Consistent with an unexpected role for MMP-12 in clearing systemic IFN-α, treatment of coxsackievirus type B3-infected wild-type mice with a membrane-impermeable MMP-12 inhibitor elevates systemic IFN-α levels and reduces viral replication in pancreas while sparing intracellular MMP-12. (nih.gov)
Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
Objectives: We evaluated the effects of CM-352 (MMP-fibrinolysis inhibitor) in an experimental ICH model associated with oral anticoagulants as compared with clinically used prothrombin complex concentrate (PCC). (unav.edu)
Finally, fibrinolytic effects of MMP-10 and rivaroxaban were evaluated by thromboelastometry and thrombin-activatable fibrinolysis inhibitor (TAFI) activation assays. (unav.edu)
Furthermore, silencing of lncRNA GAS5 expression in IL‑1β‑treated chondrocytes downregulated the protein expression of MMP-9 and MMP-13 whilst upregulating the expression of tissue inhibitor matrix metalloproteinase (TIMP)-1, TIMP-3 and type II collagen. (spandidos-publications.com)
Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. (ersjournals.com)
We review the lines of investigation that have indicated a critical role for MMPs in TB pathogenesis, consider regulatory pathways driving MMPs and propose that inhibition of MMP activity is a realistic goal as adjunctive therapy to limit immunopathology in TB. (ersjournals.com)
Lung extracellular matrix destruction is essential to TB transmission and consequently of critical importance to the global success of Mtb. (ersjournals.com)
The mechanism whereby Mtb targets the lung apices is unknown, but once it reaches the lung interstititum, breakdown of the extracellular matrix must occur for the pathogen to disseminate via the airways. (ersjournals.com)
This role links ZmpC to the group of bacterial proteases [ 19 ] involved in disruption of extracellular matrix and tissue destruction and invasion. (biomedcentral.com)
This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
Therefore, the present study aimed to investigate the potential mechanism of ABPS by focusing on its effects on the regulation of chondrocyte extracellular matrix (ECM) homeostasis, with particular emphasis on lncRNA GAS5. (spandidos-publications.com)
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. (uni-freiburg.de)
FAs are structures composed of clustered transmembrane proteins called integrins that bind to the extracellular matrix and link to the actin cytoskeleton and control cell migration, proliferation, survival and differentiation (Gardel et al. (bio2009.org)
Mice6
Our findings suggest that activated IκBα mediates the export of IFN-α from virus-infected cells and that the inability of cells in Mmp12(-/-) but not wild-type mice to express IκBα and thus export IFN-α makes coxsackievirus type B3 infection lethal and renders respiratory syncytial virus more pathogenic. (nih.gov)
To analyse the importance in virulence of three of these metalloproteinases, intranasal challenge of MF1 outbred mice was carried out using a range of infecting doses of wild type and knock-out pneumococcal mutant strains, in order to compare mice survival. (biomedcentral.com)
Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. (cancerindex.org)
The effect of CM-352 could be related to MMP-10 inhibition since Mmp10 -/- mice showed lower hemorrhage volume, better neurological score, reduced IL-6 levels and neutrophil infiltration, and increased PAI-1 after experimental ICH. (unav.edu)
Thus, mice genetically deficient in IL-1β, IL-1α, or IL-1 receptor signaling are extremely susceptible to Mtb infection ( 1 , 2 , 4 , 7 ) while in vitro stimulation of Mtb-infected macrophages with IL-1β results in reduced mycobacterial burdens ( 7 ). (frontiersin.org)
Protein6
We also identified dual-regulated substrates that are repressed both by MMP-12 binding to the substrate's gene exons and by MMP-12-mediated cleavage of the substrate protein itself. (nih.gov)
Expression of ANGPT1 and TEK mRNA or protein could not be detected in any of the infected or non-infected cells. (bvsalud.org)
