HTLVNeurologicalAsymptomaticTropicalBacterialViral infectionPrevalenceDiseasesFungal infectionsSymmetricalParesthesiaMycobacterialCranialSpinal cordSymptomsClinicalSchistosomaBlood transfusionsEpidemiologyChronicEncephalitisMyelitisDiseaseDiagnosisAntiviralInflammatory responsePatientsChildhoodVirusUnclearCasesMiceRapidlyIncludePresentTissuesHumansMainProgressive
HTLV42
- HTLV causes lifelong infection, with the overwhelming majority of cases remaining asymptomatic. (medscape.com)
- However, HTLV-1 has been linked to ATL and HTLV-associated myelopathy, or tropical spastic paraparesis (HAM/TSP). (medscape.com)
- No vaccine or antiviral therapy exists for HTLV infection, and viral management focuses on patient education to prevent further spread of infection. (medscape.com)
- Furthermore, the underlying pathophysiologic mechanisms between HTLV-1 infection and disease development are not completely described and require further research. (medscape.com)
- Additional ocular manifestations in individuals with HTLV-1 infection include retinal vasculitis, choroidopathy, and keratopathy. (medscape.com)
- It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (kegg.jp)
- HTLV-1-associated myelopathy/tropical spastic paraparesis is a slowly progressive disorder of the spinal cord caused by the human T-lymphotropic virus 1 (HTLV-1). (msdmanuals.com)
- HTLV-1-associated myelopathy/tropical spastic paraparesis is more common among women because HTLV-1 infection is more common among women. (msdmanuals.com)
- A similar disorder can result from infection with a similar virus, human T-lymphotropic virus 2 (HTLV-2). (msdmanuals.com)
- In people with HTLV-1-associated myelopathy/tropical spastic paraparesis, the muscles in both legs gradually become weak. (msdmanuals.com)
- Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (fiocruz.br)
- HTLV-I associated tropical spastic paraparesis. (fiocruz.br)
- Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil. (fiocruz.br)
- Acute HTLV infection is rarely seen or diagnosed, as most infections are asymptomatic. (medscape.com)
- When considering HTLV infection, the most important historical information pertains to risk assessment. (medscape.com)
- This chapter will provide an overview of the virus discovery, the epidemiology of HTLV-1 infection, basic virology, and basic aspects of the immunologic response to the infection. (utmb.edu)
- McKendall, RR 2014, ' Neurologic disease due to HTLV-1 infection ', Handbook of Clinical Neurology , vol. 123, pp. 507-530. (utmb.edu)
- Screening of the U.S. blood supply for HTLV-I/II, which began in 1988, identifies HTLV-I- and HTLV-II-infected persons who should be counseled regarding their infections. (cdc.gov)
- Infections with HTLV-I and HTLV-II are most easily detected serologically. (cdc.gov)
- The uncertainty regarding the identity of the infecting virus and the differing epidemiologic and clinical correlates of HTLV-I and HTLV-II infections have complicated counseling of HTLV-I/II-infected persons. (cdc.gov)
- Until recently, the only reliable way to differentiate HTLV-I from HTLV-II infection was by polymerase chain reaction (7). (cdc.gov)
- HTLV-I infection is endemic in southwestern Japan (10), the Caribbean basin (11), Melanesia (12), and in parts of Africa (13-15). (cdc.gov)
- In some areas where HTLV-I infection is endemic, prevalence rates as high as 15% have been reported in the general population. (cdc.gov)
- Introduction: tropical Spastic Paraparesis or HTLV-associated Myelopathy (HAM/TSP) is a chronic infectious and inflammatory disease that can interfere with various aspects of individuals life and, thereby alter their Quality of Life (QoL). (bvsalud.org)
- Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. (edu.pe)
- We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. (edu.pe)
- Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (edu.pe)
- Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL), as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (biomedcentral.com)
- We created a transgenic mouse model of HTLV-1 infection by using the distal promoter of Lck to express tax in mature thymocytes and peripheral T lymphocytes. (biomedcentral.com)
