Individual complex mixtures. Medical search. Frequent questions

We conclude that this analytical platform is effective for the characterization of complex bioactive samples. (hindawi.com)
The use of GC×GC for the characterization of complex petrochemical mixtures has been extensively reviewed. (wikipedia.org)
Straight-forward mass characterization of the complex mixtures could be achieved. (degruyter.com)
My research is focussed upon the characterization of complex mixtures using ultrahigh resolution mass spectrometry. (warwick.ac.uk)
Through the molecular characterization of complex mixtures, containing tens of thousands of components, profiles can be established for individual samples, serving as fingerprints. (warwick.ac.uk)

PAHs generally occur as complex mixtures (for example, as part of combustion products such as soot), not as single compounds. (cdc.gov)
It is very difficult to identify and measure the small quantities of specific PAHs in such complex mixtures. (cdc.gov)
Dr Bingham contributed to the IARC Monographs programme her own substantial expertise on the carcinogenic hazards posed by complex mixtures of PAHs, serving on two seminal Monograph Working Groups. (who.int)

Although DNA-based tests are desirable for identifying particular classes of organisms such as pathogens within these complex mixtures, they are limited in the ability to detect specific DNA sequences of targeted organisms. (genomeweb.com)
This particular algorithm challenge focuses on using DNA sequence data in identifying pathogens in complex mixtures from clinical samples. (prweb.com)

Having established this method, equimolar mixtures of Cel5A and Cel6B were applied to the cellulose substrates and binding was observed. (cornell.edu)
The aim of our work was the study of the interaction of three red wine polyphenols-quercetin, resveratrol and caffeic acid-alone and in their equimolar binary and ternary mixtures in different antioxidant/scavenging assays (inhibition of 2-deoxy-D-ribose degradation by hydroxyl radical, FRAP, Fe(III) reducing power, DPPH, ABTS and NO scavenging, respectively). (mdpi.com)

Commercial flavorings used in the flavoring manufacturing and food production industries are often complex mixtures of flavoring chemicals, many of which are volatile, meaning that they evaporate into the air from their liquid or solid form. (cdc.gov)
Even though flavorings exposures often involve multiple chemicals, diacetyl may serve as a marker or surrogate for mixed exposures to some hazardous flavorings, as it has been an ingredient in butter flavorings mixtures where disease has been observed. (cdc.gov)
These chemicals have been classified by the Endocrine Society as endocrine-disrupting chemicals (EDCs), and defined as "any exogenous chemical, or mixture of chemicals, that interferes with any aspect of hormone action. (huffpost.com)
Gasoline contains hundreds of individual organic chemicals. (edocr.com)
1 However, despite the public health significance of these toxicant exposures, comparatively little effort has been spent to assess and quantify the health risks associated with the individual chemicals in cigarette smoke, and almost nothing has been done in terms of product regulation to reduce human exposure to these constituents. (bmj.com)
In 1969, the International Agency for Research on Cancer (IARC) initiated a programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individual chemicals. (who.int)
The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and of exposures to other agents, such as radiation and viruses. (who.int)

Individual components could be observed as protonated molecular ions [M+Na] + and/or as their K + adducts in positive mode. (degruyter.com)
Semi-specific recognition, in which a molecular class rather than individual species is selected, provides an efficient solution for the uptake of complex mixtures. (rcsb.org)
Moreover, we apply the techniques we developed for identifying individual molecular structures in complex molecular mixtures. (falling-walls.com)
As we move into a new era of lipid analysis, the potential to accurately and rapidly measure hundreds of individual molecular species provides the opportunity to use more complex lipid profiles for drug discovery and disease diagnostics. (chromatographyonline.com)

It has been shown that both resolved and unresolved components of oils are subject to concurrent biodegradation, i.e. it is not a sequential process, but due to the recalcitrant nature of some components, the rates of biodegradation of individual compounds greatly varies. (wikipedia.org)
A degree of isolation/separation must be achieved to quantify individual compounds from asphalt fumes. (cdc.gov)
The volatile profiles among commercial strawberry varieties are complex and distinct, but a list of perceptually impactful compounds from the larger mixture is better defined. (who.int)
Further analysis identifies individual volatile compounds that have an enhancing effect on perceived sweetness intensity of fruit independent of sugar content. (who.int)

We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. (nature.com)
Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. (nature.com)
Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)
Based on the presence of glutamine or arginine residues in the zero layer, the SNAREs are classified as Qa- (Syntaxin-1), Qb- and Qc- (SNAP25) or R-SNAREs (Synaptobrevin-2) resulting in the formation of the ternary QabcR (3Q:1R) SNARE complex 8 . (nature.com)

