• Research including SABV has strengthened the rigor and reproducibility of findings. (wikipedia.org)
  • To improve the rigor and reproducibility of research findings, the European Commission, Canadian Institutes of Health Research, and the U.S. National Institutes of Health (NIH) established policies on sex as a biological variable (SABV). (wikipedia.org)
  • Two of the cornerstones of science advancement are rigor in designing and performing scientific research and the ability to reproduce biomedical research findings. (nih.gov)
  • It is also important to recognize and highlight the community-driven effort to reproduce the findings. (nature.com)
  • By taking these approaches, we can continue ensuring the credibility and trustworthiness of the biomedical and behavioral research findings resulting from public support. (nih.gov)
  • In the 2019 State of Open Data researcher survey , more than 70% of respondents reported that they are likely to re-use open datasets in their future research and some even rely on them to validate their own findings, to increase collaboration between partners, and to avoid duplication. (europa.eu)
  • By openly sharing these datasets, codes, and protocols, researchers eliminate barriers to future research that want to replicate and build on a previous study's findings. (europa.eu)
  • Reliability and reproducibility are especially important in the preclinical findings of new therapies and diagnostics as any issues or mistakes introduced at this stage will negatively impact later stage development. (nih.gov)
  • Thus, the consequences of such research include irreproducible data, inconsistent findings, and results that cannot be generalized to either men and/or women - leading to incomplete knowledge of the pathogenesis of disease despite a significant funding investment. (nih.gov)
  • One well-publicised example of this was brought to light in an oncology study of preclinical research findings in which researchers were able to confirm only 11% of the findings [ 8 , 9 ]. (biomedcentral.com)
  • These deficiencies are compounded when flawed or non-reproducible basic research findings are used to formulate pre-clinical and clinical studies. (nih.gov)
  • Building upon efforts begun in the National Cancer Institute and the National Institute of Neurological Disorders and Stroke, the NIH is taking steps to enhance the reproducibility and transparency of research findings. (nih.gov)
  • First, all NIH Institutes and Centers have been asked to discuss the reproducibility and transparency of research findings with their Advisory Councils and stakeholder communities and to solicit feedback. (nih.gov)
  • In recent years, our faith in peer-reviewed research has been shaken by the revelation that many published findings don't hold up when scholars try to reproduce them. (insidehighered.com)
  • Concerns about scientific validity and reproducibility have been on the rise since John Ioannidis, a professor at Stanford School of Medicine, published his 2005 article "Why Most Published Research Findings are False. (insidehighered.com)
  • Ioannidis pointed to several sources of bias in research, including the pressure to publish positive findings, small sample sizes and selective reporting of results. (insidehighered.com)
  • Within basic science research, there's been a growing awareness of the need for rigorously designed experiments to ensure data reproducibility, which refers to the ability to achieve identical findings using the original data, code, and documentation. (aacc.org)
  • Addressing this challenge by capturing all of this data is the key to ensuring reproducibility, which would improve the chance of research findings being translated into new treatments for patients around the world. (medium.com)
  • The lack of reproducibility of research findings is a continuing concern in modern science. (plos.org)
  • Bear this issue in mind when designing your methodology too, as results with general significance outside of your direct data set will tend to increase the persuasiveness of your eventual findings. (oxbridgeessays.com)
  • From enhancing rigor and reproducibility, to encouraging sharing of data and protocols, to promoting pre-prints, and to requiring timely registration and reporting of clinical trial results, NIH establishes policies to make our funded research as credible, transparent, rigorous and full of impact as possible," Lauer wrote in a blog post . (nih.gov)
  • The failure of animal studies to translate to effective clinical therapeutics has driven efforts to identify underlying cause and develop solutions that improve the reproducibility and translatability of preclinical research . (nih.gov)
  • This poster presents the rationale for considering SABV in preclinical research as a primer for investigators. (nih.gov)
  • Despite this, preclinical research often uses single-sex cells and/or animals to examine diseases that affect both men and women without evidenced-based justification. (nih.gov)
  • Clearly important for clinical research, verification is equally important for preclinical research, something we all have an equal stake in. (biomedcentral.com)
  • Better, more robust preclinical research benefits us all a . (biomedcentral.com)
  • estimated this at approximately $28 billion a year for preclinical research in the United States alone [ 10 ]. (biomedcentral.com)
  • But it is peer review and the editorial policies and practices of journals that have come under the greatest scrutiny, and in June 2014 a set of guidelines for reporting preclinical research were proposed by the NIH to meet the perceived need for more stringent standards [ 12 ]. (biomedcentral.com)
  • These guidelines ask journals to ensure, for example, that authors have included a minimum set of information on study design, that statistical checks have been carried out by reviewers, and that authors have been given enough information to enable animal strains, cell lines, reagents, and so on, to be uniquely identified reagents (for a full list of requirements, see the NIH Principles and Guidelines for Reporting Preclinical Research). (biomedcentral.com)
  • As such, it aims to increase the European Commission's understanding of the lack of reproducibility in Europe, and help design a suitable response in the context of EU Research & Innovation. (sops4ri.eu)
  • The quality and generalizability of biomedical research depends on the consideration of key biological variables, such as sex. (wikipedia.org)