- Background Clear therapeutic suggestions for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing because of the insufficient randomized double-blind controlled clinical studies. (ampkpathway.com)
- Adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are the last stage of HTLV-I infection. (springeropen.com)
- These findings have important implications in defining the epidemiological patterns of HTLV-1 infection in Nigeria. (e-cep.org)
- The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. (e-cep.org)
- Although most HTLV-1-infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. (e-cep.org)
- The human T-cell leukemia virus type 1 (HTLV-1) is the cause of serious malignant and inflammatory diseases, including adult T-cell leukemia and lymphoma and tropical spastic paraparesis. (htlv.net)
- The potential protective role of γδ T cells in HTLV-1 infection remains unclear. (htlv.net)
- Thus, our study provides initial evidence for a potential protective role of Vγ9Vδ2 T cells against HTLV-1 infection. (htlv.net)
- The mission of the International Retrovirology Association (IRVA) is to encourage research in retrovirology, especially the study of human T-lymphotropic virus (HTLV) infections and the associated diseases, to foster collaborations between research groups, provide a platform for critical analysis of new data, and contribute to the dissemination of knowledge about these infections. (htlv.net)
- Vertical transmission is a relevant concern in Brazil, as the blotting (WB) and/or polymerase chain reaction (PCR) assays prevalence of HTLV-1 infection in pregnant women ranges from as a confirmatory step. (bvsalud.org)
- A recent study evaluated the performance of commercially available serological screening tests for HTLV-1 infection in Brazil, i.e. (bvsalud.org)
- Scientific Group on Human T-Lymphotropic Virus Type-1 (HTLV-1 Infections and Associated Diseases, Kagoshima, Japan, 13-14 October 1992 : report. (who.int)
- by Scientific Group on Human T-Lymphotropic Virus Type-1 (HTLV-1) Infections and Associated Diseases. (who.int)
Neurological3
- CSF analysis was not indicative of an infectious process, neurological impairment was not present in the acute phase of the infection, and neuroimaging findings were not typical of classical toxic and metabolic disorders. (wikipedia.org)
- Infected dogs may develop neurological signs, ranging from paraparesis to generalized seizures. (vin.com)
- Neurological examination revealed paraparesis, hypoesthesia of the lower limbs with L4-L5 root distribution. (scirp.org)
Asymptomatic1
- Nevertheless, we have previously detected that the central nervous system (CNS) of both symptomatic and asymptomatic dogs undergoes inflammatory alterations after natural infection by Leishmania infantum (syn. (vin.com)
Tropical1
- Tropical myeloneuropathies were described initially in tropical countries and are classified into 2 clinical syndromes that can have overlapping features-tropical ataxic neuropathy (TAN) and tropical spastic paraparesis (TSP). (medscape.com)
Bacterial2
- An important concept in the evaluation of data regarding transfusion-transmitted bacterial infections (TTBIs) is the definition of a case. (medscape.com)
- email: [email protected] tures for mycobacterial, bacterial, and fungal infections were all negative. (cdc.gov)
Viral infection7
- The cause is often a trigger such as from viral infection or vaccinations. (wikipedia.org)
- Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. (msdmanuals.com)
- Encephalitis and myelitis associated with dengue viral infection. (aku.edu)
- Objectives: The objective of this study was to identify clinical and neuroimaging features and outcome of patients with encephalitis and myelitis associated with dengue viral infection. (aku.edu)
- Patients and methods: We retrospectively reviewed 225 cases of dengue viral infection. (aku.edu)
- Conclusion: The involvement of brain and spinal cord is uncommon in dengue viral infection. (aku.edu)
- Dive into the research topics of 'Encephalitis and myelitis associated with dengue viral infection. (aku.edu)
