Squamous cell carcinomasLesionsMalignantMelanomaExophyticProliferativePlantar surface of the footBasal cell carcLeukoplakiaCancersWarty carcinomasEpidemiologyDysplasiaHigher incidenceCuniculatumPathogenesisDifferences in the incidenceEpidermalMetastaticLesionSituPenile cancerCutaneousAggressive1948High incidencePatientsVariantInfectionScalp2019SpecimensClinicalDiagnosisOccursStagingGingivaCasesOral cancerMolecularDiagnosticPlaques
Squamous cell carcinomas3
- Bagan JV, Murillo J, Poveda R, Gavalda C, Jimenez Y, Scully C. Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. (medscape.com)
- More than 90% of invasive vulvar cancers are squamous cell carcinomas. (cancer.gov)
- Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. (ujds.in)
Lesions13
- Furthermore, the cell cycle regulatory genes p16 INK4a and p14 ARF are noted to be altered in lesions of proliferative verrucous leukoplakia. (medscape.com)
- Increased expression of immunoreactive tumor growth factor-alpha has been noted in lesions of both proliferative verrucous leukoplakia and oral squamous cell cancer, but not in healthy oral mucosa. (medscape.com)
- Flow cytometric analysis of archived lesions of proliferative verrucous leukoplakia has shown evidence of aneuploid cell lines, with DNA indexes remaining constant throughout the course of disease in most cases. (medscape.com)
- Thus, flow cytometry has been proposed as a tool to help identify lesions of proliferative verrucous leukoplakia early in the course of the disease. (medscape.com)
- Proliferative verrucous leukoplakia and its related lesions. (medscape.com)
- Epidermal nevi(EN)represent a heterogeneous group of mosaic skin lesions frequently following the lines of Blaschko. (karger.com)
- Clinically, all of them showed aggressive and multifocal lesions, varying from homogenous to non homogenous aspect with verrucous surface and erythematous areas. (bvsalud.org)
- It was suggested that PVL diagnostic criteria should include the presence of multifocal white lesions with aggressive behavior, long-term evolution, recurrences after any type of treatment, excluding the obligation of verrucous aspect on the time of diagnosis. (bvsalud.org)
- Squamous cell carcinoma and less often basal cell carcinoma can develop in long-standing lesions and/or scars. (medscape.com)
- Macroscopic examination revealed a thickened urinary vesicle mucosa, along with multiple foci of ulcerated, exophytic, verrucous, and pedunculated lesions. (pvb.com.br)
- Due to the higher incidence of aggressive lesions, treatment for melanoma is generally more invasive than for sarcoids. (weitzequine.com)
- The malignant lesions comprised three cases of ductal carcinoma in situ (DCIS) and 22 cases of infiltrating ductal carcinoma, not otherwise specified, IDC (NOS). (ijpmonline.org)
- Among the IDC (NOS) lesions, six cases of grade III breast carcinoma exhibited a positive immunohistochemical reaction, the staining index of which varied from 2-6. (ijpmonline.org)
Malignant5
- Proliferative verrucous leukoplakia (PVL) is an uncommon form of progressive multifocal leukoplakia with a high rate of malignant transformation to either squamous cell cancer or verrucous carcinoma and a high probability of recurrence. (medscape.com)
- Malignant transformation of proliferative verrucous leukoplakia to oral squamous cell carcinoma: a series of 55 cases. (medscape.com)
- It is also the key subtype that the above research focuses on, and these subtypes are related to the incidence of malignant tumors such as cervical cancer, rectal cancer, oral cancer (especially squamous cell carcinoma), and tonsil cancer. (honeyloveyou.com)
- The main categories of smokeless tobacco are oral squamous cell carcinoma, verrucous carcinoma, and other malignant disorders like erythroplakia, leukoplakia , tobacco pouch keratosis, and submucous fibrosis . (icliniq.com)
- Although the two most commonly diagnosed skin cancers are basal cell carcinoma and squamous cell carcinoma, which develop from the nonpigmented cells of the skin, the most aggressive and dangerous is malignant melanoma. (hindawi.com)
Melanoma3
- Rarely, other malignancies such as sebaceous carcinoma, microcystic adnexal carcinoma, and melanoma may complicate NS. (aad.org)
- Uveal melanomas differ significantly from cutaneous melanoma in incidence, prognostic factors, molecular characteristics, and treatment. (cancer.gov)
- 1 , 2 ] Since the early 2000s, the incidence of melanoma in people younger than 50 years declined by about 1% per year in men and stabilized in women. (cancer.gov)
Exophytic5
- Verrucous carcinoma is a relatively uncommon, locally aggressive, clinically exophytic, low-grade, slow-growing, well-differentiated squamous cell carcinoma with minimal metastatic potential. (medscape.com)
- Verrucous carcinoma manifests as a cauliflowerlike, exophytic mass that typically develops at sites of chronic irritation and inflammation. (medscape.com)
- These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. (openaire.eu)
