• The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)
  • This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
  • These mediators increase mucus secretion and promote vascular permeability and smooth muscle contraction. (tocris.com)
  • It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. (abcam.com)
  • peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. (bvsalud.org)
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
  • Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
  • vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
  • Bradykinin (10 -5 M) significantly increased permeability in the MV but not in the MA. (bvsalud.org)
  • Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (bvsalud.org)
  • COV treatment did not affect lung vascular permeability. (cdc.gov)
  • vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)
  • Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)
  • Gq-proteins in vascular smooth muscle are coupled to α 1 -adrenoceptors (bind to norepinephrine ), ET A receptors (bind to endothelin-1), AT 1 receptors (bind to angiotensin II ), V 1 receptors (bind to vasopressin ), and muscarinic (M 3 ) receptors (bind to acetylcholine ). (cvphysiology.com)
  • Acetylcholine (ACh), whether administered intravascularly or released by cholinergic autonomic (parasympathetic) nerves, binds to muscarinic receptors (M 3 ) on the vascular endothelium, which stimulates the formation and release of NO as described above to produce vasodilation. (cvphysiology.com)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • Neuropeptide Y (NPY) intensifies the proliferation of vascular smooth muscle cells (VSMCs) directly by binding with Y1 receptors. (edu.au)
  • Androgen receptors are widely distributed in several tissues, including vascular endothelial and smooth muscle cells. (gla.ac.uk)
  • 5. This increase in end-organ sensitivity might explain why LD 3098 appears as an α-adrenoreceptor agonist with preferential affinity for postsynaptic receptors when end-organ responses to nerve stimulation are measured and yet it is a preferential presynaptic agonist in 3 H-labelled transmitter-release studies. (portlandpress.com)
  • Olmesartan blocks the vasoconstrictive effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptors in vascular smooth muscle. (medscape.com)
  • In vitro study showed that, compared with control group, the DM rats exhibited a lowered endothelium-dependent relaxation and damaged structural integrity of thoracic aortas, and there was a significant increase in plasma nitrotyrosine concentration. (hindawi.com)
  • In rings from uterine arteries, smooth muscle sensitivity to K+, norepinephrine (NE), and phenylephrine (PE) was enhanced by 1.4-, 2.3-, and 9.7-fold, respectively, and endothelium-dependent relaxation was reduced by 64% in diabetic patients, as compared with control subjects. (diabetesjournals.org)
  • In contrast, subplasmalemmal Ca2+ response, which favors smooth muscle relaxation caused by activation of Ca2+-activated K+ channels, was reduced by 38% in diabetic patients as compared with control subjects, indicating a significant change in the subcellular Ca2+ distribution in vascular smooth muscle cells in diabetic patients. (diabetesjournals.org)
  • CGRP stimulates relaxation of vascular smooth muscle. (cdc.gov)
  • Increased cGMP relaxation of vascular smooth muscle involves activation of cGMP-dependent protein kinase, inhibition of calcium entry into the vascular smooth muscle, activation of K + channels (causing hyperpolarization), and decreased IP 3 . (cvphysiology.com)
  • This results in increased nitric oxide production and consequent vascular smooth muscle relaxation and an increase in vasodilation [ 1 ]. (karger.com)
  • The result of smooth muscle cell target protein phosphorylation is a decrease in intracellular calcium, increased efflux of potassium, and deactivation of myosin light chain kinase, ultimately causing smooth muscle relaxation. (nih.gov)
  • Relaxation of vascular smooth muscle in the corpus cavernosum leads to penile erection when the cavernosal sinusoids engorge with blood to compress the subtunical veins against the tunica albuginea. (nih.gov)
  • HydrALAZINE apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. (nih.gov)
  • The secretory products from hypoxia/reoxygenated endothelial cells also affected smooth muscle contractility having an anti-vasoconstrictor or relaxation property, similar to that exerted by PAF. (bl.uk)
  • This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
