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  • capsule
  • The indomethacin controlled release formulations of the present invention comprise a capsule having coated pellets which exhibit both immediate release and sustained release characteristics in the same capsule. (google.com.au)
  • dose
  • After observing the response to initial therapy with Indomethacin, the dose and frequency should be adjusted to suit an individual patient's needs. (drugs.com)
  • headache
  • Paradoxically yet uncommonly, indometacin can cause headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision (with or without retinal damage). (wikipedia.org)
  • formulation
  • In accordance with the present invention, the controlled release formulation contains coated pellets of indomethacin of only one type. (google.com.au)
  • This invention relates to a novel oral pharmaceutical formulation of indomethacin having controlled release properties. (google.com.au)
  • The formulation provides an immediate release indomethacin for elevating blood levels to pharmacologically effective levels and sustained release indomethacin for maintaining those levels. (google.com.au)
  • effective
  • The sustained release indomethacin is gradually released over time to maintain the blood levels at effective concentrations for long periods of time. (google.com.au)
  • Patent
  • Indomethacin injection is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 500 and 1750 grams. (mayoclinic.org)
  • treatment
  • In one study after one week of treatment with orally administered indomethacin, this effect on basal cerebral blood flow had disappeared. (nih.gov)