Absence of neutrophil infiltrationHypothesize that neutrophilMacrophageMediatesLymphocytes and macrophagesHuman neutrophilsInflammatory cellsExtracellularInflammationMiceMonocytesNecrosisDermal papillaeEosinophilsPathogenesisChemokineGranuleActivationPathologyBoneChemoattractantDepletionExocytosisMast cellsMigrationScheffImmuneRegulateSignificantlyCellsAirwayCytokinesReceptorBehaviorLungsProcessesProinflammatoryMechanismCxcr2ActinSecondaryFindingsFoundOutcomesStudyBloodFunctionsPotential
Absence of neutrophil infiltration2
- Then, in the absence of neutrophil infiltration, her research will assess oral cancer pain behavior and quantify and categorize inflammation in the tongue cancer microenvironment. (news-medical.net)
- In the absence of neutrophil infiltration, she will assess oral cancer pain behavior and quantify and categorize inflammation in the tongue cancer environment. (dentistrytoday.com)
Hypothesize that neutrophil2
- The authors hypothesize that neutrophil infiltration and ensuing tissue necrosis would be mitigated by removing ATP-dependent signaling at the burn site. (usuhs.edu)
- We hypothesize that neutrophil recruitment could be exploited as a therapeutic approach to alleviate oral cancer pain in female mice. (frontiersin.org)
Macrophage2
- MWCNT exposure significantly increased macrophage and neutrophil infiltration in BALF. (cdc.gov)
- Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)
Mediates3
- As Shigella infiltrates the epithelial cells, activation of nuclear factor kappa-B (NF-KB) by Shigella generates IL-8 , which in turn mediates the recruitment of polymorphonuclear neutrophils (PMN) to the site of inflammation. (wikidoc.org)
- The latter mediates aseptic abruption-related neutrophil infiltration. (scirp.org)
- This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)
Lymphocytes and macrophages1
- Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. (who.int)
Human neutrophils4
- 2002 Indeed previous research from EPZ004777 our laboratory has exhibited that inhibition of MARCKS function attenuates the β2-integrin-dependent processes of migration and adhesion in human neutrophils (Eckert et al. (research-in-field.com)
- hence, we wanted to test the hypothesis that A. actinomycetemcomitans exploits human neutrophils as a source for catecholamines. (doaj.org)
- In the present study, we showed that human neutrophils synthesize, store, and release epinephrine, one of the three main types of catecholamines. (doaj.org)
- Finally, epinephrine-containing supernatants collected from human neutrophils promoted A. actinomycetemcomitans growth and induced the expression of the qseBC operon under anaerobic conditions. (doaj.org)
Inflammatory cells1
- We have tested the hypothesis that airway infiltration by inflammatory cells reflects the severity of asthma by comparing the inflammatory cell infiltrates in fatal severe asthma and in subjects with mild to moderate asthma who died of unrelated causes. (nih.gov)
Extracellular3
- The results of this study support the role of extracellular ATP in neutrophil activity. (usuhs.edu)
- These include the production of reactive oxygen species, the release of antimicrobial peptides, and the recently discovered expulsion of their nuclear contents to form neutrophil extracellular traps. (nih.gov)
- During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)
Inflammation6
- In addition, we present more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation. (nih.gov)
- Shigella then invades macrophages and induces cellular apoptosis , which results in inflammation , generation of proinflammatory cytokines , and recruitment of polymorphonuclear neutrophils (PMNs). (wikidoc.org)
- RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. (jci.org)
- Neutrophils play an essential role in the host defense and in inflammation, but the latter may trigger and sustain the pathogenesis of a range of acute and chronic diseases. (go.jp)
- The recruitment of neutrophils in airway inflammation may account for the generation of IL-8. (go.jp)
- To evaluate the effectiveness of green tea polyphenols in the modulation of airway inflammation through the blocking of neutrophil chemokine production, nasal mucosal fibroblasts and A549 bronchial epithelial cells were analyzed for the production of IL-8. (go.jp)