  • Studies following SABV policies can identify potential hormonal variability in earlier phases of biomedical research. (wikipedia.org)
  • The over-arching goal of this NIH R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs and foster a better understanding of biomedical, behavioral and clinical research and its implications. (nih.gov)
  • and (4) foster a better understanding of biomedical, behavioral and clinical research and its implications. (nih.gov)
  • We are continuously working to enhance scientific rigor and transparency in biomedical research. (nih.gov)
  • Over time, research practice began to change, and the number of challenges organized annually has been increasing steadily (Fig. 1 a), with currently about 28 biomedical image analysis challenges with a mean of 4 tasks conducted annually. (nature.com)
  • The NIH Office of Research on Women's Health is committed to providing SABV resources to enhance rigor and reproducibility of biomedical research to promote the health of women and men. (nih.gov)
  • The overall goal is to enhance a culture of transparency in biomedical research. (nih.gov)
  • Recently, a growing number of studies examining biomedical and behavioral research have drawn attention to a lack of methodological transparency and reproducibility of results in published research, which can affect this process. (nih.gov)
  • D ata and metadata are the foundation of reproducible biomedical research . (medium.com)
  • On the 22nd of October, alongside the UKRN, we co-hosted an online workshop From Data to Metadata: Ensuring reproducibility in biomedical research , focusing on the importance of and solutions for metadata collection in biomedicine. (medium.com)
  • In the second talk, Dr Philippe Rocca-Serra from the University of Oxford covered important aspects of data and metadata stewardship in biomedical research. (medium.com)
  • The chain of discovery in biomedical research has many stakeholders who need to be able to communicate ideas and results via a facilitated knowledge exchange. (medium.com)
  • To assess the reliability, validity, and responsiveness of the 6MWT and estimate the minimal clinically important difference (MCID) in patients with IPF. (nih.gov)
  • On October 5, 2015, NIH released new guidelines for implementing rigor and transparency in research project grants. (nih.gov)
  • In January 2017, the Journal of Neuroscience Research began requiring the consideration of SABV. (wikipedia.org)
  • At PLOS, we put researchers and research first. (plos.org)
  • Researchers are satisfied with their ability to share their own research data but may struggle with accessing other researchers' data. (plos.org)
  • Most scientific results that are shared today are just a summary of what researchers did and found. (crossref.org)
  • The availability of research data and source code of publications are an important aspect for allowing researchers to verify/falsify published results and enable subsequent research. (tu-chemnitz.de)
  • Researchers also started sharing preprints of their research through their websites or through preprint servers. (signalprocessingsociety.org)
  • During the meeting primary Pfiesteria researchers presented previously unpublished results. (nih.gov)
  • By making research easy to access, and puts the academic needs of the researchers before the business interests of publishers. (intechopen.com)
  • Our results have significance for researchers in the field providing a systematic synthesis of existing work to build on, identify gaps, opportunities for collaboration and avoid duplication. (ed.ac.uk)
  • Antibody microarrays with coated NEXTERION® glass slides help researchers at the German Cancer Research Center in Heidelberg and startup Sciomics to take a small step towards reaching a very big goal: a life without cancer. (schott.com)
  • In addition, they found that researchers have reported that the availability of open data has played an important role in their work. (europa.eu)
  • Moreover, by sharing research outputs, researchers can further stimulate new fields of enquiry and increase the number of papers that research projects produce . (europa.eu)
  • To help chip away at this question, we're publishing a series of articles from researchers leading initiatives to improve how academics are trained, how data are shared and reviewed, and how universities shape incentives for better research. (insidehighered.com)
  • When combined with a lack of transparency, it can be difficult for others to know which results to trust, even if the vast majority of researchers are doing their work in good faith. (insidehighered.com)
  • Because of this potential there is increased interest from across the research enterprise (researchers, universities, funders, societies, publishers, etc.) in data sharing and related issues. (creativecommons.org)
  • Wet lab researchers, funding bodies and research managers often struggle, however, to find robust solutions for implementing smart data stewardship - collecting not only bare-minimum results data but also valuable ancillary information, including experimental process data and measurements, commonly referred to as metadata. (medium.com)
  • She argued that for experimental reproducibility to be achieved, the research community has to adopt a set of standards and policies to make data collection comprehensible and reusable for other researchers. (medium.com)
  • This project will consist of a cross-sectional and longitudinal part where multiple transfusions and a control group shall be included to test for reproducibility and specificity of the methods. (wada-ama.org)
  • Underlying our commitment to Open Science is our data availability policy which ensures every piece of your research is accessible and replicable. (plos.org)
  • STM, DataCite, and Crossref are pleased to announce an updated joint statement on research data. (crossref.org)
  • In 2012, DataCite and STM drafted an initial joint statement on the linkability and citability of research data. (crossref.org)
  • I'm sure you heard this before-data sharing and data citation are important for scientific progress. (crossref.org)
  • The underlying data are not available, making it difficult to verify and replicate results. (crossref.org)
  • If data would always be made available with publications, transparency of research would be greatly improved. (crossref.org)
  • To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on developing courses for skills development, specifically, training modules for graduate students, postdoctoral fellows, and beginning investigators designed to enhance data reproducibility. (nih.gov)
