• ischemia-reperfusion group
  • In the ischemia-reperfusion group, testicular detorsion was performed after 2 hours of left testicular torsion. (hindawi.com)
  • In the probucol-treated group, after performing the same surgical procedures as in the ischemia-reperfusion group, probucol was given intraperitoneally at testicular detorsion. (hindawi.com)
  • E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level were significantly increased, and testicular spermatogenesis was significantly decreased in the ipsilateral testes in the ischemia-reperfusion group, compared with the control group. (hindawi.com)
  • The probucol-treated group showed significant decreases in E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level and significant increase in testicular spermatogenesis in the ipsilateral testes, compared with the ischemia-reperfusion group. (hindawi.com)
  • Therapeutics
  • This report provides comprehensive information on the therapeutic development for Ischemia Reperfusion Injury, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (mynewsdesk.com)
  • inflammation
  • Continuous pressure limits blood supply and causes ischemia, and the inflammation occurs during reperfusion. (wikipedia.org)
  • We therefore hypothesize that administration of human AM/AMBP-1, even after reperfusion, improves cardiovascular function, attenuates organ injury and inflammation responses, and reduces mortality following gut I/R injury. (sbir.gov)
  • Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leighs disease, and Melas disease, and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. (wikipedia.org)
  • inflammatory
  • Some theorize that this delayed reaction derives from the various inflammatory immune responses that occur during reperfusion. (wikipedia.org)
  • These inflammatory responses cause intracranial pressure, pressure which leads to cell injury and in some situations cell death. (wikipedia.org)
  • NECROSIS
  • The Phase II clinical trial of FX06 (F.I.R.E. study) was completed in March 2008, with data indicating a statistically significant reduction in myocardial necrosis following intravenous application of FX06 concurrent with reperfusion. (innovations-report.com)
  • reduces
  • Although we have shown that administration of rat AM plus human AMBP-1 at the beginning of reperfusion is protective, it remains unknown whether a combination of human AM and human AMBP-1 is also beneficial and, if so, whether delayed administration of AM/AMBP-1 (which is more clinically relevant) reduces gut I/R-induced mortality. (sbir.gov)
  • heart
  • While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • peroxynitrite
  • Peroxynitrite (ONOO − ), a representative reactive nitrogen species, mediates excessive mitophagy activation and exacerbates cerebral I/R injury. (springer.com)
  • Therapy
  • The 12 lead ECG is used to classify patients into one of three groups: those with ST segment elevation or new bundle branch block (suspicious for acute injury and a possible candidate for acute reperfusion therapy with thrombolytics or primary PCI), those with ST segment depression or T wave inversion (suspicious for ischemia), and those with a so-called non-diagnostic or normal ECG. (wikipedia.org)
  • organ
  • As such, the development of effective strategies for preventing and treating circulatory collapse and organ injury after gut I/R is critical for the improvement of patient outcome under such conditions. (sbir.gov)
  • mechanisms
  • However, the detailed mechanisms of cell death and the structural alterations induced during different stages of reperfusion injury i.e. the early stage, are not completely determined yet. (medindia.net)
  • Regeneration
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (wikipedia.org)
  • protective effect
  • In addition, the protective effect of hypothermia on IR injury was investigated using a new method for in situ hypothermic perfusion (IHP). (uva.nl)
  • hours
  • 7. The method of claim 4 , wherein the PS-binding agent is administered to the patient up to about 6 hours prior to reperfusion. (google.com)