Immunosuppressive immune sera. Medical search. Frequent questions

Vaccination guidelines for transplant recipients include regular boosters of tetanus, diphtheria, and inactivated polio vaccine, but there are few published data on the efficacy of these vaccines in patients receiving immunosuppressive therapy. (scienceopen.com)
slightly opalescent suspension with some sediment that resuspends upon shaking to form a receiving immunosuppressive therapy, the immune response may be diminished. (who.int)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)

Two subgroups of SSD(+) and SSD(-) patients that had received ATG induction treatment were then assessed for total anti-ATG, anti-Neu5Gc, and anti-Gal antibodies using ELISA assays on sera before and after transplantation. (nih.gov)
Immunosuppressive drugs can be classified into five groups:[citation needed] glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. (wikipedia.org)
Antibodies are sometimes used as a quick and potent immunosuppressive therapy to prevent the acute rejection reactions as well as a targeted treatment of lymphoproliferative or autoimmune disorders (e.g., anti-CD20 monoclonals). (wikipedia.org)
Heterologous polyclonal antibodies are obtained from the serum of animals (e.g., rabbit, horse), and injected with the patient's thymocytes or lymphocytes. (wikipedia.org)
However, the use of equine and murine antisera as antilymphocyte or antithymocyte globulins and murine monoclonal antibodies for immunomodulation and cancer treatment has created a new group of medications that may cause serum sickness. (medscape.com)
Since the development of serum sickness is dependent on the host's ability to produce antibodies to the inciting antigen, patients who are incapable of producing antibodies, such as patients with Bruton agammaglobulinemia, will not develop serum sickness. (medscape.com)
[ 14 ] However, ATG, as well as other immunosuppressive foreign proteins, such as chimeric monoclonal antibodies that consist of murine-derived antigen-binding fragment (Fab) and human-derived crystallizable fragment (Fc) portions of antibodies, have been reported to be sufficiently immunogenic to cause serum sickness. (medscape.com)
Immune hemolytic anemia occurs when antibodies form against the body's own red blood cells. (health.am)
Normally, the body's immune system makes proteins (antibodies) to protect us against viruses, bacteria, and other foreign materials (antigens). (ndtv.com)
In an auto immune disease the immune system loses its ability to tell the difference between foreign antigens and its own antigens (cells and tissues) and starts making antibodies directed against self antigens. (ndtv.com)
However, studies of immune responses to P. jirovecii have provided important insights into its epidemiology, showing that up to 80%-100% of children have detectable P. jirovecii antibodies by 8 years of age ( 2 - 9 ). (cdc.gov)
The attack begins when antibodies, which are molecules made by the immune system to target germs, instead attach to and target the animal's own red blood cells for destruction. (petplace.com)
We assessed S100A8/A9 and S100A12 levels in SLE patient sera in relation to disease activity, clinical phenotype, presence of anti-dsDNA antibodies and ability to promote phagocytosis of necrotic cells (NCs) by PMNs. (lu.se)
Autoimmune Disorders In autoimmune disorders, the immune system produces antibodies to an endogenous antigen (autoantigen). (msdmanuals.com)