The multivariate Pearson's correlation test showed that plasma MMP-22 levels correlated positively with high-sensitive-C-reactive protein (hs-CRP) ( r =0.167, P =0.023), and MMP-29 levels correlated negatively with triglyceride ( r =−0.169, P =0.018). (zju.edu.cn)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Inhibition3
Matrix metalloproteinase (MMP) inhibition has been proposed as a novel pharmacological approach for ICH treatment. (unav.edu)
Pharmacological inhibition of cathepsin activity with CA074-Me resulted in a substantial reduction of both mature IL-1β production and caspase-1 activation in infected macrophages. (frontiersin.org)
Moreover, cathepsin inhibition abolished the interaction between NLRP3 and ASC, measured by immunofluorescence imaging in H37Rv-infected macrophages, demonstrating a critical role of the enzyme in NLRP3-inflammasome activation. (frontiersin.org)
Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
Aortic3
Methods and results: Immunoblot analysis showed that IL18 induced MMP-22 expression in human aortic smooth muscle cells. (zju.edu.cn)
Aortic atherosclerotic lesion size, plaque matrix proteins, and EMMPRIN and other inflammatory factors were measured using Oil Red O Staining, Masson's trichromestaining and immunohistochemical staining and real-time PCR. (biomedcentral.com)
dhBBR and Di-MeBBR reduced expression of EMMPRIN, CD68, and NFκB p65, and Di-MeBBR also reduced expression of matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic plaques. (biomedcentral.com)
Tuberculosis3
Approximately one-third of the world's population is thought to be infected with the causative organism, Mycobacterium tuberculosis (Mtb) [ 3 ]. (ersjournals.com)
Lung matrix destruction is critical to the life cycle of Mycobacterium tuberculosis (Mtb). (ersjournals.com)
We also found the ranges of OPG in serum of human patients infected with M. tuberculosis and M. avium had been appreciably enhanced. (cox-inhibitors.com)
H37Rv-infected murine bone marrow-derived macrophages (BMDMs) displayed both lysosomal leakage, with release of CTSB into the cytosol, as well as increased levels of mature IL-1β. (frontiersin.org)
For example, IL-1β has been shown to facilitate phagolysosomal fusion, which enhances the mycobactericidal activity of host macrophages ( 9 ). (frontiersin.org)
In addition, IL-1β through its induction of prostaglandin E2 could influence the cell death modality of Mtb-infected macrophages favoring an apoptotic over necrotic fate thus containing bacterial spread ( 7 , 10 - 13 ). (frontiersin.org)
Degradation1
coronary heart disease (CHD) is characterized by arterial wall inflammation and matrix degradation. (zju.edu.cn)
Infiltration1
RA is characterized by synovitis with infiltration of immune cells, synovial hyperplasia that arises via proliferation of synovial cells, such as macrophage-like synoviocytes (MLS) and fibroblast-like synoviocytes (FLS), and angiogenesis in the hyperplastic synovium [ 8 , 9 , 10 ]. (biomedcentral.com)
Macrophage1
We show here that after macrophage secretion, MMP-12 is transported into virus-infected cells. (nih.gov)
Cleaves1
Whereas intracellular MMP-12 mediates NFKBIA transcription, leading to IFN-α secretion and host protection, extracellular MMP-12 cleaves off the IFN-α receptor 2 binding site of systemic IFN-α, preventing an unchecked immune response. (nih.gov)
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted. (nih.gov)
In HeLa cells MMP-12 is also translocated to the nucleus, where it binds to the NFKBIA promoter, driving transcription. (nih.gov)
The angiogenic response induced by supernatants of non-infected and infected cells at 24 h.p.i. was evaluated in vivo, using the chicken chorioallantoic membrane (CAM) assay. (bvsalud.org)
CAM assays showed that the supernatants of AGS-infected cells with 26695 strain induced a significantly higher angiogenic and inflammatory response. (bvsalud.org)
Batf knockout inhibited the differentiation of T helper (Th)17 cells and the conversion of CD4 + Foxp3 + cells to CD4 + IL-17 + cells. (biomedcentral.com)
and or tumor cells infected with oncolytic viruses release PAMPs, which increases immune responses (217, 218). (azd1152.com)