  • Specifically, exportable training modules designed to enhance data reproducibility, targeted to graduate students, postdoctoral fellows, and beginning investigators. (nih.gov)
  • In addition, we have invited editors from scientific journals covering structural biology to moderate sessions and discuss issues with data reproducibility in the scientific literature. (nih.gov)
  • Systematic studies are needed to provide crucial data regarding the impact of environmental extrinsic factors on rigor and reproducibility of animal research. (nih.gov)
  • There have been three key revolutions in the way that research has become accessible: publishing, code, and data. (signalprocessingsociety.org)
  • Search engines began crawling such data sources so that research queries could be processed instantly, rather than enduring a long wait for the results of a careful library search. (signalprocessingsociety.org)
  • Submissions that facilitate reproducibility by using available data sets or making the described tools publicly available are especially encouraged. (wikicfp.com)
  • Only 14 studies made their data and 15 their code available with 10 externally validating results. (ed.ac.uk)
  • A fully packaged experiment needs to include the experimental workflow and any resulting data analysis or visualization. (anl.gov)
  • More important, in order to be easily redeployable, the experiment must be accompanied by explanatory text - information about the design and methodology choices as well as the actual experimental steps and other images or data that make reproducibility possible. (anl.gov)
  • In this post, they observe that scientific publications making data, code, and protocols appropriately accessible to the public can lead to reproducible results. (europa.eu)
  • As such, it is a central point of access to EU law, publications, open data, research results, procurement notices and other official information. (europa.eu)
  • In what has long been a highly contentious field of research, with limited reproducibility of results, this study has made all the data and analysis code freely available. (technologynetworks.com)
  • Additionally, the rarity of some of these medical conditions (e.g. lightning strike or arterial gas embolism) and challenges in data collection (e.g. difficult access to patients or transporting proper data recording equipment) has led to a paucity of scientific research in some areas. (wms.org)
  • Significant research pitfalls include not asking a pre-identified question, simply collecting data and trying to draw conclusions afterwards, attempting to ask multiple questions in a single manuscript, examining too focused of a question that will not generate enough data, or asking a question that could be impractical or too difficult to execute. (wms.org)
  • Thus it isn't surprising that reports eventually appeared in the media that some important experimental data was not reproducible…and here we are. (nih.gov)
  • Now at the National Institutes of Health (NIH) as Associate Director of Data Sciences, Bourne is concerned with the reproducibility of all NIH funded work, not just his own-and the problem is large. (biomedcentral.com)
  • In January 2014 the NIH announced they would fund more training for scientists in data management and restructure their grant review process to better value other research objects, such as data [ 11 ]. (biomedcentral.com)
  • problems in data handling and analysis which can lead to false positive results. (nih.gov)
  • Aug. 8: Can Qualitative Research Catch Up on Data Transparency? (insidehighered.com)
  • If the front stage is the paper summarizing the results, the back stage holds the details of the methodology, data and statistical code used to calculate those results. (insidehighered.com)
  • It's often possible to draw many different conclusions from the same data, and the current system rewards novel, positive results. (insidehighered.com)
  • A Laboratory Reflections article in the 2023 Special Issue of JALM, on Data Science and the Clinical Laboratory, emphasizes that reproducibility should be expected and laboratory medicine as well. (aacc.org)
  • In addition, many of our quantitative tests require some data analysis to go from a raw signal to results. (aacc.org)
  • Aside from the data themselves, the analytic computer codes are just as useful, perhaps more so, in that they allow incremental additions to methodologies in addition to reproducibility. (lww.com)
  • Fitted statistical models and other intermediate data products resulting from analytic code execution are also candidates for release, provided they do not contain the source data. (lww.com)
  • Workshop on Data Governance: Final Report = * Arlington, VA * December 14-15, 2011 * Supported by NSF #0753138 and #0830944 == Abstract == The Internet and related technologies have created new opportunities to advance scientific research, in part by sharing research data sooner and more widely. (creativecommons.org)
  • The ability to discover, access and reuse existing research data has the potential to both improve the reproducibility of research as well as enable new research that builds on prior results in novel ways. (creativecommons.org)
  • This applies to all types of research, but particularly data-intensive or "big science", and where data is expensive to produce or is not reproducible. (creativecommons.org)
  • However, our understanding of the legal, regulatory and policy environment surrounding research data lags behind that of other research outputs like publications or conference proceedings. (creativecommons.org)
  • This workshop was a first attempt to define the issues of data governance, identify short- term activities to clarify and improve the situation, and suggest a long-term research agenda that would allow the research enterprise to create the vision of a truly scalable and interoperable "Web of data" that we believe can take scientific progress to new heights. (creativecommons.org)
  • It includes the processes that insure important data are formally managed throughout an organization, including business processes and risk management. (creativecommons.org)
  • Organizations managing data are both traditional and well-defined (e.g. universities) as well as cultural or virtual (e.g. a scientific disciplines or large, international research collaborations). (creativecommons.org)
