Pressure natriuresisDiuresis and natriuresisRenalMiceRatsInhibitionAngiotensinVasodilationSodiumIntakeInhibitsHypertensionDietsIncreaseDoseEffectsResponseEffectFoundPlasmaDiuresisExcretionCauses natriuresisAngiotensin II-inducedSystemic blood pressureAcuteAldosteroneMalignant hypertensionDehydrationReceptorInhibitorsUrinaryPressureIncreasesInjuryDirectPatientsExpressionVolumeRole
Pressure natriuresis8
- Using the transporter profiling approach, Dr. McDonough and her colleagues have defined how stimuli such as dietary salts, Ang II, kidney injury, and immune cytokines increase renal sodium transport in a region specific manner along the nephron and how resultant hypertension provokes intrarenal responses to decrease sodium reabsorption (via pressure natriuresis), a response that defines the blood pressure set point in the kidney. (usc.edu)
- acute salt sensitivity, corresponding with a depressed slope of the chronic pressure natriuresis relationship). (maynoothuniversity.ie)
- For the second component ("Progressive-Irreversible"), an integrator function was used to represent the relatively slow, progressive, and irreversible effect of high salt intake on BP (corresponding with a progressive salt-induced shift of the chronic pressure natriuresis relationship to higher BP levels). (maynoothuniversity.ie)
- reduce the slope of the chronic pressure natriuresis relationship), amounting to a slow and progressive, yet reversible, component of saltinduced hypertension. (maynoothuniversity.ie)
- Conclusion: Our results suggest that the slow process of development of salt-induced hypertension in Dahl-S rats over a period of many weeks can be well represented by a combination of three components that differ in their timing, reversibility, and their associated effect on the chronic pressure natriuresis relationship. (maynoothuniversity.ie)
- Our objective was to induce pressure natriuresis in rats and measure sodium excretion during challenge with an SGLT2i. (ed.ac.uk)
- In vivo pressure natriuresis was suppressed, medullary perfusion reduced by half, and the corticomedullary oxygenation gradient disrupted. (ed.ac.uk)
- Selective P2X7R antagonism restored pressure natriuresis, promoting a significant leftward shift in the intercept and increasing the slope. (ed.ac.uk)
Diuresis and natriuresis3
- When administered intravenously, urodilatin induces strong diuresis and natriuresis with tolerable hemodynamic side effects. (wikipedia.org)
- A message for the preprohormone is transcribed in the heart and kidneys from the gene of NP type A, resulting in a cGMP-dependent signal transduction, which induces diuresis and natriuresis, differentially processed to a peptide of 32 amino acids from the same precursor as renal ANP, may not be identical to the circulating cardiac hormone ANP. (wikipedia.org)
- The highest intravenous dose of ANP also lowered blood pressure ( 3 )-to a similar extent as do sodium-glucose cotransporter 2 (SGLT2) inhibitors-through increased diuresis and natriuresis. (diabetesjournals.org)
Renal6
- Urodilatin (URO) is a hormone that causes natriuresis by increasing renal blood flow. (wikipedia.org)
- Renal clearance studies demonstrated that low potassium augmented, while high potassium diminished, hydrochlorothiazide-induced natriuresis in control mice. (elsevierpure.com)
- Musabayane CT, Cooper RG, Prasada Rao PVV, Balment RJ: Eff ects of ethanol on the changes in renal fl uid and electrolyte handling and kidney morphology induced by long-term chloroquine administration to rats. (jpccr.eu)
- We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. (eur.nl)
- Aliskiren induced a remarkable dose-related renal vasodilation in low-sodium balance. (eur.nl)
- Thus, activation of P2X7R induces microvascular dysfunction and regional hypoxia when angiotensin II is elevated and these effects may contribute to progression of renal injury induced by chronic angiotensin II. (ed.ac.uk)
Mice5
- We therefore investigated the effects of acetazolamide, furosemide, hydrochlorothiazide, and amiloride, known to preferentially inhibit sodium reabsorption at different segments of the nephron, on hypoxia-induced EPO formation in mice. (uni-regensburg.de)
- However, γC33A,C41A mice did not have reduced amiloride-sensitive Na+ currents in the distal colon or benzamil-induced natriuresis compared to WT mice. (jci.org)
