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  • Alzheimer's
  • As the prevalence of Alzheimer's disease (AD), the most common dementia in the elderly, continues to increase, neurologists will encounter a growing number of questions about genetic testing for dementia patients, their relatives, and people concerned about memory or cognitive function who have no apparent risk except advancing age. (medreviews.com)
  • We and others have examined patients with various neurodegenerative and behavioral neurological conditions, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD) and Autistic Spectrum Disorders ([ASD], including Autism, Attention Deficit Disorder, Asperger Syndrome), and found evidence for systemic intracellular bacterial and viral infections in a majority of patients. (townsendletter.com)
  • Alzheimer's neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes. (psychologytoday.com)
  • Endemic
  • Lyme disease is most endemic in Northern Hemisphere temperate regions, but sporadic cases have been described in other areas of the world. (wikipedia.org)
  • This might be due to the very low incidence in an endemic region (0.2%, CI 95% 0.0% to 1.1%) as demonstrated in 517 patients hospitalized for psychiatric diseases. (blogspot.com)
  • Prevalence of antibodies against Borrella species in patients with unclassified uveitis in regions in with Lyme disease is endemic' Clin.Diag.Labo.Immunol.2. (nii.ac.jp)
  • Neurology
  • Pediatr Res, 1993 Jan,33(1Suppl):S90-4 Dept. Neurology, University Pennsylvania School of Medicine In this abstract, Guillain-Barre disease is the topic with Lyme mentioned as well. (borrelioosi.net)
  • The American Academy of Neurology (AAN) published a practice parameter in 2001 stating that steroids are probably effective and acyclovir (with prednisone) is possibly effective for the treatment of Bell palsy. (medscape.com)
  • neuropsychiatric
  • Thus the value of careful evaluation that often includes neuropsychiatric testing, SPECT and MRI brain scans, CSF analysis when appropriate, regular input from Lyme-aware neurologists, pain clinics, and occasionally specialists in psychopharmacology. (ariplex.com)
  • neurological
  • 1-5 One of the biochemical changes found in essentially all neurological degenerative diseases is the over-expression of oxidative free radical compounds (oxidative stress) that cause lipid, protein, and genetic structural changes. (townsendletter.com)
  • Can microbes and immune reactions to them actually contribute to cognitive decline, degenerative neurological disease, developmental disabilities, mental illness, personality changes and, at the most extreme, even violent and criminal behavior? (psychologytoday.com)
  • Although most patients with Lyme/tick-borne disease do not become violent, a small percent of patients who become infected develop a type of neurological dysfunction that can increase their risk of aggressiveness. (psychologytoday.com)
  • antibiotics
  • In the US, neuroborreliosis is typically treated with intravenous antibiotics which cross the blood-brain barrier, such as penicillins, ceftriaxone, or cefotaxime. (wikipedia.org)
  • 11 In contrast, if the SF-36 was used to determine Quality of Life (QOL) in post-Lyme patients, the average SF-36 physical component summary (40±9, range 29-44) and mental component summary (39±14, range 23-46) of the QOL assessment were worse than the general USA population, and they could be significantly improved by anti-Lyme antibiotics (46% versus 18%, p =0.007). (blogspot.com)
  • In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, acne, rosacea, and rickettsial infections. (wikipedia.org)
  • pathogens
  • These recent historical, geographical and microbial data should prompt the medical community to realize that cases of persisting post tick-bite syndromes are probably due to multiple pathogens and that these occult infections will require a new approach if not an actual paradigm shift. (borrelioosi.net)
  • Africa
  • Newly discovered genospecies have also been found to cause disease in humans: B. lusitaniae in Europe (especially Portugal), North Africa and Asia. (wikipedia.org)
  • With so many vectors, the underlying assumption behind this checklist is that Lyme is not rare in North America, Europe, South America, Russia, Africa or Asia. (lymebook.com)
  • The disease is rarely detected in northern Africa and Mediterranean countries ( 3 , 6 , 7 ). (cdc.gov)
  • patients
  • Oral antimicrobials have been shown to be effective in European neuroborreliosis and presumably are equally potent in North American patients. (medreviews.com)
  • We review the neuro-ophthalmic literatureon FAS to alert neurologists to the ocular disease seen in patients with this condition. (medreviews.com)
  • It is clear that in the great majority of patients, chronic Lyme is a disease affecting predominantly the nervous system. (ariplex.com)
  • showed that patients with neuroborreliosis demonstrate a blood brain barrier disturbance with 62 % showing an elevated albumin ratio and 60 % revealing an increased IgG index, indicative of intrathecal IgG synthesis. (upmc.edu)
  • Findings showed that a group of Lyme patients had both proximal and distal paraspinal denervation on electromyographic testing (EMG) with clearly ALS signs. (borrelioosi.net)
  • Many patients with Lyme disease have had a hard hit to their immune systems by this immune-suppressing infection and many of us have had to have gammaglobulin intravenously to help us fight the infection. (borrelioosi.net)
  • Studies were performed, some on large numbers of patients, to investigate whether a correlation exists between chronic Lyme disease (defined by seropositivity) and psychiatric disorders. (blogspot.com)
  • Use of bisphosphonates in patients with conditions or diseases affecting renal function is not recommended. (issuu.com)
  • Critics argue that medical training and education surrounding the disease is still lacking with many patients left undiagnosed. (mirror.co.uk)
  • neurodegenerative
  • There appears to be a genetic link to neurodegenerative diseases, but the genetic changes that occur and the changes in gene expression that are found in these diseases are complex and not related to simple genetic mutations, deletions, or amplifications. (townsendletter.com)
  • psychiatric
  • Here to weigh in with some evidence is psychiatrist Robert Bransfield, an expert on the psychiatric manifestions of Lyme disease and founder of the mailing list, Microbes and Mental Illness, where the discussions on such topics are held. (psychologytoday.com)
  • Such infections can invade the central nervous system and may cause or mimic psychiatric disorders or cause a co-morbid condition. (blogspot.com)