  • Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. (jax.org)
  • Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice. (edu.au)
  • In "Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19," a paper published in Nature Communications , the team shows that the resulting F1 (first generation crossed) mice indeed modeled human COVID-19 severity, ranging from asymptomatic to lethal. (omniaeducation.com)
  • In a few experiments, mice had been injected with anti-CD25 mAb prior or post disease or adoptively (by intravenous path) given extremely enriched na?ve Compact disc25+ T lymphocytes ahead of infection as well as the inflammatory cytokine/chemokine amounts and success were monitored. (rawveronica.com)
  • CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. (jax.org)
  • In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. (jax.org)
  • This work aims at characterizing the ability of sera to bind to the pneumococcal surface and to mediate complement deposition, using BALB/c wild-type and interleukin-4 knockout mice. (ox.ac.uk)
  • Here, we show that IFITM3 knockout (KO) mice infected with SARS-CoV-2 experience extreme weight loss and lethality compared to mild infection in wild-type (WT) mice. (emory.edu)
  • Pneumonia virus of mice (PVM) is a natural rodent pathogen that replicates in bronchial epithelial cells and reproduces many clinical and pathological features of the more severe forms of disease associated with human respiratory syncytial virus. (nih.gov)
  • Pneumonia virus of mice (PVM) is a natural mouse pathogen that serves as a model for severe human respiratory syncytial virus disease. (nih.gov)
  • the location and proportion of antigen-positive cells appeared to vary as a function of time postinfection and age of the animal at the time of infection. (liverpool.ac.uk)
  • Mice immunized with RBD nanoparticles, but not soluble antigen, elicited cross-reactive binding and neutralization responses. (ox.ac.uk)
  • Infection and Immunity , 71 (5), 2810-8. (royalholloway.ac.uk)
  • virus-specific immunity in neonatal and adult mouse rotavirus infection. (liverpool.ac.uk)
  • mouse rotavirus (epizootic diarrhea of infant mice) was used as a model to study the role of virus-specific immunity in infection and diarrheal disease. (liverpool.ac.uk)
  • and Rocky Mountain National Laboratories Chief of Innate Immunity and Pathogenesis Sonja Best, Ph.D., crossed the original K18-hACE2 line with other mouse strains that represent broad genetic diversity. (omniaeducation.com)
  • However, the T cell immunity plateaued in both mice and rats at 10 9 and 10 10 vp/animal, respectively. (mdpi.com)
  • The immunity acquired after natural infection or vaccinations against SARS-CoV-2 tend to wane with time. (bvsalud.org)
  • In contrast, the suppression did not occur in BALB/c mice. (uky.edu)
  • Peak levels of infection typically occur in hosts aged between 10 and 14 yr in. (deepdyve.com)
  • Early wasting and subsequent mortality may occur in mice of some inbred strains following infection with Trypanosoma cruzi. (pasteur.fr)
  • Female BALB /c mice were treated intraperitoneally (i.p) with 0.75 and 1.5 mg/kg doses of melittin for 14 days (5 doses per week). (biomedcentral.com)
  • Natural Treg cells during primary exposure to malaria enhanced Th1 memory responses and increased disease severity during re-infection. (omicsonline.org)
  • Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)
  • The infected DBA/2 and C3H/He mice produced moderately suppressed responses. (uky.edu)
  • However, in BALB/c mice, the responses were not affected even by inoculation with 1 × 10 4 organisms. (uky.edu)
  • The difference in the suppressive effect of infection between B6 and BALB/c mice was also observed in the primary anti-DNP antibody responses to DNP-KLH. (uky.edu)
  • Dive into the research topics of 'Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)
  • We assessed in mice whether broad CD8+ T cell responses capable of efficient recognition of multiple HIV-1 clades could be induced using current single-clade vaccine constructs that were or will be used in clinical trials in Europe and Africa. (ox.ac.uk)
  • Moving forward, the diverse mouse strains will allow scientists to model patient variation in COVID-19 outcome and provide a platform for discovering biomarkers of disease severity, characterizing antiviral immune responses and evaluating countermeasures. (omniaeducation.com)
  • Early in the COVID-19 pandemic, it became clear that people had hugely variable responses to SARS-CoV-2 infection. (omniaeducation.com)