- Compared with wild-type, Kcnj16(-/-) mice fed a normal potassium diet had higher basolateral potassium conductance, a more negative DCT membrane potential, higher expression of phosphorylated NCC (pNCC) and total NCC (tNCC), and augmented thiazide-induced natriuresis. (touro.edu)
- High potassium intake inhibited and low intake augmented thiazide-induced natriuresis in wild-type but not in Kcnj16(-/-) mice. (touro.edu)
- T26A increased urinary sodium excretion in mice and, when added to the medium bathing isolated mouse aortas, T26A increased the net release of PGE 2 induced by arachidonic acid, inhibited serotonin-induced vasoconstriction, and potentiated vasodilation induced by exogenous PGE 2 . (elsevierpure.com)
Rats1
- A 14-day infusion of angiotensin II into F344 rats increased blood pressure by about 15 mm Hg without inducing fibrosis or albuminuria. (ed.ac.uk)
Inhibition2
- In the Akita mouse super model tiffany livingston, DPP4 inhibition induced natriuresis with linagliptin would depend on intact SDF-1 activity and it is abolished. (msi-sig.org)
- Simultaneous inhibition of MR and Ang II type 1 receptors ameliorated the enhanced ENaC activity caused by low dietary salt intake and produced significantly greater natriuresis than either inhibitor alone. (elsevierpure.com)
Angiotensin1
- Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)
Vasodilation1
- We conclude that pharmacologically inhibiting PGT-mediated prostaglandin metabolism lowers blood pressure, probably by prostaglandin-induced natriuresis and vasodilation. (elsevierpure.com)
Sodium4
- Acutely and chronically, lithium salts produce a natriuresis that is associated with an impaired regulation of the expression of the epithelial sodium channel in the cortical collecting tubule. (medscape.com)
- It appeared not to depend on the metabolic acidosis induced by the drug, since the simultaneous administration of sodium bicarbonate, which restored standard bicarbonate levels to normal, did not diminish the inhibitory effect of acetazolamide on EPO production. (uni-regensburg.de)
- Acute increases in BP induce natriuresis and diuresis, reflecting diminished tubular sodium reabsorption. (ed.ac.uk)
- Chronic systemic Ang II infusion induced more than 2 times greater increase in ENaC activity than observed during dietary sodium restriction. (elsevierpure.com)
Intake1
- While the 3 component model was limited in its ability to follow the BP response to rapid and/or brief transitions in salt intake, it was able to accurately follow the slower steady state components of salt-induced BP changes. (maynoothuniversity.ie)
Inhibits1
- Cooper RG, Osim E, Musabayane CT, Forsling ML, Balment RJ: Ethanol inhibits the chloroquine-induced natriuresis in the anaesthetised rat by increasing plasma aldosterone concentration. (jpccr.eu)
Hypertension2
- To better understand these components, the present study sought to model the dynamics of salt-induced hypertension in the Dahl salt sensitive (Dahl-S) rat using 3 sets of time course data. (maynoothuniversity.ie)
- These components are important to distinguish since each may represent a unique set of underlying mechanisms of salt-induced hypertension. (maynoothuniversity.ie)
Diets1
- As another functional index of the effect of aliskiren, we found significant natriuresis on both diets. (eur.nl)
Increase2
- Administration of low doses (25 mg) of DHEA positively modulates several endocrine parameters in early and late postmenopausal women, inducing the increase of the androgenic, estrogenic, and progestogenic milieu and reducing the climateric symptoms, similarly to estroprogestin replacement therapy. (cesupplement.com)
- 1 ) propose a further loop to the β-hydroxybutyrate hypothesis by recalling that atrial natriuretic peptide (ANP) induces an increase in lipid oxidation and a ketone response by virtue of its intrinsic lipolytic properties. (diabetesjournals.org)
Dose1
- This inhibitory effect of acetazolamide was dose dependent and correlated with the natriuresis induced. (uni-regensburg.de)
Effects1
- The effects were longer lasting and were associated with significant natriuresis. (eur.nl)
Response1
- Added successively to untreated vessels, increasing concentrations of Up4A (10,7,10,5 mol L,1) induced a biphasic response of contraction followed by relaxation. (academicconcepts.net)
