DifferentiationLeukemia cellsInhibitionCaspaseSecretionDysfunctionCytotoxicityShown to induceAntiproliferativeDrug-inducedBiologicalProliferationInhibitsInductionChemotherapy-inducedProgenitorGenesDopamine ReleaseMarkersPathwayLiverOxidative stressInhibitorsIC50MacrophageActivatorArsenicAutophagicStemApoptoticMetabolitesGene expressionSurvivalAutophagyProtective effectsCellularCharacterizationMacrophagesTriggersCytotoxicPathwaysProteinLesionsPancreaticEffectsMolecularRespiratoryEpithelial cellsAnticancerProteinsProgrammed cellFibroblastVitro and in vivoClinicalInfectionRats
Differentiation17
- MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells. (ac.rs)
- We investigated the mechanisms and the role of autophagy in the differentiation of HL-60 human acute myeloid leukemia cells induced by protein kinase C (PKC) activator phorbol myristate acetate (PMA). (ac.rs)
- PMA-triggered differentiation of HL-60 cells into macrophage-like cells was confirmed by cell-cycle arrest accompanied by elevated expression of macrophage markers CD11b, CD13, CD14, CD45, EGR1, CSF1R, and IL-8. (ac.rs)
- Pharmacological or genetic inhibition of ERK or JNK suppressed PMA-triggered nuclear translocation of TFEB and FOXO1/3, ATG expression, dissociation of pro-autophagic beclin-1 from its inhibitor BCL2, autophagy induction, and differentiation of HL-60 cells into macrophage-like cells. (ac.rs)
- Pharmacological or genetic inhibition of autophagy also blocked PMA-induced macrophage differentiation of HL-60 cells. (ac.rs)
- Therefore, MAP kinases ERK and JNK control PMA-induced macrophage differentiation of HL-60 leukemia cells through AMPK/mTORC1-independent, TFEB/FOXO-mediated transcriptional and beclin-1-dependent post-translational activation of autophagy. (ac.rs)
- Mandic M, Misirkic Marjanovic M, Vucicevic L, Jovanovic M, Bosnjak M, Perovic V, Ristic B, Ciric D, Harhaji-Trajkovic L, Trajkovic V. MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells. (ac.rs)
- Induction of differentiation rescues HL-60 cells from Rana catesbeiana ribonuclease-induced cell death. (eurogentec.com)
- We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
- We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
- Baicalein and baicalin are potent inhibitors of angiogenesis: inhibition of endothelial cell proliferation, migration and differentiation. (epnet.com)
- Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM). (fishersci.com)
- Other phenolic constituents such as phytic acid was shown to exhibit anticancer properties through the regulation of vital cellular functions such as signal transduction, cell proliferation and differentiation ( Vucenik and Shamsuddin, 2006 ). (scialert.net)
- In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells. (fishersci.com)
- Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
- A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
- Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Leukemia cells7
- However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
- In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
- 8-10 It inhibits nitric oxide production 11 and cyclooxygenases 1 and 2, 9 and induces apoptosis in HL-60 leukemia cells via caspase 3 activation. (ascopost.com)
- polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. (ascopost.com)
- Testosterone levels315, an integrin-linked kinase (ILK) inhibitor, provides been proven to suppress the growth of breasts cancers, abdomen chronic and tumor lymphocytic leukemia cells. (exposed-skin-care.net)
- In fact, A variety of polyphenolic extracts from acai pulp were shown to exhibit anticarcinogenic effects in an in vitro model with leukemia cells. (amazonthunder.com)
- Electric and magnetic noise blocks the 60 Hz magnetic field enhancement of steady state c-myc transcript levels in human leukemia cells med. (emf-portal.org)
Inhibition4
- It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
- A combination of pyrotinib and 5-FU resulted in the synergistic inhibition of the growth of the 5-FU-resistant SKBR-3/FU and MDA-MB-453/FU cell lines and the parental cell lines. (techscience.com)
- Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
- Dynorphin is the ligand for kappa receptors and is responsible for analgesic properties, and it can induce anxiety with its weak respiratory inhibition effects. (uspharmacist.com)
Caspase7
- In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
- Testosterone levels315 Induces Apoptosis, Caspase Account activation and (PARP) Cleavage in AML Cell Lines In purchase to determine if PARP cleavage and caspase account activation take place in Testosterone levels315-mediated cytotoxicity, HL-60 and THP-1 cells had been incubated with Testosterone levels315 at 0, 1, 2 or 3 mol/M for 24 l. (exposed-skin-care.net)
- Traditional western blotting demonstrated that Testosterone levels315 activated PARP cleavage and caspase-3 and caspase-7 account activation in HL-60 and THP-1 cell lines in a dose-dependent way (Body 3A). (exposed-skin-care.net)
- The time course of PARP caspase-3 and cleavage activation induced by T315 is shown in Rabbit Polyclonal to HEY2 Figure 3C. (exposed-skin-care.net)
