Induces stat6 transcription factor. Medical search. Frequent questions

STAT6-mediated signaling pathway is required for the development of T-helper type 2 (Th2) cells and Th2 immune response. (wikipedia.org)
Activation of STAT6 signaling pathway is necessary in macrophage function, and is required for the M2 subtype activation of macrophages. (wikipedia.org)
Activation of nuclear factor-κB (NF-κB) signaling pathway has been shown to be associated with inflammatory response induced by SCI. (biomedcentral.com)
Macrophage polarization is mediated in part, through the canonical Janus- or TYK2-kinases (JAK)-Signaling signal transducers and activators of transcription (STAT) signaling pathway. (biorxiv.org)

These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)
In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
It has been known that macrophages are involved in the initiation and termination of inflammation, secretion of growth factors, phagocytosis, cell proliferation, and collagen deposition in wound, which is the key factor during wound healing. (biomedcentral.com)
Further, our ELISA, FCM, qPCR and western blot results showed that IL-6 was highly enriched in S-IT MSCs and acted as a key regulator to induce macrophages convert to the M2 phenotype through IL-6-dependent signaling pathways, ultimately achieving the above function of promoting wound repair. (biomedcentral.com)
Parasitic helminths generally induce strong type 2 immunity that normally controls parasite infection and is characterized by production of type 2 cytokines like interleukin- (IL-) 4, IL-5, and IL-13 by innate cells (group 2 innate lymphoid cells (ILC2s), basophils, eosinophils, neutrophils, and macrophages) and CD4 + T helper 2 (Th2) lymphocytes. (hindawi.com)
Using various transgenic mouse models to manipulate the macrophage mitochondrial matrix iron content in an inducible fashion, we demonstrate that lowering macrophage mitochondrial matrix iron increases numbers of M2-like macrophages in adipose tissue, lowers iron levels in adipocytes, attenuates inflammation and protects from high-fat-diet-induced metabolic deterioration. (biomed.news)
Conversely, elevating macrophage mitochondrial matrix iron increases M1-like macrophages and iron levels in adipocytes, exacerbates inflammation and worsens high-fat-diet-induced metabolic dysfunction. (biomed.news)
Our preliminary results pinpoint that the heme-regulated transcription factor, BACH1 is an important regulator in macrophages. (unideb.hu)
MiRNA-9 levels were synergistically increased following IFNγ/LPS co-exposure in isolated macrophages and in vivo, in an IFN-γ/LPS-induced mouse model of steroid-resistant airway hyperresponsiveness (AHR) [ 2 ] . (encyclopedia.pub)
At the other extreme, M2-like macrophages are induced by the interleukins (IL)-4 and −13, cytokines secreted by activated Th2 cells [ 16 ]. (biorxiv.org)

Recent evidence shows that the stimulator of interferon genes (STING) pathway is essential for anti-tumor immunity via inducing the production of downstream inflammatory cytokines. (bvsalud.org)
GSDMC-mediated IL-33 secretion was indispensable for effective anti-helminth immunity and contributed to induced intestinal inflammation. (umn.edu)
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C . Immunity , 55 (4), 623-638.e5. (umn.edu)
These proteins, ROP18 (a Toxoplasma -secreted kinase) and ROP5 (a family of secreted pseudokinases), cooperatively block the murine interferon-gamma (IFN)γ-induced immunity related GTPases (IRGs), thereby preventing destruction of the vacuole in which the parasite lives. (saeijlab.com)
Recent data also suggest that the potential of cDC2s to induce pure Th2 immunity or a mixed Th2/Th17 type of response is tightly regulated by cell intrinsic mechanisms, including fine tuning of TLR signalling pathways and metabolic programming (Sinclair et al. (icem2012.org)
Around this time, TH2 cells were also discovered in response to extracellular pathogens and parasites e.g. helminths, and these cells induce humoral immunity via immunoglobulin G4 (IgG4) and IgE production. (thenewstandardgallery.com)