Effect1
- Tsen and coworkers postulated that fs laser induced disease inactivation is definitely a nonthermal effect that results from impulsive stimulated Raman scattering (ISRS) driven breaking of non-covalent bonds in the disease6,10. (engineering-gdfsuez.com)
Found1
- A meta-analysis (27 trials, 1,843 patients with colorectal cancer) also found reductions in chemotherapy-induced nausea and vomiting (risk ratio = 0.65 [0.59-0.71], I(2) = 28%) following concurrent use of astragalus with chemotherapy compared with chemotherapy alone. (ascopost.com)
Plasma1
- Presumably, however, the segment of the BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial population with prevalent or incident heart failure would have had markedly elevated plasma ANP levels, which have been shown to retain the ability to induce the sequence lipolysis-ketogenesis-thrifty substrate supply to the heart (cited in ref. 1 ). (diabetesjournals.org)
Diuresis10
- When administered intravenously, urodilatin induces strong diuresis and natriuresis with tolerable hemodynamic side effects. (wikipedia.org)
- A message for the preprohormone is transcribed in the heart and kidneys from the gene of NP type A, resulting in a cGMP-dependent signal transduction, which induces diuresis and natriuresis, differentially processed to a peptide of 32 amino acids from the same precursor as renal ANP, may not be identical to the circulating cardiac hormone ANP. (wikipedia.org)
- The effect of metoclopramide and domperidone, two dopamine antagonists, administered to cirrhotic patients with ascites and secondary hyperaldosteronism, was examined to evaluate the changes in plasma aldosterone levels and in spironolactone-induced diuresis. (nih.gov)
- may be recommended to remove excess circulating urate in severe cases where diuresis cannot be induced with a loop diuretic and IV saline. (msdmanuals.com)
- 3. When volume expansion was induced in ten rats by infusion of equilibrated whole blood (28 ml/kg body weight) there was a brisk rise in systemic blood pressure, diuresis, natriuresis and kaliuresis. (portlandpress.com)
- Since phosphate reabsorption takes place largely in the proximal tubule, phosphaturia during bumetanide-induced diuresis is indicative of this additional action. (nih.gov)
- Source: Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Busslinger M, Dominguez Rieg JA, Rieg T. Caffeine-Induced Diuresis and Natriuresis Is Independent of Renal Tubular NHE3. (ispyphysiology.com)
- Increased excretion of urine (diuresis) and sodium (natriuresis), and decreased arterial blood pressure were observed in female dogs following intravenous (i.v.) injection of a single dose of 2.5 mg (0.014 mmol) luminol (duration of observation period was not specified). (nih.gov)
- In addition, while glucose induced diuresis does not appear to result in dehydration inside the vast majority of cases of FRG, the mild diuretic properties of dapagliflozin may need cautious monitoring to make sure ample fluid intake and warrants more investigation. (pdgfrinhibitors.com)
- Dehydration resulting from osmotic diuresis and natriuresis is one such condition that is mentioned in the FDA label warning and could particularly affect frail patients on diuretics, they note. (medscape.com)
Excretion6
- increase cardiac output and cardiac index , stroke work and volume , lower renovascular resistance, and lead to increased natriuresis (excretion of sodium in the urine ). (wikidoc.org)
- Among its other functions, this hormone has also been shown to promote sodium excretion into urine (natriuresis) via a direct action on the kidney itself. (ucc.ie)
- Extra data are needed to thoroughly elucidate the long run effects of glucose excretion induced by dapagliflozin. (pdgfrinhibitors.com)
- They explained that when blood pressure increases for any reason, renal perfusion pressure also increases thereby enhancing sodium and water excretion, which Guyton referred to as pressure-natriuresis. (heighpubs.org)
- Furthermore, a permissive modification of the pressure-natriuresis response has been predictably required to perpetuate a chronic elevation in intra-arterial pressure, whereby the equilibrium point for salt and water excretion is shifted to a higher level of arterial blood pressure [3]. (heighpubs.org)
