• dGTP = 5'-(2'-deoxy)-guanosine-triphosphate) were investigated. (bvsalud.org)
  • What Is Deoxyguanosine Triphosphate (dGTP)? (excedr.com)
  • Deoxyguanosine triphosphate (dGTP) is a nucleotide with a purine base (guanine), deoxyribose sugar, and three phosphate groups. (excedr.com)
  • dGTP is also referred to using the names 2′-deoxyguanosine-5′-triphosphate, 2′-deoxyguanosine triphosphate, and deoxy-GTP. (excedr.com)
  • In this article, we will cover the functions of dGTP, how it performs those functions, its structural characteristics, and how it is different from GTP (guanosine triphosphate). (excedr.com)
  • dGTP is a nucleoside triphosphate having extensive roles and uses in organisms and in vitro lab workflows. (excedr.com)
  • The second assay, a forward mutation assay, tests the mispairing potential of any altered nucleotide 1) during incorporation as substrate nucleotide, and 2) after multiple incorporations into a single-stranded DNA gap region of M13mp2. (psu.edu)
  • 2022. Ribonucleotide incorporation by eukaryotic B-family replicases and its implications for genome stability. (nih.gov)
  • 2022. Ribonucleotide incorporation by eukaryotic B-family DNA replicases and its consequences. (nih.gov)
  • This result opens avenues for the possible incorporation of other metalated nucleobases analogues, with potential antitumor and/or antiviral activity, into RBCs. (bvsalud.org)
  • In both cycling and quiescent cells, the import of deoxynucleotides formed by cytosolic ribonucleotide reductase accounted for most of the synthesis of mitochondrial dGTP, with minor contributions by cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. (nih.gov)
  • 14 Ara-GMP is then monophosphorylated by deoxyguanosine kinase and deoxycytidine kinase to ara-G diphosphate, and then subsequently to the active ara-G triphosphate (ara-GTP). (drugbank.com)
  • Pyrosequencing reaction: chemiluminescent cascade to detect incorporation of nucleotides according to the sequence of the template strand. (medscape.com)
  • At time intervals we determined the labeling of deoxyguanosine nucleotides and DNA and the turnover of dGTP from its specific radioactivity in the separated mitochondrial and cytosolic pools. (nih.gov)
  • Organisms possess an enzyme, 8-oxo-dGTPase, which catalyzes the hydrolysis of 8-oxo-dGTP to the corresponding nucleoside monophosphate, thereby preventing the occurrence of mutation. (elsevierpure.com)
  • As a nucleoside analog, Ara-GTP competes with endogenous deoxyGTP (dGTP) for incorporation into DNA. (drugbank.com)
  • Tenofovir diphosphate inhibits HBV replication through incorporation into viral DNA by the HBV reverse transcriptase, which results in DNA chain-termination. (medscape.com)