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Total synthesis of strychnineWoodwardResearchers
Total synthesis of strychnine4
  • The first total synthesis of strychnine was reported by the research group of R. B. Woodward in 1954, and is considered a classic in this field. (wikipedia.org)
  • Woodward succeeded in the total synthesis of (-)-strychnine in 1954, but there were no other reports of the total synthesis of strychnine for about 40 years. (heterocycles.jp)
  • In 1992, Magnus succeeded in the total synthesis of (-)-strychnine and then due to the dramatic progress of synthetic organic chemistry and organometallic chemistry, many researchers tried to synthesize (±)- and (-)-strychnine by their original methods. (heterocycles.jp)
  • Modifying this method, the total synthesis of (-)-strychnine was achieved. (heterocycles.jp)
Woodward2
  • An early synthetic chemist targeting strychnine, R.B. Woodward, quoted the chemist who determined its structure through chemical decomposition and related physical studies as saying that "for its molecular size it is the most complex organic substance known" (attributed to Sir Robert Robinson). (wikipedia.org)
  • The Woodward account published in 1954 was very brief (3 pp.), but was followed by a 42-page report in 1963. (wikipedia.org)
Researchers1
  • As early researchers noted, the strychnine molecular structure, with its specific array of rings, stereocenters, and nitrogen functional groups, is a complex synthetic target, and has stimulated interest for that reason and for interest in the structure-activity relationships underlying its pharmacologic activities. (wikipedia.org)