- Methods: The effects of acute administration of glyburide (0.3 mg/kg), a prototype sulfonylurea, on ANP release and sodium excretion were measured in vivo in a canine model of pacing-induced acute heart failure characterized by acute atrial stretch. (elsevierpure.com)
Causes natriuresis2
- Urodilatin (URO) is a hormone that causes natriuresis by increasing renal blood flow. (wikipedia.org)
- Inhibition of Rho-kinase reduces renal Na-H exchanger activity and causes natriuresis in rat. (ncats.io)
Angiotensin II-induced2
- Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. (nih.gov)
- Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle. (ncats.io)
Systemic blood pressure1
- 8. Effect of isradipine on renal haemodynamics and systemic blood pressure changes induced by intravenous infusion of endothelin in healthy humans. (nih.gov)
Acute4
- Acute BP-lowering effects of sEH inhibition in I3C-induced rats was associated with a marked increase in renal epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids ratio and acute natriuresis. (nih.gov)
- And the possibility of SGLT-2 inhibitor-induced acute hypoxic kidney injury "should be thoroughly investigated and validated in humans," they add. (medscape.com)
- Conclusions: Glyburide delays release of ANP in acute heart failure resulting in impaired natriuresis. (elsevierpure.com)
- Myeloma-Induced Acute Kidney Injury: Medicine vs Machine Higher-tech or more aggressive treatment doesn't necessarily mean better, cautions Tejas Desai, MD, in his review of studies on treatment strategies for myeloma-induced acute kidney injury. (medscape.com)
Aldosterone1
- C carriers had higher diastolic blood pressures and aldosterone:renin and waist:hip ratios but lower furosemide-induced fractional excretions of Na and K than TT. (nih.gov)
Malignant hypertension1
- Many years later, Harry Goldblatt also induced malignant hypertension in dogs by obstructing one of the renal arteries [1]. (heighpubs.org)
Dehydration1
- Dry mouth is induced by dehydration of the oral mucosa, resulting from an imbalance of fluid supply and clearance within the oral cavity. (stanford.edu)
Receptor2
- This suggests that prorenin receptor is unlikely to play a role in lithium-induced urinary concentration defect. (inhn.org)
- The authors employ many state-of-the-art techniques to demonstrate that T1r receptors from Medaka fish bind chloride and that this binding induces a conformational change in the heteromeric receptor. (elifesciences.org)
Inhibitors1
- Renin Angiotensin System (RAS) inhibitors, vasodilators, and β-blockers work to facilitate pressure-natriuresis. (heighpubs.org)
Urinary1
- The observed improvement of urinary concentration in lithium-induced NDI likely indicates a direct effect of Aliskiren in the collecting ducts, in particular in the principal cells. (inhn.org)
Pressure4
- The aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients. (hindawi.com)
- Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity confers a pronounced and long-lasting blood pressure lowering effect in addition to significant weight loss. (coek.info)
- Roux-en-Y gastric bypass (RYGB) is superior in achieving blood pressure targets versus several intensified lifestyle modification approaches [5-7]. (coek.info)
- Stevia rebaudiana is a rich source of Stevioside, which suppresses high blood pressure by inducing vasorelaxation of the blood vessels. (herbconer.com)
Increases1
- Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus. (inhn.org)
Injury1
- Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. (ncats.io)
Direct1
Patients1
- To measure the plasma concentrations of ADM, ANP, and BNP and evaluate their prognostic value in uroseptic patients induced by URS, we measured the values of the three peptides in untreated patients with unilateral ureteral obstruction (UUO) secondary to ureteral stones and compared the results with those of healthy control subjects. (hindawi.com)
Expression1
- The purpose of their 2017 study was to investigate whether Aliskiren regulates AQP2 expression in the collecting duct principal cells and whether Aliskiren treatment attenuates lithium-induced nephrogenic diabetes insipidus (NDI). (inhn.org)
Volume1
- 16. Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids. (nih.gov)
Role1
- A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis. (ncats.io)