Prevalence2
- The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. (edu.pe)
- One of the few studies that attempted to estimate the prevalence of infection to supply mothers with formula to discourage breastfeeding, in a general population was conducted in the city of Salvador, similar to what already exists for pregnant women infected reported to be approximately 1.8% with HIV. (bvsalud.org)
Diseases1
- Many diseases of nerves, muscles and neuromuscular junctions may have presentation like paraparesis. (medanta.org)
Fungal infections1
- 1,3 The mechanisms include hypoperfusion and septic or thrombotic emboli with cardiomyopathy or endocarditis, thrombocytopenia, and infectious vasculitis of intracranial vessels caused by cytomegalovirus (CMV), varicella zoster virus (VZV), and mycobacterial or fungal infections. (neurology.org)
Symmetrical4
- The HAM/TSP-like disease with symmetrical paraparesis of the hind limbs in transgenic mice was not inflammatory, unlike that found in HAM/TSP patients, but instead involved the invasion of histiocytic sarcoma cells into the lumbar spinal cord from the bone marrow where they had undergone extensive proliferation. (biomedcentral.com)
- There are no reports of spontaneous symmetrical paraparesis caused by histiocytic sarcoma in mice. (biomedcentral.com)
- These include history of antecedent infection, monophasic disease course and symmetrical cranial or limb weakness. (bmj.com)
- 1 The common pathogenesis of these disorders is mirrored by several shared clinical features, including: history of antecedent infection, monophasic disease course and symmetrical cranial or limb weakness. (bmj.com)
Paresthesia1
- Post-operative complications were paresthesia and wound infection seen in significant number of patients of both groups who were recovered within 3-6 months. (backbonejournal.com)
Mycobacterial1
- Mycobacterial meningomyelitis associated with human immunodeficiency virus infection. (jmgumst.com)
Cranial1
- Additional symptoms include hemiparesis, paraparesis, and cranial nerve palsies. (wikipedia.org)
Spinal cord2
- The spinal cord is more frequently affected in Schistosoma mansoni or S. haematobium infections. (who.int)
- However, both direct infection of the spinal cord and excessive inflammatory response to primary Covid-19 infection may cause spinal cord damage. (uludag.edu.tr)
Symptoms3
- Symptoms usually begin 1-3 weeks after infection. (wikipedia.org)
- The second patient was admitted with paraparesis and urinary-stool retention on the 12th day from the onset of symptoms of Covid-19 infection. (uludag.edu.tr)
- Symptoms of pharyngitis range from a mild upper respiratory tract infection to exudative pharyngitis. (scirp.org)
Clinical2
- Therefore, we compared the virulence and dissemination of Australian clinical isolates collected during October 1989-October 2012 from patients with neurologic and nonneurologic melioidosis after intranasal and subcutaneous infection of mice in an experimental model. (cdc.gov)
- Subclinical or clinical interstitial pneumonia, indurative mastitis ("hard udder"), and chronic wasting have also been attributed to infection with this virus. (merckvetmanual.com)
Schistosoma1
- Ce sont les infections à Schistosoma mansoni ou à S. haematobium qui s'accompagnent le plus d'une atteinte de la moelle épinière. (who.int)
Blood transfusions1
- Seven patients acquired HIV infection perinatally, five patients were infected by blood transfusions, and one patient had both risk factors. (neurology.org)
Epidemiology1
- Cultural factors and the epidemiology of malaria and viral infections in women : a study in Madang, Papua New Guinea / Loretta Brabin. (who.int)
Chronic1
- Chronic HIV infection leads to acquired immunodeficiency syndrome (AIDS). (springeropen.com)
Encephalitis2
- Caprine arthritis and encephalitis (CAE) is a persistent lentiviral infection of goats. (merckvetmanual.com)
- Caprine arthritis and encephalitis virus (CAEV) infection is manifested clinically as polysynovitis-arthritis in adult goats and less commonly as leukoencephalomyelitis (progressive weakness, ataxia, proprioceptive deficits) in kids. (merckvetmanual.com)
