• The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)
  • There are several hypotheses about the mechanisms by which calcium antagonists induce gingival hyperplasia, but further investigation is still needed. (medscape.com)
  • Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)
  • Drug-induced liver injury (DILI) and herb-induced liver injury is a hot topic for clinicians, academia, drug companies and regulators, as shown by the steadily increasing number of publications in the past 15 years. (wjgnet.com)
  • The second section will address novel agents associated with liver injury in 2014 (referred to as "signals"), especially in terms of clinical, research and drug development implications. (wjgnet.com)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • In addition, factors such as rapid infusion, concurrent use of more than one drug known to prolong QT interval, diuretic treatment, electrolyte derangements (hypokalemia, hypomagnesemia, or hypocalcemia), advanced age, bradyarrhythmias, and female sex have all been shown to be risk factors for developing drug-induced QT prolongation. (wikipedia.org)
  • Researchers have found an association between the prescription drug olmesartan and severe gastrointestinal (GI) issues such as nausea, vomiting, diarrhoea, weight loss, and electrolyte abnormalities. (glutenfreesociety.org)
  • The clinical study group, Groupe d'Etudes de la Pathologie Pulmonaire Iatrogene (GEPPI), maintains an active website listing of drugs that have been associated with pulmonary toxicity, which provides details on the frequency with which toxicities have been associated with individual drugs. (medscape.com)
  • Although conventional chest radiography is the first choice among imaging options for identifying patients with pulmonary manifestations of drug toxicity, limitations of the pattern approach often necessitate the use of other imaging techniques, in addition to clinical and laboratory assessments. (medscape.com)
  • Objectives We systematically reviewed the literature to identify evidence-informed recommendations regarding the detection of drug-induced pancreatitis (DIP) and, secondarily, to describe clinical processes for the diagnosis of DIP. (bmj.com)
  • The aim of this study is to clarify clinical features of ADV-related HO in Chinese chronic hepatitis B patients with long-term ADV treatment in Chinese and non-Chinese comparative case series. (biomedcentral.com)
  • Comparisons involving demographics, clinical manifestations, tests, treatment and prognosis were conducted between the two groups. (biomedcentral.com)
  • To further determine the clinical features of ADV-induced HO in Chinese chronic hepatitis B patients, we investigated the demographics, clinical spectrum, laboratory tests, treatment and prognosis of ADV-induced HO through a comparison of Chinese and non-Chinese case series. (biomedcentral.com)
  • This article describes that neurologic pathology and answers common questions about the clinical workup and treatment of catatonia. (mhaus.org)
  • Now we are learning that one of the top prescribed drugs in the United States has side effects that can create symptoms of clinical celiac disease. (glutenfreesociety.org)
  • In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
  • Individuals in the United States can also be exposed to radioiodine, primarily 123I and 131I, as a result of clinical procedures in which radioiodine compounds are administered to detect abnormalities of the thyroid gland or to destroy the thyroid gland to treat thyrotoxicosis or thyroid gland tumors. (cdc.gov)
  • Early recognition is important because drug-induced lung disease can often be reversed if appropriate therapy is instituted soon after the onset of symptoms. (medscape.com)
  • Lack of response to empiric antibiotic treatment and an imaging pattern of organizing pneumonia should raise suspicion of everolimus-induced pneumonitis in patients undergoing therapy with this drug. (medscape.com)
  • Busulfan toxicity causes drug-induced pulmonary damage after prolonged exposure, usually after 3-4 years of therapy. (medscape.com)
  • If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
  • Drug discontinuation and therapy reconciliation remain the mainstay in patent's management to minimize occurrence of acute liver failure. (wjgnet.com)
  • Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
  • Celecoxib is among the more potent and better clinically studied, nonsteroidal anti-inflammatory drugs (NSAID) for use as a chemoprevention agent for colorectal cancer. (bvsalud.org)