  • Effects of increasing extracellular Mg ++ concentration ([Mg ++ ] e ) on vasopressin (AVP)-induced [Ca ++ ] i responses were determined in primary cultured unpassaged vascular smooth muscle cells from mesenteric and aortic vessels (representing resistance and conduit arteries, respectively) of Wistar Kyoto rats (WKY) and SHR. (aspetjournals.org)
  • There are several signal transduction mechanisms that modulate intracellular calcium concentration and therefore the state of vascular tone. (cvphysiology.com)
  • In contrast to cardiac cells, Gs-protein stimulated increases in cAMP do not increase intracellular calcium. (cvphysiology.com)
  • Treatment with Pi significantly increased intracellular calcium deposition and ALP activity, which were suppressed by PQS in a concentration-dependent manner. (biomedcentral.com)
  • However, the role and mechanism of PQS in vascular calcification are not unclear. (biomedcentral.com)
  • The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
  • However, the underlying mechanisms of vascular calcification have not been established. (biomedcentral.com)
  • For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)
  • Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
  • The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
  • Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
  • Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
  • Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
  • Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)
  • Of interest, aging itself is accompanied by endothelial and vascular smooth muscle dysfunction. (gla.ac.uk)
  • However, little is known about changes in smooth muscle contractility and the intracellular mechanisms contributing to altered responsiveness of blood vessels of diabetic patients. (diabetesjournals.org)
  • Hypoxia-driven pulmonary vascular remodelling is one of the underlying mechanisms, although many other mechanisms may contribute [ 5 ]. (ersjournals.com)
  • Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies International Journal of Molecular Sciences. (nottingham.ac.uk)
  • Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
  • Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
  • Exendin-4 also significantly alleviated the increased malondialdehyde (MDA), nitrotyrosine content, and inducible nitric oxide synthase (iNOS) expression induced by high glucose in HUVECs. (hindawi.com)
  • A third mechanism that is very important in regulating vascular smooth muscle tone is the nitric oxide (NO)-cGMP system . (cvphysiology.com)
  • This study investigated the modulatory effect of magnesium (Mg ++ ) on basal and agonist-stimulated intracellular free calcium (Ca ++ ) concentration ([Ca ++ ] i ) in vascular smooth muscle cells from spontaneously hypertensive rats (SHR). (aspetjournals.org)
  • HydrALAZINE, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. (nih.gov)
  • We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both in vivo and in vitro and explore the role of nitrooxidative stress in endothelium-protective action of exenatide. (hindawi.com)
  • In conclusion, this study demonstrates that exenatide treatment can alleviate the vascular endothelial injury, as well as attenuating the nitrooxidative stress in hyperglycemia, implying that the endothelium-protective effect of exenatide might be related to the reduction of nitrooxidative stress. (hindawi.com)
  • Given that the proliferation and the phenotypic transformation of VSMCs increase the risk for progression of atherosclerosis, we focus on the role of geminin interference in determining the fate of VSMCs. (edu.au)
  • The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
  • The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)
  • Sildenafil also has FDA approval for the treatment of World Health Organization Group I pulmonary hypertension (also known as pulmonary arterial hypertension (PAH)) in adults to improve exercise tolerance and delay clinical worsening. (nih.gov)
  • Testosterone interferes with the vascular function by increasing the production of pro-inflammatory cytokines and arterial thickness. (gla.ac.uk)
  • the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage. (bvsalud.org)
  • HydrALAZINE also maintains or increases renal and cerebral blood flow. (nih.gov)
  • Entre las muchas respuestas mediadas por estos receptores están la contracción del músculo liso, el incremento de la permeabilidad vascular, la liberación de hormonas y la gluconeogénesis cerebral. (bvsalud.org)
