by building up artificial retinal cell interfaces using stimulation devices and by tuning the biocompatibility of the stimulation electrodes and their surface interactions with neurons, we proposed to fabricate microelectrodes and microelectrode arrays (MEAs) as well as ion sensitive field effect transistors (ISFETs) for medical applications in vivo. (europa.eu)
Using electrochemistry, we are able to synthesize individually addressable molecular surfaces on microelectrode arrays and then utilize the surface to probe interactions between receptors and their biological targets. (wustl.edu)
Therefore, it is extremely important to develop methods that allow us to calibrate the signals produced and recorded on the microelectrode arrays and optimize those signals in a reproducible way. (wustl.edu)
found that electrical activity can be recorded extracellularly with microelectrode arrays (MEA). (multichannelsystems.com)
However, electrode arrays with many contacts that are individually wired to external recording systems are cumbersome and make recordings in freely behaving rodents challenging. (duke.edu)
The trend in neural recording interfaces toward employing high-channel-count probes or 2D microelectrodes arrays with densely spaced recording sites for recording large neuronal populations makes it harder to save on resources. (csic.es)
Here, we demonstrate how porous Pt-black electrodes, arranged in high-density microelectrode arrays, can be used to record intracellular-like signals of cardiomyocytes at large-scale repeatedly over an extended period of time. (mxwbio.com)
Our approach involves the use of multiple microelectrodes arranged in compact arrays and moved simultaneously parallel to the cortical laminas. (jneurosci.org)
To evaluate the effect of HDBS in PAG/DRN on the nociceptive pathways related to pain perception, microelectrode recordings were made in cortical areas known to be involved in the sensory-discriminative and affective aspects of pain. (lu.se)
Performance comparisons were made using microelectrode recordings from rat cortex and subdural/depth recordings from epileptic patients. (dovepress.com)
However, few studies have systematically investigated chronic neural recordings from an implanted microelectrode array in the human brain. (biomedcentral.com)
Thoracic ducts were harvested from 43 patients and mounted in a wire myograph for isometric force measurements or membrane potential recordings with an intracellular microelectrode. (limkinase-signal.com)
Neurons3
Another approach to recording from individual neurons for many months uses slowly inserted microwires, inserted individually or in small groups in various locations around the brain. (scholarpedia.org)
Using microelectrodes, the team measured the responses of 104 different neurons in the monkeys' inferotemporal (IT) visual cortex, a brain region important for visual recognition. (mit.edu)
As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. (lidsen.com)
Electrophysiological1
These columns have been investigated extensively by electrophysiological recording of neuronal responses along individual microelectrode penetrations. (jneurosci.org)
Responses3
The selected microelectrode combinations also reduced nociceptive-evoked cortical responses (related to both discriminative and affective pain) in normal conditions and during hyperalgesia. (lu.se)
But this change obeys a remarkably systematic rule: The neuron's response to two objects together is the average of its responses to each item separately -- halfway between the responses elicited by a key and wallet individually. (mit.edu)
Electrical stimulation of the inferior colliculus with microelectrodes can trigger specific orienting responses. (romainbrette.fr)
Neural2
Neuroscience research into how complex brain functions are implemented at an extra-cellular level requires in vivo neural recording interfaces, including microelectrodes and read-out circuitry, with increased observability and spatial resolution. (csic.es)
In this study, we show the applicability of wavelet decomposition method to extract and demonstrate the utility of long-term stable features in neural signals obtained from a microelectrode array implanted in the motor cortex of a human with tetraplegia. (biomedcentral.com)
Activate2
Then NCD neuro-compatible interfaces will be fabricated and tested in vitro for their ability to activate neurones that will be recorded individually with the patch clamp technique. (europa.eu)
The main aim was to elucidate whether stimulation of individually selected microelectrodes can selectively activate the anti-nociceptive pathways without activating networks that provoke side effects. (lu.se)
To address this challenge, we developed and implanted in rodents, a novel probe for high-definition brain stimulation (HDBS) based on the spread in 3D of ultra-flexible microelectrodes in PAG/DRN. (lu.se)
The probe comprised 16 ultra-flexible microelectrodes embedded in a gelatine needle-like probe. (lu.se)
Approach1
An approach that allowed for individually tuned classifier topologies was opted for. (biomedcentral.com)