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Cell Line HEK293 Cells Cell Line, Tumor Cells, Cultured HeLa Cells COS Cells Cell Nucleus NIH 3T3 Cells Cytoplasm Tumor Cells, Cultured Cell Membrane Fibroblasts X Chromosome CHO Cells Oocytes

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Escherichia coli Saccharomyces cerevisiae Mice, Knockout Cercopithecus aethiops Cattle Cricetinae Bacteriophage T4 Mice, Inbred C57BL Bacillus Mice, Transgenic

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Genomic Instability

Chemicals and Drugs96

Proteins Proteasome Endopeptidase Complex Guanidine Ubiquitin Ubiquitin-Protein Ligases Recombinant Proteins RNA, Messenger Bacterial Proteins Urea DNA-Binding Proteins Transcription Factors Nuclear Proteins Muramidase Solvents Tumor Suppressor Protein p53 Recombinant Fusion Proteins Mutant Proteins Cysteine Amino Acids Tumor Suppressor Proteins Sodium Channels Carrier Proteins Lysine Protein-Serine-Threonine Kinases Proto-Oncogene Proteins c-mdm2 Leupeptins Cell Cycle Proteins DNA Primers Repressor Proteins Glycogen Synthase Kinase 3 Serine RNA, Small Interfering Membrane Proteins Salts Disulfides Multiprotein Complexes DNA Proteasome Inhibitors F-Box Proteins Ribonucleases Peptides Trans-Activators Histidine Protein Subunits Solutions Water Proto-Oncogene Proteins c-myc Enzyme Inhibitors Saccharomyces cerevisiae Proteins Alanine Protein Isoforms Cullin Proteins Hypoxia-Inducible Factor 1, alpha Subunit Multienzyme Complexes Proline Apoproteins Peptidylprolyl Isomerase Peptide Hydrolases Lactalbumin Proto-Oncogene Proteins Complex Mixtures Escherichia coli Proteins Ubiquitins Molecular Chaperones SUMO-1 Protein Cysteine Endopeptidases Tryptophan PTEN Phosphohydrolase Ubiquitin-Specific Proteases Calcium Intracellular Signaling Peptides and Proteins HSP90 Heat-Shock Proteins Kv1.4 Potassium Channel RNA-Binding Proteins SKP Cullin F-Box Protein Ligases Plant Proteins Potassium Channels Threonine Von Hippel-Lindau Tumor Suppressor Protein Micrococcal Nuclease Arginine Endopeptidases Ligands Cycloheximide Adaptor Proteins, Signal Transducing Methylamines Macromolecular Substances Cyclin-Dependent Kinase Inhibitor p21 Ribonuclease T1 Thermolysin Green Fluorescent Proteins Buffers Potassium Channels, Voltage-Gated Protein Synthesis Inhibitors Muscimol Peptide Fragments

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Enzyme Stability Drug Stability Protein Denaturation Models, Molecular Circular Dichroism Mutagenesis, Site-Directed Amino Acid Substitution Virus Inactivation Protein Engineering Protein Unfolding Calorimetry, Differential Scanning Models, Biological Models, Chemical Transfection Spectrometry, Fluorescence Sequence Alignment Crystallography, X-Ray Blotting, Western Immunoprecipitation Immunoblotting Cloning, Molecular Reverse Transcriptase Polymerase Chain Reaction Patch-Clamp Techniques Electrophoresis, Polyacrylamide Gel Spectrophotometry, Ultraviolet Sequence Analysis, Protein Calorimetry Two-Hybrid System Techniques Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular Magnetic Resonance Spectroscopy Chromatography, High Pressure Liquid DNA Mutational Analysis Gene Knockdown Techniques Polymerase Chain Reaction Microscopy, Fluorescence Precipitin Tests