  • [7] When PDE5 becomes inhibited, the accumulation of cGMP leads to increased cGMP-dependent protein kinase activity, which phosphorylates multiple targets in the smooth muscle cell. (nih.gov)
  • Glucagon-like peptide-1 (GLP-1) is an important endogenous incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreatic islet cells and supports glucose homeostasis [ 7 ], as well as stimulating β -cell proliferation and inhibiting β -cell apoptosis, increasing insulin sensitivity, and inhibiting glucagon secretion and gastrointestinal motility [ 7 - 10 ]. (hindawi.com)
  • Human diabetes is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution. (diabetesjournals.org)
  • In contrast to the altered Ca2+ signaling found in freshly isolated cells from diabetic patients, in cultured smooth muscle cells isolated from control subjects and diabetic patients, no difference in the intracellular Ca2+ signaling to stimulation with either K+ or NE was found. (diabetesjournals.org)
  • Incubation of freshly isolated smooth muscle cells from control subjects with the *O2- -generating system xanthine oxidase/hypoxanthine mimicked the effect of diabetic patients on subcellular Ca2+ distribution in a superoxide dismutase-sensitive manner. (diabetesjournals.org)
  • Here, we find that the immunosuppressor FK506 increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells and enhances the TGF-β1/ALK1 signaling pathway and endothelial cell functions like tubulogenesis and migration. (aspetjournals.org)
  • Hyperglycemia results in increased gingival crevicular fluid glucose levels, which may significantly alter periodontal wound-healing events by changing the interaction between cells and their extracellular matrix within the periodontium. (health.am)
  • Vascular smooth muscle cells (VSMCs) are an important component of blood vessels. (onteenstoday.com)
  • The cells are located in the medium part of a blood vessel, that is, tunica media , where they are oriented in a circle around the vascular lumen and form numerous layers. (onteenstoday.com)
  • HydrALAZINE usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. (nih.gov)
  • Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)
  • the rest being primarily muscle cells called vascular smooth muscle cells that line the aorta. (medlineplus.gov)
  • Together, elastic fibers and vascular smooth muscle cells provide flexibility and resilience to the aorta. (medlineplus.gov)
  • To compensate, the smooth muscle cells that line the aorta increase in number, making the aorta thicker and narrower than usual. (medlineplus.gov)
  • Combined HFWD+silica exposure increased bronchoalveolar lavage (BAL) total cells, leukocytes, and BAL lactate dehydrogenase compared to STD+silica exposure controls at all timepoints. (cdc.gov)
  • citation needed] Upon increase in carbon dioxide level at central chemoreceptors, it stimulates the sympathetic system to constrict vessels. (wikipedia.org)
  • Like heart muscle , the Gs-protein coupled pathway in smooth muscle stimulates adenylyl cyclase (AC), which catalyzes the formation of cAMP . (cvphysiology.com)
  • Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes. (diabetesjournals.org)
  • Erectile dysfunction (ED). Taking Panax ginseng by mouth seems to improve sexual function in adults with ED. (webmd.com)
  • 2] Systolic dysfunction is characterized by diminished ventricular contractility that results in an impaired ability to increase the stroke volume to meet systemic demands. (medscape.com)
  • Factors such as anatomic stresses (eg, coarctation of the aorta) that contribute to an increased afterload (end-systolic wall stress), as well as neurohormonal factors that increase systemic vascular resistance, also lead to systolic dysfunction. (medscape.com)
  • Diastolic dysfunction results from decreased ventricular compliance, necessitating an increase in venous pressure to maintain adequate ventricular filling. (medscape.com)
  • Causes of primary diastolic dysfunction include an anatomic obstruction that prevents ventricular filling (eg, pulmonary venous obstruction), a primary reduction in ventricular compliance (eg, cardiomyopathy, transplant rejection), external constraints (eg, pericardial effusion), and poor hemodynamics after the Fontan procedure (eg, elevated pulmonary vascular resistance). (medscape.com)
  • The loss of myocytes leads to cardiac dilation and an increased afterload and wall tension, which results in further systolic dysfunction. (medscape.com)
