EpigeneticGeneticExpressed genesParticipantsStressesQualitativeTranscription factorsTypicallyHumansBiologyMiceRolesSubstancePrevalenceResponsesYearsStudyAlcoholFindingsScientistsDiseasesGroupResearchCharacteristicsChildrenCellGenderCommonTypeAnalysisPublicationInfluenceGrowthModelsBrainMakeFigureDataProduceCreateFoundDesignAffectMemoryLeadTypesEffectsLifeSimilarCellsSchoolPhysicalYearWorkDetermine
Epigenetic2
- If epigenetic loss drives aging, can you recover it, thereby reversing the aging process, and if you do that, do you get the youthful function of a complex tissue back again? (the-scientist.com)
- These experiments are closely linked to epigenetic analysis and gene editing experiments performed in cell culture models of glioma. (lu.se)
Genetic3
- Temperature was the most important environmental factor, explaining 33% of nestling non-genetic growth. (diva-portal.org)
- So they conducted genetic tests that showed the greatest response to the young spinal fluid was found in some specialized cells in the hippocampus, an area that's important to memory. (ijpr.org)
- In an attempt to address these issues with a genetic intervention, scientists reprogrammed neurons in mouse eyes to regrow after inducing glaucoma or crushing the optic nerve, and restored visual acuity in healthy, middle-aged mice to that of younger mice by expressing a set of genes known to revert cells to a pluripotent state, according to a study published in Nature Wednesday (December 2). (the-scientist.com)
Expressed genes1
- We predict several transcription factors to regulate differentially expressed genes between mLT-HSCs and other LT-HSC subsets. (biorxiv.org)
Participants3
- Immediately, a striking difference appeared between the older and younger study participants, said Yankner: The longest-lived people-those over 85-had lower expression of genes related to neural excitation than those who died between the ages of 60 and 80. (medicalxpress.com)
- After the functional MR imaging experiment, participants were tested for recognition of the encoded objects. (ajnr.org)
- The type of neurological condition (epilepsy or MS) did not influence these preferences, nor did the age, gender, or mental health status of the participants. (kcl.ac.uk)
Stresses1
- The key in this signaling cascade appears to be a protein called REST, previously shown by the Yankner Lab to protect aging brains from dementia and other stresses. (medicalxpress.com)
Qualitative1
- Results: Analysis of the responses to the discrete choice experiment validated previous qualitative findings that a higher level of privacy, greater clinical support, increased perceived benefit, and better device accuracy are important to people with a neurological condition. (kcl.ac.uk)
Transcription factors5
- Researchers repaired what is otherwise irreversible damage in the animals' ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells. (the-scientist.com)
- They looked to genes that encode transcription factors that de-differentiate cells. (the-scientist.com)
- In a 2016 Cell paper, a different group of scientists had activated these transcription factors in mice with progeria, a condition that causes premature aging, and found that the treatment alleviated symptoms and extended their lifespan by a matter of weeks. (the-scientist.com)
- The next challenge: to see if these transcription factors could successfully revert old and injured neurons back to a more youthful and healthy state. (the-scientist.com)
- To test whether adult mice can regain this ability, the researchers crushed the optic nerves of some mice and induced glaucoma in another set of mice by inserting tiny beads into their eyes, then injected the virus encoding the three transcription factors into all the mice's eyes. (the-scientist.com)
Typically1
- Typically the value of an experimental factor is varied between samples or group of samples. (lu.se)
Humans2
- Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)
- Although previous studies had suggested that parts of the nervous system influence aging in animals, the role of neural activity in aging, especially in humans, remained murky. (medicalxpress.com)
Biology2
- An intriguing aspect of our findings is that something as transient as the activity state of neural circuits could have such far-ranging consequences for physiology and life span," said study senior author Bruce Yankner, professor of genetics at HMS and co-director of the Paul F. Glenn Center for the Biology of Aging. (medicalxpress.com)
- However, how exactly aging contributes to disease penetrance and pathology remains largely unknown, since it has been notoriously difficult to study the biology of human aging in the lab. (lu.se)
Mice6
- LT-HSCs from young and aged mice have differential responses to acute inflammatory challenge. (biorxiv.org)
- One of the LT-HSC subsets is more prevalent in young and the other in aged mice. (biorxiv.org)
- The memory of aging mice improved when they received a substance found in the spinal fluid of young animals. (ijpr.org)