However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). (nih.gov)
Serum sickness is an immune complex-mediated hypersensitivity reaction characterized by fever, rash, arthritis, arthralgia, and other systemic symptoms. (medscape.com)
Von Pirquet and Schick first described and popularized the term serum sickness at the turn of the 20th century, using it to describe patients who had received injections of heterologous (nonhuman) antitoxins for the treatment of diphtheria and scarlet fever . (medscape.com)
Classic serum sickness is now rarely seen because the use of foreign proteins is limited to antitoxins such as those used to treat botulism, diphtheria, rabies , and snake, scorpion, and spider venom. (medscape.com)
Serum sickness-like reaction (SSLR) is clinically similar to the classic or primary form described above and is attributed to many nonprotein drugs, including beta-lactam antibiotics, ciprofloxacin, sulfonamides, bupropion, streptokinase, metronidazole, and others. (medscape.com)
With regard to patient education on serum sickness, the patient and his or her family should be advised of the nature of the offending agent. (medscape.com)
Serum sickness is a type III hypersensitivity reaction mediated by immune complex deposition with subsequent complement activation. (medscape.com)
Large amounts of antigen exposure can lead to widespread deposition of complement-fixing immune complexes and the clinical presentation of serum sickness. (medscape.com)
Classic serum sickness can be induced by antithymocyte globulin (ATG), a heterologous serum protein generated by immunization of horses or rabbits with human thymic tissue. (medscape.com)
The mechanism of many of the drugs responsible for serum sickness-like reaction is not well known. (medscape.com)
The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behaviors. (frontiersin.org)
In severe serum sickness (mediated by immune complexes), parenteral steroids may reduce the inflammatory effects. (medscape.com)
Hence, methylprednisolone is used with antithymocyte globulin (ATG) to decrease the adverse effects (eg, allergic reactions, serum sickness). (medscape.com)
High doses or long duration may be needed if serum sickness occurs with ATG. (medscape.com)
Monitor patients for signs and symptoms of serum sickness. (pfizermedicalinformation.com)

The exact amount of systemic corticosteroids and the duration of their administration needed to suppress the immune system of an otherwise healthy child are not well defined. (cdc.gov)
Treatments for lupus include anti-inflammatory drugs, antimalarials, corticosteroids and drugs approved for other purposes, such as immunosuppressive agents given to cancer patients undergoing chemotherapy or medicines developed to treat arthritis patients. (biospace.com)
In the most severe cases, or those cases that fail to respond to corticosteroids, other immunosuppressive agents may be utilized. (petplace.com)

In small doses, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemias, granulomatosis with polyangiitis, and other immune diseases. (wikipedia.org)
Immunosuppressive therapy will be given if the person does not respond to prednisone and splenectomy. (health.am)
These titers did not show statistically significant differences between the double and triple immunosuppressive therapy groups. (scienceopen.com)
5,6 In addition, immunosuppressive therapy can be useful in patients with inflammatory cardiomyopathy and negative viral PCR results. (revespcardiol.org)
As previously stated, options in immunosuppressive treatment include combination therapy, including antithymocyte globulin (ATG), cyclosporin-A (CSA), and methylprednisolone, with or without cytokine support. (medscape.com)
When used without hematopoietic growth factor in children, ATG and cyclosporine-based immunosuppressive therapy has been shown to lead to an excellent response and survival rate with low incidence of clonal evolution. (medscape.com)
Eltrombopag has gained FDA approval for severe aplastic anemia and may be considered in patients who fail immunosuppressive therapy. (medscape.com)
While most systemic symptoms respond to hydroxychloroquine and non-steroidal anti-inflammatory medications, immunosuppressive therapy (steroids and cyclophosphamide) may be required for kidney or brain involvement. (ndtv.com)
Furthermore, although most patients respond well to immunosuppressive therapy, progression and end-stage liver disease occur in 10%-20% of cases and liver transplantation may be necessary [ 4 ]. (hindawi.com)
This paper summarizes the work done in animal models to investigate the immune effects induced by the combination of ablative therapy and immunomodulation. (biomedcentral.com)
Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
Immunosuppressive therapy was associated with a reduction of S100A8/A9 serum levels (p = 0.002). (lu.se)

The patient that presents with recurrent infections may have an underlying immune deficiency or dysfunction. (dvm360.com)
1990. Biomarkers of organ damage or dysfunction for the renal, hepatobiliary, and immune systems. (cdc.gov)

3 Some immunosuppressive or antiviral therapies can be useful in the subacute or chronic phase. (revespcardiol.org)
Immunosuppressive therapies may diminish the immune response to AFLURIA. (drugs.com)
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. (bmj.com)
By destroying readily accessible tumors, ablative therapies make tumor antigens available as an in-situ cancer vaccine which can lead to the initiation of a systemic antitumor immune response that can affect and potentially eliminate occult, metastatic tumors [ 3 , 4 ]. (biomedcentral.com)

