• How are adoptive cellular therapies used in cancer treatment? (richardvigilantebooks.com)
  • In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)
  • Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
  • Cellular senescence is one of the root causes of aging, and there are at present serious, well-funded efforts underway to produce rejuvenation therapies based on the selective destruction of senescent cells in old tissues. (fightaging.org)
  • Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
  • Cellular and genetic therapies play a crucial role in regenerative medicine and cancer treatment. (zebvoo.com)
  • These cellular therapies are associated with severe on / off-target toxicities. (zebvoo.com)
  • The logistics of producing virus-specific T cells has, however, limited the application of cellular therapies, particularly following the introduction of more-recent regulatory stipulations. (ox.ac.uk)
  • Immunotherapies: These are treatments that use certain parts of the immune system to fight diseases, including cancer therapies like checkpoint inhibitors or adoptive cell transfer. (adooq.com)
  • Interest therefore exists in enhancing immune reconstitution through regenerative or cell therapies for boosting thymus activity in vivo, or providing customized in vitro generated T cell repertoires for adoptive transfer. (ed.ac.uk)
  • Syngeneic lymphocytes were transferred from rodents heavily immunized against the tumor to inhibit growth of small established tumors, becoming the first example of ACT. (wikipedia.org)
  • In 2002, lymphodepletion using a nonmyeloablative chemotherapy regimen administered immediately before TIL transfer increased cancer regression, as well as the persistent oligoclonal repopulation of the host with the transferred lymphocytes. (wikipedia.org)
  • The purpose of the study is to evaluate the feasibility, safety and tolerability of intravesical adoptive cell therapy using TIL (tumor infiltrating lymphocytes) in participants with urothelial cell carcinoma (UCC) non-muscle invasive bladder cancer (NMIBC). (moffitt.org)
  • Adoptive transfer with T and B lymphocytes from sensitized mice indicated that both cellular and humoral immunity played a role in the asthma response. (cdc.gov)
  • For tumors such as melanoma, in which tumor-specific T cells can be readily identified and isolated, the adoptive transfer of "tumor-infiltrating lymphocytes" (TILs) already appears to offer significant patient benefit and this approach now warrants further development. (eur.nl)
  • Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
  • Specifically, they cover the following areas: a) cellular vaccine approaches using tumor cell-based or dendritic cell (DC)-based vaccines, and b) adoptive cell transfer (ACT) approaches, including lymphokine-activated killer (LAK) cells, γδ T cells, tumor-infiltrating lymphocytes (TIL), chimeric antigen receptor (CAR)-T cells and T-cell receptor (TCR) transduced T cells. (escholarship.org)
  • The transfer of lymphocytes or ethylene di-isocyanate (HDI), which are used in a serum from sensitized mice can cause clinical disease in naive variety of industries including polyurethane foam mice. (cdc.gov)
  • I am involved in developing a high-throughput platform to interrogate patients' immunity against private antigens and to identify highly functional T cells (and TCRs) for adoptive cell therapy (ACT). (unil.ch)
  • For immunological studies, we use different animal and cellular models (i.e. knock-out mice, OT-1 and OT-2 transgenic mice, adoptive transfer of immunity, models of protective and therapeutic vaccine against tumors, in vivo analysis of antigen persistence in cell and tissues). (leloir.org.ar)
  • The identification of CMV-CTL clones is one method used to assess cellular immunity against CMV. (nature.com)
  • However, these reports have focused on the entire non-specific immune diversity, and not directly on the cellular immunity specific to virus. (nature.com)
  • The concept of enhancing cellular immunity through the transfer of ex-vivo expanded T cells was pioneered by Greenberg et al. (biomedcentral.com)
  • The R&D activities are further resulting in the advent of mAbs, which have effects like antigen specificity, adaptive immunity, and antibody-dependent cellular toxicity. (medgadget.com)
  • BACKGROUND: Adoptive transfer of virus-specific T cells may accelerate reconstitution of antigen-specific immunity and limit the morbidity and mortality of viral infections following allogeneic hematopoietic stem cell transplantation. (ox.ac.uk)
