• Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • CONCLUSIONS: Statins inhibit proliferation and induce apoptosis in EAC cells via inhibition of Ras farnesylation and inhibition of the ERK and Akt signaling pathways. (uea.ac.uk)
  • We inferred that Rab21 silencing can induce apoptosis and inhibit proliferation in human glioma cells, indicating that Rab21 might act as an oncogene and serve as a novel target for glioma therapy. (biomedcentral.com)
  • The MTT assay assessed cell viability, and autophagy was detected by electron microscopy. (medscimonit.com)
  • Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
  • Cell viability was ascertained through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after deployment of TO in different doses. (jcimjournal.com)
  • TO demonstrated a dose-dependent decrease in viability of A549 cells after 24 h of exposure. (jcimjournal.com)
  • Effects of Thuja occidentalis ethanolic extract on viability of A549 cell line (A) and L-132 cell line (B) Cells were exposed to Thuja occidentalis ethanolic extract for 24 h at different concentrations and the cell viability was determined by MTT assay. (jcimjournal.com)
  • In this study, our data show that Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver, and Tβ4 significantly suppressed cell viability and migration of HSCs. (oncotarget.com)
  • In addition, we designed and screened a panel of gomesin analogues with amino acid modifications that were predicted to influence cell viability. (nature.com)
  • BQ788 and A192621 reduced glioma cells viability and proliferation assessed by BrdU incorporation and cell cycle analysis by flow cytometry, while in contrast the ETA receptor antagonist BQ123 had no effect on cell survival. (unipv.it)
  • Outcomes Leucine deprivation decreases viability of tumor cells We 1st determined the result of leucine deprivation on viability of tumor cells. (racetab.org)
  • Open up in another window Shape 1 The result of leucine deprivation on cell viability(A and B) Cells had been incubated in charge BAY 293 (+leu) or leucine-deficient (?leu) moderate for indicated period, accompanied by MTT assay. (racetab.org)
  • Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)
  • We compared viability of JAR and JEG-3 cells in response to luteolin alone or in combination with other chemotherapeutic drugs (etoposide, cisplatin, and paclitaxel) and found that luteolin has synergistic effects with the conventional chemotherapeutic drugs as an anticancer agent. (ewha.ac.kr)
  • Pancreatic cancer cells (MIA PaCa-2, BxPC-3, and CFPAC-1) and non-tumorigenic pancreas cells (HPDE) were treated with oleuropein, hydroxytyrosol and tyrosol to determine their effect on cell viability. (uaeu.ac.ae)
  • Recently, T β 4 has have been shown to promote the differentiation of progenitor cell lines to cardiomyocytes [ 8 ]. (oncotarget.com)
  • Mechanical modulation of stem cell proliferation and differentiation indicates a unique therapeutic target to aid in tissue regeneration and repair and may represent the basis of a nonpharmacologic strategy to simultaneously prevent obesity and osteoporosis. (elsevierpure.com)
  • Since interleukin-7 is a crucial cytokine for proliferation and differentiation of T cells in the thymus, the present study indicates that interleukin-7 may contribute to the disturbance of immune regulatory T cells in ulcerative colitis. (elsevierpure.com)
  • The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. (molvis.org)
  • MMC significantly blocked TGFβ-induced cell proliferation and myofibroblast differentiation in cultured quiescent keratocytes and altered the transcriptional regulation of macrophage chemotactic protein-1 (MCP-1) and alpha smooth muscle actin (αSMA). (molvis.org)
  • They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)
  • Effects of Thuja occidentalis ethanolic extract on cellular proliferation tested by BrdU incorporation assay Cells were exposed to three different concentration of Thuja occidentalis ethanolic extract for 6, 12 and 24 h along with incorporation of BrdU. (jcimjournal.com)
  • Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
  • Cell proliferation was reduced in a time-dependent manner of drug exposure as revealed from BrdU incorporation and migration studies. (jcimjournal.com)
  • Effects of Thuja occidentalis ethanolic extract on A549 cell migration (Light microscopy, ×20) Wound-healing assays were performed to assess cell migration. (jcimjournal.com)