  • Sharing and integrating scientific research data are common requirements for international and interdisciplinary data intensive research collaborations but are often difficult for a variety of technical, cultural, policy and legal reasons. (creativecommons.org)
  • Reproducing research - a core scientific principle - also depends on effective sharing of research data along with documentation on its production, processing and analysis workflow (i.e. its provenance) and its formatting and structure. (creativecommons.org)
  • Without access to the supporting data and the means to interpret and compare it, scientific research is not entirely credible and trustworthy, and this access again depends on data governance. (creativecommons.org)
  • The research community recognizes that data governance issues, such as legal licensing and the related technical issue of attribution of Web-based resources would benefit from wider community discussion. (creativecommons.org)
  • The LOCS III criterion as an economic cataract grading system provides data that are in satisfactory concordance with the results obtained using the Pentacam Scheimpflug system. (bmj.com)
  • The workshop featured five talks covering different aspects of how to best support research reproducibility and which frameworks have been designed for experimental data collection so far. (medium.com)
  • To make matters worse, the data generated often misses metadata records, which are critical to make experimental results findable, accessible, interoperable, and reusable. (medium.com)
  • This manual takes a holistic approach to data governance, and is designed to enlist the help of different research team members, transitioning into a FAIR-compliant research process. (medium.com)
  • Xenon lamps have replaced older tungsten and deuterium lamps, resulting in better quality of data analysis. (labmanager.com)
  • Editorial policies were established by various scientific journals recognizing the importance and requiring research to consider SABV. (wikipedia.org)
  • This is the second of three workshops sponsored by the NIH Office of the Director on the important topic of reproducibility, the subject of recent editorials in leading scientific journals. (nih.gov)
  • In this study, you investigate the scientific quality criteria of Reproducibility and Replicability in the field. (tu-chemnitz.de)
  • Applicants are strongly encouraged to consult with NIH Scientific/Research staff when planning a cooperative agreement application. (nih.gov)
  • Early contact provides an opportunity for Scientific/Research staff to provide further guidance on program scope, goals, and developing appropriate milestones. (nih.gov)
  • Applicants should contact Scientific/Research staff at least 12 weeks before a receipt date. (nih.gov)
  • Open Access is an initiative that aims to make scientific research freely available to all. (intechopen.com)
  • Information provided on this webpage provides information about the efforts underway by NIH to enhance rigor and reproducibility in scientific research. (nih.gov)
  • Scientific rigor is the strict application of the scientific method to ensure unbiased and well-controlled experimental design, methodology, analysis, interpretation and reporting of results. (nih.gov)
  • Learn how to address rigor and reproducibility in your grant application and discover what reviewers are looking for as they evaluate the application for scientific merit. (nih.gov)
  • NIH has hosted a number of meetings and workshops focused on rigor, reproducibility, and transparency in scientific research. (nih.gov)
  • The National Institutes of Health (NIH) is the largest source of funding for medical research in the world, funding thousands of scientists and supporting many innovative training programs and funding mechanisms that foster scientific creativity and exploration. (nih.gov)
  • Avoiding adverse effects is important for scientific as well as ethical and legal reasons, as they can cause biological changes which may affect the blood sample and hence the validity and reproducibility of the research results. (nc3rs.org.uk)
  • The committee has put together this introduction to wilderness medicine research projects as a reference for those interested in pursuing scientific endeavors. (wms.org)
  • Each year the NIH Women Scientist Advisory (WSA) Committee selects two or three female FARE award winners to be honored as WSA Scholars for their outstanding scientific research. (nih.gov)
  • Applications for research grants and mentored career development awards submitted in 2016 must include information on scientific rigor and reproducibility. (nih.gov)
  • The scientific premise of the proposed research - This is the research used to form the basis for the proposed research question(s). (nih.gov)
  • A key feature is that the continuing battle for precious space in a scientific journal has led to exceptional brevity in scientific writing, resulting in rather cryptic Methods sections. (nih.gov)
  • Finally, NIH will continue to collaborate with scientific journals and the research community on efforts to improve the rigor of the review process for publications. (nih.gov)
  • Improving the reproducibility and transparency of the scientific research that we support is of paramount importance to the NIH, and we look forward to your input and feedback as we move forward on this initiative. (nih.gov)
  • How do we know which scientific results to trust? (insidehighered.com)
  • Scientific progress is real, but can be hindered by shortcomings that diminish our confidence in some results, and need to be addressed. (insidehighered.com)
  • There has been plenty of coverage about the reproducibility crisis and its implications (including debate over whether to call it a crisis) in both scientific publications and mainstream outlets like The New York Times , The Atlantic , Slate and FiveThirtyEight . (insidehighered.com)
  • Schema/ontology discovery and sharing, including governance (e.g. licenses for ontologies) The primary goal of the workshop was to develop a better shared understanding of the topic, and a set of recommendations to research sponsors and the broader community of scientific stakeholders for useful activities to be undertaken. (creativecommons.org)
  • 402(g)(2) of this Act granted the Secretary of the Department duct and coordinate scientific research within NIH relating to of Health and Human Services the authority to issue current dietary supplements and the extent to which their use can limit good manufacturing practices (cGMPs) for dietary supple- or reduce the risk of diseases and conditions such as heart dis- ments. (nih.gov)