Although many studies have hinted at the critical role of nerves in regulating inflammation, there largely remains undetermined how hepatic nerves mediate immune inflammation and how the inflammatory factors released by these nerves are involved in the process of liver injury. (bvsalud.org)
Carbon nanotube (CNT)-induced lung fibrosing lesions are delineated by an acute inflammation followed by chronic interstitial fibrosis, for which the molecular mechanism is largely unknown. (cdc.gov)
The histological feature of AR is typical type 2 inflammation is induced mainly by the type 2 cytokines interleukin (IL)-4, IL-15, and IL-13. (balkanmedicaljournal.org)
9 In lung fibroblasts, expression of IL-13-induced inflammation-related factors (such as CCL26) was downregulated by silencing SOX11. (balkanmedicaljournal.org)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

STAT6 also plays a critical role in Th2 lung inflammatory responses including clearance of parasitic infections and in the pathogenesis of asthma. (wikipedia.org)
An aerosol antigen challenge of an appropriately sensitized asthmatic patient can induce two types of airway responses. (jci.org)
Activation of Th2-type responses is featured by the activation of Il-4Ra/STAT6 and the up-regulation of GATA-3, which serves as a transcription factor and mediates the transactivation of Th2 target genes, in CD4+cess. (cdc.gov)
Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. (hindawi.com)
An important aspect about type 2 cell-mediated responses against parasitic helminths is that they are induced for controlling parasite infection but they also mediate the tolerance of parasite persistence [ 1 ]. (hindawi.com)
Rabbit polyclonal to STAT6.STAT6 transcription factor of the STAT family.Plays a central role in IL4-mediated biological responses.Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. (biomasswars.com)
SRY-box transcription factor 11 (SOX11) was reported to play important roles in inflammatory responses, but its role in AR is poorly understood. (balkanmedicaljournal.org)
1 The clinical manifestations of AR are caused by a series of inhalant allergen-induced type 2 helper T (Th2) cell responses, including excessive allergen-specific immunoglobulin E (IgE) release, mast cell activation, eosinophil infiltration, and goblet cell hyperplasia. (balkanmedicaljournal.org)
Unlike IgE, switching to IgG1 can still be induced, albeit at lower ICG-001 novel inhibtior levels, during T cellCdependent responses in the absence of the IL-4/STAT6 pathway (17, 18). (healthcarecoremeasures.com)
A big question in the field is whether subsets of cDC2s exist Tedalinab that would preferentially induce TFH over effector Th2 immune responses. (icem2012.org)
B cells can induce Th2 and TFH responses and elicit help from CD4+ T cells in an MHC-II dependent manner, but using T cell antigen receptor Tedalinab (TCR) transgenic Tedalinab 1-DER mice that react to the type 2 antigen Der p 1 of the house dust mite (Dullaers et al. (icem2012.org)

STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. (wikipedia.org)
STAT6 is activated by cytokines interleukin-4 (IL-4), and interleukin-13 (IL-13) with their receptors that both contain the α subunit of the IL-4 receptor (IL-4Rα). (wikipedia.org)
Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. (uchicago.edu)
In human nasal mucosa epithelial cells, interleukin-13 enhanced SOX11 expression in a time-dependent manner, and signal transducer and activator of transcription 6 (STAT6) was involved in the interleukin-13-mediated expression of SOX11 by regulating transcription. (balkanmedicaljournal.org)

STAT6 protein also regulates other transcription factor as Gata3, which is important regulator of Th2 differentiation. (wikipedia.org)
2005). At the T cell level, Th2 differentiation starts with induction of a TCR driven activation of GATA3 transcription factor, and induction of STAT5 phosphorylation, triggered by IL-2, or TSLP (Zhang et al. (icem2012.org)
IL-4 and IL-2 induce this subset, by IL-4R directed phosphorylation of STAT6 which, with GATA-sequence binding protein 3 (GATA3), causes transcription of IL-4. (thenewstandardgallery.com)
We found that primary human astrocytes are unable to induce GATA3 after injury. (frontiersin.org)
Lentivirus-mediated overexpression of GATA3 significantly increased the number of GFAP/SOX2 double positive astrocytes and expression of pro-neural factor ASCL1, but failed to induce neurogenesis, suggesting that GATA3 is required for enhancing the neurogenic potential of primary human astrocytes and is not sufficient to induce neurogenesis alone. (frontiersin.org)
Primary human astrocytes do not induce GATA3 after injury. (frontiersin.org)
GATA3 reduces lesion-induced scar-like collagen deposition. (frontiersin.org)