  • We have previously demonstrated that Ganoderma lucidum down-regulated the expression of NF-kappaB-regulated urokinase plasminogen activator (uPA) and uPA receptor (uPAR), which resulted in suppression of cell migration of highly invasive human breast and prostate cancer cells. (greenmedinfo.com)
  • Acitvated HSCs trigger the expression of α-smooth muscle actin (α-SMA) and production of abnormal ECM, along with enhanced proliferation and migration [ 4 - 5 ]. (oncotarget.com)
  • and Liu, Shin, "Bromoenol Lactone Attenuates Nicotine-induced Breast Cancer Cell Proliferation and Migration" (2016). (eku.edu)
  • The effects of iPLA 2 β (Ca 2+ -independent Phospholipase A 2 β) and MMP-9 (Matrix Metalloproteinase-9) on the migration of cancer cells have been a recent focus for biomedical research and have been found to be over-expressed. (eku.edu)
  • In-vitro and in-vivo results suggest that MMP-9 behaves in an iPLA 2 β-dependent manner and consequently mediates nicotine-induced breast cancer cell migration and proliferation. (eku.edu)
  • It also exhibited greater suppression on cell proliferation as well as cell migration or invasion capabilities and induction of apoptosis in Hep3B cells than single siRNA simultaneously. (biomedcentral.com)
  • Silencing of VEGF and KSP plays a key role in inhibiting cell proliferation, migration, invasion and inducing apoptosis of Hep3B cells. (biomedcentral.com)
  • The current research aimed to analyze the impression of H1975 cell crosstalk with PLTs on the proliferation, migration and tube formation of HUVECs. (inacj.com)
  • As well as, the next relative migration price, better variety of migrated cells, stronger tube-forming means and elevated expression of VEGF and VEGF R2 had been detected within the Exp_HP group in contrast with the management group. (inacj.com)
  • FBLN-5 overexpression also augmented the tumorigenicity of human HT1080 fibrosarcoma cells by increasing their DNA synthesis, migration toward fibronectin, and invasion through synthetic basement membranes. (elsevierpure.com)
  • Experiments using the MTT assay, cell cycle analysis, apoptosis assay, real-time PCR and western blot were performed to establish the expression levels of related genes. (biomedcentral.com)
  • Human Rab21siRNA were transfected into T98G ( a ) and U87 ( b ) cells, followed by cell proliferation determination using the CCK-8 assay. (biomedcentral.com)
  • Following the BEL treatment, the in-vitro results exhibited a significant debilitation of 4T1 cell proliferation for both basal and nicotine-induced, as shown in the MTT proliferation assay. (eku.edu)
  • Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
  • Pig bone marrow mononuclear cells had been remoted and cultured in EGM-2 medium to acquire bone marrow-derived EPCs (BM-EPCs) that had been characterised by immunostaining and the tube formation assay. (inacj.com)
  • A limiting dilution assay was used to determine the frequencies of T cells that could be induced to proliferate and kill by Con A and TCGF. (elsevierpure.com)
  • MMC also induced phosphorylation of the nuclear histone marker of DNA damage, γH2AX (a member of the H2A histone family), without induction of cell cycle entry or immediate DNA repair measured by Comet assay. (molvis.org)
  • IgE was recently shown to induce HASM cell proliferation but the detailed mechanisms remain unknown. (harvard.edu)
  • Collectively, our data provide mechanisms of a novel function of IgE which may contribute, at least in part, to airway remodeling observed in allergic asthma by directly inducing HASM cell proliferation. (harvard.edu)
  • The underlying molecular mechanisms by which androgen-independent PC cells acquire the capacity to proliferate remain largely unclear. (go.jp)
  • The T cell-intrinsic mechanisms that prevent excessive homoeostatic T-cell responses and consequent overt autoreactivity remain poorly defined. (monash.edu)
  • Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. (greenmedinfo.com)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • The purpose of BAY 293 our current research would be to investigate the result of leucine deprivation on breast tumor cells and also to elucidate the root mechanisms. (racetab.org)
  • In addition, these inhibitors were used to verify phosphorylation of AKT, GSK3beta, and ERK1/2 and to confirm mechanisms regulated by luteolin in JAR and JEG-3 cells. (ewha.ac.kr)