  • its content is the issue of the reproducibility of scientific results, based on a field review and on an expert seminar on the opportunity of policy action in Europe. (sops4ri.eu)
  • PLOS Global Public Health is a global journal for public health research of the highest ethical and methodological rigor that reaches across disciplines and regional boundaries to address some of the biggest health challenges and inequities facing our society today. (plos.org)
  • No matter what type of research, there are almost always a number of methodological approaches available. (oxbridgeessays.com)
  • Essential considerations in all types of research, issues of reliability and validity must be explicitly discussed. (oxbridgeessays.com)
  • Questions concerning sampling techniques and sample size can be considered under reliability and validity, but are often important enough to be given special attention. (oxbridgeessays.com)
  • With both approaches, proteins expressed at a low level are discovered as a result of the reduced complexity subjected to analysis by LC-MS/MS. [ 7 ] Advances in methods and technologies enable construction of a comprehensive biomarker pipeline from six essential process components: candidate biomarker discovery, qualification, verification, research assay optimization and validation, as well as commercialization. (medscape.com)
  • Issued NOT-DA-14-007 "Improving Reporting of Research Methods and Results in Translational Addiction research Involving Animals is a NIDA Commitment. (nih.gov)
  • Current methods of predicting filter breakthrough are inexact and inefficient, so the development of a real-time, quantitative respirator sensor is an important achievement. (cdc.gov)
  • I remember very well my frustration as a postdoc of trying to replicate someone's exciting results in an effort to extend their observations, using their published Methods. (nih.gov)
  • The development of methods for identifying toxic chemicals has been the focus of substantial research efforts by the National Institute of Environmental Health Sciences (NIEHS), the National Toxicology Program (NTP), the Environmental Protection Agency (EPA), the Agency for Toxic Substances and Disease Registry (ATSDR), the Food and Drug Administration (FDA), and other agencies at various levels of government. (nationalacademies.org)
  • The existing methods for predicting long-term chemical toxicity-for example, analysis of structure-activity relationships (SAP,) and other correlational techniques, in vitro and in vivo short-term tests (STTs), and longer-term animal bioassays-all have valid, if different, uses at present and promise to become increasingly effective in the future, given appropriate research for their further development, validation, and integration. (nationalacademies.org)
  • It's especially important in ``methods'' chapters to think about reproducibility. (overleaf.com)
  • It is absolutely essential that you provide sound reasons for the methods your have chosen to conduct your research. (oxbridgeessays.com)
  • Results from these methods are not always as comparable as scientists would like. (technologynetworks.com)
  • Our results show that the proportion of unstable OTUs varies for different clustering methods. (biomedcentral.com)
  • OTU stability is an important consideration when analyzing microbial diversity and is a feature that should be taken into account during the development of novel OTU clustering methods. (biomedcentral.com)
  • The goal of this review is to examine the current literature for the most commonly researched biomarkers for predicting outcome to neoadjuvant CRT in LARC patients. (hindawi.com)
  • A systematic review of research articles published between 1990 and 2018 on efficacy testing of malaria vaccines and drugs using sporozoite challenge and sporozoite infectivity studies was conducted using Pubmed, Scopus, Embase and Cochrane Library, ClinicalTrials.gov and Trialtrove. (biomedcentral.com)
  • The GPC published Sex and Gender Equity in Research (SAGER) guidelines in 2016. (wikipedia.org)
  • By 2016, when Nature surveyed 1,500 scholars, over half expressed the view that there is a significant "reproducibility crisis" in science. (insidehighered.com)
  • Since the article was published, in 2016, the FAIR guidelines became an internationally accepted guidebook for increasing transparency and reproducibility in research. (medium.com)
  • chapter{Conclusions} A good conclusion will concisely summarise/highlight what you found, how it relates to your research questions/hypotheses, and what implications it has for other research. (overleaf.com)
  • Therefore, immunofluorescence intensity measurements do not necessarily correlate with the actual protein levels, especially in ischemia-affected tissue and should always be complemented by different techniques to enhance reproducibility and to hopefully overcome the translational roadblock from bench to bedside. (frontiersin.org)
  • In 2003, the European Commission (EC) began influencing investigators to include sex and gender in their research methodologies. (wikipedia.org)
  • Enrolling both men and women in clinical trials can impact the application of results and permit the identification of factors that affect the course of disease and the outcome of treatment. (wikipedia.org)
  • Including SABV in basic research and preclinical studies can reduce costs and time requirements to test sex differences in clinical trials. (wikipedia.org)
  • This program will support two career paths for learning new genomic medicine skills: (1) Genomic medicine focus for basic research and/or (2) Genomic medicine focus for clinical research (not for clinical care of patients). (nih.gov)
  • This is especially important for clinical trials in humans, which are built on studies that have demonstrated a particular effect or outcome. (nih.gov)
  • Automated understanding of clinical narratives of the radiology reports has the potential to enhance the healthcare process and we show that research in this field continues to grow. (ed.ac.uk)
  • Reproducibility and explainability of models are important if the domain is to move applications into clinical use. (ed.ac.uk)
  • LOCS III is well recognised as an age-related cataract grading scheme and is widely used for clinical and research study. (bmj.com)
  • Sex as a biological variable (SABV) is a research policy recognizing sex as an important variable to consider when designing studies and assessing results. (wikipedia.org)