  • Innate Immunity: This is the first line of defense and includes barriers like the skin and mucous membranes, as well as cellular responses by natural killer cells, macrophages, and neutrophils. (adooq.com)
  • During my PhD, I have worked on the development of NeoTIL, a novel strategy to generate adoptive cell transfer products for next-generation cellular immunotherapies. (unil.ch)
  • You will take advantage of machine learning methods for single-cell multi-omics in order to decipher disease pathogenesis in relation to treatment response and side effects of cellular immunotherapies. (academics.com)
  • Herein, the authors review recent and current studies using cellular immunotherapies for malignant gliomas. (escholarship.org)
  • Methods: The aim of this trial is to determine whether adoptive transfer of autologous Tregs into HLA sensitised patients can suppress memory T and B cell responses against specific HLA antigens. (kcl.ac.uk)
  • Additional studies involving passive transfer and the use of transgenic FcErIg knockout mice, which lack IgE and IgG Fc receptors, established the importance of reagenic antibodies. (cdc.gov)
  • Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
  • Here, we evaluated the safety issues raised by the risk of TAA-TCR gene transfer-associated on/off-target toxicities and the therapeutic potential in relevant transgenic mouse models of adoptive transfer. (unimedizin-mainz.de)
  • Results Herein we reveal a new way to reverse the tolerant state of adoptively transferred CD8 + T cells against tumors using TLR-activated B cells. (bmj.com)
  • The inhibitory KIRs 2DL1 (CD158a), 2DL2/3 (CD158b), and 3DL1 (CD158e1) are such surface receptors and allow adoptively transferred donor NK cells to exert potent antileukemic effects if the cognate HLA class I ligands are absent in the recipients [ 3 ]. (biomedcentral.com)
  • The adoptive transfer of genetically modified T cells, such as CAR-T cells, can trigger immune reactivity against cancerous cells. (zebvoo.com)
  • By genetically altering immune T cells in a lab, the transfer of these "living drugs" through CAR T-cell therapy has had significant clinical success in targeting and destroying tumor cells more effectively. (yale.edu)
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
  • The major areas of recent interest in the lab have been augmentation of anti-tumor immune effects, the tumor microenvironment, mechanisms of T cell dysfunction, and adoptive T cell transfer with an increasing focus on lung cancer. (upenn.edu)
  • As a senior scientist in the Hi-TIDe , I'm currently responsible for the high-throughput discovery and characterization of cellular immune responses directed against unknown, shared and private tumor epitopes and participate in the development of new adoptive cell therapy strategies. (unil.ch)
  • Given this, it should not be a surprise to find that cellular senescence can be implicated in the way in which visceral fat accelerates aging: their presence in visceral fat tissue and the immune cells interacting with that tissue fits right in with the broader picture of inflammation and bad cellular behavior. (fightaging.org)
  • TIL therapy is a type of adoptive cellular therapy leveraging the patient's own immune system to treat tumors. (biomedcentral.com)
  • Published today in Nature Biomedical Engineering , the scientists show how the new system delivers transgenes into human immune cells and other cell types with higher efficiency, lower cellular toxicity, and stable transgene expression to safely produce CAR-T cells and other therapeutic immune cells. (yale.edu)
  • vivo activation and expansion of T cells or NK cells and passive transfer of these cells into the cancer patient. (richardvigilantebooks.com)
  • Expansions of both CD4(+) and CD8(+) cytomegalovirus-specific T cells were observed in vivo within days of adoptive transfer. (ox.ac.uk)
  • IVIM in vivo imaging was used to observe that heparin promoted the infiltration of transferred CD8+ T cells into Panc02 orthotopic tumors. (figshare.com)
  • After obtaining my Master's in Biochemistry at the University of Geneva in 1994, I worked for Glaxo and Serono Pharmaceutical Research Institute in the Chemokines and Functional Genomics fields where I acquired a variety of techniques in molecular and cellular biology. (unil.ch)
  • Since joining the Department of oncology UNIL CHUV in 2013, I performed, validated and implemented cellular and molecular assays to interrogate T cells from clinical samples for research and in the context of clinical trials (immunological monitoring). (unil.ch)
