• adverse
  • Almost all cases of CPH respond positively and effectively to indometacin, but as much as 25 percent of patients discontinued use of the drug due to adverse side effects, namely complications in the gastrointestinal tract. (wikipedia.org)
  • prostaglandins
  • Since indomethacin is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues. (nih.gov)
  • For instance, indometacin inhibits both cyclooxygenase-1 and cyclooxygenase-2, which then inhibits the production of prostaglandins in the stomach and intestines responsible for maintaining the mucous lining of the gastrointestinal tract. (wikipedia.org)
  • ulcer
  • The number of ulcer count was reduced to 0.1 ± 0.3 per rat in GSPEs treated group compared to 1.4 ± 0.5 per rat in indomethacin control group. (hindawi.com)
  • sodium
  • All NSAIDs, including indometacin, also increase plasma renin activity and aldosterone levels, and increase sodium and potassium retention. (wikipedia.org)
  • headache
  • Indomethacin/prochlorperazine/caffeine: a review of its use in the acute treatment of migraine and in the treatment of episodic tension-type headache. (uspharmacist.com)
  • Paradoxically yet uncommonly, indometacin can cause headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision (with or without retinal damage). (wikipedia.org)
  • effective
  • The sustained release indomethacin is gradually released over time to maintain the blood levels at effective concentrations for long periods of time. (google.com.au)
  • The formulation provides an immediate release indomethacin for elevating blood levels to pharmacologically effective levels and sustained release indomethacin for maintaining those levels. (google.com.au)
  • treatment
  • In one study after one week of treatment with orally administered indomethacin, this effect on basal cerebral blood flow had disappeared. (nih.gov)
  • reduce
  • We hypothesized that, by scavenging free radicals, GSPEs would relieve oxidative stress in the small intestinal mucosa and reduce the injury induced by indomethacin. (hindawi.com)