  • NIH expects that sex as a biological variable will be factored into research designs, analyses, and reporting in vertebrate animal and human studies. (wikipedia.org)
  • NOT-OD-15-102 Guidance: Consideration of Sex as a Biological Variable in NIH-funded Research" (PDF). (wikipedia.org)
  • NOT 16-011) highlights the importance of sex as a biological variable (SABV) in research investigations. (nih.gov)
  • A systematic analysis of large databases revealed that sex/gender remains an independent and important biological variable that influences disease development and outcomes, even after controlling for age, comorbidities, scored risk factors, and ethnicity. (nih.gov)
  • We invite high quality submissions describing original and unpublished results of theoretical, empirical, conceptual, and experimental software engineering research. (wikicfp.com)
  • Such a number is surprising, given the theoretical reproducibility of computational research and given Bourne was attempting to reproduce work done in his own lab. (biomedcentral.com)
  • We have invited several world-class scientists who will speak about important technologies in structural biology. (nih.gov)
  • As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
  • When a result can be reproduced by multiple scientists, it validates the original results and readiness to progress to the next phase of research. (nih.gov)
  • For many applications, especially high-throughput ones, multiplexing has offered consistency and has allowed scientists to significantly improve the reproducibility of their assays. (technologynetworks.com)
  • The SABV policy aims to promote transparency, enhance rigor and reproducibility. (nih.gov)
  • But we also must develop policies that better support this process-policies, for example, that promote transparency and allow for improved verification of research. (biomedcentral.com)
  • The project leading to this application has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 824481. (sops4ri.eu)
  • In 2010, the National Centre for the Replacement, Refinement and Reduction of Animals in Research published the ARRIVE guidelines which promotes incorporating SABV in animal studies. (wikipedia.org)
  • To overcome these problems, we recommend best practice guidelines and define open research questions to be addressed in the future. (nature.com)
  • You can find the current guidelines and more information about how to include them in your application on the Office of Extramural Research website. (nih.gov)
  • 6 One important criticism of these guidelines is their rigid, one-size-fits-all nature, focusing on reproducibility rather than advancement. (lww.com)
  • The panel evaluated peer-reviewed and non-peer-reviewed literature available through June 2000 in a systematic conceptual framework that moved from the source of exposure, through exposure research and dose, to human health effects. (nih.gov)
  • But, ultimately, reproducibility efforts should be peer reviewed. (nature.com)
  • Research published in peer-reviewed academic journals has typically been considered the gold standard, having been subjected to in-depth scrutiny -- or so we once thought. (insidehighered.com)
  • NIH has taken - and continues to take - many steps to ensure the credibility of the research it supports. (nih.gov)
  • Publications using such practices may call into question the credibility of the research they report. (nih.gov)
  • in the humanities also, reproducibility indicates greater credibility and usefulness. (oxbridgeessays.com)
  • My name is Luis, and I've recently started a new role as the Technical Community Manager at Crossref, where I aim to bridge the gap between some of our services and our community awareness to enhance the Research Nexus. (crossref.org)
  • Explore principles to enhance rigor and further support research that is reproducible, robust, and transparent, developed by journal editors at a workshop representing over 30 basic/preclinical science journals. (nih.gov)
  • Public research institutions including the European Commission, Canadian Institutes of Health Research, and the U.S. National Institutes of Health have instituted SABV policies. (wikipedia.org)
  • NIH should encourage and support work to better understand, monitor, record, and report important extrinsic factors related to animal care that may affect research results. (nih.gov)
  • Advance the application of new technologies to support research resources and improve the generation, care, preservation, and distribution of animal models. (nih.gov)
  • Nature will endeavour to help the field to achieve its promise, and is looking at ways to support and encourage this reproducibility enterprise. (nature.com)
  • Applicants should describe the general strengths and weaknesses of the prior research they cite as crucial to support the application. (nih.gov)
  • Systemic reactions to autologous transfusions were supported by the analysis of classical markers such as serum ferritin and hematology measurements showing significant changes which support the high value of serum ferritin as an important marker of autologous transfusion. (wada-ama.org)
  • We conducted a systematic review of the literature to establish aggregate evidence on the reproducibility of a malaria sporozoite challenge model. (biomedcentral.com)
  • Even when a working algorithm is created, investigators typically don't share algorithm code because of concerns related to privacy, cost of sharing large datasets, protecting their research and intellectual property. (technologynetworks.com)
  • The reproducibility was also satisfactory with values of 0.865 and 0.871, respectively. (karger.com)
  • Reproducibility in microbial ecology research depends on the reliability of OTU-based 16S ribosomal subunit RNA (rRNA) analyses. (biomedcentral.com)
  • The workshop revealed that many repositories do a lot of work to establish links between articles and datasets, thereby significantly contributing to transparency in research. (crossref.org)
  • This downstream enrichment of metadata is useful, but it would be more effective if all stakeholders strive to establish these links at a much earlier stage in the research communication process. (crossref.org)
  • With this high throughput method, large numbers of individual genes can be investigated to establish whether the missing gene is important to eye function. (nih.gov)
  • With this method, they can test a single gene at a time to try to establish whether the missing gene is important to metabolism or other biological processes. (nih.gov)
