• biosynthesis
  • This enzyme catalyses the following chemical reaction indole + NAD(P)H + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } indolin-2-one + NAD(P)+ + H2O Indole-2-monooxygenase is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants. (wikipedia.org)
  • bacteria
  • But when it accompanies 200 ppm of indole (half of that haxane's bacteria-inhibiting dose), a mere 6. (thefreedictionary.com)
  • Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. (wikipedia.org)
  • Like many biochemical tests on bacteria, results of an indole test are indicated by a change in color following a reaction with an added reagent. (wikipedia.org)
  • Bacteria which give negative results for the indole test include: Actinobacillus spp. (wikipedia.org)
  • Syntheses
  • The proposal aims at addressing the collective syntheses of a series of bioactive indole alkaloids (strictamine, aspidophylline A and alsmaphorazine C) from a common intermediate. (thefreedictionary.com)
  • Other solid-phase indole syntheses were also reported, some of which use different scaffolds and metal catalysts to drive the reaction to completion. (wikipedia.org)
  • systematic name
  • Indole-2-monooxygenase (EC 1.14.13.137, BX2 (gene), CYP71C4 (gene)) is an enzyme with systematic name indole,NAD(P)H:oxygen oxidoreductase (2-hydroxylating). (wikipedia.org)
  • The systematic name of this enzyme class is (indol-3-yl)acetaldehyde:oxygen oxidoreductase. (wikipedia.org)
  • rightleftharpoons
  • In enzymology, an indole-3-acetaldehyde oxidase (EC 1.2.3.7) is an enzyme that catalyzes the chemical reaction (indol-3-yl)acetaldehyde + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } (indol-3-yl)acetate + H2O2 The 3 substrates of this enzyme are (indol-3-yl)acetaldehyde, H2O, and O2, whereas its two products are (indol-3-yl)acetate and H2O2. (wikipedia.org)
  • formula
  • The correct structural formula of strychnine was determined only in 1947, although the presence of the indole nucleus in the structure of strychnine was established somewhat earlier. (wikipedia.org)
  • Indole-3-butyric acid (1H-Indole-3-butanoic acid, IBA) is a white to light-yellow crystalline solid, with the molecular formula C12H13NO2. (wikipedia.org)
  • generate
  • Originally disclosed in a patent in 1976, this method is high-yielding and can generate substituted indoles. (lycaeum.org)
  • nucleus
  • They are produced by methylation of indole nucleus at position 3 and the subsequent nucleophilic addition at the carbon atom in positions 2 with the closure of the ethylamino group into a ring. (wikipedia.org)
  • cyclization
  • Cyclization and tautomerization give intermediate 10, which will react with a third equivalent of the Grignard reagent (2) to give a dimagnesium indole salt (12). (wikipedia.org)
  • The reaction can begin with either an ortho-isocyanostyrene or a 2-alkenylthioanilide derivative, both forming the indole through Radical cyclization via an α-stannoimidoyl radical. (wikipedia.org)
  • methyl
  • A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a 1 H -indol-3-yl group. (ebi.ac.uk)
  • reacts
  • The para-Dimethylaminobenzaldehyde reacts with indole present in the medium to form a red rosindole dye. (wikipedia.org)
  • Pathways
  • Kundu A et al demonstrated that the anticancer property of Indole-3-carbinol is driven by specific targeting of oncogenic pathways. (wikipedia.org)
  • Overall scientific evidence shows that in melanoma, Indole-3-carbinol specifically inhibits the two most commonly associated driver mutation signaling pathways to cause antiproliferation, a fact that can be used to design clinical trial to treat human patients with Indole-3-carbinol in future. (wikipedia.org)
  • carcinogens
  • Controlled studies have been performed on such animals as rats, mice, and rainbow trout, introducing various controlled levels of carcinogens, and levels of Indole-3-carbinol into their daily diet. (wikipedia.org)
  • Antioxidant
  • Indole-3-carbinol is the subject of on-going biomedical research into its possible anticarcinogenic, antioxidant, and anti-atherogenic effects. (wikipedia.org)
  • known
  • In female rats, they discovered that a specific indole , known as indole -3-carbinol, significantly boosted the rate at which an enzyme converted a form of estrogen to 2-hydroxyestrone, an inactive version that doesn't trigger mammary tumor growth. (thefreedictionary.com)
  • The action of some indole alkaloids has been known for ages. (wikipedia.org)
  • Some 200 dimeric indole alkaloids are known with two indole groups. (wikipedia.org)
  • The number of known non-isoprenoid indole alkaloids is small compared to the number of indole alkaloids. (wikipedia.org)
  • Indole-3-propionic acid (IPA)] has previously been identified in the plasma and cerebrospinal fluid of humans, but its functions are not known. (wikipedia.org)
  • give
  • Notably, sprouts of many broccoli cultivars contain negligible quantities of indole glucosinolates, which predominate in the mature vegetable and may give rise to degradation products (e. (thefreedictionary.com)
  • The 3-position thiomethyl group is often removed using Raney nickel to give the 3-H-indole. (wikipedia.org)
  • If desired, 4 can be decarboxylated with heat to give indole 5. (wikipedia.org)