By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. (wikipedia.org)
EVs collected from the serum of leukemic samples might correlate with disease stage, drug-/immunological resistance, or might correlate with antileukemic immunity/immune response. (nature.com)
Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions (eg, delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, graft versus host disease) for a variety of organs. (medscape.com)
One potential way to overcome the challenge of micrometastases is to induce systemic antitumor immunity by activating the immune system. (biomedcentral.com)

Immunosuppressive medicines (these medicines suppress the immune system). (medlineplus.gov)

Furthermore, other cells at the interface of the innate and the adaptive immune system (e.g cytokine-induced killer cells (CIK) or invariant natural killer T-cells (iNKT)) are important mediators in antitumor-, autoimmune-, and antimicrobial responses and tumor surveillance. (nature.com)
4 Liontos M, Anastasiou I, Bamias A, Dimopoulos MA.DN A damage, tumor mutational load and their impact on immune responses against cancer. (jcimjournal.com)
On the other hand, posttranplant immunosuppression may impair immune responses and thus the efficacy of the vaccination. (scienceopen.com)
The vaccine was safe and well tolerated, induced potent serum IgG & IgA responses waning post last vaccination, and low and intermittent mucosal IgG, but did not induce neutralizing activity neither in serum nor vaginal samples. (europa.eu)
We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii . (cdc.gov)
Rezaeipoor R, Saeidnia S, Kamalinejad M . Immunosuppressive activity of Achillea talagonica on humoral immune responses in experimental animals. (jcimjournal.com)
While genetic and environmental factors contribute to the pathogenic process of AIH [ 2 ], dysfunctional immune responses are also crucial for the development and progression of AIH [ 3 ]. (hindawi.com)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
The immune responses induced by ablation monotherapy are well documented, but independently they tend to be incapable of evoking a robust antitumor response. (biomedcentral.com)
Many of these methods have been in use for decades, but their ability to trigger systemic immune responses is just beginning to be fully appreciated. (biomedcentral.com)

When the antigen and antibody molecules are present in approximately equal molar ratios (slight antigen excess), known as the zone of equivalence, cross-linking and lattice formation occur forming intermediate and large immune complexes. (medscape.com)
Lymphocyte immune globulin inhibits the cell-mediated immune response by altering T-cell function or by eliminating antigen-reactive cells. (medscape.com)
It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)
This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)

Lupus erythematosus (LE) is a chronic auto immune inflammatory disease that can affect various parts of the body, especially the skin, joints, blood, and kidneys. (ndtv.com)

These tissue-deposited immune complexes activate complements, which lead to the clinical manifestation of the disease (eg, inflammatory changes in the renal glomeruli and in the skin). (medscape.com)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
What is the Clinical Evidence for Erythrocyte Immune Destruction? (vin.com)
With neuro-muscular junction immune related inflammation (myasthenia gravis), clinical expression is mainly characterized by generalized weakness although more focal forms exist (oesophagus, ocular muscle). (vin.com)

If the cause of antibody formation is disease or medication, it is referred to as secondary immune hemolytic anemia. (health.am)
After 6 and 12 weeks, serum samples obtained again to determine H. influenzae type b antibody titers. (scienceopen.com)
Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)
IMNM includes symptoms such as muscle weakness, increased serum CK, positive anti-HMG CoA reductase antibody, and necrotizing antibody. (insulin-store.com)

Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. (nih.gov)
Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system. (wikipedia.org)
and improvement with immunosuppressive agents. (nih.gov)
Agents that suppress immune function by one of several mechanisms of action. (lookformedical.com)
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. (wakehealth.edu)
If IMNM occurs, patients should be treated with immunosuppressive agents. (insulin-store.com)

however, this is not the case in the presence of a high concentration of immune complexes or if the removal system is not functioning well. (medscape.com)
Immune hemolytic anemia is a disorder characterized by anemia due to premature destruction of red blood cells by the immune system. (health.am)
EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
The innate immune system includes macrophages, dendritic cells (DC), and natural killer (NK) cells, which respond quickly to an immunological threat. (nature.com)
In sum, elements of the immune system may be associated with gregariousness, even outside of major disease events. (frontiersin.org)
Similarly, long-term activation of the immune system, such as during cancer, systemic infections or autoimmune disorders, can lead to the development of depressive symptoms in susceptible individuals. (frontiersin.org)
for others, such as HIV infection, the spectrum of disease severity due to disease or treatment stage will determine the degree to which the immune system is compromised. (cdc.gov)
Interferon-1β (IFN-1β) is a molecule secreted by immune system cells, mainly fibroblasts. (revespcardiol.org)
In either case it is possible to carefully dissect the function of the immune system to determine which if any of the immune functions are abnormal. (dvm360.com)
Many dogs with IMHA have severe leukocytosis (with or without left shift) and also considerable serum liver enzyme elevations (prior to prednisolone) suggestive of serious inflammatory processes, which may enhance the immune destruction by activating the macrophage system and the thrombotic tendency. (vin.com)
Immune system is involved in the etiology and pathophysiologic mechanisms of inflammation. (jcimjournal.com)
Immune mediated hemolytic anemia (IMHA), also known as auto-immune mediated hemolytic anemia (AIHA, is a disease in which the body's immune system, which is designed to attack and kill germs, attacks and kills the body's own red blood cells. (petplace.com)
While some cases of IMHA may be associated with a triggering event (cancer, infection, and perhaps even vaccinations), these events do not explain why the immune system misdirects its arsenal of weapons against the animal it is meant to protect. (petplace.com)
The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
An IDF brochure, along with other resources for children, parents, and adult patients to learn about their immune system and PI and find support. (primaryimmune.org)
Crohn's disease (CD), a form of inflammatory bowel disease (IBD), is an immune system-mediated, chronic systemic condition characterized by gastrointestinal inflammation and dysregulation of the mucosal-associated immune system [ 1 , 2 ]. (biomedcentral.com)
The pathogenesis is complex, featuring disturbance of the innate immune system and reduced gastrointestinal barrier protection. (biomedcentral.com)
False negatives exist if the immune system of the patient is depressed or if high dose of steroids have been given the days prior to CSF collection. (vin.com)
But the form I have - what's called idiopathic multicentric Castleman disease - is a deadly form where the immune system attacks and shuts down the vital organs for an unknown reason. (medscape.com)
In this disease, the immune system of the body mistakenly attacks healthy tissue. (medlineplus.gov)
The age at which recurrent infections began provides a clue as to which component of the immune system is affected. (msdmanuals.com)

However, they are added primarily to other immunosuppressives to diminish their dosage and toxicity. (wikipedia.org)

Sera concentration of circulating sCD40L and IL-10 were assayed using ELISA in 30 HCV-positive patients with HCC, 30 HCV-positive patients with liver cirrhosis and 30 age-matched healthy volunteers with negative anti-HCV-Ab as a control group. (who.int)
Also, the serum levels of IL-17A and IL-22 were correlated positively with liver injury (ALT/AST), whereas the serum levels of IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH patients. (hindawi.com)
Autoimmune hepatitis (AIH) is a type of autoimmune inflammatory liver disease characterized by hypergammaglobulinaemia, circulating autoantibodies, and the liver injury with elevated levels of serum liver enzymes [ 1 ]. (hindawi.com)
Rare but potentially severe adverse events include liver injury, myopathy, rhabdomyolysis, and immune-mediated necrotizing myopathy. (nih.gov)