  • By clearly defining your research question, you establish the direction and purpose of your study and ensure its relevance in the field of wilderness medicine. (wms.org)
  • Maintaining public trust in research is important, stressed Dr. Michael Lauer, NIH Deputy Director for Extramural Research. (nih.gov)
  • The National Institute of General Medical Sciences' PRAT fellows conduct research while in an NIH intramural research program (IRP) lab. (nih.gov)
  • likewise, reproducible research can still be incorrect. (biomedcentral.com)
  • Implementing FAIR standards in this field will foster the shift into more reproducible research for both academia and industry. (medium.com)
  • It encourages innovation by avoiding incremental research that does not improve upon what has already been performed. (signalprocessingsociety.org)
  • Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. (hindawi.com)
  • This report summarize a workshop held in Washington, D.C., on December 13-15, 1989, on research to improve the methodology for predicting the long-term toxicity of chemicals. (nationalacademies.org)
  • Understanding the mechanisms of action at relevant exposure concentrations and times should improve the accuracy of predictions from laboratory results W humans. (nationalacademies.org)
  • A general understanding of the effects of each performance attribute on the outcome of the measurements will help to improve the results from the UV-Vis test. (labmanager.com)
  • There are a few different approaches to multiplexing, but in general, multiplex assays improve the quality of your results by testing many targets or analytes in a single reaction. (technologynetworks.com)
  • I am delighted to introduce Dr. Larry Tabak, NIH's Principal Deputy Director, who recently spoke to the NIAMS Advisory Council about an important new initiative in which all of the NIH Institutes and Centers will participate. (nih.gov)
  • The first will maintain the existing program focused on genomic sciences research for graduate students and postdoctoral fellows (See NOT-HG-14-01 6). (nih.gov)
  • The second will create new programs focused on genomic medicine research for postdoctoral fellows (the subject of this Notice). (nih.gov)
  • To address key elements of method validation, three research laboratories used the same experimental protocols to enumerate viable organisms from uniformly viable and heat-killed cultures of three species of phytoplankton. (springer.com)
  • Journals clearly have an important part to play in helping to ensure as far as possible that experimental design and analysis are appropriate, and that reporting standards are met. (biomedcentral.com)
  • While we are reaching out to our stakeholder communities, we will also be working within NIH to develop a pilot training module on research integrity as it relates to experimental biases and study design. (nih.gov)
  • Collecting such a rich dataset to form a complete experimental record - one that includes the most minute and seemingly irrelevant physical conditions of a given experiment - poses a challenge for research groups around the world. (medium.com)
  • 1, 2 Additionally, using identical experimental conditions for all of the analytes you test makes the results generated between analytes more easily comparable. (technologynetworks.com)
  • When I was a graduate student, it was part of the learning process to reproduce the results from another paper. (signalprocessingsociety.org)
  • The result is a vast literature that is difficult to compare and impossible to reproduce. (technologynetworks.com)
  • How easy would it be to reproduce the results of a computational biology paper? (biomedcentral.com)
  • Despite being scrutinized and tested by seven referees, it still took about half a man-month worth of resources to reproduce the results reported in just one of the tables [ 4 ]. (biomedcentral.com)
  • If you were to give this dissertation to another SLP student in a year's time, would they be able to reproduce your results? (overleaf.com)
  • Provide a detailed description of your techniques, such that those wishing to challenge your position could, if they wished, reproduce the same research. (oxbridgeessays.com)
  • Given this hostility, there's a concern that reproducibility issues may undermine public confidence in science or lead to diminished funding for research. (insidehighered.com)
  • ACM provides independent, nonpartisan, and technology-neutral research and resources to policy leaders, stakeholders, and the public about public policy issues, drawn from the deep technical expertise of the computing community. (acm.org)
  • Empowering a community publishing articles in all areas of Infectious Disease research, including antimicrobial resistance, public health, outbreak science, drug development, vaccine research, and much more. (plos.org)
  • We are looking for research that uses climate change to address effects on public health with a particular focus on the spread of infectious diseases. (plos.org)
  • Emerging areas of research reported during the CDC National Conference on Pfiesteria: from biology to public health. (nih.gov)
  • To protect public health, the panel suggests that priority be given research that will provide better insight into the effects of Pfiesteria on human health. (nih.gov)
  • The negative results of some of these efforts were made public informally during the controversy, but for some lengthy experiments this was not possible. (nature.com)
  • As a result, all claims of considerable importance should be verified with utmost care before being made public. (nature.com)
  • However, as most research is paid for through tax payers, public trust in research is essential. (biomedcentral.com)
  • His presentation invited considerable discussion on enhancing research reproducibility and transparency, a topic of great interest to the NIH, the research community, and the public. (nih.gov)
  • Research on liver cancer using proteomics has concentrated on difference analysis based on 2DE and MS and other related technologies. (medscape.com)
  • The other presents the results of a genomic analysis of the claimed STAP cells, performed as part of a 2014 investigation by Japan's RIKEN institute but not previously published ( D. Konnoetal.Naturehttp://dx.doi.org/10.1038/nature15366;2015 ). (nature.com)
  • Using sequencing-based approaches, this analysis shows that all of the claimed STAP cell lines were contaminated with embryonic stem cells, and that this contamination affected the results. (nature.com)