- Verrucous carcinoma (VC) was first described in 1948 as a slow-growing exophytic and papillary lesion [ 1 ]. (jwmr.org)
- Verrucous carcinomas an exophytic, well differentiated form of oral cancer. (experts.com)
Proliferative25
- The etiology of proliferative verrucous leukoplakia (PVL) is unknown. (medscape.com)
- [ 1 ] Furthermore, because multiple cancers occur in proliferative verrucous leukoplakia-afflicted patients (ie, field-cancerization phenomenon), this suggests an infectious agent is responsible for the tumors. (medscape.com)
- [ 6 ] However, a role for the TP53 gene mutation or inactivation has not been found in the pathogenesis of proliferative verrucous leukoplakia. (medscape.com)
- Proliferative verrucous leukoplakia (PVL) is an uncommon variant of oral leukoplakia, occurring in less than 1% of adults. (medscape.com)
- No data on the worldwide incidence of proliferative verrucous leukoplakia are reported. (medscape.com)
- Although most studies of proliferative verrucous leukoplakia have been reported from western populations in the United States, Great Britain, Spain, and Italy, cases of possible proliferative verrucous leukoplakia have been reported in people of Indian and Chinese origin living in Malaysia. (medscape.com)
- Proliferative verrucous leukoplakia is usually seen in adults older than 40 years. (medscape.com)
- Nearly all cases of proliferative verrucous leukoplakia (PVL) develop into malignancy. (medscape.com)
- Patients with proliferative verrucous leukoplakia (PVL) should avoid other known factors associated with development of oral squamous cell carcinoma, such as tobacco, alcohol, and betel. (medscape.com)
- Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. (medscape.com)
- Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. (medscape.com)
- Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. (medscape.com)
- Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia. (medscape.com)
- Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. (medscape.com)
- Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma. (medscape.com)
- Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma: an immunohistochemical study. (medscape.com)
- DNA ploidy in proliferative verrucous leukoplakia. (medscape.com)
- Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. (medscape.com)
- Zakrzewska JM, Lopes V, Speight P, Hopper C. Proliferative verrucous leukoplakia: a report of ten cases. (medscape.com)
- Silverman S Jr, Gorsky M. Proliferative verrucous leukoplakia: a follow-up study of 54 cases. (medscape.com)
- Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not? (medscape.com)
- Proliferative verrucous leukoplakia, squamous cell carcinoma and axillary metastasis. (medscape.com)
- Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. (medscape.com)
- The proliferative verrucous leukoplakia (PVL) is a rare entity, with a high malignancy potential, classified as a subtype of oral leukoplakia (OL). (bvsalud.org)
- Hypertrophic or verrucous (relatively rare): This proliferative reaction, with the formation of large vegetating masses, may resemble genital warts. (medscape.com)
Plantar surface of the foot1
Basal cell carc2
- As a dermatology resident in the early 1980s, the risk of developing a basal cell carcinoma (BCC) was considered considerable (I vaguely recall learning that it was in the 30% range). (aad.org)
- The relatively avascular epidermis houses both basal cell keratinocytes and squamous epithelial keratinocytes, the source cells for basal cell carcinoma and squamous cell carcinoma, respectively. (cancer.gov)
Leukoplakia3
- Additionally, detection and quantification of Candida colonies and its correlation with various grades of oral leukoplakia and oral carcinomas have not been explored much. (iranpath.org)
- Sections were stained with calcofluor white (CFW) and 10% KOH for the observation under fluorescent microscopy and correlated with different grades of oral leukoplakia and oral carcinomas. (iranpath.org)
- Salivary ELISA for vimentin has been attempted to evaluate the secretion of vimentin in samples from normal healthy volunteers comparing with saliva from patients presenting with oral leukoplakia, OSMF and Oral squamous cell carcinoma. (researchsquare.com)
Cancers2
- Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among head and neck cancers. (bvsalud.org)
- Oral Tongue Squamous cell carcinoma (OTSCC) represents a major portion of oral cavity cancers, especially in India. (researchsquare.com)
Warty carcinomas2
- Cutaneous verrucous carcinomas may be confused with warty carcinomas, but the higher-grade cytological atypia and the more infiltrative growth pattern of warty carcinomas can help to differentiate. (medscape.com)
- About 75% to 100% of basaloid and warty carcinomas harbor HPV infection. (cancer.gov)
Epidemiology1
- PURPOSE OF REVIEW: To summarize the recent literature on epidemiology, clinical findings, treatment, and survival of laryngeal verrucous cell carcinoma (LVC). (bvsalud.org)