Cell culture media range from simple components to complex chemically defined mixtures. (bioprocessintl.com)

One of the main advantages is the very high separation power, making the technique ideal for unravelling the composition of complex mixtures. (wikipedia.org)
Ever since I first got involved with chromatography - the separation of a mixture of substances - in my second semester, I knew: this is what I want to do. (basf.com)
For example, the first successful separation of a substance from a complex mixture is an overwhelming moment. (basf.com)

Exposures to mixtures of agents may occur in occupational exposures and as a result of personal and cultural habits (like smoking and dietary practices). (who.int)

In a study of the potential for UCM-dominated oil to be further degraded, it was concluded that even using bacteria specifically adapted for complex UCM hydrocarbons in conjunction with nutrient enrichment, biodegradation rates would still be relatively slow. (wikipedia.org)
Bacterial degradation of hydrocarbons is complex and will depend on environmental conditions (e.g. aerobic or anaerobic, temperature, nutrient availability, available species of bacteria etc. (wikipedia.org)
This chapter addresses questions related to the first point: what are the levels of contamination in the environment, what happens to petroleum hydrocarbons in the environment, and what is the likelihood that individuals or populations will be exposed to petroleum hydrocarbons at levels thought to be of concern? (cdc.gov)
Gasoline is a complex mixture of hydrocarbons. (edocr.com)

however, interpreting sequence data from complex mixtures of viruses at a population-level remains challenging ( 11 ). (cdc.gov)

Emissions statistics are usually lacking for TPH or most TPH fractions since there is no record keeping associated with smaller internal combustion engines used in cars and trucks or fuel oil boilers for individual buildings or homes. (cdc.gov)
however, not as the mixtures found in combustion products. (cdc.gov)

Using this technique, we observed the emergence of the B.1.351 (Beta) variant in Linn County, Oregon, USA, in wastewater 12 days before this variant was identified in individual clinical specimens. (cdc.gov)
The Algorithm Challenge was an open competition with a $1 million prize for the individual or team that developed an algorithm which can most rapidly and accurately characterize a complex clinical sample based solely on raw DNA sequence data. (prweb.com)
It is a complex mixture of system and human factors with elements of poor clinical decision making. (bmj.com)

Surprisingly, telomerase reconstitutions yielded heterogeneous DNA-bound TERT monomer and dimer complexes in relative amounts that varied with assembly and purification method. (elifesciences.org)
[ 2 ] In addition, individuals who spend significant amounts of time near major roadways or in traffic may be at considerably increased risk of long-term exposure. (medscape.com)

Another advantage of tandem MS is its ability to quantify individual lipid species. (premierbiosoft.com)

By leveraging these sequence learning techniques, we introduce a state transition model (STM) that is able to learn a variety of complex motion sequences in joint position space. (arxiv.org)
While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. (nature.com)

Inhalation of butter flavoring chemical mixtures, including diacetyl, has been associated with severe obstructive lung disease popularly know as "popcorn lung. (cdc.gov)
His curiosity led him to pursue a doctorate in chromatography, a chemical analysis method used to separate and precisely determine the individual components of mixtures of substances. (basf.com)
They may contain a number of chemical components, each with individual chemical properties - and any variation in which ingredients can affect cell culture processes and biological products being manufactured. (bioprocessintl.com)
Using a home-built atomic force microscope (AFM), functionalized a with single CO molecule at its tip, operated at 5 Kelvin, we can not only see individual chemical bonds in a molecule but even form and break them. (falling-walls.com)
Information on the chemical and toxicological properties of individual ergot alkaloids is too limited at the present time for their selection as individual marker toxins when it comes to monitoring the extent of contamination. (thebeefsite.com)

Microorganisms in the environment are typically in complex mixtures of hundreds or more individual species. (genomeweb.com)
To address this challenge, tandem MS (MS/MS) has been developed that allows for the identification of individual lipid species based on their characteristic fragment ions. (premierbiosoft.com)
This is particularly important in the analysis of complex lipid mixtures, where the abundance of different lipid species can vary significantly. (premierbiosoft.com)
By quantifying individual lipid species, researchers can gain insight into the regulation of lipid metabolism in various biological systems. (premierbiosoft.com)

the sucrose fatty acid esters are mixture of two types of nonionic surfactants: sucrose palmitates and sucrose stearates. (degruyter.com)

