• Benign lesions include placental site nodule and hydatidiform moles while malignant lesions have four subtypes including invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (wikipedia.org)
  • Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
  • An ADC with the Company's technology comprises an antibody that binds to a target found on tumor cells and is conjugated to one of its potent anti-cancer agents as a payload to kill the tumor cell once. (stockhouse.com)
  • The advent of monoclonal technology has increased the potential utility of antibody-dependent tumor marker assays in gynecologic oncology. (duke.edu)
  • The availability of unlimited quantities of several pure monoclonal antibodies directed against novel epitopes on tumor-associated antigens has permitted development of highly sensitive assays for serum markers. (duke.edu)
  • Besides CAR-T cell therapy, other adoptive cell therapies that use your body's own T-cells to destroy the cancer are being developed including tumor-infiltrating lymphocyte (TIL) therapy. (webmd.com)
  • Its ELAHERE (Mirvetuximab Soravtansine) is a first-in-class ADC targeting folate receptor alpha (FRa), a cell-surface protein over-expressed in a number of epithelial tumors, including ovarian, endometrial, and non-small-cell lung cancers. (stockhouse.com)
  • Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors. (enzolifesciences.com)
  • Solid tumors pose significant challenges for immunotherapies including those employing phagocytic macrophages as effector cells. (aiche.org)
  • Thus, our in vitro and in vivo models utilizing gene-edited cells, monoclonal antibodies for opsonization and checkpoint blockade, and cell therapy begin to define the parameters required for successful immunotherapy of solid tumors including (i) macrophage density, (ii) inhibitory checkpoint disruption, and (iii) IgG-opsonization. (aiche.org)
  • Tumors presented primarily in the subcutaneous tissues of the ventral neck (74% of the myoepitheliomas evaluated) but were observed in several other subcutaneous locations, including the head, perineum, and ventral abdomen. (jax.org)
  • The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). (wikipedia.org)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (childrensmercy.org)
  • Sp17 is highly expressed in benign, borderline, and low grade malignant serous ovarian neoplasms and can be quantified in serum. (biomedcentral.com)
  • At present, serum CA-125 is the most extensively used biomarker to preoperatively discriminate between benign and malignant ovarian neoplasms, detect recurrence, and monitor response to treatment. (biomedcentral.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
  • Antithyroglobulin and thyroid antimicrosomal antibodies are measured in serum. (teknon.es)
  • Serum was analysed by immunoassay specific for prostate cancer and other fac- using a monoclonal antibody kit (Kavoshyar tors such as benign prostatic hyperplasia, Iran, Islamic Republic of Iran). (who.int)
  • The overal prevalence of positive tion was found between C. trachomatis C. trachomatis );and2)Giemsastaining serum antibodies for C. trachomatis in- and cervical neoplasia [ 4 ]. (who.int)
  • The D-L antibody is known to bind to various antigens such as I-, i-, p-, Pr-, on the RBC surface, but the glycosphingolipid P antigen is considered its primary target. (medscape.com)
  • In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
  • Neuro-ophthalmic manifestations frequently are encountered in persons with multiple sclerosis (MS) and other central nervous system (CNS) inflammatory disorders, including neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). (medscape.com)
  • We searched PubMed and Medline for studies published during the last 10 years with the general term "optic neuritis" and specific terms like "typical optic neuritis," "atypical optic neuritis," "multiple sclerosis," "neuromyelitis optic neuritis," and "myelin oligodendrocyte glycoprotein antibody. (lww.com)
  • 9,10 Thus, detection of CK5 in prostatic basal cells with anti-Cytokeratin 5/6 (D5/16B4) antibody may be used to aid in the differentiation of benign and malignant prostate lesions. (roche.com)
  • ProductData": { "ID": "RTD000669", "ProductType": "Others", "BrandName": "anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody", "ProductNameAddition": "", "RegulatoryDisclaimer1": "For in vitro diagnostic use. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 5 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. (roche.com)
  • One 5 mL dispenser of anti-Cytokeratin 5/6 (D5/16B4) antibody contains approximately 52 μg of a mouse monoclonal antibody. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody (anti-Cytokeratin 5/6 (D5/16B4) antibody) is a mouse monoclonal antibody raised for the detection of cytokeratin (CK) 5. (roche.com)