- A) T315 induced poly-ADP-ribose polymerase (PARP) cleavage and activation of caspase-3 and caspase-7 in HL-60 and THP-1 cells at 24 h. (exposed-skin-care.net)
- Protein draw out of 20 g from … In order to further validate the caspase-3 activation induced by T315, Doramapimod HL-60 cells were incubated with T315 for 24 h with or without pretreatment of 50 mol/T Z-Val-Ala-Asp(OMe)-fluoromethyl ketone (Z-VAD(OMe)-FMK), a pan-caspase inhibitor (Physique 3D). (exposed-skin-care.net)
- Alperujo and hydroxytyrosol also exhibited notable antiproliferative and caspase 3-dependent proapoptotic effects toward the human tumoral cell line HL60. (bvsalud.org)
Secretion7
- Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
- Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)
- Acid secretion by gastric epithelial cells is related to the physiologic function of oxyntic cells, which are called parietal cells. (medscape.com)
- Parietal cells are responsible for the secretion of hydrochloric acid and also produce intrinsic factor. (medscape.com)
- In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
- Genetic ablation of a Na + /H + exchanger (NHE2), which is expressed in the stomach at high levels, leads to a decrease in gastric acid secretion, along with decreased viability of parietal cells, severe metaplasia, and hyperplasia of the gastric mucosa. (medscape.com)
- In addition, abnormal hormone secretion can alter parietal cell function. (medscape.com)
Dysfunction3
- Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. (epnet.com)
- Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
- In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies. (medscape.com)
Cytotoxicity3
- cell loss of life in Testosterone levels315-mediated cytotoxicity. (exposed-skin-care.net)
- This suggested that T315 induced cytotoxicity of AML cells through an ILK-independent manner. (exposed-skin-care.net)
- Hypodense eosinophils are activated cells with increased survival and an increased capacity for cytotoxicity, and their release of inflammatory mediators, such as leukotrienes, is increased. (medscape.com)
Shown to induce1
- Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
Antiproliferative1
- Green husk extract generates an antiproliferative effect in HL-60 cells, which is related to an induction of the early stages of apoptosis and a loss of mitochondrial membrane potential. (ejbiotechnology.info)
Drug-induced3
- The term drug-induced liver injury (DILI) may be used to mean clinically significant liver injury or all (including asymptomatic) liver injury. (msdmanuals.com)
- Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study. (msdmanuals.com)
- Pharmacovigilance of drug-induced rare diseases such as EMS are being monitored by the French Network of Regional Pharmacovigilance Centers. (medscape.com)
Biological3
- My lab studies the mechanism and regulation of immune checkpoints, using a combination of biophysical, cell biological and immunological approaches. (mpg.de)
- The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
- For example, comment on the shape of the dose- traversing, producing chemical and cobalt-60 -rays have an LET of response curve and the associated biological damage. (who.int)
Proliferation4
- Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
- Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
- In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
- We evaluated the influence of T315 on the manifestation of pThr173-ILK and total ILK, as well as proteins regulating cell proliferation and survival in AML cells (Physique 2). (exposed-skin-care.net)
Inhibits2
- Lee, Y.J. and Shacter, E. (1999) Oxidative stress inhibits apoptosis in human lymphoma cells. (scirp.org)
- 4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells. (fiocruz.br)
Induction3
- These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
- Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
- The generality of induction of Two major issues faced when city in humans is clear, but in other and response to radiation damage studying radiation carcinogenesis is cases the data are few or non-exist- is discussed for all types of ionizing that radiation-induced cancers are ent. (who.int)
Chemotherapy-induced3
- Weijl, N.I., Leton, F.J. and Osanto, S. (1997) Free radi- cals and antioxidants in chemotherapy-induced toxicity. (scirp.org)
- The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
- Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
Progenitor2
- Arsenic and fluoride induce neural progenitor cell apoptosis. (eurogentec.com)
- To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
Genes3
- PMA also increased nuclear translocation of autophagy transcription factors TFEB, FOXO1, and FOXO3, as well as the expression of several autophagy-related (ATG) genes in HL-60 cells. (ac.rs)
- These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
- explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
Dopamine Release1
- the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)
Markers2
- 2009) Concurrent decline of several antioxidants and markers of oxidative stress during combination chemotherapy for small cell lung cancer. (scirp.org)