  • Renal effects of testosterone and the use of testosterone to prevent vascular dysfunction in elderly are also addressed. (gla.ac.uk)
  • Therefore, smooth muscle and endothelial cell function were assessed in 20 patients with diabetes and compared with 41 age-matched control subjects. (diabetesjournals.org)
  • Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)
  • HO-1 was significantly increased by CBD in an ROS-depentent manner. (uni-rostock.de)
  • In the chronic intervention study FVPD consumption was found to significantly increase dietary carotenoids ( P =0·001) and vitamin C ( P =0·003). (cambridge.org)
  • Conversely, poorly controlled diabetic subjects have significantly increased gingivitis, compared to either well-controlled diabetic or nondiabetic individuals. (health.am)
  • In large epidemiologic studies, diabetes has been shown to significantly increase the risk of attachment loss and alveolar bone loss approximately threefold when compared to nondiabetic control subjects. (health.am)
  • Defects in this first line of defense against periodontopathic microorganisms may significantly increase periodontal destruction. (health.am)
  • Monocytes and macrophages in diabetic individuals are often hyper-responsive to bacterial antigens.65 This up-regulation results in a significantly increased production of proinflammatory cytokines and mediators. (health.am)
  • Elevated levels significantly increased risk more than severity of pre-eclampsia. (who.int)
  • This suggests a role of p22phox in ventilation/perfusion ratio matching, vascular remodelling and loss of perfused lung area. (ersjournals.com)
  • When there is an increase in perfusion, the vascular smooth muscle stretches, causing it to constrict the artery. (onteenstoday.com)
  • Increased stiffness and decreased elastic recoil in the aortic wall lead to reduced coronary perfusion and concentric ventricular hypertrophy [ 9 ]. (biomedcentral.com)
  • AGE-stimulated smooth-muscle proliferation increases the thickness of vessel walls. (health.am)
  • The NAPDH oxidase (Nox) family is emerging as a key disease-related factor in vascular diseases, but currently its role in hypoxia-induced pulmonary remodelling in COPD remains unclear. (ersjournals.com)
  • The increase in allergic diseases industrialized countries over the past decades has been attributed to a decline in infections during childhood, also known as the hygiene hypothesis. (tocris.com)
  • The reported incidence of tickborne rickettsial diseases in the United States has increased during the past decade ( 3 - 5 ). (cdc.gov)
  • Diabetes increases not only the prevalence and severity of periodontitis but also the progression of bone loss and attachment loss over time. (health.am)
  • This lack of significant differences in the primary bacteriologic agents of periodontal disease suggests that differences in host response may play a role in the increased prevalence and severity of periodontal destruction seen in patients with diabetes. (health.am)
  • In addition, it has also shown beneficial effects on both cardiac [ 11 - 13 ] and vascular endothelial functions [ 14 - 19 ]. (hindawi.com)
  • Also hypovolaemic patients often react with an increased vasoconstriction and atypical cardiac reactions. (medicines.org.uk)
  • and an increased heart rate, stroke volume, and cardiac output. (nih.gov)
  • The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. (nih.gov)
  • Results of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial confirmed that this practice independently associated with improved graft patency, as demonstrated by coronary angiography and saphenous vein graft intravascular ultrasonography. (medscape.com)
  • One hypothesis is related to hypertensive encephalopathy and vascular injury. (ajnr.org)
  • Here we investigate the role of p22phox, a regulatory subunit of Nox, in COPD lungs, hypoxic pulmonary vasoconstriction (HPV), hypoxia-induced pulmonary vascular remodelling and pulmonary hypertension. (ersjournals.com)
  • ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
  • This reduces heart rate and vascular resistance. (wikipedia.org)
  • Elevated intraocular pressure (IOP) in glaucomatous eyes is often due to increased resistance to aqueous outflow. (molvis.org)
  • Previous studies have shown that increased extracellular material deposition in outflow pathways leads to increased resistance to aqueous outflow, and transforming growth factor (TGF)-β seems to play a role in the deposition of extracellular material. (molvis.org)
