• rejection
  • Induction agents, or intense immunosuppression given at the time of transplant to prevent acute rejection, include polyclonal antibodies (e.g., antithymocyte globulins) or monoclonal antibodies (e.g., basiliximab and alemtuzumab). (springer.com)
  • With the advent of more powerful and specific IS agents, e.g. calcineurin-inhibitors (CNIs) cyclosporine (CyA) and tacrolimus (TAC), graft rejection rates significantly declined and short and long term graft/patient survival dramatically improved. (clinicaltrials.gov)
  • Aims Mizoribine can be an oral immunosuppressive agent approved in several countries for prevention of rejection in renal transplantation. (welbourneprimary.com)
  • The understanding of the cellular and molecular mechanisms operant in tolerance vs allograft rejection is important for developing new agents to improve long-term outcome, minimize infectious complications (including recurrence of hepatotropic viruses), and deliver immunosuppression without long-term toxicity. (nih.gov)
  • This review describes the unique aspects of the hepatic immune response, the pathways involved in T-cell activation and alloantigen recognition, effector cells and pathways mediating liver allograft rejection, the role of regulatory T cells, and targets of current and future immunosuppressive agents. (nih.gov)
  • inhibitors
  • Objective To compare the risk of serious infections associated with use of systemic steroids, non-biologic agents, or tumor necrosis factor α (TNF) inhibitors in pregnancy. (bmj.com)
  • No statistically significant differences in the risk of serious infections during pregnancy were observed among users of the three immunosuppressive drug classes: non-biologics v steroids, hazard ratio 0.81 (95% confidence interval 0.48 to 1.37), TNF inhibitors v steroids 0.91 (0.36 to 2.26), and TNF inhibitors v non-biologics 1.36 (0.47 to 3.93). (bmj.com)
  • several
  • Subsequent tapering of the dose or switching to an oral agent is continued over several weeks to months. (medscape.com)
  • conditions
  • Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. (pharmacycode.com)
  • different
  • Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. (pharmacycode.com)