  • These findings indicate that the colonic mucosal injury induced by FC-exposure are associated with oxidative stress generation, inflammation response and cell apoptosis, as well as the changes in gut microbes diversity and composition. (bvsalud.org)
  • We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells. (nih.gov)
  • [ 9 ] Likewise, bilateral pleural effusion and extensive pulmonary interstitial prominence suggesting pulmonary fibrosis on CT scan in a patient presenting with dyspnea and dry cough may alert the clinician to pulmonary injury resulting from use of nitrofurantoin for treatment of an uncomplicated urinary tract infection. (medscape.com)
  • At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. (nih.gov)
  • SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
  • And inflammation could be potentiated by the use of drugs good about themselves while on anabolic steroids, but researchers report that extreme mood swings can also occur. (puregracefarms.com)
  • Generalized spasms occur, frequently induced by sensory stimuli. (cdc.gov)
  • Are there other drugs that can contribute to the development of or mimic celiac disease? (glutenfreesociety.org)
  • One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
  • The AAS-induced reduction in nucleus accumbens dynorphin can be at risk of drug accumulation because of reduced clearance. (puregracefarms.com)
  • Class III Class III antiarrhythmic drugs are potassium channel blockers that cause QT prolongation and are associated with TdP. (wikipedia.org)
  • Pacerone® (Amiodarone HCl) Tablets are a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration in 100 mg and 200 mg strengths of amiodarone hydrochloride. (rxlist.com)
  • Therefore, for patients taking drug combinations, imaging findings alone may not reveal the culprit. (medscape.com)
  • In select cases, high-resolution computed tomography (HRCT) and radionuclide imaging play a role in detecting lung toxicity early, when it is still reversible, or in differentiating drug toxicity from other lung pathology. (medscape.com)
  • The major problem with all imaging techniques is that drug-related lung toxicity has a nonspecific appearance, and patterns similar to those of many interstitial lung diseases have been described. (medscape.com)
  • In addition, lung toxicity resulting from various drugs can induce similar changes. (medscape.com)
  • In these and many other cases, early detection of pulmonary toxicity would allow prompt treatment and could prevent significant pulmonary damage. (medscape.com)
  • Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity. (ersjournals.com)
  • The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
  • Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)
  • A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
  • In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)
  • Identification of more dystonia genes may lead to better understanding and treatment of these largely nondegenerative disorders. (medscape.com)
  • Bexarotene (Bxt) is a retinoid-X receptor agonist used in the treatment of cutaneous lymphoma with a favorable safety profile whose effects have been recently investigated in other neurodegenerative diseases. (frontiersin.org)
  • For the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability and poor frustration tolerance. (nih.gov)
  • Prompt Control of Severe Symptoms - Initial treatment should be with intramuscular chlorpromazine. (genesight.com)
  • Nervous system abnormalities, as well as a variety of complications related to severe spasm and prolonged hospitalization, can accompany generalized tetanus. (cdc.gov)
  • When starting treatment with [HA628 trade name], careful consideration should be given to the treatment history of the patient and the presence of darunavir resistance associated mutations (see sections 4.2, 4.4 and 5.1). (who.int)
  • The indication for treatment-naïve pediatric patients or antiretroviral treatment-experienced patients with no darunavir resistance associated substitutions is based on one open-label Phase 2 trial of 48 weeks duration in antiretroviral treatment-naïve subjects 12 to less than 18 years of age and pharmacokinetic modeling and simulation for patients 3 to less than 12 years of age. (wikidoc.org)
  • To help you solve this dilemma, we describe our diagnosis and treatment decisions for a patient we call Mr. C. We explain how our process was guided by recent understandings of an abnormal neural circuit that appears to cause catatonia's complex motor and behavioral symptoms. (mhaus.org)