- When we put the factor in the mice, they actually are better able to perform a memory task where they have to remember something that happened to them (a small electric shock)," Wyss-Coray says. (ijpr.org)
- In a painstaking process that took many months, Iram was able to collect enough spinal fluid from young mice to conduct an experiment that infused the liquid into older animals. (ijpr.org)
- To avoid such out-of-control proliferation, which would risk causing cancerous growth, Sinclair's team eliminated one of the Yamanaka factors from their study- MYC , which is a known oncogene-and fitted the remaining three into an adeno-associated virus and injected it into mice. (the-scientist.com)
Roles1
- Among these, we show that Klf5 , Ikzf1 and Stat3 play important roles in age-related inflammatory myeloid bias. (biorxiv.org)
Substance3
- Academic and psychosocial impairments are particularly important in pediatric substance abuse. (medscape.com)
- A family history of substance abuse may be a risk factor for early cocaine use and for rapid dependence on cocaine. (medscape.com)
- 1 See the WHO web site for further information about the process of implementing resolution WHA61.4 and links to the various documents referred to in this report: http://www.who.int/substance_abuse/activities/globalstrategy/en/index.html. (who.int)
Prevalence1
- Prevalence of cocaine use in this age group was similar to the use of ecstasy and inhalants but was notably less than cigarettes, alcohol, or marijuana. (medscape.com)
Responses1
- With age, however, they produce a myeloid-biased output that may lead to poor immune responses to infectious challenge and the development of myeloid leukemias. (biorxiv.org)
Years7
- Study included 600 children (ages 1-5 years) from the Brazilian Public Health System in Petropolis (BPHSP), Rio de Janeiro. (naturalmedicinejournal.com)
- Of the children who completed the entire study period, the mean age was 2.4 years without differences among groups. (naturalmedicinejournal.com)
- This study investigates, in the literature mentioned, the existence of sufficient educational strategies for the prevention of the use of alcohol and drugs by elementary school students in Brazil, in particular between 9 and 11 years of age (students from the third to the fifth grade). (bvsalud.org)
- Using a multistage sampling design, a sample of 2479 youth aged between 14 and 35 years was taken randomly from 20 districts. (who.int)
- The proportion of youth using drugs is gradually in- creasing with age varying from 30.77% among those aged between 10-14 years old to 68.54% among those aged between 31-35 years old (p=0.000). (who.int)
- In a cross-sectional, descriptive study 853 children aged 6-15 years (520 boys and 333 girls) were assessed by questionnaire and clinical examinations. (who.int)
- 1] The 1998 National Household Survey on Drug Abuse revealed that 0.8% of US children aged 12-17 years had used cocaine in the previous month. (medscape.com)
Study4
- A growth factor found in the fluid also improved memory, though to a lesser degree, says Tony Wyss-Coray , a neuroscientist and senior author of the study. (ijpr.org)
- The finding hints at "a whole new era" in the search for treatments for Alzheimer's disease and other age-related conditions that affect a person's memory and thinking, says Maria Lehtinen , a neuroscientist at Harvard Medical School, who wrote a commentary that accompanied the study. (ijpr.org)
- A risk of using Yamanaka factors in vivo is that dedifferentiation can cause cells to divide rapidly, so researchers in the Cell study only turned them on in short bursts. (the-scientist.com)
- After preparing an integrative review of the scientific literature and discovering the lack of research studies specifically aimed at this age group within the school context, our study points to the relevance of the role of the school in multidisciplinary and interdisciplinary programs of prevention against the use of alcohol and drugs. (bvsalud.org)
Alcohol2
- Después de elaborar una revisión de integración de la literatura científica y hacer el descubrimiento de la inexistencia de investigaciones específicamente dirigidas a esa banda etaria en el ámbito escolar, el trabajo apunta para la relevancia del papel de la escuela en programas multidisciplinares e interdisciplinares de prevención contra el uso de alcohol y drogas. (bvsalud.org)
- Children and adolescents rarely experiment with an illicit drug such as cocaine prior to trying alcohol and cigarettes. (medscape.com)
Findings1
- These findings raised the possibility that Yamanaka factors could hold the key to counteract aging. (the-scientist.com)
Scientists1
- The brain's neural activity-long implicated in disorders ranging from dementia to epilepsy-also plays a role in human aging and life span, according to research led by scientists in the Blavatnik Institute at Harvard Medical School. (medicalxpress.com)