Myelitis1
- Covid-19 infection as a possible risk factor for longitudinally extensive transverse myelitis! (uludag.edu.tr)
Disease2
- Infection might be diagnosed after an attempted blood donation, a familial history of the infection, or workup of a disease caused by the virus (eg, a recent diagnosis of ATL or HAM/TSP). (medscape.com)
- Disease onset or relapses were preceded by infection, vaccination, or pregnancy/delivery in several cases. (mendeley.com)
Diagnosis1
- A diagnosis of mycobacterium avium intracellular (MAI) infection was confirmed by lymph node biopsy, and antimycobacterial therapy was started. (neurology.org)
Antiviral1
- In parallel IFN-α has been reported to exert antiviral immunomodulatory and antiproliferative effects in several types of human cancer and viral infections [14]-[16]. (ampkpathway.com)
Inflammatory response1
- Altogether, these data are further evidence that there is in the brain an inflammatory response during the peripheral infection by this zoonotic protozoan and that the brain should be included in the list of the affected organs during visceral leishmaniasis. (vin.com)
Patients3
- Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
- Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. (scielo.br)
- Regarding perioperative complications transient dysphagia was seen in 5 (12.5%) patients and transient paraparesis was observed in 2 (5%) patients. (backbonejournal.com)
Childhood1
- however, opportunistic CNS infections and primary lymphomas are very uncommon in childhood. (neurology.org)
Virus2
- 2009 virus infection. (who.int)
- sexual transmission is also an important infection route in Given the importance of virus transmission through blood Brazil5. (bvsalud.org)
Unclear1
- Whether certain Burkholderia pseudomallei strains are more likely than other strains to cause central nervous system infection and whether route of infection influences the neurotropic threat remain unclear. (cdc.gov)
Cases3
- In this report, we present 2 LETM cases that are possibly associated with Covid-19 infection. (uludag.edu.tr)
- Methods Here, we present 2 cases that subsequently developed LETM following Covid-19 infection. (uludag.edu.tr)
- Results In these 2 cases, LETM developing following Covid'19 infection was associated with Covid-19 infection. (uludag.edu.tr)
Mice1
- Alternatively, a variety of transport hosts including: mice, hedgehogs, lizards, birds, and rabbits may ingest beetles and remain infected with encysted larvae as paratenic hosts which transmit the infection to carnivores when killed and ingested as prey. (vin.com)
Rapidly1
- The ability of B. pseudomallei to cause severe, rapidly fatal, invasive infections and to persist in the environment for extended periods, plus its intrinsic resistance to many antibacterial drugs, make B. pseudomallei a desirable candidate for use as a bioterrorism agent ( 1 ). (cdc.gov)
Include1
- Sources of hematogenous or contiguous spread of infection include the genitourinary tract, skin, infected catheters, endocarditis and dental infections. (scirp.org)
Present1
- I have been promising, the long-term magician of that CNS disorder got worse whenever I horny my manduction so I don't want to scream but know that I got this lung infection that also made my stomach at the present time INDERAL is the first line last week well pain. (angelfire.com)
Tissues1
- Rather, a distinct subset of B. pseudomallei strains appear to have heightened pathogenic potential for rapid dissemination to multiple tissues, including the central nervous system, irrespective of the infection route. (cdc.gov)
Humans1
- Flaccid paraparesis, commonly documented in animals with B. pseudomallei infection, also has been reported in humans ( 6 , 10 , 15 ). (cdc.gov)
Main1
- Although vertical in the overall population remains unknown transmission has been considered the main infection route, 4. (bvsalud.org)
Progressive1
- Lentivirus Pneumonia in Sheep and Goats Lentiviral infection causes a progressive, interstitial pneumonia typically observed in mature sheep. (merckvetmanual.com)