Dysplasia7
- Verrucous carcinoma is a rarely occurring, low-grade variant of squamous cell carcinoma, slow-growing verrucous and with minimal dysplasia. (units.it)
- The current retrospective study included 80 samples from archives consisting of 60 samples in the study group (10 cases each of mild, moderate, and severe epithelial dysplasia (totally 30) and 30 cases of oral carcinoma). (iranpath.org)
- The study groups of oral carcinoma and dysplasia showed a significant association with Candida sp. (iranpath.org)
- When carcinoma was compared with each grade of dysplasia, except mild dysplasia (P=4.4E-05), both moderate (P=0.402195) and severe dysplasia (P=0.558746) showed an insignificant P-value. (iranpath.org)
- When the groups of mild (13.3%), moderate (30%), and severe (33.3%) dysplasia were considered independently, the incidence of Candida sp. (iranpath.org)
- The number of colonies have been counted and the maximum number of colonies have been observed in carcinoma and the least have been observed in mild dysplasia. (iranpath.org)
- The study group consisted of 60 samples (10 samples each from diagnosed cases of mild, moderate, and severe dysplasia (totally 30), as per 2005 World Health Organization (WHO) classification), and 30 samples with oral carcinoma). (iranpath.org)
Higher incidence2
- Uncircumcised men have higher incidence of urine pooling between the prepuce and glans penis, whereupon occlusion precipitates a Koebner phenomenon and subsequent inflammation. (medscape.com)
- Nine patients were found between 2007 and 2011, and there were higher incidence among women with no smoking or drinking habits with an average age of 73 years old. (bvsalud.org)
Cuniculatum3
- [ 1 ] Aird et al first described cutaneous verrucous carcinoma (carcinoma cuniculatum) in 1954, and it was named as such because of its characteristic cryptlike spaces on histology. (medscape.com)
- Carcinoma Cuniculatum: Usefulness of Radiological Assessment. (units.it)
- 1] The incidence of epithelioma cuniculatum is unknown, with a predominance for men in their fifth-sixth decades. (units.it)
Pathogenesis1
- The pathogenesis of verrucous carcinoma is not yet fully elucidated. (medscape.com)
Differences in the incidence2
- This cohort study examines raw and age-adjusted differences in the incidence of keratinocyte carcinoma among Medicare beneficiaries by race and ethnicity. (jamanetwork.com)
- Again, investigators found no differences in the incidence of such autoimmune diseases as GBS and multiple sclerosis in vaccinated people compared with background rates of these diseases. (medscape.com)
Epidermal1
- Waltz KM, Helm KF, Billingsley EM: The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus. (karger.com)
Metastatic1
- however, verrucous carcinoma has low metastatic potential. (medscape.com)
Lesion1
- The glottic location of most LVC leads to detection of this lesion in its early stages, with ensuing better survival and outcomes after surgery compared with the classic form of squamous cell carcinoma. (bvsalud.org)
Situ1
- Entre as neoplasias foram encontrados papiloma, carcinoma in situ, carcinoma urotelial (baixo e alto grau), variantes invertida, microcística e trabecular, carcinoma urotelial com diferenciação divergente (escamosa e glandular), carcinoma de células escamosas, linfangioma, hemangioma e hemangiossarcoma. (pvb.org.br)
Penile cancer5
- The State of Rio Grande do Norte has a high incidence of penile cancer with a high frequency of locally advanced tumors at diagnosis and in younger patients younger than 50. (clinmedjournals.org)
- Brazil is one of the countries with the highest incidence of penile cancer in the world [ 5 , 6 ] which may correspond to 2.1% of all neoplasms in men, being five times more prevalent in the North and Northeast regions [ 7 ], where most of the procedures are performed. (clinmedjournals.org)
- Among these regions, Brazilian studies indicate that the State of Maranhão (Northeast of Brazil) has the highest incidence of penile cancer in Brazil, with an age-standardized incidence of 6.15 cases/100,000 habitants, with approximate statistics of one new case every 17 days [ 6 ]. (clinmedjournals.org)
- Therefore, the Brazilian Penile Cancer Consensus argues that reducing the incidence of this cancer is possible by encouraging intimate hygiene education, neonatal circumcision, smoking cessation, vaccination against HPV among young people, and the use of condoms [ 4 ]. (clinmedjournals.org)
- The incidence of the penile cancer peaks in the sixth decade of life even though it may occur in younger patients. (biomedcentral.com)
Cutaneous1
- However, recurrence of cutaneous carcinoma with clear surgical margins has been reported. (medscape.com)
Aggressive2
- Verrucous carcinoma is slow growing, but may display locally aggressive behavior. (medscape.com)
- Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer with high morbidity and mortality rates, despite multimodality management. (researchsquare.com)
