• Sporadic inclusion body myositis (s-IBM) has been traditionally classified as one of the idiopathic inflammatory myopathies along with dermatomyositis (DM) and polymyositis (PM). However, the pathologic findings of sporadic inclusion body myositis (s-IBM) involve both inflammatory and degenerative characteristics, and the true primary pathogenesis of the disease remains a subject of significant debate. (medscape.com)
  • The idiopathic inflammatory myopathies (IIM) encompass eight categories: 1) dermatomyositis (DM) in adults, 2) juvenile dermatomyositis, 3) amyopathic DM, 4) cancer-associated DM, 5) polymyositis, 6) immune-mediated necrotizing myopathy, 7) inclusion body myositis, and 8) overlap myositis.1 These categories help classify the myopathies based on clinical and histologic features. (the-rheumatologist.org)
  • We employ JIA as a prototype for childhood rheumatologic disease, which broadly encompasses JIA, systemic lupus erythematosus (SLE), Sjögren syndrome, idiopathic inflammatory myopathies (namely juvenile dermatomyositis, or JDM), systemic and localized sclerodermas, systemic vasculitides, sarcoidosis, and autoinflammatory syndromes (among others). (biomedcentral.com)
  • Introduction: The idiopathic inflammatory myopathies traditionally comprise dermatomyositis, polymyositis, the anti-synthetase syndromes, immune-mediated necrotizing myopathy and inclusion body myositis. (unifg.it)
  • IBM is often confused with an entirely different class of diseases, called hereditary inclusion body myopathies (hIBM). (wikipedia.org)
  • Multiple genetic diseases that feature inclusion bodies have been grouped into "hereditary inclusion body myopathies (hIBM). (wikipedia.org)
  • Sporadic inclusion body myositis (s-IBM) and hereditary inclusion body myopathies (h-IBM) encompass a group of disorders sharing the common pathological finding of vacuoles and filamentous inclusions. (medscape.com)
  • One of the most common disabling inflammatory myopathies in those over the age of 50 is inclusion body myositis (IBM). (mdqld.org.au)
  • Myositis, Inflammatory Myopathies, including Dermatomyositis (DM), Juvenile Myositis (JM/JDM) or Polymyositis (PM) and Inclusion Body Myositis (IBM). (yorkhospitals.nhs.uk)
  • Dermatomyositis is in a group known as inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. (azivinfusion.com)
  • Dermatomyositis (DM) is the easiest form of myositis to diagnose due to the purple-red rashes in the shape of the heliotrope flower . (healthline.com)
  • Antisynthetase syndrome may be a further complication for someone with polymyositis or dermatomyositis. (myositis.org.uk)
  • This study was aimed at evaluating the aerobic capacity of patients with antisynthetase syndrome (ASS) and dermatomyositis (DM) and analyzing possible relationships between aerobic capacity and disease status, cardiovascular diseases and their risk factors. (biomedcentral.com)
  • Degeneration is characterized by the appearance of holes, deposits of abnormal proteins, and filamentous inclusions in the muscle fibers. (wikipedia.org)
  • Dermatomyositis affects muscles mainly in the arms, legs, and trunk, as well as those that help you swallow. (upmc.com)
  • In inclusion body myositis, which typically affects men more than women, weakness usually starts in the upper legs and later affects the upper arms and muscles farther away from the center of the body, such as the hand, wrist and lower legs. (creakyjoints.org)
  • With inclusion body myositis, the muscles have an abnormal protein called amyloid, similar to the amyloid that forms in the brain in people with Alzheimer's disease, but the reason it forms is unknown. (creakyjoints.org)
  • Autoimmune myositis causes inflammation and weakness in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). (msdmanuals.com)
  • 1. Dermatomyositis (DM) is characterised by muscle weakness around the neck, shoulders, trunk, and hips (proximal muscles). (portmelbournephysio.com.au)
  • The term "sporadic inclusion body myositis" (sIBM) was introduced as a way to refer to IBM to avoid confusion with hIBM. (wikipedia.org)
  • Various dermatologic manifestations of dermatomyositis. (wikem.org)
  • The potential for error, due to a lack of specific detail in defining the individual manifestations and inclusion of non-rosacea disease, still persists," he says. (dermatologytimes.com)
  • In persons with Kawasaki disease and dermatomyositis, IVIG is thought to inhibit the generation of membrane attack complexes (C5b-C9) and subsequent complement-mediated tissue damage by binding the activated components C3b and C4b, thus preventing their deposition on target surfaces. (medscape.com)
  • The cause of dermatomyositis is unknown, but the disease has much in common with autoimmune disorders, in which your immune system mistakenly attacks your body tissues. (azivinfusion.com)
  • Although their clinical presentations (aside from the presence of certain skin findings in dermatomyositis, some of which are pathognomonic) and treatments are similar, the two diseases are pathologically distinct. (mhmedical.com)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • Their inclusion in this category is due to the presence of inflammation seen on nerve biopsy and their response to immunosuppressant or immunomodulatory treatments. (medlink.com)