  • However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
  • Therefore, we believe that the investigation of the molecular events induced by LPLI could eventually reveal the mechanisms of LPLI. (biomedcentral.com)
  • then we review the studies on the molecular mechanisms of LPLI-induced proliferation since January 1999, which will serve as a reference for the researchers in this field. (biomedcentral.com)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • Gene expression analysis revealed putative mechanisms of action, which suggested that c-Jun and c-Fos are involved in oleuropein and hydroxytyrosol induced apoptosis of MIA PaCa-2 cells. (uaeu.ac.ae)
  • These results suggest that ABs, through iPGE2-dependent mechanisms, might have a relevant role in the natural history of cisplatin-induced acute kidney failure because they contribute first to the propagation of the noxious effects of cisplatin to non-injured PTC and then to the promotion of the proliferative tubular response required for proximal tubule repair. (uah.es)
  • This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. (upm.edu.my)
  • Therefore, the search for novel agents, which induce apoptosis in cancer cells while displaying limited toxicity towards normal cells, is paramount. (uaeu.ac.ae)
  • Rab21 is a member of the Rab subfamily, which has been identified as required for tumor-associated fibroblasts to promote the invasion of squamous carcinoma cells. (biomedcentral.com)
  • Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
  • TK is believed to be a biological indicator of senescence in rats, which can be measured by the level of endothelial cell production during the aging process. (wikipedia.org)
  • The copper (II) complex of salicylate phenanthroline inhibits proliferation and induces apoptosis of hepatocellular carcinoma cells. (bvsalud.org)
  • Simultaneous silencing of VEGF and KSP using siRNA cocktail yields promising results for eradicating hepatocellular carcinoma cells, a new direction for liver cancer treatment. (biomedcentral.com)
  • However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. (eurekamag.com)
  • This is the first report that targeting the BAFF cytokine network inhibits both humoral and cellular immune responses induced by memory CD4 T cells. (duke.edu)
  • In contrast, mice on a fiber-rich diet were completely protected from irradiation-induced bacterial infiltration and exhibited a similar serum cytokine profile as sham-irradiated mice on a fiber-rich diet. (lu.se)
  • The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. (nih.gov)
  • We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation stimulated by fetal calf serum. (nih.gov)
  • Taken together, these data suggest for the first time that, in proliferating rat mesangial cells, B2 receptor stimulation is able to induce, via a pertussis insensitive pathway, the inhibition of tyrosine kinase activity and mesangial cell proliferation. (nih.gov)
  • Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
  • The enhanced LIP is attributed to elevated T-cell receptor-dependent, but not interleukin-7-dependent responses, results in a skewed T-cell receptor repertoire and the development of autoimmunity. (monash.edu)
  • The proliferative and antiapoptotic actions of endothelin (ET)-1 in cancer cells have been documented and ET receptor antagonists have been exploited as potential anticancer drugs. (unipv.it)
  • In this study we have investigated the effects of two structurally unrelated ETB receptor antagonists, BQ788 and A192621, on cell survival, proliferation and apoptosis in 1321-N1, U87 and IPDDCA2 glioma cell lines. (unipv.it)
  • The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. (medlineplus.gov)
  • This positioning allows the receptor to attach (bind) to other proteins, called ligands, outside the cell and to receive signals that help the cell respond to its environment. (medlineplus.gov)
  • Lung cancers with EGFR gene mutations tend to respond to treatments that specifically target the overactive epidermal growth factor receptor protein that allows cancer cells to constantly grow and divide. (medlineplus.gov)
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • We have recently shown that the cyclo-oxygenase-2 (COX2)/intracellular prostaglandin E2 (iPGE2)/EP receptor pathway mediates the apoptotic effect of cisplatin on human proximal tubular HK-2 cells. (uah.es)
