• divergent viruses
  • Since there are no recognized alignment programs that can adequately accommodate very divergent sequences, a method has been devised to construct and analyse a substantially improved 3′UTR alignment between these highly divergent viruses, based on the concept that deletions and/or insertions, in addition to substitutions, are important drivers of 3′UTR evolution. (microbiologyresearch.org)
  • One of the reasons for that is certainly the extensive sequence variation between the used antigens that were derived from lab adapted virus strains and the genetically divergent viruses circulating throughout the testing areas such as Thailand. (allindianpatents.com)
  • Rous Sarco
  • The SV40 promoter was conventionally used until research showed that vectors driven by the Rous Sarcoma Virus (RSV) promoter had much higher expression rates. (wikipedia.org)
  • avian
  • In avian sarcoma and leucosis viruses (ASLV) however, the SU-receptor interaction only potentiates Env for subsequent low pH‐induced activation in the endosome ( Mothes et al , 2000 ). (embopress.org)
  • complexes
  • We show here that all Env subunits of the virus form disulphide‐linked SU-TM complexes that can be disrupted by treatment with NP‐40, heat or urea, or by Ca 2+ depletion. (embopress.org)
  • membrane
  • The virus factory is often enclosed by a membrane derived from the rough endoplasmic reticulum or by cytoskeletal elements. (wikipedia.org)
  • The membrane fusion activity of murine leukaemia virus Env is carried by the transmembrane (TM) and controlled by the peripheral (SU) subunit. (embopress.org)
  • prevent
  • The viroplasm could also prevent virus degradation by proteases and nucleases. (wikipedia.org)
  • Alternatively, the activation of host defense mechanisms may involve sequestration of virus components in aggregates to prevent their dissemination, followed by their neutralisation. (wikipedia.org)
  • However, the outcome of these studies was somewhat disappointing in that the vaccines not only failed to induce broadly cross neutralizing antibody and T cell responses, but could not even prevent breakthrough infections that have been reported for some of the vaccinated individuals. (allindianpatents.com)
  • cells
  • Viroplasms are localized in the perinuclear area or in the cytoplasm of infected cells and are formed early in the infection cycle. (wikipedia.org)
  • In animal cells, virus particles are gathered by the microtubule-dependent aggregation of toxic or misfolded protein near the microtubule organizing center (MTOC), so the viroplasms of animal viruses are generally localized near the MTOC. (wikipedia.org)
  • among
  • Among those, clade C HIV-1 strains play a leading role both regarding the total number of infected people as well as the high incidence of new infections especially in South America and Asia. (allindianpatents.com)
  • treatment
  • The polynucleotides and polypeptides may be used as medicaments, vaccines or diagnostic substances, preferably for the treatment, prevention or diagnostic of HIV infections. (allindianpatents.com)
  • DTT treatment of alkylated Env resulted in cleavage of the SU-TM disulphide‐bond and rescue of virus fusion. (embopress.org)
  • important
  • Coronaviruses are positive-strand RNA viruses that are important infectious agents of both animals and humans. (mdpi.com)
  • high
  • Further studies showed that virus fusion was specifically inhibited by high and enhanced by low concentrations of Ca 2+ . (embopress.org)
  • early
  • Since early 1995, a rapid increase of HIV infection was clearly seen in many provinces of China Compared with accumulated 1774 cases of HIV and AIDS detected from 1985 to 1994, 1421 cases were detected in 1995 and more than 4000 cases in 1997 alone. (allindianpatents.com)
  • generation
  • Different subtypes cocirculating in the population of a geographic region represent the molecular basis for the generation and distribution of interclade mosaic viruses. (allindianpatents.com)
  • least
  • and re-inserting into said genome the deleted sequences within the defective genome wherein said sequences have a homology of at least 60% to the natural sequence of the virus, wherein said sequences code for an RNA-dependent RNA polymerase and at least one structural or non-structural protein, and wherein a fragment of said DNA is capable of being transcribed into RNA and assembled to a virion. (patentsencyclopedia.com)