  • De Los Angeles and colleagues' BCA also includes an analysis of sequencing results published in the original papers, and reaches similar conclusions regarding contamination. (nature.com)
  • A number of analysis charts, protein distributions, and flyers with study results hang on the walls. (schott.com)
  • The head of the Division of Functional Genome Analysis at the German Cancer Research Center (DKFZ) in Heidelberg was a key thought leader in the development of microarray analysis. (schott.com)
  • The NIH have recently taken bold steps to begin to tackle the need for better design, more appropriate analysis, and greater transparency in the conduct and reporting of research. (biomedcentral.com)
  • Slides for the paper 'Challenging the Myth of Graph Collaborative Filtering: a Reasoned and Reproducibility-driven Analysis', accepted and presented at the 17th ACM Conference on Recommender Systems (RecSys'23). (slideshare.net)
  • UV-Vis analysis of solid samples and materials continues to grow in areas such as solar cell research, semiconductor products, and coating materials. (labmanager.com)
  • Section 3 presents research covering the detection, measurement and analysis of web tracking technologies. (nowpublishers.com)
  • Find answers to questions on rigor and reproducibility policy, applications, review, and pre- and post-award administration. (nih.gov)
  • The NIH policy expects that the sex of vertebrate animals and humans will be factored into research designs, analyses, and reporting. (nih.gov)
  • Closer to home, GigaScience has carried out similar work to quantify reproducibility in their content. (biomedcentral.com)
  • Spurred by the American government's interest in measuring vitamin content in soldiers' rations using ultraviolet and visible (UV-Vis) light, this research culminated in the commercial launch of UV-Vis spectrophotometers in the early 1940s. (labmanager.com)
  • Facilitate the development and ensure the availability of the highest-quality and most useful animal models and related resources for the advancement of research on human disease. (nih.gov)
  • After proteomics became one of the robust research tools of the post-genome era, it was applied to the study of various diseases. (medscape.com)
  • Although the relevance of more robust research is clear in the area of oncology, it is also important for more exploratory research that might never make it to the preclinical setting. (biomedcentral.com)
  • The UKRN is a national peer-led consortium investigating the factors that contribute to robust research, promoting training activities, and disseminating best practice. (medium.com)
  • Through the setting up of proteomic maps of normal and pathologic liver, important foundation for disease prevention, diagnosis, therapy and development of new therapeutic agents can be provided. (medscape.com)
  • Based on this document, NHGRI worked towards redefining the specific goals for its research and training and career development programs. (nih.gov)
  • Developing a method for sequencing the human hereditary material while he worked as a postdoc at the Imperial Cancer Research Fund in London was the reason why Hoheisel concentrated on the development of microarrays. (schott.com)
  • As a result, Controlled Human Malaria Infection (CHMI) has become an important approach for accelerated development of malarial vaccines and drugs. (biomedcentral.com)
  • Some of these genes may also be important in human eye development and vision, offering hope of increased understanding of vision disorders and ultimately new treatments for individuals with hereditary eye disease. (nih.gov)
  • Provided funding for the development of novel software tools to help design proper animal studies and provide transparency when there is disagreement on published results in peer review publications. (nih.gov)
  • The development of new and unique polymer and ceramic composite materials for sensors has resulted in a sensor that is responsive to a wide range of toxic organic gases. (cdc.gov)
  • Our current research focuses on two broad areas of study: neuroinflammation and cyclic adenosine monophosphate (cAMP) signaling. (nih.gov)
  • To ensure a fair comparison of the algorithms, the participants of the study had no knowledge of the gold standard results until after their results had been submitted. (nature.com)
  • A clear research question can help you decide what study type will be best suited to answer your question. (wms.org)
  • The authors applied the technique to dorsolateral prefrontal cortex tissue from two sources, the Religious Orders Study and Memory and Aging Project (ROSMAP) and the Banner Sun Health Research Institute. (alzforum.org)
  • 4 Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, USA. (nih.gov)
  • The outcomes are clear and relevant to the research question, highlighting the benefits that the intervention may provide. (wms.org)
  • When you choose to publish with PLOS, your research makes an impact. (plos.org)
  • PLOS Digital Health brings together research into water sanitation and hygiene measures, as well as the sustainable consumption, management and supply of water as a vital resource for societies in every region of the world. (plos.org)
  • PLOS is Open so that everyone can read, share, and reuse the research we publish. (plos.org)
  • The methodology typically follows your literature review, so for the purposes of clarity and regaining focus it is useful briefly to recap the central research questions of your dissertation. (oxbridgeessays.com)
  • Give an overview of your approach to primary research in order to guide the reader and contextualise your methodology . (oxbridgeessays.com)
  • Consider whether your research methodology is typical of comparable research projects within your particular subject area. (oxbridgeessays.com)
  • This aspect is particularly important when adopting a novel or non-standard methodology. (oxbridgeessays.com)
  • The impact of sample size upon statistical significance of your results is an issue of such importance that you should be mindful of this when designing and writing up your methodology. (oxbridgeessays.com)
  • First, reproducibility and interpretation of the results is often hampered as only a fraction of relevant information is typically provided. (nature.com)
  • In her talk, Sussana discussed the importance and opportunities for science stemming from the implementation of FAIR principles for research. (medium.com)