• gene
  • A major advance was the discovery that 1 in 4 patients with familial DCM carry truncating variants in the TTN gene that encodes the giant sarcomeric protein, titin. (renalandurologynews.com)
  • Analysis of genotypes at 26 microsatellite loci in 1015 individuals from across the range of the three species showed substantial introgression between geographically proximal populations of H. annuus and H. petiolaris, limited introgression between H. annuus and H. argophyllus, and essentially no gene flow between the allopatric pair, H. argophyllus and H. petiolaris. (academicconcepts.net)
  • Background We have identified the cardiomyopathy‚Äźsusceptibility gene vinculin ( VCL ) mutation M94I may account for a sudden unexplained nocturnal death syndrome ( SUNDS ) case. (ahajournals.org)
  • left
  • Additionally, the early transient idiopathic left ventricular hypertrophy in the SS-16 BN /Mcwi may be related to altered myocyte sensitivity to growth factors. (physiology.org)
  • Our previous characterization of this model indicated that despite early transient idiopathic LVH, aging SS-16 BN /Mcwi rats did not experience the impaired left ventricle function or pathological tissue remodeling characteristic of the SS/Mcwi parental strain. (physiology.org)
  • likely
  • The incidence of DCM is likely higher than originally reported due to subclinical phenotypes and underdiagnosis, with recent estimates suggesting that DCM affects approximately 1 in every 250 people. (mayomedicallaboratories.com)