• adhesins
  • This pathogen is equipped with an armamentarium of surface-exposed adhesins and virulence factors contributing to pneumonia and invasive pneumococcal disease (IPD). (jove.com)
  • 2002). "A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A". EMBO J. 21 (24): 6660-72. (wikipedia.org)
  • complement
  • A gene cluster responsible for secretion of the polysaccharide capsule has been identified and shown to inhibit the antibiotic effect of complement when grown on ascites fluid. (wikipedia.org)
  • Because of its role in the innate immune system classical complement has been implicated in a number of pathogen related disorders. (wikipedia.org)
  • Complement is responsible for immune inflammatory response in adipose tissues which has been implicated in the development of obesity. (wikipedia.org)
  • This is important for targeting the virus in its intracellular phase because the antibodies specific to the synthetic peptides can trigger the classical complement pathway and induce the death of HIV infected cells. (wikipedia.org)
  • species
  • E. coli is the most widely studied prokaryotic model organism, and an important species in the fields of biotechnology and microbiology, where it has served as the host organism for the majority of work with recombinant DNA. (wikipedia.org)
  • proteins
  • Staphylococcus aureus surface proteins interfere with neutrophil mobilization and activation, while others inhibit neutrophil serine proteases. (embopress.org)
  • ADEP binding induces ClpP proteolytic activation that leads to the proteins degradation in the cell, especially nascent proteins and the Ftsz protein which is an important protein in cell division. (wikipedia.org)
  • These chaperone proteins are responsible for hydrolyzing ATP to ADP, harnessing the energy, and then taking folded proteins and unfolding them. (wikipedia.org)
  • resistance
  • Recently, it has been found that this class of compounds might be also important as chemotherapeutic agents, especially against the proliferation of various cancer cells, including those displaying multi-drug resistance and against cancer stem cells (CSCs). (pjmonline.org)
  • How important is the issue of antibiotic resistance in the context of surgical site infections? (clinicaladvisor.com)
  • To overcome this problem, knowledge of the pathogenesis, antibiotic resistance mechanisms, and prospective treatment options of A. baumannii is important. (wikipedia.org)
  • human
  • Immunology research is important for understanding the mechanisms underlying the defense of human body and to develop drugs for immunological diseases and maintain health. (wikipedia.org)
  • gene
  • We confirmed that the fliC mutation is solely responsible for the observed changes in gene expression in the mutant strain since expression profiles were restored to that of the wild-type strain in the fliC-complemented strain. (jove.com)
  • predict
  • New basic understanding of B. subtilis will inform and enhance our ability to predict the physiology and regulatory processes of many pathogens. (europa.eu)
  • type
  • I work in public health but am not familiar with this type of staphylococcus . (healthcaremagic.com)
  • These wide variations in cost of care reflect the complex nature of SSIs, which may substantially differ in severity depending on the causative pathogen, type of surgical procedure performed, patient's underlying health condition, and other factors. (clinicaladvisor.com)
  • high
  • For instance, tuberculosis is an important consideration among healthcare workers, incarcerated individuals, and recent immigrants from high incidence regions. (oncologynurseadvisor.com)
  • This is due to increasing evidence from a growing number of studies that many patients defined as having HCAP are not at high risk for MDR pathogens. (wikipedia.org)
  • genetic
  • Racial and genetic factors are increasingly recognized as important predisposing factors associated with severe disease manifestations from a variety of pathogens. (oncologynurseadvisor.com)
  • Many factors are responsible for a given organism's optimal temperature range, but evidence suggests that the expression of particular genetic elements (alleles) can alter the temperature-sensitive phenotype of the organism. (wikipedia.org)