  • From 2008 to 2011, physicians from the Mayo Clinic, Rochester, Minnesota, treated 22 patients with symptoms similar to celiac disease, including intestinal inflammation and abnormalities. (glutenfreesociety.org)
  • Thus we have identified novel components of a complex, coordinated genetic program that is induced in striatal cells in response to various dopaminergic manipulations. (jneurosci.org)
  • The use of other active agents with Darunavir/ritonavir is associated with a greater likelihood of treatment response. (wikidoc.org)
  • Results from two trials in treatment-experienced pediatric subjects 3 to less 18 years of age demonstrating similar darunavir plasma exposures, virologic response rate and safety profile compared to treatment-experienced adults. (wikidoc.org)
  • Results from one trial in treatment-naive pediatric subjects 12 to less than 18 years of age demonstrating similar darunavir plasma exposures, virologic response rate and safety profile compared to treatment-naive adults. (wikidoc.org)
  • E2 administration also increased the amplitude of bmal1 expression in the lungs, which implicates altered functioning of peripheral oscillators in response to E2 treatment. (bvsalud.org)
  • Particularly, it reduced the neuronal loss and the chromatolytic response, induced nucleolar hypertrophy, decreased the formation of ubiquitylated inclusions, and modulated the lysosomal response. (frontiersin.org)
  • Our Pacerone (Amiodarone HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • However, the status of oral health prior to onset of gingival overgrowth combined with the medication are both clearly involved in the onset of drug-induced gingival hyperplasia. (medscape.com)
  • Is the intestinal inflammation being caused by the action of the drug or an unintended side effect of the fillers found in the medication? (glutenfreesociety.org)
  • Catatonic signs develop when aberrant signals from neurochemical abnormalities trigger a neural circuit that affects the medial gyrus of the orbital frontal lobe, the lateral gyrus, caudate nucleus, globus pallidus, and thalamus ( Box ). (mhaus.org)
  • These complications, largely reflecting the consequences of global immunosuppression and drug toxicities, are the subject of this article. (ersjournals.com)
  • Diabetes, a history of immunosuppression, and intravenous drug use may be risk factors for tetanus. (cdc.gov)
  • Results from population pharmacokinetic modeling and simulation in children 3 to less than 12 years of age predicting similar darunavir plasma exposures compared to treatment-naïve adults. (wikidoc.org)
  • Approximately 1-10% of patients taking the drug are affected. (medscape.com)
  • Serial monitoring may be useful to guide early discontinuation of DIP-associated drugs in high-risk patients, but not in lower-risk patients. (bmj.com)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
  • Unfortunately it is not uncommon for doctors to prescribe these drugs to patients who have gluten sensitivity. (glutenfreesociety.org)
  • Because of the risk of significant comorbidity, surgical approaches are reserved for patients with disabling dystonia in whom other treatment modalities have been exhausted. (medscape.com)
  • As an adjunct in the treatment of tetanus. (nih.gov)
  • Even as the threat of war slowly fades, the common citizen in Syria is having to deal with acute drug shortages with people such as Syrian father Motaz having to decide on whether to put food on the table or pay astronomical prices to import insulin for his diabetic son. (medindia.net)
  • Failure to correctly co-administer Darunavir with ritonavir will result in plasma levels of darunavir that will be insufficient to achieve the desired antiviral effect and will alter some drug interactions. (wikidoc.org)
  • Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)
  • Drugs that adversely affect the respiratory system present a great challenge to physicians. (medscape.com)
  • Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. (medindia.net)
  • Acute Schizophrenic or Manic States - It is recommended that initial treatment be with chlorpromazine hydrochloride injection until patient is controlled. (genesight.com)
  • Consideration should be given to official guidelines for treatment of HIV-1 infection (e.g. those by WHO). (who.int)
  • Darunavir is a protease inhibitor that is FDA approved for the treatment of human immunodeficiency virus ( HIV-1 ) infection. (wikidoc.org)