Diseases2
- High levels of homocysteine correlate strongly with most degenerative diseases of aging , especially heart attacks and strokes. (selfgrowth.com)
- Aging is the single most important risk factor in the development of many diseases including chronic neurodegenerative disorders of the central nervous system. (lu.se)
Group4
- Harvard Medical School geneticist David Sinclair and his colleagues aimed to reset the biological clocks of a group of cells to see if they could rejuvenate injured and aging cells. (the-scientist.com)
- Most recently, the 2004 National Survey on Drug Use and Health (NSDUH), formerly called the National Household Survey on Drug Abuse, focused on 3 major age groups, including the 12- to 17-year-old age group. (medscape.com)
- The 2004 NSDUH reported that 2.4% of the 12- to 17-year-old age group used cocaine at some point in their life, 1.6% used cocaine within the past year, and 0.5% used cocaine within the past month. (medscape.com)
- In 2004, 22% of those surveyed in the 12- to 17-year-old age group received treatment or counseling within the past year for emotional or behavioral problems. (medscape.com)
Research6
- From 1900 through to 2000 this field of research underwent three significant phases in the United States: (1) Golden Age of Research (1900-1930) which has been described as a multiple-factor approach, (2) Golden Age of Theory (1930-1960) which endeavored to show the limits of systematically connecting criminological research to theory, and (3) a 1960-2000 period, which was seen as a significant turning point for criminology. (wikipedia.org)
- Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
- Basé à la Southern Africa Labour & Development Research Unit à l'Université du Cap en Afrique du Sud depuis 2010, J-PAL Afrique travaille à l'amélioration des programmes sociaux visant à réduire la pauvreté en Afrique subsaharienne. (povertyactionlab.org)
- Établit en 2007 à l'Institute for Financial Management and Research (IFMR) en Inde, J-PAL Asie du Sud vise à renforcer l'efficacité des programmes de lutte contre la pauvreté en apportant aux décideurs des données scientifiques probantes. (povertyactionlab.org)
- Ouvert en 2012 à l'Institute for Economic and Social Research de l'Universitas Indonesia, J-PAL Asie du Sud-Est exerce des activités de recherche, de renforcement des capacités et de diffusion de connaissances dans le domaine du développement et contribue à ce que les politiques publiques s'appuient sur des preuves scientifiques. (povertyactionlab.org)
- New ideas and concepts are therefore vitally important for future research in this area. (lu.se)
Characteristics2
- None of the other body characteristics were linked to survival within sex and age categories. (diva-portal.org)
- It's equally important to recognize the characteristics of the most successful startups so that you can emulate them. (hitsteps.com)
Children1
- Among a subgroup of 1670 children with complete additional viral testing, we described the association between presence of codetections and severe respiratory illness using age-stratified multivariable logistic regression models. (cdc.gov)
Cell3
- Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
- Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
- Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
Gender1
- Subgroup analyses explored the effects of demographic factors (such as age, gender, and education), acceptance of and familiarity with mobile technology, neurological diagnosis (MS or epilepsy), and symptoms that could influence motivation (such as depression). (kcl.ac.uk)
Common3
- L oss of visual acuity is a common feature of aging, whether it's from age-related conditions such as glaucoma, an impaired ability for cells to respond to damage, or degeneration. (the-scientist.com)
- Objective: To determine preferences and the relative importance of user-generated factors influencing engagement with mHealth technologies for 2 common neurological conditions with a relapsing-remitting course: multiple sclerosis (MS) and epilepsy. (kcl.ac.uk)
- This derivation, although historically important, has lost much of its significance, since plant rather than animal products are more common vehicles. (cdc.gov)
Type5
- Systemic blockade of corticotropin-releasing factor (CRF) type 1 receptors (CRFR1s) reduces stress-induced thermal hyperalgesia. (nature.com)
- Obesity is a major risk factor for type 2 diabetes mellitus development and is characterized by an abnormal expansion of adipose tissue and low-grade chronic inflammation that contribute to insulin resistance. (bvsalud.org)
- The raw data type to use in the experiment. (lu.se)
- A description of the experiment type. (lu.se)
- In the BASE world an experimental factor is the same as an annotation type. (lu.se)
Analysis3
- The current paper highlights a new, interactive Shiny App that can be used to aid in understanding and teaching the important task of conducting a prior sensitivity analysis when implementing Bayesian estimation methods. (researchgate.net)