  • With the mouse panel, the team was able to further investigate differences in the innate immune responses that had been implicated in human patient variability. (omniaeducation.com)
  • The research team found that the highly resistant PWK F1 mice exhibited early control of virus replication in the lungs, with phased amplification and resolution of pro-inflammatory responses and prevention of virus dissemination to other organs. (omniaeducation.com)
  • We therefore postulate that although both DNA and recombinant protein immunizations are able to protect mice against intraperitoneal pneumococcal challenge, an optimized response would be achieved by using a DNA vaccine and other strategies capable of inducing balanced Th1/Th2 responses. (ox.ac.uk)
  • Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. (ox.ac.uk)
  • When immunized IM, mice had substantially higher antibody responses at the higher vaccine doses, whereas, the IN immunized mice showed a lower response to the higher rAd vaccine doses. (mdpi.com)
  • The IM immunized mice and rats also showed significant dose-dependent T cell responses to the rAd vaccine. (mdpi.com)
  • Additionally, the highest dose of vaccine in mice and rats did not improve the T cell responses. (mdpi.com)
  • A final vaccine analysis using a lethal influenza virus challenge showed that despite the differences in the immune responses observed in the mice, the mice had very similar patterns of protection. (mdpi.com)
  • Both H-2-linked and -nonlinked genes appeared to be responsible for the regulation of the immunosuppression, since the suppressive effect of infection in B10.D2 mice, which have the B10 background and the same H-2 haplotype as BALB/c, was weaker than that of B10 mice, but stronger than in BALB/c mice. (uky.edu)
  • In mice that were intranasally inoculated with IFV, oral administration of MM-2 for 17 consecutive days improved clinical symptoms, reduced mortality, suppressed inflammation in the lower respiratory tract, and decreased virus titers, cell death, and pro-inflammatory cytokines such as IL-6 and TNF-α in bronchoalveolar lavage fluid. (nih.gov)
  • At the same time, failure to regulate it and reduce signaling once acute infection is over can lead to ongoing inflammation and adverse health consequences. (omniaeducation.com)
  • The timing and strength of innate immune activity and interferon signaling, the front-line cellular defense against microbial infection, were implicated in this variability, but the underlying factors determining disease severity between individuals remained poorly understood. (omniaeducation.com)
  • In a study conducted in 2005, melittin's antimicrobial properties on Chlamydia trachomatis and Mycoplasma hominis infections were evaluated, and it was concluded that this substance could act as an agent for the prevention/control of urogenital infections [ 8 ]. (biomedcentral.com)
  • Field studies of schistosomes and the major intestinal nematodes Trichuris trichiura and Ascaris lumbricoides repeatedly demonstrate that the intensity and prevalence of infection exhibit marked dependency on host age. (deepdyve.com)
  • We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
  • Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. (jax.org)
  • Infection with a fungus of the genus CANDIDA. (lookformedical.com)
  • It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (lookformedical.com)
  • Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (lookformedical.com)
  • Small intestinal tissue sections from euthymic and athymic (nude) mice, and mice with combined deficiency in T-cell receptor beta and delta genes [TCR(beta/delta)-/-] infected orally with T. spiralis larvae, were examined by electron microscopy and after histochemical and lineage-specific immunohistochemical staining. (ox.ac.uk)
  • Compared with uninfected controls, Paneth and intermediate cell numbers increased significantly in infected euthymic and nude mice but not infected TCR(beta/delta)-/- mice. (ox.ac.uk)
  • Furthermore, we demonstrated that gamma interferon and tumor necrosis factor alpha were strongly induced after intraperitoneal pneumococcal challenge only in mice immunized with the DNA vaccine. (ox.ac.uk)
  • The present study shows that administration of COVAXIN® booster dose will enhance the vaccine effectiveness against the Delta variant infection and give protection against the BA.1.1 and BA.2 variants. (bvsalud.org)
  • With the advent of genetic engineering technology, genetically modified mice can be generated to order and can cost hundreds of dollars each. (wikipedia.org)
  • Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice. (ox.ac.uk)
  • Transfer of mesenteric lymph node cells before infection led to an increase in Paneth and intermediate cells in TCR(beta/delta)-/- mice. (ox.ac.uk)
  • In infected euthymic mice, Paneth cells and intermediate cells expressed cryptdins (alpha-defensins) but not intestinal trefoil factor (ITF), and goblet cells expressed ITF but not cryptdins. (ox.ac.uk)
  • In conclusion, a unique, likely thymic-independent population of mucosal T cells modulates innate small intestinal host defense in mice by increasing the number of Paneth and intermediate cells in response to T. spiralis infection. (ox.ac.uk)
  • Experiments with B cell deficient mice have demonstrated that B cells and antibodies are essential for complete clearance of parasites from blood of the host [2]. (omicsonline.org)
  • We found that both antibodies recognized mouse RANK with high affinity, while RANK-02 and R12-31 recognized human RANK with high and lower affinities, respectively. (cnrs.fr)
  • Kumar V, Rakha A, Saroa R, Bagai U (2015) CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice. (omicsonline.org)
  • thus, both infected reservoirs and ticks that can transmit the infection must be available to maintain the agent in nature. (cdc.gov)
  • These data help explain pneumococcal virulence after IAV infection and have important implications for studies of S. pneumoniae pathogenesis. (lu.se)
  • According to our results, melittin at 0.75 and 1.5 mg/kg doses could not induce significant changes on immune parameters and as a result, melittin was found to be safe for the mice immune system. (biomedcentral.com)
  • We have shown previously that administration of immunobiotic Lactobacillus directly to the respiratory mucosa protects mice from the lethal sequelae of PVM infection in association with profound suppression of the virus-induced inflammatory response. (nih.gov)
  • Chimeric mouse production consists of injecting embryonic stem cells provided by the investigator into 150-175 blastocysts, representing three days of work. (wikipedia.org)
  • Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. (jax.org)
  • In contrast, AP-Variant 1 does not infect the white-footed mouse, DBA/2, and severely immunocompromised (SCID) mice ( 8 ). (cdc.gov)
  • Even in non-infected mice, MM-2 administration also induced significant enhancement of both IFN-γ production by Peyer's patch cells (PPs) and splenetic NK cell activity. (nih.gov)
  • In B6 mice, an injection with 1 × 10 2 organisms of T. gondii induced a suppressed elicitation of the memory cells to DNP-KLH. (uky.edu)
  • These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. (jax.org)
  • Laboratory mice reared in specific-pathogen-free (SPF) conditions usually have a rather immature immune system with a deficit of memory T cells. (wikipedia.org)
  • Second, we are developing humanized mouse models of vitiligo, where we transfer human T cells, or both T cells and skin, from vitiligo patients to immunosuppressed mice that permit the growth of human tissues. (umassmed.edu)
  • The benefit of this approach is that we can study the key cells that participate in vitiligo directly from patients, without variables that may change them, including their transfer into mice. (umassmed.edu)
  • Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. (umassmed.edu)
  • Within 24 h of infection, cells found in the marginal zone of the spleen begin to produce lysozyme mRNA. (ox.ac.uk)
  • Later in the infection, other cells in the red and white pulp of the spleen, and cells in granulomas in the liver, become lysozyme-positive. (ox.ac.uk)
  • Lysozyme mRNA levels in liver granulomas remain relatively constant during the infection, and lysozyme is produced by most granuloma cells. (ox.ac.uk)
  • We have investigated the role of T cells in effecting alterations in small intestinal epithelial cell populations induced by infection with the nematode Trichinella spiralis. (ox.ac.uk)
  • The neurovirulence for mice and derivation of the genomic RNA segments were determined for the reassortants. (ox.ac.uk)
  • The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease. (jax.org)
  • Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. (omniaeducation.com)
  • First, we use a mouse model of vitiligo that we developed, where the mice get spots of vitiligo on their ears, tails, feet and noses. (umassmed.edu)
  • At first, the hACE2 was only present in a single inbred mouse line, known as K18-hACE2, which always developed severe/lethal disease. (omniaeducation.com)