  • The pathophysiological processes leading to increased resistance in outflow pathways remain debatable. (molvis.org)
  • Basal airway resistance was increased 90 d post-sub-chronic exposure, but reactivity to methacholine (MCh) was unaffected. (cdc.gov)
  • An imbalance between the rate of ECM synthesis and its breakdown leads to increased ECM deposition in aqueous outflow pathways. (molvis.org)
  • This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
  • Taking Panax ginseng by mouth might improve thinking, arithmetic skills, and reaction times in healthy, middle-aged people but not in young adults. (webmd.com)
  • Taking panax ginseng alone doesn't seem to help memory, but taking it with ginkgo leaf extract seems to improve memory in healthy people between the ages of 38 and 66. (webmd.com)
  • Fatigue in people with multiple sclerosis (MS). Taking Panax ginseng by mouth daily for 3 months reduces feelings of tiredness and improves quality of life in females with MS. (webmd.com)
  • Taking Panax ginseng alone or with other ingredients by mouth seems to improve sexual arousal and satisfaction in postmenopausal adults. (webmd.com)
  • Taking Panax ginseng by mouth for up to 8 weeks doesn't improve athletic performance. (webmd.com)
  • Panax ginseng seems to increase the activity of the immune system . (webmd.com)
  • Some people use Panax ginseng to help them cope with stress and as a general tonic for improving well-being. (emedicinehealth.com)
  • Evidence shows that taking Panax ginseng root daily for 12 weeks can improve mental performance in people with Alzheimer's disease. (emedicinehealth.com)
  • Taking Panax ginseng by mouth seems to improve lung function and some symptoms of COPD . (emedicinehealth.com)
  • Panax ginseng alone does not seem to improve memory. (emedicinehealth.com)
  • But there is some evidence that a combination of Panax ginseng and ginkgo leaf extract can improve memory in otherwise healthy people between the ages of 38 and 66. (emedicinehealth.com)
  • This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. (nih.gov)
  • In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. (hindawi.com)
  • We conclude that in diabetic subjects, smooth muscle reactivity is increased because of changes in subcellular Ca2+ distribution on cell activation. (diabetesjournals.org)
  • Regulation of geminin by neuropeptide Y in vascular smooth muscle cell" by Shi-Yu Liang, You-Li Zhou et al. (edu.au)
  • Once membrane depolarization is complete, the membrane becomes impermeable to sodium ions again, and the conductance of potassium ions into the cell increases. (medscape.com)
  • HFWD+silica exposure increased BAL proinflammatory cytokines at 4 and 8 wk compared to STD+silica exposure. (cdc.gov)
  • La concentration sérique pour ces facteurs chez les femmes non encein- tes était similaire à celle des femmes enceintes en bonne santé. (who.int)
  • Toutefois, la concentration sérique était significativement plus élevée en présence d'une prééclampsie bénigne ou grave par rapport aux grossesses normales et significativement plus élevée pour les prééclampsies graves par rapport aux prééclampsies bénignes. (who.int)
  • Slight chemical alterations to the compounds have imparted beneficial characteristics, including increased duration and potency, to each. (medscape.com)
  • Gi-proteins in vascular smooth muscle are coupled to α 2 -adrenoceptors . (cvphysiology.com)
  • Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
  • Diabetes is associated with increased gingival inflammation in response to bacterial plaque, but the degree of glycemic control is an important variable in this relationship. (health.am)
  • The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. (ersjournals.com)
  • Our results suggest an increased susceptibility to silica-induced lung disease caused by HFWD consumption. (cdc.gov)
  • Myogenic theory: Myogenic regulation is intrinsic to the vascular smooth muscle. (onteenstoday.com)
  • In the isolated, perfused trachea preparation the inhibitory effect of the airway epithelium on reactivity to MCh was increased at 90 d post-exposure. (cdc.gov)
  • In this study, we investigated the effects of, and determine interactions between, HFWD-consumption and silica-exposure on airway epithelial ion transport and smooth muscle reactivity in the F344 rat. (cdc.gov)
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
  • In 2020, global CRC cases increased by 6%, with a mortality rate of 29 per 100,000 people in men and 20 per 100,000 people in women ( 1 ). (frontiersin.org)