  • Inhibition of the COX-2/iPGE2/EP receptor pathway in these cells prevented the effects of ABs without interfering with their internalization. (uah.es)
  • ABs released by cells undergoing apoptosis upon treatment with ABs) did not trigger apoptosis in naïve HK-2 cells, and stimulated cell proliferation through the COX-2/iPGE2/EP receptor pathway. (uah.es)
  • Since iPGE2 also mediates both cisplatin-induced HK-2 cell apoptosis, intervention in the COX-2/iPGE2/EP receptor pathway might provide us with new therapeutic avenues in patients with cisplatin-induced acute kidney injury. (uah.es)
  • Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
  • Studies have confirmed that TEOA has significant cytotoxicity on gastrointestinal cancer cells. (figshare.com)
  • BAY 293 We looked into the cytotoxicity of leucine deprivation on regular cells further, including major hepatocytes, brownish adipose cells (BAT) and MCF-10A cells. (racetab.org)
  • The olive biophenols, oleuropein, hydroxytyrosol and tyrosol, have displayed cytotoxicity towards cancer cells without affecting non-tumorigenic cells in cancers of the breast and prostate. (uaeu.ac.ae)
  • Treated vs untreated tumor sections were also compared for proliferation and angiogenesis markers by immunohistochemistry.Results: The combination of dovitinib and oxaliplatin showed higher in vitro cytotoxicity in colon cell lines irrespective of their RAS-RAF status as compared to either of the drugs alone. (tmu.edu.tw)
  • Cisplatin-induced cytotoxicity appears to be multifactorial and involves inflammation, oxidative stress as well as apoptosis. (uah.es)
  • the presence of nicotine-induced tumors in lung tissue was reduced significantly. (eku.edu)
  • Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. (biomedcentral.com)
  • Immunohistochemistry of post treatment tumors showed a significant decrease in proliferation and angiogenesis as compared to either of the treatments alone.Conclusions: This study demonstrates the synergistic antitumor activity of combination of dovitinib and oxaliplatin against colon cancer with different RAS-RAF status. (tmu.edu.tw)
  • The ability of ALDH+ cells to form tumors in immunodeficient mice could not be challenged by radiation therapy. (lu.se)
  • We next found that BK induced a dose-dependent inhibition of phospho-tyrosine kinase activity. (nih.gov)
  • RESULTS: All three statins reduced viable cell number and inhibited proliferation in a similar dose-dependent manner. (uea.ac.uk)
  • Cu(sal)(phen) inhibited the proliferation of HCC cells (HepG2 and HCC-LM9) and induced apoptosis of HCC cells in a dose -dependent manner by upregulating mitochondrial reactive oxygen species (ROS) production . (bvsalud.org)
  • The results demonstrated that TEOA inhibited proliferation and induced apoptosis in time-and dose-dependent manners. (figshare.com)
  • To study the possible anticancer and antiproliferative activities of ethanolic leaf extract of Thuja occidentalis (TO) on A549 non-small lung carcinoma cells in vitro . (jcimjournal.com)
  • Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
  • Somatic mutations in the EGFR gene most often occur in a type of lung cancer called non-small cell lung cancer, specifically a form called adenocarcinoma. (medlineplus.gov)
  • When these genetic changes occur in cells in the lungs, lung cancer can develop. (medlineplus.gov)
  • Four varieties of tumor cells were examined: malignant melanoma A375, lung caner A549, ovarian carcinoma breast and A2780 cancer MCF-7 and MDA-MB-231 cells. (racetab.org)
  • Cigarette smoking is the strongest risk factor for developing lung cancer, which is conceivably initiated by proliferation. (caluniv.ac.in)
  • Here, we show that low concentration of aqueous extract of cigarette smoke (AECS) causes excessive proliferation of human lung epithelial cells (A549) without any apoptotic cell death. (caluniv.ac.in)
  • Vitamin C and/or antibody to p-BQ prevents AECS/p-BQ-induced proliferation of lung cells apparently by inactivating p-BQ and thereby preventing activation of EGFR and the downstream signaling molecules. (caluniv.ac.in)
  • Whether or not co-culture of lung carcinoma with PLTs improves the perform of human umbilical vein endothelial cells (HUVECs) requires additional investigation. (inacj.com)
  • it is also a calciumdependent elastin-binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the skin, lung, and vasculature. (elsevierpure.com)
