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  • biosynthesis
  • This enzyme catalyses the following chemical reaction indole + NAD(P)H + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } indolin-2-one + NAD(P)+ + H2O Indole-2-monooxygenase is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants. (wikipedia.org)
  • pathways
  • Kundu A et al demonstrated that the anticancer property of Indole-3-carbinol is driven by specific targeting of oncogenic pathways. (wikipedia.org)
  • Overall scientific evidence shows that in melanoma, Indole-3-carbinol specifically inhibits the two most commonly associated driver mutation signaling pathways to cause antiproliferation, a fact that can be used to design clinical trial to treat human patients with Indole-3-carbinol in future. (wikipedia.org)
  • pyrrole
  • Unlike most amines, indole is not basic: just like pyrrole, the aromatic character of the ring means that the lone pair of electrons on the nitrogen atom is not available for protonation. (wikipedia.org)
  • Notably
  • Notably, sprouts of many broccoli cultivars contain negligible quantities of indole glucosinolates, which predominate in the mature vegetable and may give rise to degradation products (e. (thefreedictionary.com)
  • cruciferous
  • Indole-3-carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. (wikipedia.org)
  • A recent review of the biomedical research literature found that "evidence of an inverse association between cruciferous vegetable intake and breast or prostate cancer in humans is limited and inconsistent" and "larger randomized controlled trials are needed" to determine if supplemental indole-3-carbinol has health benefits. (wikipedia.org)
  • bacteria
  • Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. (wikipedia.org)
  • Like many biochemical tests on bacteria, results of an indole test are indicated by a change in color following a reaction with an added reagent. (wikipedia.org)
  • Bacteria which give negative results for the indole test include: Actinobacillus spp. (wikipedia.org)
  • But when it accompanies 200 ppm of indole (half of that haxane's bacteria-inhibiting dose), a mere 6. (thefreedictionary.com)
  • systematic name
  • Indole-2-monooxygenase (EC 1.14.13.137, BX2 (gene), CYP71C4 (gene)) is an enzyme with systematic name indole,NAD(P)H:oxygen oxidoreductase (2-hydroxylating). (wikipedia.org)
  • The systematic name of this enzyme class is (indol-3-yl)acetaldehyde:oxygen oxidoreductase. (wikipedia.org)
  • rightleftharpoons
  • In enzymology, an indole-3-acetaldehyde oxidase (EC 1.2.3.7) is an enzyme that catalyzes the chemical reaction (indol-3-yl)acetaldehyde + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } (indol-3-yl)acetate + H2O2 The 3 substrates of this enzyme are (indol-3-yl)acetaldehyde, H2O, and O2, whereas its two products are (indol-3-yl)acetate and H2O2. (wikipedia.org)
  • formula
  • The correct structural formula of strychnine was determined only in 1947, although the presence of the indole nucleus in the structure of strychnine was established somewhat earlier. (wikipedia.org)
  • Indole-3-butyric acid (1H-Indole-3-butanoic acid, IBA) is a white to light-yellow crystalline solid, with the molecular formula C12H13NO2. (wikipedia.org)
  • cyclization
  • Cyclization and tautomerization give intermediate 10, which will react with a third equivalent of the Grignard reagent (2) to give a dimagnesium indole salt (12). (wikipedia.org)
  • methyl
  • A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a 1 H -indol-3-yl group. (ebi.ac.uk)
  • reacts
  • The para-Dimethylaminobenzaldehyde reacts with indole present in the medium to form a red rosindole dye. (wikipedia.org)
  • carcinogens
  • Controlled studies have been performed on such animals as rats, mice, and rainbow trout, introducing various controlled levels of carcinogens, and levels of Indole-3-carbinol into their daily diet. (wikipedia.org)
  • undergo
  • Other precursors to indole include formyltoluidine, 2-ethylaniline, and 2-(2-nitrophenyl)ethanol, all of which undergo cyclizations. (wikipedia.org)
  • generate
  • citation needed] Originally disclosed in a patent in 1976, this method is high-yielding and can generate substituted indoles. (wikipedia.org)
  • known
  • Indole-3-propionic acid (IPA)] has previously been identified in the plasma and cerebrospinal fluid of humans, but its functions are not known. (wikipedia.org)
  • In female rats, they discovered that a specific indole , known as indole -3-carbinol, significantly boosted the rate at which an enzyme converted a form of estrogen to 2-hydroxyestrone, an inactive version that doesn't trigger mammary tumor growth. (thefreedictionary.com)