Mice9
- We demonstrate a significant attenuation of neutrophil infiltration in Cxcr2−/− mice at 12 hours and 7 days after CHI, despite increased levels of CXC neutrophil-attracting chemokines in the lesioned cortex. (edu.au)
- Remarkably, Ager AHA/AHA mice phenocopied Ager −/− mice in two different pathophysiological processes, namely bone remodeling and neutrophil-mediated liver injury, which demonstrates that HS-induced RAGE oligomerization is essential for RAGE signaling. (elifesciences.org)
- Finally, we have performed RNA-seq analysis of neutrophils and lungs and found that while Ager −/− mice had a broad alteration of transcriptome in both tissues compared to wild-type mice, the changes of transcriptome in Ager AHA/AHA mice were much more restricted. (elifesciences.org)
- We show that, using the ME7 model of prion disease, intracerebral challenge with LPS results in dramatic interleukin-1β (IL-1β) expression, neutrophil infiltration, and inducible nitric oxide synthase expression in the brain parenchyma of prion-diseased mice compared with the same challenge in normal mice. (jneurosci.org)
- We previously demonstrated that male mice with carcinogen-induced oral SCC exhibit less nociceptive behavior and a higher concentration of neutrophils in the cancer microenvironment compared to female mice with oral SCC. (frontiersin.org)
- We found that recombinant G-CSF (rG-CSF, 5 μg/mouse, intraperitoneal) significantly increased circulating Ly6G + neutrophils in the blood of male and female mice within 24 h of administration. (frontiersin.org)
- In an oral cancer supernatant mouse model, rG-CSF treatment increased cancer-recruited Ly6G + neutrophil infiltration and abolished orofacial nociceptive behavior evoked in response to oral cancer supernatant in both male and female mice. (frontiersin.org)
- Chronic rG-CSF treatment (2.5 μg/mouse, every 72 h) increased the HSC-3 recruited Ly6G + neutrophils, increased β-endorphin protein content in the tongue and attenuated nociceptive behavior in female mice with HSC-3 tumors. (frontiersin.org)
- RESULTS: BALB/c and C57Bl/6J mice showed infiltration of neutrophils to the lung, and an increase in total protein concentration and LDH activity in response to dsRNA administration. (lu.se)
Monocytes2
- The following cells were identified: mast cells (AA1:tryptase), eosinophils (EG1:stored cationic protein and EG2: secretory form of cationic protein), monocytes/macrophages (CD68), neutrophils (elastase), CD3+ and CD8+ T cells (CD3 polyclonal Ab and CD8+ mAb, respectively). (nih.gov)
- Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
Necrosis2
- The authors demonstrate that ATP hydrolysis at the burn site allays the neutrophil response to thermal injury and reduces tissue necrosis. (usuhs.edu)
- Lymph node histopathology of KD is diagnostic, revealing characteristic necrosis, histiocytic infiltration, and karyorrhectic debris without neutrophils. (medscape.com)
Dermal papillae1
- In the 1950s Pierard described the presence of clusters of neutrophils and eosinophils in the dermal papillae, especially in more recent lesions. (scielo.br)
Eosinophils1
- There is dermal infiltration of neutrophils and eosinophils. (webpathology.com)
Pathogenesis3
- This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. (jci.org)
- Neutrophils are key first-responders in the innate immune response to C. difficile infection (CDI) and play a central role in disease pathogenesis. (frontiersin.org)
- However, despite a key role for neutrophils in disease pathogenesis, the underlying biological mechanisms that regulate systemic and tissue neutrophil numbers after CDI remain poorly defined. (frontiersin.org)
Chemokine2
- This study highlights the deleterious contribution of neutrophils to posttraumatic neurodegeneration and demonstrates the importance of CXC chemokine signaling in this process. (edu.au)
- C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
Granule2
- Human neutrophil challenge with A. actinomycetemcomitans induced exocytosis of neutrophil granule subtypes: secretory vesicles, specific granules, gelatinase granules, and azurophilic granules. (doaj.org)