Expression of Th2 cytokines, including IL-4, IL-13, and IL-5, was reduced in STAT6-deficient mice. (wikipedia.org)
It was found that STAT6 induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. (wikipedia.org)
To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
However, no difference in active STAT-4 expression was seen between CD patients and controls, suggesting that Th1 polarisation was not induced by local IL-12. (bmj.com)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
Yet, the existence of the polymorphic allele of C2892T increased STAT6 gene expression significantly compared to the wildtype allele. (tum.de)
In addition, in vivo STAT6 expression was affected by the polymorphism C2892T. (tum.de)
In funktionellen Studien wurde STAT6 Intron2 als ein Repressorelement identifiziert, wobei die Expression des polymorphen Allels von C2829T die STAT6 Expression im Vergleich zum Wildtyp sowohl in Zelllinien als auch in einer in vivo Genexpressionsstudie signifikant erhöhten. (tum.de)
We demonstrated that MWCNT induced the expression of Th2 cytokines interleukin (IL)-4 and IL-13, and a panel of signature downstream target genes including I14i1, Chia, and Cc11 1/Eotaxin, at the protein level in the lungs. (cdc.gov)
Meanwhile, STAT6 O-GlcNAcylation activated the expression of Gsdmc family genes. (umn.edu)
It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. (bio-rad-antibodies.com)
Here our experiments show that rTgPrx promotes AAM as indicated by high arginase-1 (arg-1), YM1 and FIZZ expression via both signal transducer and activator of transcription (STAT)6-dependent and -independent mechanisms. (biomedcentral.com)

Cytotoxic T cells directly kill infected cells by inducing them to undergo apoptosis, these cells like a "killer" or cytotoxin because they kill cells of interest that produce a particular antigen. (nutritionfit.org)
Canonical NF-κB pathway activation underlines much of the immune response after SCI including cytokine, chemokine, and apoptosis-related factor production as well as immune cell activation and infiltration. (biomedcentral.com)

Here, we report that epithelial O-linked N-Acetylglucosamine (O-GlcNAc) protein modification was induced upon helminth infections. (umn.edu)
Dive into the research topics of 'Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C'. Together they form a unique fingerprint. (umn.edu)

Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
The cytokine profile for this cell includes IL-4 and IL-13 (which induce IgE class switching), IL-5 and Amphiregulin (for eosinophil recruitment) and IL-25 (a self-stimulating cytokine)[1-5]. (thenewstandardgallery.com)
They are induced by the presence of IL-2, high levels of TGFï¿½ but absolutely no proinflammatory cytokine presence. (thenewstandardgallery.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)

STAT6 is a key mediator in the activation of the IL-4/IL-13 pathway inducing the class-switch to IgE. (tum.de)
Carries out a dual function: signal transduction and activation of transcription. (ucsc.edu)
without inhibiting the initial proliferative response of T cells or promoting activation-induced cell death. (healthcarecoremeasures.com)
IL-4 signaling induces germ line transcription of C1 and C through the activation of signal transducer and activator of transcription (STAT)-6, a transcription factor that binds to cis-elements in the C1 and C promoters (16). (healthcarecoremeasures.com)
Furthermore, TNF interfered with the activation of IL-6-induced gp130-signal transducer and activator of transcription (STAT) 3 and IL-4-STAT6 signaling, thereby abrogating IL-6-facilitated M2 macrophage polarization. (edu.au)
IL-12Rï¿½2, on the CD4+ cell, then induces phosphorylation of the signal transducer and activator of transcription 4 protein (STAT4) and T-bet activation. (thenewstandardgallery.com)
Lastly, IL-21 also promotes activation of the STAT3 promoter and other transcriptional factors. (intechopen.com)

The past decade has seen the discovery of an ever-growing number of CD4 T helper cell subsets, with unique transcriptional programs governed by lineage-defining transcription factors. (nutritionfit.org)

Association studies searching for relation of polymorphisms in STAT6 with IgE level or asthma discovered a few polymorphisms significantly associated with examined traits. (wikipedia.org)
Only two polymorphisms showed repeatedly significant clinical association and/or functional effect on STAT6 function (GT repeats in exon 1 and rs324011 polymorphism in intron 2). (wikipedia.org)
Aim of the present work was to identify STAT6 polymorphisms which may influence the predisposition for atopic diseases in children. (tum.de)
We demonstrated that C2892T in intron2 of STAT6 strongly contributes to the genetic control of IgE and the development of asthma, interacting also with other polymorphisms of the IL-4/IL-13 pathway. (tum.de)