- We performed high resolution time-lapse microscopy of mouse and human neutrophils (PMN) and differentiated HL60 neutrophil-like cells (dHL-60) labelled with fluorescent markers of the cytoskeleton and organelles and stimulated with ionomycin, lipopolysaccharides or C. albicans to induce NETosis. (mpg.de)
Pathway2
- High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
- This pathway should be particularly important during inflammation whereby oxidative/nitrosative burst generated by macrophages may cause direct nitrosylation or trans-nitrosylation of APT in target cells. (cdc.gov)
Liver2
- Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. (epnet.com)
- AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury. (msdmanuals.com)
Oxidative stress1
- The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
Inhibitors1
- Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H + /K + -ATPase activity can induce achlorhydria. (medscape.com)
IC502
- The IC50 of T315 for AML cells was significantly lower than the IC50 for normal marrow cells (= 0.003). (exposed-skin-care.net)
- Pyrotinib decreased significantly the IC50 values of 5-FU and the thymidylate synthase (TS) mRNA expression levels in the 5-FU-resistant SKBR-3/FU and MDA-MB-453/FU cell lines and the parental cell lines and increased significantly the intracellular concentration of 5-FU in SKBR-3/FU and MDA-MB-453/FU cells. (techscience.com)
Macrophage2
- We speculate that macrophage induced nitrosative stress contributes to effective clearance of apoptotic cells. (cdc.gov)
- Three cytokines, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), and interleukin 5 (IL-5) have been shown to promote the growth and the maturation of eosinophils and to induce the conversion of normal eosinophils to hypodense eosinophils. (medscape.com)
Activator1
- Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation. (go.jp)
Arsenic1
- Supporting the notion of noncanonical autophagy, we found that ATRA-induced autophagy was Beclin1-independent compared to starvation- or arsenic trioxide- (ATO-) induced autophagy. (hindawi.com)
Autophagic5
- This research displays that autophagic cell loss of life and apoptosis cooperatively contribute to the anticancer activity of Testosterone levels315 in AML cells. (exposed-skin-care.net)
- In bottom line, the contrasting jobs of apoptotic and autophagic cell loss of life should be considered in the future assessment of the translational value of T315 in AML therapy. (exposed-skin-care.net)
- T315 Induces Autophagic Cell Death in AML Cell Lines Autophagy is usually a physiological process in which cellular components are degraded by lysosomal activity. (exposed-skin-care.net)
- Either autophagic cytoprotection or autophagic cell death has been shown to be important for the antileukemic effect of different chemotherapeutic brokers [6]. (exposed-skin-care.net)
- Amount 4 Testosterone levels315 induce autophagic cell loss of life but not really defensive autophagy in AML cells. (exposed-skin-care.net)
Stem5
- The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
- Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
- We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
- The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
- The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
Apoptotic1
Metabolites1
- Furthermore, di-GA inhibited the generation of lymphendothelial gaps by cancer cell spheroid-secreted lipoxygenase metabolites. (nature.com)
Gene expression1
- In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Survival7
- Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)
- Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
- Furthermore, activation of autophagy allows to extend cell survival when exposed to different types of stressors such as starvation or cytotoxic drugs. (hindawi.com)
- While the importance of autophagy for cell homeostasis and survival has long been appreciated, its role in tumorigenesis and cancer progression is still developing [ 10 , 11 ]. (hindawi.com)
- This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
- Neurotrophic factors, including brain-derived neurotrophic factor (BDNF), are indispensable regulators for the survival of glial cells and neurons in the central nervous system (CNS) [ 13 ]. (degruyter.com)
- The cell survival rate was measured using the principle of water-soluble tetrazolium salt-1 assay, which is a measurement method for cell survival rate. (researchgate.net)
Autophagy1
- The ULK1 protein complex including ULK1, ATG13, and FIP200 coordinates the autophagy initiation from different upstream signaling pathways to induce autophagy [ 6 , 7 ]. (hindawi.com)
Protective effects1
- Despite high ORAC values, neither purified juglone nor the extract showed protective effects on HL-60 cells under oxidative conditions. (ejbiotechnology.info)
Cellular3
- Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
- Opioids have considerable effects on cellular function across many immune cell lineages, affecting both the innate and adaptive immune systems. (uspharmacist.com)
- This study is demonstrated using UVA-induced cellular aging model of human dermal fibroblast. (researchgate.net)
Characterization1