  • Five of 6 patients with myeloproliferative neoplasms had a negative antibody response, and all 5 of these patients had received ruxolitinib (Jakafi) therapy. (theoncologypharmacist.com)
  • Anti-Cytokeratin 5/6 (D5/16B4) antibody is a monoclonal antibody produced as cell culture supernatant. (roche.com)
  • One vial containing 420 mg of trastuzumab, a humanised IgG1 monoclonal antibody produced by mammalian (Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)
  • Current diagnostic criteria for MS include clinical and paraclinical measures (Table 1). (medscape.com)
  • The Company is advancing PVEK in clinical trials for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myeloid leukemia (AML). (stockhouse.com)
  • Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
  • Clinical features suggestive of paraneoplastic AN include the development of AN in nonobese elderly persons and the rapid extensive progression of florid skin lesions in unusual locations, such as the mucosal membranes, palms, and soles of the feet. (medscape.com)
  • Antiaquaporin4 antibodies and antimyelin oligodendrocytes antibodies are now considered as distinct entities of optic neuritis with their specific clinical presentation, neuroimaging characteristics, treatment options, and course of the disease. (lww.com)
  • Its clinical picture includes thyrotoxicosis, exophthalmia and pretibial myxedema. (teknon.es)
  • Clinical trials frequently include multiple end points that mature at different times. (nih.gov)
  • This difference was observed across different clinical and laboratory variables, including neutropenia and lymphopenia, and subsets. (theoncologypharmacist.com)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • Co-expression of chromogranin A, neuron specific enolase (NSE) is common in neuroendocrine neoplasms. (enquirebio.com)
  • The co-expression of chromogranin, NSE is typical of neuroendocrine neoplasms. (enquirebio.com)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • Neoplasms encountered (confirmed histologically in 33%) included 18 carcinomas, 5 adenomas, 1 thymoma, and 3 hematologic malignancies. (qxmd.com)
  • 44% female), including 338 with hematologic malignancies. (jhoponline.com)
  • Of the 338 patients with hematologic malignancies, 67% had myeloid neoplasms and 33% had lymphoid neoplasms. (jhoponline.com)
  • Jeffrey Lancet, MD, Chair, Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, presented findings from an observational study evaluating antibody response to the mRNA 1273 COVID-19 vaccine in patients who had been treated for AML and MDS at his center. (theoncologypharmacist.com)
  • In all, 16 patients had high-risk disease, including 12 with active malignancy at the time of transplant. (nih.gov)
  • These pathways complement our catalog of research reagents for the study of Hemangioma including antibodies and ELISA kits against VEGFA, CD34, PECAM1, HBA1, VIM. (novusbio.com)
  • The Interaction With Host Pathway complements our catalog of research reagents including antibodies and ELISA kits against TNF, IL6, IL2, TLR2, TLR4. (novusbio.com)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • The histologic type of the associated neoplasm is usually carcinoma or lymphoma. (childrensmercy.org)
  • [ 3 , 4 ] These antibodies are approved for the treatment of advanced EGFR-expressing colorectal cancer, and cetuximab is also approved for treatment of squamous cell carcinoma of the head and neck. (medscape.com)
  • The sample second after lung cancer as the most preva- size was calculated with level of 0.05 and lent neoplasm in men. (who.int)
  • Specific antibody concentration is approximately 10.4 μg/mL. (roche.com)
  • An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
  • Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. (wikipedia.org)
  • Vaccination against human papillomavirus (HPV) is recommended to prevent HPV infections and HPV-associated diseases, including cancers. (cdc.gov)
  • Female canine mammary neoplasms (CMNs) are defined as a heterogeneous group of diseases of complex classification, diagnosis, and prognosis. (scielo.br)
  • Of the 56 patients with no seroconversion, 40 (72%) had lymphoid neoplasms, which "reflects 36% of all patients with lymphoid diseases," said Dr Rotterdam. (jhoponline.com)
  • A substantial number of patients with hematologic diseases do not have adequate antibody response, and might therefore not have sufficient protection from vaccination," said Dr Rotterdam. (jhoponline.com)
  • Results from 2 single-center studies presented at the ASH 2021 Annual Meeting and Exposition showed that nearly 1 in 6 patients with hematologic diseases had no or low antibody response after a second COVID-19 vaccination, but that the mRNA 1273 COVID-19 vaccine induced a strong antibody response in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). (theoncologypharmacist.com)