Ziel dieser Studie war es, genetische Varianten im STAT6 Gen zu identifizieren und ihre funktionelle Rolle bei der Entwicklung von Asthma und Atopie zu charakterisieren. (tum.de)

IL-4 stimulates the phosphorylation of IL-4 receptor, which recruits cytosolic STAT6 by its SH2 domain and STAT6 is phosphorylated on tyrosine 641 (Y641) by JAK1, which results in the dimerization and nuclear translocation of STAT6 to activate target genes. (wikipedia.org)

Amplification STAT6 is amplified in a subset of dedifferentiated liposarcoma. (wikipedia.org)

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (bio-rad-antibodies.com)
MiRNA-9 production decreased protein phosphatase 2A (PP2A) activity and also inhibited steroid-induced glucocorticoid receptor (GR) nuclear translocation. (encyclopedia.pub)
Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)

Phospho-STAT6 (Thr645) Antibody detects endogenous levels of STAT6 only when phosphorylated at Threonine 645. (affbiotech.cn)
Western blot analysis of whole cell lysates probed with Mouse anti Human STAT6 antibody ( VMA00228 ) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P ) and visualized on the ChemiDoc MP with 7 second exposure. (bio-rad-antibodies.com)
Mouse anti Human STAT6 antibody recognizes the signal transducer and activator of transcription 6 (STAT6) also known as interleukin 4-induced and transcription factor IL-4 STAT. (bio-rad-antibodies.com)

These cells produce suppressive cytokines such as IL-10 and IL-35, and sometimes, by IL-10, iTregs can induce plasticity of different CD4+ subsets or production of IL-10 by TH cells, thus making them self-regulatory[2,6,9].Treg cells are responsible for resisting hyperactivity of all TH cells, including TH1, TH2 and TH17. (thenewstandardgallery.com)

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. (wikipedia.org)
Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. (wikipedia.org)
STAT6 shares structural similarity with the other STAT proteins and is composed of the N-terminal domain, DNA binding domain, SH3- like domain, SH2 domain and transactivation domain (TAD). (wikipedia.org)
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
STAT6 transcription factor of the STAT family. (affbiotech.cn)
Encoded by the STAT6 gene, signal transducer and activator of transcription 6 is a member of the STAT family of transcription factors. (bio-rad-antibodies.com)
The protein encoded by this gene is a member of the STAT family of transcription factors. (ucsc.edu)
Belongs to the transcription factor STAT family. (ucsc.edu)
Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN-α). (rndsystems.com)

By modifying and activating the transcription factor STAT6, O-GlcNAc transferase promoted the transcription of lineage-defining Pou2f3 in tuft cell differentiation and IL-25 production. (umn.edu)

Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Intracellular markers include transcription factors that control CD4 + T cell differentiation as well as signature cytokines as they traffic through secretory organelles. (rndsystems.com)
We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
SRY-box transcription factor 11 (SOX11) is a member of the SOX C protein family and is implicated in multiple biological processes, such as neurogenesis, cell differentiation, and embryonic development. (balkanmedicaljournal.org)

During the process of liver injury, massive inflammatory cytokines are stimulated by these hazardous factors, leading to a systemic inflammatory response syndrome, followed by a compensatory anti-inflammatory response, which causes immune cell dysfunction and sepsis, subsequent multi-organ failure. (bvsalud.org)
Our study demonstrated that metformin downregulated ZIKV-induced inflammatory response in microglia in a time- and dose-dependent manner. (bvsalud.org)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)

In the human genome, STAT6 protein is encoded by the STAT6 gene, located on the chromosome 12q13.3-q14.1. (wikipedia.org)
Gene fusion Recurrent somatic fusions of the two genes, NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors. (wikipedia.org)
Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
Unlike miRNAs whose central function is to restrain mRNA translation by inducing degradation, lncRNAs can act as numerous roles to exert their functions by directly or indirectly interacting with DNA, RNA or protein, even can encode some short peptides (Fig. 3 a-d) [ 6 ]. (biomedcentral.com)

2) We will identify the mechanism and the putative anti-inflammatory role of IL-4/STAT6 signaling-mediated active repression during ex vivo and in vivo alternative macrophage polarization. (unideb.hu)