Sabouraud Dextrose Agar (SDX, SDA) is a complex medium for cultivation and isolation of a wide range of yeasts and molds. (sigmaaldrich.com)

The citrate and tartrate complexes of antimony are soluble and reasonable stable in solution. (sciencemadness.org)
To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)

Complex biological samples have also been successfully separated in multiple dimensions at the protein level. (hindawi.com)
While modern proteomics experiments permit the analysis of hundreds to thousands of proteins in complex samples, the most powerful use of this data would combine information on protein activity with the identities of the active proteins. (hindawi.com)
Within an individual protein there may be a number of cysteines which could allow for multiple thiol modifications. (hindawi.com)
The end product of protein digestion is a complex mixture of primarily dipeptides and tripeptides, along with individual amino acids [ 14 ]. (springer.com)
The analysis of protein hydrolysates using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) can be complex. (springer.com)
The center of telomerase has a protein called TERT that forms complexes with other proteins. (elifesciences.org)
However, it is not known how many copies of the TERT protein are present in each complex. (elifesciences.org)
Further experiments used a mutant form of the TERT protein that cannot interact with other TERT molecules and found that complexes that contain this mutant protein still have normal enzyme activity. (elifesciences.org)
The SNARE complex assembles from the vesicular protein Synaptobrevin-2 as well as SNAP25 (synaptosome-associated protein of 25 kDa) and Syntaxin-1, which are both anchored to the presynaptic membrane 2 . (nature.com)

Our method allows for the identification of the proteins, identification of redox-sensitive cysteines within proteins, and quantification of the redox status of individual cysteine-containing peptides. (hindawi.com)
In proteins where cysteine is not within the active site, activity can be modulated by changing conformation or by influencing its regulatory role, for example, iron sulfur complexes (ISCs) in aconitase possess cysteines required for its activity [ 7 ]. (hindawi.com)
Redox proteomics has taken advantage of the thiol specificity of ICAT reagents not only to identify targets of ROS but also to quantify oxidative thiol modifications in individual proteins. (hindawi.com)
However, many enzymes can bind to different combinations of proteins to form groups (or 'complexes') with a variety of three-dimensional shapes, so there may be a variety of enzyme complexes in the solution. (elifesciences.org)
The experiments show that these complexes can contain either one or two TERT proteins. (elifesciences.org)

In this study, we describe new approaches of subunit labeling for single-molecule imaging, applied to determine the TERT content of complexes assembled in cells or cell extract. (elifesciences.org)
Triacylglycerols (TAGs) are complex lipids that consist of three fatty acid molecules esterified to a glycerol molecule. (premierbiosoft.com)
Phospholipids are complex lipids that contain a phosphate group, a glycerol molecule, and two fatty acid molecules. (premierbiosoft.com)

A fragrance is usually composed of a mixture of many different scented substances. (innovations-report.com)
Each of these individual substances can react with several of the approximately 347 scent receptors in our nose and show a complex scent. (innovations-report.com)
Although simple substances can be identified easily using well-known classical methods such as Fourier-transform infrared spectroscopy (FTIR), analysis becomes more challenging when dealing with complex mixtures. (bioprocessintl.com)
These selected substances bind ergot alkaloids in the gastrointestinal tract, reduce their bioavailability and increase their excretion as an adsorbent-toxin complex, thus helping control the negative impacts of these mycotoxins. (thebeefsite.com)

It was found that the composition of the collagen hydrolysates prior to and after ingestion was highly complex and dynamic, which made it challenging to predefine a strategy for a targeted analysis. (springer.com)

He added that nearly 3,000 individual researchers across the globe submitted algorithm solutions. (prweb.com)
Lund University researchers find that individual blood stem cells (depicted as snowflakes in this image) express stress-related transcripts when subjected to experimental procedures involving cell incubation at elevated temperatures. (lu.se)

Unresolved complex mixture (UCM), or hump, is a feature frequently observed in gas chromatographic (GC) data of crude oils and extracts from organisms exposed to oil. (wikipedia.org)
Identifying novel enzymes from the organisms that can be incorporated into synergistic mixtures will allow for greater diversity in biomass feedstocks and greater efficiency in conversion. (cornell.edu)

Mass spectrometry (MS) is a powerful analytical technique that can be used to identify and characterize lipids in complex biological samples. (premierbiosoft.com)

Using native mass spectrometry, we identify the stoichiometry of sub-complexes and monitor oligomerisation of various assemblies. (nature.com)