Phenomena and Processes95

Protein Stability Enzyme Stability Protein Denaturation Thermodynamics Protein Folding Mutation Amino Acid Sequence Kinetics RNA Stability Protein Conformation Temperature Protein Binding Protein Structure, Tertiary X Chromosome Inactivation Ubiquitination Protein Structure, Secondary Proteolysis Amino Acid Substitution Virus Inactivation Hot Temperature Binding Sites Hydrogen-Ion Concentration Base Sequence Protein Unfolding Phosphorylation Half-Life Structure-Activity Relationship Protein Processing, Post-Translational Signal Transduction Transcription, Genetic Time Factors Mutation, Missense Hydrogen Bonding Transfection Gene Expression Regulation Static Electricity Amino Acid Motifs Sequence Homology, Amino Acid Gene Silencing Point Mutation Transition Temperature Dosage Compensation, Genetic Ion Channel Gating Plasmids Hydrophobic and Hydrophilic Interactions Phenotype Enzyme Activation Membrane Potentials Gene Deletion Mutagenesis Down-Regulation Cell Cycle Protein Structure, Quaternary Solubility Dimerization Substrate Specificity Protein Transport Promoter Regions, Genetic Sequence Deletion Protein Biosynthesis Apoptosis Oxidation-Reduction Protein Multimerization Sumoylation RNA Interference Catalysis Entropy Cell Proliferation Gene Expression Ultraviolet Rays Molecular Structure Conserved Sequence DNA Damage Catalytic Domain Molecular Dynamics Simulation Genomic Instability Gene Expression Regulation, Neoplastic Protein Interaction Domains and Motifs Algorithms Hydrolysis Transcriptional Activation Biophysical Phenomena Gene Expression Regulation, Bacterial Acetylation Physicochemical Phenomena X Chromosome Gene Expression Regulation, Enzymologic Cell Survival Genes, Tumor Suppressor Osmolar Concentration Glycosylation Dose-Response Relationship, Drug Alleles Genes, Reporter Up-Regulation

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Biophysics Electrophysiology Chemistry, Physical

Information Science6

Molecular Sequence Data Amino Acid Sequence Base Sequence Computer Simulation Molecular Dynamics Simulation Algorithms

Health Care4

Temperature Hot Temperature Ultraviolet Rays Disinfection

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Protein Stability Enzyme Stability Drug Stability Protein Denaturation Thermodynamics Protein Folding Mutation Molecular Sequence Data Models, Molecular Amino Acid Sequence Kinetics RNA Stability Protein Conformation Proteins Temperature Protein Binding Protein Structure, Tertiary X Chromosome Inactivation Ubiquitination Circular Dichroism Proteasome Endopeptidase Complex Protein Structure, Secondary Proteolysis Cell Line Mutagenesis, Site-Directed Amino Acid Substitution Virus Inactivation Hot Temperature Guanidine Ubiquitin Protein Engineering Binding Sites Hydrogen-Ion Concentration Base Sequence Ubiquitin-Protein Ligases Protein Unfolding Escherichia coli Phosphorylation Recombinant Proteins RNA, Messenger Calorimetry, Differential Scanning Half-Life Structure-Activity Relationship HEK293 Cells Protein Processing, Post-Translational Bacterial Proteins Cell Line, Tumor Signal Transduction Models, Biological Urea DNA-Binding Proteins Transcription, Genetic Transcription Factors Time Factors Mutation, Missense Models, Chemical Nuclear Proteins Muramidase Solvents Tumor Suppressor Protein p53 Hydrogen Bonding Transfection Recombinant Fusion Proteins Gene Expression Regulation Static Electricity Mutant Proteins Cells, Cultured Amino Acid Motifs Sequence Homology, Amino Acid Gene Silencing Point Mutation Transition Temperature Spectrometry, Fluorescence Cysteine Dosage Compensation, Genetic HeLa Cells Ion Channel Gating Amino Acids Sequence Alignment Plasmids Tumor Suppressor Proteins Sodium Channels Hydrophobic and Hydrophilic Interactions Computer Simulation Crystallography, X-Ray Carrier Proteins Lysine Protein-Serine-Threonine Kinases Proto-Oncogene Proteins c-mdm2 Blotting, Western Leupeptins Cell Cycle Proteins COS Cells DNA Primers Saccharomyces cerevisiae Repressor Proteins Phenotype Enzyme Activation Glycogen Synthase Kinase 3 Serine

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