The results of phase I and II trials showed that the use of Newcastle virus-infected tumor cells reduced recurrence and increased OS in CRC patients (44, 219). (azd1152.com)
Serum1
Moreover, early decreases in serum form IIA procollagen amino terminal propeptide, CRP, and/or matrix metalloproteinase 3 inside of 12 weeks can predict for that preventive results of TCZ on one 12 months progression of joint destruction in RA. (cox-inhibitors.com)
Regulate1
IL18 may regulate MMP-22 and -29 expression, which may correlate with CHD progression. (zju.edu.cn)
Pneumoniae3
Streptococcus pneumoniae possesses large zinc metalloproteinases on its surface. (biomedcentral.com)
Except for one serine protease, these enzymes are zinc metalloproteinases and are thought of contributing to the virulence of S. pneumoniae . (biomedcentral.com)
Large scale studies, carried out to identify virulence genes in S. pneumoniae , report different results concerning surface zinc metalloproteinases. (biomedcentral.com)
Substrate1
This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better! (wikigenes.org)
Vascular1
However, BATF did not modulate the functions of fibroblast-like synoviocytes (FLS), including the expressions of chemokines, matrix-degrading enzymes, vascular endothelial growth factor, and receptor activator of NF-κB ligand (RANKL). (biomedcentral.com)
Therapeutic1
In view of the important roles of MMP-9 and EMMPRIN in vulnerability of atherosclerotic plaques, MMP-9 and EMMPRIN are potential targets for therapeutic inventions to inhibit plaque rupture and acute medical conditions. (biomedcentral.com)
Expression1
These responses were diminished in BMDM infected with a mutant H37Rv deficient in ESAT-6 expression. (frontiersin.org)
Levels1
The Mann Whitney test from a prospective study of 194 CHD patients and 68 non-CHD controls demonstrated higher plasma levels of IL18, MMP-22 and -29 in CHD patients than in the controls. (zju.edu.cn)
Human2
Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease[J]. Journal of Zhejiang University Science B, 2017, 18(8): 685-695. (zju.edu.cn)
matrix metalloproteinase (MMP)-22 and -29 and pro-inflammatory cytokine interleukin-18 (IL18) are present in human hearts. (zju.edu.cn)
Studies3
The mechanisms whereby Mtb disseminates from the initial Ghon focus are not well understood, but studies in the zebrafish model of M. marinum infection suggest that Mtb is transported within infected monocytes [ 4 ]. (ersjournals.com)
Although the classical paradigm primarily developed from the rabbit model of TB proposes that it is the rupture of caseous material into airways that leads to cavitation [ 9 ], post mortem studies in man suggest that cavitation starts in areas of lipoid pneumonia as opposed to in association with well-formed granulomas [ 10 ]. (ersjournals.com)
Cellular studies of NTD and CTD oligomerization interface mutants demonstrate the importance of each interface in matrix assembly. (uci.edu)
Destruction2
Cavities are often several centimetres across, so there must be very extensive lung matrix destruction for such cavitation to occur. (ersjournals.com)
Once implanted at the apex, Mtb must engage the host immune response to drive matrix destruction, resulting in cavities within which it proliferates exponentially. (ersjournals.com)
Found1
Finally, we found that CM-352 reduced MMP-10 and rivaroxaban-related fibrinolytic effects in thromboelastometry and TAFI activation. (unav.edu)
Host1
The MARV matrix layer confers the virion filamentous shape and stability but how host lipids modulate mVP40 oligomerization is mostly unknown. (uci.edu)
Patients1
The most highly infectious patients are those who develop cavitatory lung disease [ 1 ], since each cavity may contain up to 10 9 mycobacteria [ 5 ], and these patients can be regarded as the aerosol supershedders that drive the global pandemic. (ersjournals.com)
Plasma1
A logistic regression test suggested that plasma IL18 (odds ratio (OR)=1.131, P =0.007), MMP-22 (OR=1.213, P =0.040), and MMP-29 (OR=1.198, P =0.033) were independent risk factor s of CHD. (zju.edu.cn)