- Experiments are the starting point for analysis. (lu.se)
- To be able to use the values of the experimental factors in the analysis of your data the values must be accessible from the raw bioassays. (lu.se)
Publication1
- On this tab you can enter information about a publication that is the result of the experiment. (lu.se)
Influence2
- It is possible that associations of GWG with outcomes do not result from GWG itself, but rather to underlying factors that influence both weight gain and the outcomes (e.g., maternal diet composition or physical activity level). (nationalacademies.org)
- Neural excitation appears to act along a chain of molecular events famously known to influence longevity: the insulin and insulin-like growth factor (IGF) signaling pathway. (medicalxpress.com)
Growth1
- More tests suggested that the oligodendrocytes were responding to a growth factor in spinal fluid called FGF17, which dwindles with age. (ijpr.org)
Models1
- Bayes factors provide a continuous quantification of relative evidence, where a Bayes factor exceeding 1 indicates evidence supporting one of the models (usually referred to as the numerator), while a Bayes factor less than 1 indicates evidence in favor of the other model (the denominator). (researchgate.net)
Brain4
- These cells, called oligodendrocytes, create the myelin sheath that insulates wiring in the brain and is also important to memory. (ijpr.org)
- FGF17 is probably just one of many substances involved in brain aging, Wyss-Coray says. (ijpr.org)
- An aging brain with memory loss is a bit like "an old car that has broken down," he says. (ijpr.org)
- Yankner and colleagues began their investigation by analyzing gene expression patterns-the extent to which various genes are turned on and off-in donated brain tissue from hundreds of people who died at ages ranging from 60 to over 100. (medicalxpress.com)
Make2
- People were prepared to trade a modest amount of accuracy to achieve an improvement in privacy, but less likely to make this compromise for other factors. (kcl.ac.uk)
- Since you probably have lots of annotations on your items that are not relevant for the experiment you must select the annotations types that should make up the experimental factors of the experiment. (lu.se)
Figure1
- That was a remarkable result, but the team still needed to figure out why the experiment worked. (ijpr.org)
Data2
- Some of the more physical aspects were confirmed by actual experiment and the less tangible considerations tested against observable data and evaluated for consistency. (wanttoknow.info)
- When you have uploaded and imported your raw data, collected and registered all information and annotations about samples, hybridizations, and other items, it is time to collect everything in an experiment. (lu.se)
Produce1
Create2
Found1
- Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in odds of miscarriage, stillbirth, low birth weight, and small for gestational age. (cdc.gov)
Design1
- An explanation of the experiment design. (lu.se)
Affect1
- These experiments revealed that altering neural excitation does indeed affect life span-and illuminated what might be happening on a molecular level. (medicalxpress.com)
Memory1
- The team's success improving memory with FGF17 is important because it could lead to a drug that could be mass produced. (ijpr.org)
Lead1
- These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Types1
- Use the Add annotation types button to select the annotation types that should be used as experimental factors. (lu.se)
Effects1
- Observational studies are often susceptible to mixing effects of confounding factors with the predictor of real interest, in this case GWG. (nationalacademies.org)
Life1
- Was this disparity in neural excitation merely occurring alongside more important factors determining life span, or were excitation levels directly affecting longevity? (medicalxpress.com)
Similar1
- factor de crecimiento similar a la insulina y la enzima sirtuina, generando un efecto neuroprotector. (bvsalud.org)
Cells2
- One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
- These so-called Yamanaka factors, named after biologist Shinya Yamanaka, are widely used to generate induced pluripotent stem cells (iPSCs). (the-scientist.com)
School1
- The Positivist school argues criminal behaviour comes from internal and external factors out of the individual's control. (wikipedia.org)
Physical1
- related chemical compounds, physical agents (such as radiation) and biological factors (such as viruses). (who.int)
Year1
Work1
- For the plug-in to work, it is important to understand that information recorded in BASE should be formatted following a small number of rules. (lu.se)
Determine1
- In particular, it is important to determine whether these relationships are independent of prepregnancy body mass index (BMI) or if they differ by prepregnancy BMI. (nationalacademies.org)