  • Unlike its proliferative response in fibroblasts, FBLN-5 overexpression in mink lung Mv1Lu epithelial cells resulted in an antiproliferative response, reducing their DNA synthesis and cyclin A expression. (elsevierpure.com)
  • Further analysis of IgE-induced signaling depicted an IgE-mediated activation of Erk 1/2, p38, JNK MAPK, and Akt kinases. (harvard.edu)
  • The activation of resident HSCs into fibroblast-like cells is a hallmark of hepatic fibrogenesis [ 3 ]. (oncotarget.com)
  • It has been proposed that metformin inhibits proliferation via activation of AMP-activated protein kinase (AMPK) or by blocking proliferation at the G0/G1 phase in the cell cycle with a reduction in cyclin D1. (uwm.edu)
  • In addition, TEOA induced the activation of the p38 MAPK pathway and pretreated with p38 inhibitor SB20358 or ROS scavenger could block TEOA-induced DNA damage. (figshare.com)
  • Taken together, these results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage. (figshare.com)
  • Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
  • LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
  • These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
  • Subsequent analysis of Bcl-2 family proteins and caspase 3/7 activation determined that oleuropein and hydroxytyrosol induced apoptosis in MIA PaCa-2 cells, while oleuropein displayed a protective effect on HPDE cells. (uaeu.ac.ae)
  • Overexpression of FBLN-5 in 3T3-L1 cells increased DNA synthesis and enhanced basal and TGF-β-stimulated activation of ERK1/ERK2 and p38 mitogen-activated protein kinase (MAPK). (elsevierpure.com)
  • Our findings identify FBLN-5 as a novel TGF-β-inducible target gene that regulates cell growth and motility in a context-specific manner and affects protein kinase activation by TGF-β. (elsevierpure.com)
  • Rather, we found that phosphorylated activation loop Y842 serves as a binding site of SHP2, which is required for FLT3-induced activation of RAS/ERK pathway. (lu.se)
  • We show that the effects on cell cycle progression stemmed from reduced ribosome content and translational capacity, which suppressed the accumulation of cyclins at the translational level. (nih.gov)
  • The expression of MMP-9 was discovered to have behaved in an iPLA 2 β-dependent manner, which further supports the idea that iPLA 2 β plays a significant role, concerning the mediation of basal and nicotine-induced cancer cell progression. (eku.edu)
  • Although the role of inflammatory lipid-mediators in CRC progression is well known, their role in the promotion of cancer-initiating cells remains to be elucidated. (lu.se)
  • We showed that LTD4 and PGE2 enriched the ALDH+ cell population and augmented the colonies formation and tumor progression in xenograft mice model. (lu.se)
  • In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. (scilifelab.se)
  • HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs), and overexpression of Sik1 specifically in β cells blocks the effect of HG-9-91-01 on β cell proliferation. (scilifelab.se)
  • Statins induced apoptosis and enhanced the antiproliferative effect of NS-398, a selective cyclooxygenase (COX)-2 inhibitor. (uea.ac.uk)
  • BEL (bromoenol lactone), a suicide inhibitor of iPLA 2 β, was hypothesized to decrease the intensity of the effects of nicotine-induced breast cancer. (eku.edu)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • Treatments with pertussis-toxin, inhibition of phospholipase C and protein kinase C inhibitors and chelation of free cytosolic calcium did not change the bradykinin-induced inhibition of phosphotyrosine kinase. (nih.gov)
  • We report here that IgE sensitization induces HASM cell proliferation, as measured by 3H-thymidine, EdU incorporation, and manual cell counting. (harvard.edu)
  • Addition of purified tryptase was found to stimulate thymidine incorporation, but induced little alteration in cell numbers, suggesting it is not a growth factor for HUVEC. (eurekamag.com)
  • Proliferation was quantified by thiazoyl blue colormetric and bromodeoxyuridine incorporation assays. (uea.ac.uk)
  • Mesangial expansion caused by cell proliferation and glomerular extracellular matrix accumulation is one of the earliest renal abnormalities observed at the onset of hyperglycemia in diabetes mellitus. (dsmc.or.kr)
  • Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. (musc.edu)