- Based on our findings, we propose that A. actinomycetemcomitans promotes azurophilic granule exocytosis by neutrophils as an epinephrine source to promote bacterial survival. (doaj.org)
Activation4
- By preventing neutrophil-dependent Notch activation, via blocking degranulation, we were able to significantly offset the radiation-enhanced metastases. (nature.com)
- Fig. 2: Radiation exposure induces the infiltration and local activation of lung neutrophils. (nature.com)
- While neutrophils exhibit many integrin heterodimers in the β1 β2 and β3 families intraluminal adhesion and migration are dependent on activation of β2-integrins EPZ004777 specifically (Schmidt et al. (research-in-field.com)
- 2013 You will find three key actions to activation of β2-integrins in neutrophils. (research-in-field.com)
Pathology2
- On microscopic pathology, infiltration of PMN and inflammatory pseudomembranes are characteristic features. (wikidoc.org)
- Pathology shows a septal necrotizing panniculitis with neutrophil infiltration. (hss.edu)
Bone4
- Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
- Figure 2: (A) Right hand MRI T1 coronal image showing patchy infiltration of the bone (arrowheads) and patchy infiltration of the fat (arrows). (hss.edu)
- and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
- In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
Chemoattractant2
- Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
- Infiltration of neutrophils occurs as a response to chemoattractant molecules by resident tissue cells. (go.jp)
Depletion1
- Studies have clearly shown that tissue neutrophil numbers need to be tightly regulated for optimal CDI outcomes: while excessive colonic neutrophilia is associated with severe CDI, neutrophil depletion also results in worse outcomes. (frontiersin.org)
Exocytosis1
- 1) Increased surface expression of β2-integrins is usually achieved when secretory vesicles which contain high numbers of preformed β2-integrins on their membranes fuse with the neutrophil plasma membrane during exocytosis. (research-in-field.com)
Mast cells1
- These integrin receptors are present on a number of immune cells such as mast cells, neutrophils, and T cells. (wikipedia.org)
Migration2
- Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. (edu.au)
- To this end we measured the β2-integrin-dependent neutrophil functions of migration adhesion and respiratory burst essential for β2-integrin-independent functions (PMA-mediated respiratory burst) in equine neutrophils. (research-in-field.com)
Scheff5
- Dr. Scheff expects that male patients reporting less pain will have a greater number of infiltrating neutrophils in the cancer microenvironment. (news-medical.net)
- To measure the effect of neutrophils on oral cancer pain, Dr. Scheff will remove neutrophils from the model during oral cancer development. (news-medical.net)
- Scheff will determine if the patient's sex affects the relationship between neutrophil count and reported pain score using a pain questionnaire. (dentistrytoday.com)
- Scheff will remove neutrophils from the model during oral cancer development. (dentistrytoday.com)
- Scheff expects oral cancer pain behavior to increase with the loss of neutrophils. (dentistrytoday.com)
Immune4
- Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in organisms ranging from slime molds to mammals. (nih.gov)
- Neutrophils isolated from the cancer-induced inflammatory microenvironment contain β-endorphin protein and are identified by the Ly6G + immune marker. (frontiersin.org)
- Moreover, our research showed that high DOK5 could predict high-level infiltration of several GC immune cells, as evidenced by M1, TAM, M2, B cell, and T cell failure. (hindawi.com)
- Our results clarified the significant role of DOK5 in the prognosis of GC and offer a potential mechanism by which DOK5 expression might monitor tumor immunity-regulation of the infiltration of immune cells in GC. (hindawi.com)
Regulate1
- Here, we investigated the biological mechanisms that regulate neutrophil CXCR2 expression after CDI, and the influence of host genetics on this process. (frontiersin.org)
Significantly1
- The count of neutrophils was reduced significantly in test group compared with control along absence of eosinophil. (ijpsonline.com)
Cells5
- Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. (jci.org)
- Treatment was associated with the early appearance of CD4 cells, activated dendritic cells and macrophages, with later infiltration by CD8 T cells. (nih.gov)
- There were comparatively few neutrophils or gammadelta T cells. (nih.gov)
- Granulomas are exclusively found in GPA and form around multinucleated giant cells (MGCs), at sites of microabscesses, containing apoptotic and necrotic neutrophils. (bmj.com)
- infiltration after continued therapy and with 3 months cells included many plasma cells and some follow-up. (who.int)
Airway1
- Neutrophil infiltration is a prominent feature in a number of pathologic conditions affecting horses including recurrent airway obstruction ischemia-reperfusion injury EPZ004777 and laminitis. (research-in-field.com)
Cytokines1
- RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)
Receptor1
- We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
Behavior1
- Her expectation is that oral cancer pain behavior will increase with the loss of neutrophils. (news-medical.net)
Lungs1
- Fig. 3: Primed neutrophils support metastatic colonization in irradiated lungs. (nature.com)
Processes1
- Taken together these EPZ004777 results strongly suggest that MARCKS function is essential to β2-integrin-dependent processes in neutrophils. (research-in-field.com)
Proinflammatory1
- To achieve this, we assessed proinflammatory cytokine expression, inflammatory cell infiltration, and expression of effector enzymes such as cyclooxygenase 2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) after intracerebral and intraperitoneal LPS challenges. (jneurosci.org)
Mechanism3
- however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. (jci.org)
- We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). (frontiersin.org)
- We infer that rG-CSF-induced Ly6G + neutrophils drive an endogenous analgesic mechanism. (frontiersin.org)
Cxcr21
- RR genotype) was associated with higher CXCR2 expression and more tissue neutrophils. (frontiersin.org)
Actin1
- We hypothesized that MARCKS serves as a link between the actin cytoskeleton and integrin function in neutrophils. (research-in-field.com)
Secondary1
- The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. (edu.au)
Findings2
- Our findings support the assertion that inhibitors of MARCKS should have further research as potential therapies for neutrophil mediated tissues injury. (research-in-field.com)
- Based on her findings, she hypothesizes that infiltrating neutrophils in the cancer microenvironment contribute to sex difference in oral cancer pain. (news-medical.net)
Found1
- We found that locally activated neutrophils were key drivers of the tumor-supportive preconditioning of the lung microenvironment, governed by enhanced regenerative Notch signaling. (nature.com)
Outcomes2
- Therefore, neutrophil numbers need to be tightly regulated for optimal CDI outcomes. (frontiersin.org)
- During this time we have enrolled over 500 critically ill patients and volunteers in our cohort studies, made new observations about the relationships between NO metabolism, red blood cell dysfunction, neutrophil dysfunction, vascular function, and clinical outcomes, and forged strong collaborations with clinical and basic science investigators across a number of university departments. (rochester.edu)
Study1
- 2009 In the current study our TLR3 goal was to further investigate the potential link between β2-integrin-dependent neutrophil functions and MARCKS. (research-in-field.com)
Blood1
- For everyone neutrophil tests 30 ml of entire blood was gathered using heparinized syringes in the jugular vein of adult horses. (research-in-field.com)
Functions2
- This work highlights a pro-tumorigenic activity of neutrophils, which is likely linked to their tissue regenerative functions. (nature.com)
- Here we discuss these primordial neutrophil functions, which also play key roles in tissue injury, by providing details of neutrophil cytotoxic functions and congenital disorders of neutrophils. (nih.gov)
Potential1
- From these data, we conclude that neutrophil-mediated endogenous opioids warrant further investigation as a potential strategy for oral cancer pain treatment. (frontiersin.org)