• Rifapentine
  • Three randomized controlled trials have shown that a new combination regimen of isoniazid (INH) and rifapentine (RPT) administered weekly for 12 weeks as directly observed therapy (DOT) is as effective for preventing TB as other regimens and is more likely to be completed than the U.S. standard regimen of 9 months of INH daily without DOT ( 2 5 ). (cdc.gov)
  • InhA
  • For example, there are many mutations that confer resistance to isoniazid (INH), including in the genes katG, inhA, ahpC and others. (wikipedia.org)
  • liver
  • Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form. (wikipedia.org)
  • 140/90 mmHg), or arteriosclerosis Liver pathologies Infection (Hepatitis C) Hemochromatosis Gastroparesis Polycystic ovary syndrome (PCOS) Hypercortisolism (e.g. (wikipedia.org)
  • prevent
  • Vitamin B6 is used to prevent isoniazid-induced B6 deficiency and neuropathy in people with a risk factor, such as pregnancy, lactation, HIV infection, alcoholism, diabetes, kidney failure, or malnutrition. (wikipedia.org)
  • A Cochrane review investigated whether giving isoniazid to HIV-positive children can help to prevent this vulnerable group from getting tuberculosis. (wikipedia.org)
  • avium
  • M. avium and M. haemophilum infections in children form a distinct clinical entity, not associated with abnormalities of the immune system. (wikipedia.org)
  • fatal
  • Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. (wikipedia.org)
  • People
  • Up to 20% of people taking isoniazid experience peripheral neuropathy when taking doses of 6 mg/kg of weight daily or higher. (wikipedia.org)
  • People taking isoniazid and acetaminophen are at risk of acetaminophen toxicity. (wikipedia.org)
  • When people have acute HIV infection, they have a large amount of virus in their blood and are very contagious. (wikipedia.org)
  • People with acute infection experience a flu-like illness and are often unaware that they're infected. (wikipedia.org)
  • months
  • Isoniazid (INH) daily for 9 months (240 to 270 total doses). (clinicaltrials.gov)
  • Eligible individuals were randomly allocated (1:1) to receive 6 months' open-label isoniazid followed by 30 months' masked placebo (control group) or 6 months' open-label isoniazid followed by 30 months' masked isoniazid (continued isoniazid group) on the basis of a computer-generated randomisation list with permuted blocks of ten at each clinic. (www.gov.uk)
  • Iron
  • citation needed] D - Diabetic ketoacidosis U - Uremia M - Methanol P - Paraldehyde S - Salicylates A - Alcoholic ketoacidosis L - Lactic acidosis E - Ethylene Glycol The mnemonic for the [rare, in comparison] toxins is ACE GIFTs: Aspirin, Cyanide, Ethanolic ketosis, Glycols [ ethylene and propylene ], Isoniazid, Ferrous iron, Toluene. (wikipedia.org)
  • especially
  • Conditions that impair cellular immunity, especially HIV infection, increase the likelihood of TB developing at any interval after infection. (cdc.gov)
  • It can cause post-traumatic wound infections especially those following open fractures and with associated osteomyelitis and chronic lipoid pneumonia. (wikipedia.org)
  • together
  • It boosts levels of isoniazid when taken together and can lead to increased rates of peripheral neuropathy and hepatotoxicity. (wikipedia.org)
  • cause
  • MAC infections can cause fevers, diarrhea, malabsorption, as well as loss of appetite and weight loss, and can disseminate to the bone marrow. (wikipedia.org)
  • MAC bacteria are common in the environment and cause infection when inhaled or swallowed. (wikipedia.org)
  • among
  • The rate of incident TB cases (representing new infection and reactivation of latent infection) among foreign-born persons in the United States was 12 times greater than among U.S.-born persons. (cdc.gov)