19481
- In 1948, Ackerman first described verrucous carcinoma in the oral cavity as a low-grade tumor that generally is considered a clinicopathologic variant of squamous cell carcinoma . (medscape.com)
High incidence1
- In São José do Barreiro County, São Paulo, some farmers in areas with a high incidence of bovine EH have been replacing cattle with buffaloes, based on the premise that the latter would be more resistant to poisoning by ingestion of Pteridium spp. (pvb.com.br)
Patients4
- In addition, patients with a history of verrucous carcinoma should be evaluated with regular skin examinations at 3- to 12-month intervals. (medscape.com)
- The incidence is decreasing, while most patients are male individuals and smokers. (bvsalud.org)
- All patients were diagnosed with squamous cell carcinoma, mainly aged over 50 years, from the state's interior, brown, illiterate, or with incomplete primary education. (clinmedjournals.org)
- This link explains the increasing incidence (25%) of young, non-smoking oral cancer patients. (crookesandjenkinsdental.com.au)
Variant1
- Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. (openaire.eu)
Infection2
- Epidemiological screening of HPV infection in my country has not seen a large-scale report, but the incidence of genital warts among sexually transmitted diseases caused by HPV infection is rising rapidly, and it is estimated that the incidence rate should be among the top among sexually transmitted diseases because there are A large number of under-reporting and non-reporting. (honeyloveyou.com)
- The prevailing evidence favors HPV infection as a causative factor in many genital tract carcinomas. (cancer.gov)
Scalp1
- [ 10 ] Finally, HPV type 33 has been reported in a verrucous carcinoma of the scalp. (medscape.com)
20191
- From 2015 to 2019, the incidence in people aged 50 years and older stabilized in men and increased by about 1% per year in women. (cancer.gov)
Specimens1
- All skin biopsy specimens obtained to diagnose verrucous carcinoma must reach at least the depth of the mid dermis to allow for determination of the presence or absence of invasive disease. (medscape.com)
Clinical2
- A skin biopsy is always required for definitive diagnosis of verrucous carcinoma, despite the fact that the diagnosis is suspected strongly on clinical grounds. (medscape.com)
- SUMMARY: LVC presents different clinical, pathological, and survival outcomes when compared with the classic laryngeal squamous cell carcinoma. (bvsalud.org)
Diagnosis2
- Since the diagnosis changed to VC, and the resection margin was involved by the carcinoma, the patient underwent an amputation procedure at the proximal phalangeal base. (jwmr.org)
- Some authors make the diagnosis after a long-term follow-up, observing initial stages until the development of verrucous areas or carcinomas. (bvsalud.org)
Occurs2
- The peak incidence occurs in women aged 60-70 years. (medscape.com)
- Verrucous carcinoma occurs most often in those individuals over the age of seventy. (experts.com)
Staging1
- Computed tomography or magnetic resonance imaging may be used to demonstrate the exact location and extent of the verrucous carcinoma for preoperative staging and surgical planning. (medscape.com)
Gingiva1
- The most common location for verrucous carcinomas is the buccal mucosa and gingiva. (experts.com)
Cases3
- Most cases occur in females, with a female-to-male incidence ratio of approximately 4:1. (medscape.com)
- The labia majora are the most common sites of vulvar carcinoma and account for about 50% of cases. (cancer.gov)
- The labia minora account for 15% to 20% of vulvar carcinoma cases. (cancer.gov)
Oral cancer3
- Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
- According to the Indian Council of Medical Research (ICMR), the incidence of oral cancer in India is high, and it is one of the most common types of cancer in the country. (cowurine.com)
- This retrospective study lays the foundation for further investigation of the incidence of oral cancer and its associated characteristics in different regions across the Madhesh province of Nepal. (binayfoundation.org)
Molecular2
- CK 5/6 expression breast carcinoma implies a 'basal like' molecular phenotype and is associated with poor prognosis. (ijpmonline.org)
- The present review spotlights on understanding the molecular mechanism and the genetic factors which is responsible for alteration in the cell which leads to oral squamous cell carcinoma. (ujds.in)
Diagnostic1
- Despite a lower incidence of laryngeal carcinoma, new diagnostic techniques, and more targeted therapies, the overall survival has not changed significantly in the last decades, leading to a negative prognosis in advanced stages. (bvsalud.org)
Plaques1
- A 46-year-old female with common variable immunodeficiency presented with verrucous papules and crusted plaques from the right knee to the distal shin of 20years duration, associated with prior physical trauma. (cdc.gov)