  • The rate of negative antibody results was highest among those with lymphoid neoplasms-a group of diseases that include lymphoma, myeloma, and lymphoid leukemia. (theoncologypharmacist.com)
  • Neoplasms that arise from endocrine tissue may also secrete hormones, resulting in excessive levels of these hormones in the body and potentially a wide variety of symptoms. (rarediseases.org)
  • this antibody can be used for staining of paraffin-embedded tissue sections fixed in neutral buffered formalin and is compatible with most commonly used histological fixatives. (enzolifesciences.com)
  • Disease and disorder research has been conducted in relation to the Interaction With Host Pathway and Infective Disorder, Tissue Adhesions, Cell Invasion, Neoplasms, Pneumonia. (novusbio.com)
  • Immunohistochemical (IHC) staining with anti-Sp17 antibody was performed on tissue specimens and the intensity scored as weak, moderate, or strong. (biomedcentral.com)
  • Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • The antibody thermal activity range of paroxysmal cold hemoglobinuria is simlar to that of cold hemagglutinin disease (CHD), the more common cold variant of autoimmune hemolytic anemia. (medscape.com)
  • Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
  • In autoimmune limbic encephalitis, it is assumed that these auto-antibodies diffusely interfere with basal synaptic transmission or neural excitability and weaken overall functions of the temporal lobe [ 18 ]. (springer.com)
  • Evaluation for VGKC antibodies is recommended in the comprehensive autoimmune serologic testing of subacute idiopathic neurologic disorders. (qxmd.com)
  • In addition, 2 (21.4%) patients had myeloid neoplasms and 4 (7.1%) had autoimmune disease. (jhoponline.com)
  • The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
  • Forty myoepitheliomas were tested by the avidin-biotin complex technique with a panel of antisera specific for mouse keratins, intermediate filaments, and other cytoskeletal proteins to determine the cell type from which this neoplasm originated. (jax.org)
  • Plasma cells help your body fight infection by producing proteins called antibodies . (medlineplus.gov)
  • Antibody specificity was confirmed in all cases by immunoprecipitation of detergent-solubilized brain synaptic proteins complexed with (125)I-alpha-dendrotoxin. (qxmd.com)
  • These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
  • Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - health professional version. (medlineplus.gov)
  • Elotuzumab ( Empliciti ) is a monoclonal antibody that attaches to the SLAMF7 protein to kill multiple myeloma cells. (webmd.com)
  • Tissues from cancer patients, for instance, have their own distinct pattern of Chromogranin A / CHGA expression as measured by anti-Chromogranin A / CHGA antibody immunohistochemical staining. (enquirebio.com)
  • Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. (abcam.com)
  • Antibodies directed against the specific mouse keratins K5, K6, and K14, and a broadly cross-reactive cytokeratin antibody stained acinar and ductal myoepithelial cells in normal mammary, salivary, and Harderian glands, and neoplastic cells in all cases. (jax.org)
  • CK5 is a type II CK (high molecular weight, 62 kDa) expressed in the basal and myoepithelial cells of various epithelia and glandular structures including the bronchi, prostate and breast. (roche.com)
  • 13-15 Several MEC markers exist and recommendations include use of IHC studies for at least two markers to demonstrate the presence or absence of myoepithelial cells. (roche.com)
  • Introduction: Malignant lymphomas are heterogeneous group of neoplasm comprising of proliferating lymphoid cells or their precursors. (aacrjournals.org)
  • Targeted therapy with antibody and small molecules may be more suitable for malignant lymphomas. (aacrjournals.org)
  • It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). (enquirebio.com)
  • Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) antibody contains sufficient reagent or 50 tests. (roche.com)
  • In addition, CK5 is expressed in mesothelial cells of the pulmonary pleura and is overexpressed in epithelioid malignant mesothelioma (MM). 6 CK5 is consistently absent in pulmonary ADC that confounds the diagnosis of epithelioid MM. 6,7 Thus, detection of CK5 with anti-Cytokeratin 5/6 (D5/16B4) antibody can be used to aid in the differential diagnosis of epithelioid MM from lung ADC. (roche.com)
  • 13-15 The detection of CK5 in breast MECs with anti-Cytokeratin 5/6 (D5/16B4) antibody may be used to aid in distinguishing non-invasive from invasive breast neoplasms. (roche.com)
  • In PCH, the red blood cells are targeted by an autoantibody, the Donath-Landsteiner antibody, whose formation is most often triggered by infectious disease or neoplasms. (medscape.com)