  • To investigate the cellular and molecular mechanisms underlying differential organ rejection, we developed a rat model in which heart and lung allografts were transplanted sequentially. (northwestern.edu)
  • Inflammation: Researchers study the molecular and cellular processes of inflammation to understand various chronic diseases, including cancer, heart disease, and diabetes. (adooq.com)
  • Here, we review current understanding of cellular and molecular regulation of thymus organogenesis, focusing on the epithelial component of the thymic stroma which provides many of the specialist functions required to mediate T cell differentiation and T cell repertoire selection. (ed.ac.uk)
  • Cellular therapy of cancer will need continued preclinical evaluation as well as carefully designed clinical trials addressing the various issues. (eur.nl)
  • This is a two-part, multi-centre, prospective clinical trial, comprising an observational phase (Part 1) aiming to identify patients with unregulated cellular memory responses to HLA (Pure HLA Proteins) followed by an interventional phase (Part 2). (kcl.ac.uk)
  • We determined if adoptive transfer of natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donors may prolong event-free survival in children with intermediate-risk AML who were in first complete remission after chemotherapy. (biomedcentral.com)
  • Patients may alternatively receive lympho-depleting chemotherapy followed by adoptive transfer of purified NK cells from an alloreactive donor, resulting in homeostatic lymphocyte proliferation with transient donor NK cell expansion in recipients [ 7 ]. (biomedcentral.com)
  • He is recognized for his groundbreaking work in developing the first gene-edited cell therapy for cancer and for demonstrating that adoptive T-cell therapy can induce remission and in some cases cure patients with advanced cancer. (aacr.org)
  • But these sources have limitations due to their relative safety to make, shortness of lifespan, and in some cases their heightened risk of cellular toxicity. (yale.edu)
  • PSB1115 treatment decreased both known degrees of IL-10 and MCP-1 and Compact disc11b+Gr1+ cellular number in melanoma lesions. (biospraysehatalami.com)
  • Administration of IL-2 after cell transfer enhanced therapeutic potential. (wikipedia.org)
  • Adoptive transfer of Compact disc11b+Gr1+ cells abrogated the antitumor activity of PSB1115. (biospraysehatalami.com)
  • Cellular Basis for the Enhanced Efficacy of the Fms-Like Tyrosine Kinase 3 Ligand (FL) Adjuvanted VCG-Based Chlamydia abortus Vaccine. (cdc.gov)
  • Most importantly, the derived N-doped carbon nanotubes tightly connect the adjacent nanosheets to construct the special 3D interconnected conductive network, which effectively accelerates the charge transfer and improves the conduction loss. (bvsalud.org)
  • Background Adoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of T cells with poor function or persistence. (bmj.com)
  • This technology, which involves the genetic reengineering of a patient's T cells to combat their disease, is the first gene transfer therapy technique that has demonstrated sustained success in cancer patients and has shown tremendous promise for the treatment of hematologic malignancies. (aacr.org)
  • 1. Gene Transfer Therapy: The therapy helps to introduce genetic material into the cell machinery. (zebvoo.com)
  • Discussion: This is a prospective study aiming to identify patients with unregulated cellular memory responses to Pure HLA Proteins and determine baseline variation in these patterns of response. (kcl.ac.uk)
  • Using limiting dilution analysis and adoptive transfer studies, we found that some recipients had developed suppressor cells while others demonstrated anergy. (northwestern.edu)
  • Adoptive cell transfer (ACT) is the transfer of cells into a patient. (wikipedia.org)
  • Adoptive cellular therapy provides the promise of a potentially powerful general treatment for cancer. (eur.nl)
  • Nonetheless, it is gratify to watch the spreading realization that cellular senescence plays a role in many areas of health and biology associated with aging. (fightaging.org)
  • Gene switches have played a crucial role in delivering adoptive cell therapy. (zebvoo.com)
  • Technological advancements have made it possible to have reversible control of cellular products either through protein-based regulators supply or by removal of small molecules and through physical stimuli such as ultrasound, light, and heat. (zebvoo.com)
  • A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)