  • Mechanistically, both peptides caused a significant reduction at G0/G1 phase, in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated generation of reactive oxygen species and diminished mitochondrial membrane potential, all hallmarks of cellular stress. (nature.com)
  • TEOA induced reactive oxygen species (ROS) generation, which was reversed by N-acetyl cysteine (NAC). (figshare.com)
  • In mice, basal and nicotine-induced tumor growth was significantly decreased, in comparison with the control group. (eku.edu)
  • For this thesis, we investigated the role of eicosanoids - leukotriene D4 (LTD4) or prostaglandin E2 (PGE2) - on CIC properties and changes occurring in the tumor environment that could possibly support CIC-induced tumor growth. (lu.se)
  • In immunodeficient mice, LTD4 or PGE2 treatment amplified CIC-induced tumor growth. (lu.se)
  • Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)
  • We found that a significant increase occurred in Rab21 expression in T98G and U87 glioma cell lines and that downregulation of Rab21 using specific-siRNA transfected with two glioma cell lines (T98G and U87) significantly inhibits cell growth and remarkably induces cell apoptosis. (biomedcentral.com)
  • This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
  • However, there is no available information to address that TF affects murine leukemia cells in vitro and in vivo. (upm.edu.my)
  • Here, we investigated in vitro and in vivo effects of TF on murine leukemia WEHI-3 cells. (upm.edu.my)
  • The long-term ability of quiescent keratocytes to repair MMC induced damage in vivo was evaluated in rabbits treated with MMC 2 months before 100 μm deep lamellar keratectomy (LK) injury. (molvis.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • There are new opportunities to using data from molecular and cellular studies in order to bring together a fuller biological understanding of how chemicals induce neoplasia. (cdc.gov)
  • Metformin increased intracellular PEDF in LNCaP cells, and extracellular PEDF in RWPE-1 and LNCaP cells. (uwm.edu)
  • Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
  • Transforming growth factor-β (TGF-β) regulates the production of cytokines, growth factors, and extracellular matrix proteins by a variety of cell types and tissues. (elsevierpure.com)
  • Human ASM (HASM) cells express both low affinity (FcεRII/CD23) and high affinity IgE Fc receptors (FcεRI), and IgE can modulate the contractile and synthetic function of HASM cells. (harvard.edu)
  • The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
  • In human BCa tissues, we observed that LAPTM5 was significantly induced at both mRNA and protein levels, which is consistent with our microarray result. (spandidos-publications.com)
  • Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
  • Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
  • In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
  • The expression of Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver. (oncotarget.com)
  • Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating. (oncotarget.com)
  • Here, through a new high-throughput screen using a luminescence ubiquitination-based cell cycle indicator (LUCCI) in zebrafish, we identify HG-9-91-01 as a driver of proliferation and confirm this effect in mouse and human β cells. (scilifelab.se)
  • In human malignancies, including glioma, abnormal expression of Rabsled to aberrant tumor cell behavior. (biomedcentral.com)
  • Human glioma cell lines U251, T98G, SHG44, U87 and U373 were obtained from the Cell Bank of Chinese Academy of Sciences. (biomedcentral.com)
  • The purpose of this study is to examine the therapeutic potential of dual gene targeted siRNA cocktail on human hepatocellular carcinoma Hep3B cells. (biomedcentral.com)
  • It has been known that human cancer is a gene-related disease involving abnormal cell growth. (biomedcentral.com)
  • Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)
  • The antitumor effects of either of the drugs were compared to the combination using human colon carcinoma cell line HT-29 xenograft model. (tmu.edu.tw)
  • The strong evidence was primarily from studies in human primary cells and studies in experimental systems, supported by studies on DNA adducts in humans. (who.int)
  • This strong evidence was from studies in human primary cells and in various experimental systems. (who.int)