  • Intravascular hemolysis occurs preferentially at 37°C, at which temperature the antibody activates the classical complement cascade, providing the biphasic nature of the disease of D-L antibody binding at cold temperatures and hemolysis at wamer temperatures. (medscape.com)
  • Statistically significant associations included the following: infections in the neonatal period (MS-LCH, odds ratio (OR) = 2.2), solvent exposure (SS-LCH, OR = 54.9), childhood vaccinations (MS-LCH and SS-LCH, OR = 0.4), thyroid disease in the proband (MS-LCH and SS-LCH, OR = 21.6), and family history of thyroid disease (MS-LCH and SS-LCH, OR = 1.4). (thedoctorsdoctor.com)
  • Prophylaxis of venous thromboembolic disease in moderate and high risk surgical patients, in particular those undergoing orthopaedic or general surgery including cancer surgery. (medicines.org.uk)
  • The discovery of new antibodies has improved our understanding of the pathology of the disease. (lww.com)
  • The development of new immunosuppressant drugs and monoclonal antibodies has reduced the relapses and improved the prognosis of optic neuritis as well as an associated systemic disease. (lww.com)
  • Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. (enquirebio.com)
  • The trial enrolled patients with relapsed or refractory, CD20-positive mature B-cell neoplasms who previously received 2 or more lines of antineoplastic therapy, including at least 1 anti-CD20 monoclonal antibody.1 Patients were required to have measurable disease by PET/CT and an ECOG performance status of 0 to 2. (targetedonc.com)
  • Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. (loinc.org)
  • Positive seroconversion, defined as ≥0.8 U/mL antibody titer, was demonstrated for 85% of patients, with a mean titer value of 197 U/mL. (jhoponline.com)
  • Of the patients with a positive antibody titer, 89 (28%) had a response between 0.8 U/mL and 250 U/mL. (jhoponline.com)
  • A neoplasm is an abnormal growth in your body that may be cancerous. (msdmanuals.com)
  • Treatment of acute ST-segment elevation myocardial infarction (STEMI) including patients to be managed medically or with subsequent percutaneous coronary intervention (PCI). (medicines.org.uk)
  • however, the mRNA-1273 SARS CoV-2 vaccine induces a strong antibody response in patients with acute myeloid leukemia (AML) or with myelodysplastic syndrome (MDS). (jhoponline.com)
  • GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
  • This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)
  • Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
  • Cerebellar degeneration associated with a remote neoplasm. (childrensmercy.org)
  • Paraneoplastic syndromes are a heterogeneous group of disorders caused by an abnormal immune response to a neoplasm. (lecturio.com)
  • The Company is focused on developing and commercializing of antibody- drug conjugates (ADCs) to improve outcomes for cancer patients. (stockhouse.com)
  • The Alexa Fluor®, Pacific Blue™, and Cascade Blue® dye antibody conjugates in this product are sold under license from Molecular Probes, Inc. for research use only, excluding use in combination with microarrays, or as analyte specific reagents. (bdbiosciences.com)
  • Only 1 of 101 patients with chronic myeloid leukemia had no antibody response. (jhoponline.com)
  • This study showed a strong antibody to mRNA vaccines in patients with AML and MDS. (jhoponline.com)
  • This condition was first described in 1854 as an abrupt onset of systemic manifestations, including severe anemia and hemoglobinuria, occurring upon exposure to cold temperatures and resulting from massive intravascular hemolysis. (medscape.com)
  • The spectrum of neurologic manifestations and neoplasms associated with voltage-gated potassium channel (VGKC) autoimmunity is broader than previously recognized. (qxmd.com)
  • Developed utilizing the DuoBody platform, epcoritamab is a CD3xCD20 bispecific antibody that received accelerated approval from the FDA in May 2023 for use in adult patients with relapsed/refractory DLBCL not otherwise specified, including DLBCL arising from indolent lymphoma, and HGBCL, following at least 2 lines of systemic treatment. (targetedonc.com)
  • this included 148 patients with DLBCL and HGBCL, 4 patients with PMBCL, and 5 patients with follicular lymphoma grade 3b. (targetedonc.com)
  • in 25% of patients a neoplasm is detected after neurologic symptoms onset (most common being ovarian teratoma). (medlink.com)
  • Widespread data on the antibody responses and vaccine efficacy in allo-HSCT recipients is limited. (bvsalud.org)
  • Antibody levels increased dramatically following the second vaccine dose, which indicated the potential utility of serial vaccination, with good efficacy in poorly responsive patients after the first vaccine dose," Dr Lancet said. (jhoponline.com)