  • Phenytoin has been shown to induce gingival overgrowth by its interaction with a subpopulation of sensitive fibroblasts. (medscape.com)
  • When the drug concentration is at a low to normal concentration, the potassium channel blocking activity takes precedence over the sodium channel blocking activity Disopyramide Procainamide Propafenone Quinidine Because of the predominance of the potassium blocking activity, TdP is seen more frequently with therapeutic levels of quinidine. (wikipedia.org)
  • Catatonia is caused by neurochemical abnormalities including low GABA activity in the frontal cortex, low dopamine (D2) activity in the basal ganglia, high glutamate-N-methyl-D-aspartate (NMDA)-activity in the parietal cortex, or a combination of these. (mhaus.org)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • citation needed] Although it is difficult to predict which individuals will be affected from drug-induced long QT syndrome, there are general risk factors that can be associated with the use of certain medications. (wikipedia.org)
  • citation needed] The main groups of drugs that can cause QT prolongation are antiarrythmic medications, psychiatric medications, and antibiotics. (wikipedia.org)
  • For anabolic steroid drugs to normalize higher quality of results compared to the anti-depressants and anti-anxiety medications. (puregracefarms.com)
  • Abnormalities in the lung parenchyma may partially or completely resolve after the drug is withdrawn. (medscape.com)
  • Several drugs are either banned or withdrawn after introduction in the market. (medindia.net)
  • The common reasons for prolonged hospitalization were mandatory isolation 28% ( n = 62), hospital-acquired infections 17% ( n = 37), acute respiratory distress syndrome 15% ( n = 32), myopathy/neuropathy 14% ( n = 31), pulmonary fibrosis requiring oxygen supplementation 14% ( n = 31), and completion of COVID-19 treatment 12% ( n = 25). (who.int)
  • BETASERON is an interferon beta indicated for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. (nih.gov)
  • Although ultrasonography has no direct role in the management of drug-induced lung disease, it is useful in confirming pleural effusions and in assessing pleural intervention. (medscape.com)
  • By binding to and inhibiting the "rapid" delayed rectifier potassium current protein, certain drugs are able to decrease the outward flow of potassium ions and extend the length of phase 3 myocardial repolarization, resulting in QT prolongation. (wikipedia.org)
  • Source: Class IA Class IA antiarrhythymic drugs work by blocking sodium and potassium channels. (wikipedia.org)
  • Extent to which hGH stanozolol- and HCG-induced CVT was entertained that clomiphene citrate, after prolonged use may be associated with an increased risk for ovarian cancer. (puregracefarms.com)
  • Cases of drug-induced lupus erythematosus have been reported. (nih.gov)
  • Overall, these neuroprotective effects suggest that treatment with Bxt could be useful in ALS, particularly in those cases related to SOD1 mutations. (frontiersin.org)
  • Intravenous drug users accounted for 14% of cases from 2000 through 2019. (cdc.gov)
  • Steroid users who abuse other drugs often choose stimulants drug testing was achieved with its use in the detection of HGH for sale legally tetrahydrogestrinone (THG). (puregracefarms.com)
  • But the Central Bank has halted all transfers at the official exchange rate, forcing factories to stop producing several drugs because of the higher costs. (medindia.net)
  • Furthermore, the effect of age, sex, and duration and dosage of the drug in the pathogenesis of gingival overgrowth is not clearly understood. (medscape.com)
  • Many of the persistent consequences of dopaminergic drugs appear to result from changes in striatal physiology, including altered sensitivity to neurotransmitters. (jneurosci.org)
  • Treatment history and, when available, genotypic or phenotypic testing should guide the use of Darunavir/ritonavir. (wikidoc.org)
  • With a history of drug abuse anabolic steroids vs testosterone. (puregracefarms.com)
  • Generally, as the dose of a drug increases, the risk of QT prolongation increases as well. (wikipedia.org)
  • Future potential exploration using mtDNA markers can be considered more accurate hallmarks for diagnosis and monitoring treatment of human diseases. (nih.gov)
  • Coagulation HGH for sale legally abnormalities associated with treatment for this patient. (puregracefarms.com)
  • Additionally, current treatments for DR are performed in advanced stages of the disease and are associated with significant adverse effects. (molvis.org)