- There are currently no validated or widely accepted methods/models for the identification and characterization of chemicals that have the potential to induce allergic sensitization of the respiratory tract. (cdc.gov)
Macrophages1
- RAW 264.7 macrophages elicited enhanced phagocytizing activity towards "nitrosylated" HL-60 cells. (cdc.gov)
Triggers2
- Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells. (eurogentec.com)
- Synergism of Rana catesbeiana ribonuclease and IFN-γ triggers distinct death machineries in different human cancer cells. (eurogentec.com)
Cytotoxic1
- No cytotoxic effects were induced by either of the transnitrosating agents. (cdc.gov)
Pathways1
- In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
Protein5
- Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
- T315 Induces Down-Regulation of Protein Kinase W (Akt) and Phosphorylated Akt in AML Cell Lines T315 has been reported as an ILK inhibitor [2]. (exposed-skin-care.net)
- T315 treatment did not switch the protein manifestation of pThr173-ILK and total ILK in either HL-60 or THP-1 cells (Physique 2A). (exposed-skin-care.net)
- In addition, pyrotinib reduced the ABCG2 mRNA and protein expression levels in SKBR-3/FU and MDA-MB- 453/FU cells and downregulated the protein expression levels of pAKT, pHER2, and pHER4 in all four cell lines. (techscience.com)
- 13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
Lesions2
- Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
- The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
Pancreatic1
- Type 1 DM is caused by the autoimmune destruction of the pancreatic β-cells resulting in reduced insulin production ( 4 ). (spandidos-publications.com)
Effects6
- Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. (epnet.com)
- The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. (spandidos-publications.com)
- The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. (spandidos-publications.com)
- It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. (degruyter.com)
- Therefore, a better understanding of the mechanism underlying propofol-induced neurotoxicity is favorable for eliminating the side effects of propofol. (degruyter.com)
- The nature of ionizing these effects can vary significant- fects, including DNA damage, chro- radiation ly, depending on the resulting dose mosomal aberrations, mutations, cell distribution or distribution of radionu- transformation, and cell killing (NRC, Ionizing radiation is a term used for clides throughout the body. (who.int)
Molecular2
- In 1994, through application of broad range molecular cell signal transduction and possibly eukaryotic transcrip- amplification and DNA sequencing, the causative agent tion. (cdc.gov)
- The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
Respiratory1
- Chemicals known to cause allergic sensitization of the Some chemicals are able to induce various types of aller- respiratory tract resulting in occupational asthma include gic disease. (cdc.gov)
Epithelial cells1
- The gut barrier is made up of the mucus layer, gut microbiome, epithelial cells, and immune cells in the lamina propria. (medscape.com)
Anticancer1
- Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
Proteins5
- In this study we focused our attention on the behavior of four nuclear matrix proteins during the various stages of apoptosis in the HL-60 cell line exposed to the DNA topoisomerase I inhibitor, camptothecin. (nih.gov)
- Body 2 Testosterone levels315 induce dephosphorylation of proteins kinase T (Akt) without transformation of integrin-linked kinase (ILK) in AML cell lines. (exposed-skin-care.net)
- Cells (0.25 106 cells/mL) had been treated with T315 at the indicated focus or DMSO for 24 they would, and 20 g proteins … 2.3. (exposed-skin-care.net)
- Treatment with Testosterone levels315 for 24 l activated dose-dependent boosts in microtubule-associated proteins 1A/1B light stores 3B (LC3C)-II reflection in HL-60 and THP-1 cells (Amount 4A). (exposed-skin-care.net)
- In the older cells of aging animals, to take one example, researchers have found that one out of every three proteins is rendered dysfunctional by unchecked free radical damage. (lifeextension.com)
Programmed cell1
- This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
Fibroblast1
- under these conditions, normal fibroblast cells were not affected. (ejbiotechnology.info)
Vitro and in vivo1
- We hypothesized that the combination of pyrotinib and 5-FU would show synergistic antitumor activity, and pyrotinib could reverse 5-FU resistance in HER2+ breast cancer cells in vitro and in vivo. (techscience.com)
Clinical1
- Natural product library has been applied for drug development, therefore more than 60 percent of the clinical drugs are originated from natural compounds. (go.jp)
Infection2
- Following the infection of a cell, individual particles from some RNA viruses are capable of producing large numbers of extremely diverse progeny. (mpg.de)
- Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
Rats2
- In this study we examined the preventive properties of Rice Bran (RB) and germ on the incidence of azoxymethane induced colon tumorigenesis in Fisher 344 male rats. (scialert.net)
- 0.05) reduced the incidence of AOM induced colon tumors in Fisher 344 male rats. (scialert.net)