  • Vaccine-related antibodies were measured at a median of 12 weeks after final vaccination. (theoncologypharmacist.com)
  • Approximately 85% of patients tested positive for vaccine-related antibodies and 15% tested negative. (theoncologypharmacist.com)
  • Among these patients, 36% tested negative for vaccine-related antibodies. (theoncologypharmacist.com)
  • Results showed that after the first vaccine dose, 69.6% of patients had an antibody response and after the second dose, 95.7% had an antibody response. (theoncologypharmacist.com)
  • Blood specimens were collected from patients prior to the first and second vaccine doses and approximately 28 days after the second vaccine dose for antibody analyses. (theoncologypharmacist.com)
  • High-risk groups for HCC in which screening could be considered include HBV carriers (6,8), patients with cirrhosis of any etiology or hemochromatosis (9,10), and possibly patients with hepatitis C virus infection and other non-A, non-B hepatitis infections (11,12). (cdc.gov)
  • The participants concluded that other issues requiring further study include 1) the frequency of screening, 2) the effectiveness of using AFP as a primary screening marker for HCC, with ultrasound as an adjunct in patients with elevated AFP values, 3) the use of ultrasound as a primary screening marker for HCC, and 4) the development of more specific screening markers for HCC. (cdc.gov)
  • Viral coinfections were identified in four patients, including both SARS-CoV-2 and rhinovirus (one patient), respiratory syncytial virus (one), human metapneumovirus (one), and SARS-CoV-2 (one). (cdc.gov)
  • Underlying health conditions or risk factors included substance abuse (nine patients), current smoking (five), alcoholism (three), and diabetes (one). (cdc.gov)
  • However, no conclusion could be drawn since only one MDS patient was included in that single-center study of 180 patients with TAK. (nature.com)
  • The study included 982 patients with benign, borderline, and malignant ovarian neoplasms and normal ovary. (biomedcentral.com)
  • A second group of seven patients received CD45 monoclonal antibodies in addition. (nih.gov)
  • Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
  • Subcutaneous epcoritamab is a bispecific antibody with high single-agent activity in patients with relapsed or refractory LBCL. (targetedonc.com)
  • Negative seroconversion occurred predominantly in patients with lymphoid neoplasms. (jhoponline.com)
  • For example, among the 6 patients with MPN, 5 patients received ruxolitinib therapy, and all 5 had no antibody response. (jhoponline.com)
  • CONCLUSIONS: fTg of ≥33.5 ng/mL was the most important risk factor for prediction of treatment failure after RIT and could be included in decision algorithms regarding intensity of treatments in low/intermediate risk patients with DTC. (minervamedica.it)
  • The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. (enquirebio.com)
  • Jil Rotterdam, MD, Medizinische Klinik, Medizinische Fakultät Mannheim, Universität Heidelberg, Germany, presented findings from an observational study, which showed that approximately 15% of patients with hematologic disorders had a negative antibody response at least 2 weeks after receiving their second COVID-19 vaccination. (theoncologypharmacist.com)
  • Although it is encouraging that 85% of patients did show an antibody response following vaccination, she said, the results from this study suggest that additional precautions may be necessary to prevent COVID-19 infection in these vulnerable individuals. (theoncologypharmacist.com)
  • Antibodies against a presynaptic structure, the voltage-gated potassium channels of peripheral nerves, have been detected in patients with neuromyotonia with or without thymoma. (medscape.com)
  • Neuromyotonia and antibodies to the voltage-gated potassium channels have also been found in patients with MG. Twenty percent of patients with MG and neuromyotonia have been demonstrated to have thymoma. (medscape.com)
  • Although these drugs have been proven to be very effective for normally untreatable advanced neoplasms, EGFRIs cause cutaneous side effects in 50% or more of patients undergoing treatment. (medscape.com)
  • Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
  • Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large, small intestine, adrenal medulla, pancreatic islets. (enquirebio.com)
  • The choriocarcinoma has 2 significant subtypes including gestational and non-gestational and they are differentiated by their different biological feature and prognosis. (wikipedia.org)
  • Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. (loinc.org)
  • The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. (lookformedical.com)