  • As an upstream signature component of FcεRI signaling, inhibition of spleen tyrosine kinase (Syk) abrogated the IgE-induced HASM proliferation. (harvard.edu)
  • Here we show that protein tyrosine phosphatase N2 (PTPN2) is elevated in naive T cells leaving the thymus to restrict homoeostatic T-cell proliferation and prevent excess responses to self-antigens in the periphery. (monash.edu)
  • Next, we established effects of luteolin in the presence of pharmacological inhibitors of PI3K/AKT, ERK1/2 MAPK, and mTOR on proliferation of JAR and JEG-3 cells. (ewha.ac.kr)
  • Moreover, FBLN-5 synergizes with TGF-β in stimulating AP-1 activity in Mv1Lu cells, an effect that was abrogated by overexpression of dominant-negative versions of either MKK1 or p38 MAPKα. (elsevierpure.com)
  • Accordingly, both the stimulation and duration of ERK1/ERK2 and p38 MAPK by TGF-β was enhanced in Mv1Lu cells expressing FBLN-5. (elsevierpure.com)
  • This observation prompted us to characterise the cell-autonomous cytotoxic and anti-proliferative profile of gomesin in DFTD cells and in comparison, to non-transformed (healthy) Tasmanian devil fibroblasts (FIBS). (nature.com)
  • The Sp1-decoy oligodeoxynucleotide suppressed transcription of these cytokines and proliferation of primary rat mesangial cells in response to high glucose. (dsmc.or.kr)
  • Scholars@Duke publication: B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells. (duke.edu)
  • The goal of this study was to investigate the role of B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in alloresponses driven by memory CD4 T cells. (duke.edu)
  • Though gene transfer-enhanced endothelial progenitor cells (GTE-EPCs) present effectiveness in MI remedy in small animal fashions, no scientific trials utilizing GTE-EPCs have been documented. (inacj.com)
  • We have investigated the proinflammatory actions of the major mast cell product tryptase on HUVEC. (eurekamag.com)
  • Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. (elsevierpure.com)
  • Recent evidence suggests that IgE sensitization can enhance the survival and mediator release in inflammatory cells. (harvard.edu)
  • Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • As a result, signaling pathways within the cell are triggered that promote cell growth and division (proliferation) and cell survival. (medlineplus.gov)
  • Donor-reactive memory T cells undermine organ transplant survival and are poorly controlled by immunosuppression or costimulatory blockade. (duke.edu)
  • The short-term neutralization of BAFF alone or BAFF plus APRIL synergized with anti-CD154 mAb to prolong heart allograft survival in recipients containing donor-reactive memory CD4 T cells. (duke.edu)
  • Additional depletion of CD8 T cells did not enhance the prolonged allograft survival suggesting that donor-reactive alloAbs mediate late graft rejection in these recipients. (duke.edu)
  • Our results suggest that reagents neutralizing BAFF and APRIL may be used to enhance the efficacy of CD40/CD154 costimulatory blockade and improve allograft survival in T cell-sensitized recipients. (duke.edu)
  • While chemotherapy and radiotherapy can kill most tumor cells, those that survive typically regrow. (biomedcentral.com)
  • Chemotherapy-induced oral mucositis causes the mucosal lining of the mouth to atrophy and break down forming ulcers. (medscape.com)
  • The diagnosis of chemotherapy-induced oral mucositis is based on clinical findings and the chronology of the development of lesions. (medscape.com)
  • Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
  • Tolentino, Miguel Angel, "Metformin-Induced PEDF Expression Regulates Cell Proliferation and Lipid Metabolism in Prostate Cancer Cells" (2013). (uwm.edu)
  • It was found that the growth of leukemia cells in vitro was inhibited by the various extracts of TF. (upm.edu.my)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • Neointima stained positive for both -smooth muscle actin and PCNA indicating proliferation of smooth muscle cells possibly mediated by growth factors TGF-β 1 , PDGF-A and PDGF-B, while TUNEL indicated apoptosis in the intimal layer in affected arteries. (biomedcentral.com)
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
  • impaired placental blood flow, which then presentation after 20 weeks gestation with induces the release of a critical placental sustained and elevated blood pressure (BP) substance into the maternal circulation. (who.int)