In addition, it was recently shown that Th17 cells that were generated with transforming growth factor (TGF)-β and IL-6 were not pathogenic and did not induce EAE without exposure to IL-23 (ref. 23 ). (nature.com)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)

Rilzabrutinib demonstrated dose-dependent improvement of clinical scores and joint pathology in a rat model of collagen-induced arthritis and demonstrated reductions in autoantibody-mediated FcγR signaling in vitro and in vivo, with blockade of rat Arthus reaction, kidney protection in mouse Ab-induced nephritis, and reduction in platelet loss in mouse immune thrombocytopenia. (aai.org)

More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)
TH17 lineage is first induced by low levels of transforming growth factor ï¿½ (TGFï¿½), and IL-1ï¿½/IL-6. (thenewstandardgallery.com)
To maintain the population of TH17, IL-23 is required, otherwise the cells dissipate[1,2,4,6,8].The final type of CD4+ cell to be considered is the CD4+CD25+ Treg cell, and this is due to the close relationship between TH17 and induced Treg (iTreg) cells. (thenewstandardgallery.com)

We performed a genome-wide microarray analysis of lungs exposed to single dose multi-walled CNT (MWCNT) by pharyngeal aspiration for 7 days and compared to vehicle and carbon black controls, to identify differentially expressed genes and mechanisms that potentially function in the development of CNT-induced lung fibrosis. (cdc.gov)

Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
Wound healing is a complex process and overlapping continuous process that depends on the presence of various types of cells, growth factors, cytokines and extracellular matrix elements. (biomedcentral.com)

This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. (haematologica.org)

Wir konnten zeigen, dass SNP C2892T in STAT6 Intron2 signifikant zur IgE Regulation und der Asthmaentstehung beiträgt und mit anderen Polymorphismen der IL-4/IL-13 Signalkaskade interagiert. (tum.de)
Wir konnten zeigen, dass SNP C2892T in STAT6 Intron2 signifikant zur IgE Regulation und der Asthmaent. (tum.de)
3) We are also planing to study the anti-proliferative and/or pro-apoptotic action of IL-4-induced mir-342-3p during the posttranscriptional regulation of macrophage viability. (unideb.hu)

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
As a multifunctional oncoprotein, AEG-1 has been shown to overexpress in multiple types of human cancer, and the elevation of AEG-1 in tumor cells leads to enhanced phenotypes characteristic of malignant aggressiveness, including increased abilities to proliferate robustly, to invade surrounding tissues, to migrate, to induce neovascularization, and to enhance chemoresistance. (biomedcentral.com)
Inhibition of the Kir2.1 potassium channel induced metabolic reprogramming and repolarization of pro-tumor M2-TAMs to tumoricidal M1-like states. (biomed.news)
The absence of tumor necrosis factor (TNF) causes lethal infection by Leishmania major in normally resistant C57BL/6J (B6.WT) mice. (edu.au)

In particular we are interested in understanding how lipid-regulated transcription factors, among them nuclear receptors, participate in such processes. (unideb.hu)

Tyrosine phosporylation of STAT6 after stimulation by IL-4 results in the formation of STAT6 homodimers that bind specific DNA elements via a DNA-binding domain. (wikipedia.org)
This suggests that stimulation of MSC by acute inflammatory factors confers on MSC an enhanced ability to promote wound repair. (biomedcentral.com)

Here we describe a model of immunization-induced hyper IgE in mice that carry monoclonal populations of T and B lymphocytes. (healthcarecoremeasures.com)

Th2-cell derived cytokines as IL-4 and IL-13 induce the production of IgE which is a major mediator in allergic response. (wikipedia.org)

Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)
Therefore, a critical role may exist for short-range acting factors, such as cell surface molecules. (nutritionfit.org)

Determining how particular Toxoplasma genotypes differ in their capacity to induce pathology in a particular animal species could enable prediction of the outcome of infection based on the genotype of the infecting organism. (saeijlab.com)

STAT6 is also required for the development of IL-9-secreting T cells. (wikipedia.org)
Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
CD4 + T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD + ) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ + IL-10 + T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. (nature.com)

A high total serum immunoglobulin E level has been identified as a risk factor for the development of KVE. (medscape.com)

Arrow points to STAT6 (molecular weight 100 kDa). (bio-rad-antibodies.com)

Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)
TGF-β), growth factors (e.g. (biomedcentral.com)

Anatomy16

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