Welders, firefighters, military and aerospace personnel, individuals working with explosives, traffic personnel, and farmers generally have higher risk of short-term exposure than those in other occupations. (medscape.com)

In many symptomatic individuals exposed to flavoring who have undergone lung biopsy, an irreversible type of lung damage called constrictive bronchiolitis has been found. (cdc.gov)

Our approach enables the robot to accomplish complex behaviors from high-level instructions that would require laborious hand-engineered sequencing of trajectories with traditional motion planners. (arxiv.org)
Cellulase binding and synergistic behaviors on simple and complex cellulose structures can be studied using advanced imaging techniques with high temporal and spatial resolution. (cornell.edu)

Even in monozygotic twins, a benchmark for assessing genetic risk complex in non-Mendelian disease, scientists have found only about 15 percent of breast cancers can be attributed to genetics, 25 to 45 percent for diabetes, 50 percent for schizophrenia, and 30 percent for bipolar disorder. (huffpost.com)
In this respect, 2′-fucosyllactose (2′-FL) is the major short chain HMO found in the milk of secretor (FUT2)-positive women, accounting for more than 30% of the total HMOs mixture ( 5 ). (frontiersin.org)
This is important because lipids are often found in complex mixtures, such as biological fluids and tissues. (premierbiosoft.com)

Analysis of the hydrocarbon fraction of crude oils by GC reveals a complex mixture containing many thousands of individual components. (wikipedia.org)
Methods for UV filter analysis followed the principles of European standardized methods for pesticide residue analysis (EN 15289). (researchgate.net)

Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. (arxiv.org)
Analyzing these data in terms of measured individual and group characteristics is a complex, multidimensional problem. (cdc.gov)
To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium. (bvsalud.org)

Inside, the samples are split into their individual components. (basf.com)
By separating individual components, we generate valuable information about their properties and interactions. (basf.com)
The determination of the water solubility according to EU Method A.6 and OECD Guideline 105 was not successful due to the fact that L-threonine mother liquor has a complex compostion with individual water solubilities of the separate components. (europa.eu)

The determination of the partition coefficient is not applicable for complex mixtures (UVCB-substance). (europa.eu)

In 1990, she chaired the Working Group for Volume 53, which evaluated the carcinogenicity of occupational pesticide spraying and 17 individual pesticides. (who.int)

In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1. (nature.com)

Simply putting it, chemistry is incredibly complex. (basf.com)

From the extrapolated results of those narrowly focused analyses, we sought to understand more than we could reasonably expect to know: the multifaceted mechanisms of action and the effects of drugs, the causes of complex diseases and the intricate biological alterations associated with those diseases. (chromatographyonline.com)

In addition, laboratory studies document that diacetyl has toxic properties as a single component that parallel the effects of exposure to a butter flavoring mixture. (cdc.gov)
Additionally, individuals living in particular urban areas or near congested highways may have increased risk of long-term low-level exposure. (medscape.com)

It involves custom-designed hardware with complex algorithms and software. (southampton.ac.uk)

Communal considerations and individual musings combine, suggesting the idea of a complex society. (galerievoss.de)

Corporations, in Ecuador, are the most flexible form of entity, allowing a mixture of foreign and local capital. (escapeartist.com)

Human milk oligosaccharides are unconjugated complex glycans present in high concentration in human milk that serve as pre-biotics and immunomodulators. (frontiersin.org)

The movement of raw petroleum to automobile fuel tanks or fuel oil boilers is part of a complex bulk product distribution and storage system, providing many opportunities for accidents, spills, leaks, and losses from simple volatilization. (cdc.gov)

Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers. (mdpi.com)

Anatomy6

Organisms4

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology1

Phenomena and Processes29

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science6

Health Care16

Characterization5

PAHs3

Pathogens2

Equimolar2

Chemicals7

Molecular4

Compounds4

Ternary4

Chemically1

Separation3

Exposures1

Hydrocarbons4

Viruses1

Combustion2

Clinical3

Amounts2

Quantify individual1

Sequence2

Chemical5

Species4

Esters1

Isolation1

Soluble2

Protein9

Proteins5

Molecule3

Substances4

Composition1

Researchers2

Organisms2

Characterize1

Mass1

Occupations1

Symptomatic1

Behaviors2

Found3

Analysis2

Data3

Components3

Substance1

Occupational1

Regulation1

Chemistry1

Diseases1

Exposure2

Involves1

Considerations1

Form1

Present1

System1

Feature1