An autoimmune myopathy known as immune-mediated necrotizing myopathy (IMNM) has occurred in patients using statins. (insulin-store.com)

higher doses or more frequent boosters may be required, although even with these modifications, the immune response may be suboptimal. (cdc.gov)
Forty-three renal transplant recipients with well-functioning allografts were immunized with H. influenzae type b vaccine in order to investigate the immune response. (scienceopen.com)
Immunocompromised persons may have a diminished immune response to AFLURIA. (drugs.com)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
When an isoantigen is encountered by species members who lack it, an immune response is induced. (lookformedical.com)
Deliberate prevention or diminution of the host's immune response. (lookformedical.com)
Immune-mediated hemolytic anemia (IMHA) arises when an immune response targets directly or indirectly erythrocytes and hemolytic anemia ensues. (vin.com)
However, the erythroid response in the bone marrow may be blunted by the immune process or the underlying disease, thereby leading to non-regenerative anemias. (vin.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
Anti-acethyl choline receptor measurement is the most sensitive test to diagnose an immune response directed against the posts synaptic neuro-muscular junction (myasthenia gravis). (vin.com)
By adding immunomodulators to traditional ablative techniques, several researchers have sought to amplify the induced immune response and trigger systemic antitumor activity. (biomedcentral.com)
This aspect of ablation is responsible for its ability to trigger a systemic antitumor immune response where surgical resection would not [ 2 , 11 ]. (biomedcentral.com)
Dendritic cells that present antigens on major histocompatibility complex (MHC) molecules and show co-stimulators stimulate T-cells and promote a systemic immune response [ 2 , 14 , 15 ]. (biomedcentral.com)
Conclusions Elevated serum levels of S100A8/A9 may be used to monitor disease activity and response to treatment in SLE patients, especially in patients with glomerulonephritis. (lu.se)

Statins have been shown to increase levels of serum transaminases over 3 times the upper limit of normal (ULN). (insulin-store.com)
Increases in serum transaminases can occur. (zypitamag.com)

EVs were isolated from the serum of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL) patients, and healthy volunteers. (nature.com)
9. Significant medical conditions including chronic, immunosuppressive, malignant, or gastrointestinal diseases (e.g. (who.int)

Serum-mediated phagocytosis of NCs by PMNs was analysed by flow cytometry. (lu.se)

Serum complement estimation to determine the total level of a group of proteins which can be consumed in immune reactions and determination of Complement proteins C3 and C4. (ndtv.com)

There are a variety of assays available to test immune function in the dog. (dvm360.com)
Induction of binding Abs was measured by ELISA and neutralizing activity by PBMC and TZM-bl assays in all serum and vaginal samples. (europa.eu)

The patients received a double or a triple immunosuppressive protocol. (scienceopen.com)
After obtaining basal serum samples, the patients and the control subjects were immunized with H. influenzae type b conjugate vaccine. (scienceopen.com)
H. influenzae type b vaccination is safe and effective in patients with well-functioning renal allografts and should be recommended to renal transplant recipients who may have the risk of invasive disease on the basis of the immunosuppressive state. (scienceopen.com)
Its serum levels are decreased in patients with myocarditis and persistent virus in the myocardium 6 and it is therapeutically useful in patients with dilated cardiomyopathy and polymerase chain reaction (PCR) detection of a viral genome. (revespcardiol.org)
Serum sCD40Lshowed statistically-significant high levels in HCV-HCC patients compared to HCV-cirrhotic patients and normal controls (P (who.int)
Serum sCD40L had higher diagnostic value in HCC patients compared with serum AFP. (who.int)
Assessment of serum IL-10 levels in HCV patients may provide a possible predictive marker for disease progression. (who.int)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Significant differences were found in the serum of OGC patients compared to the control group for IL-2, IL-10, TNF-α, IFN-γ and IL-17. (biomedcentral.com)
Preclinical data from animal models suggest that MEDI-545 may suppress the abnormal immune activity associated with lupus by binding to multiple interferon-alpha subtypes seen in the serum of lupus patients. (biospace.com)
In a previous study, plasma from patients with graft-versus-host disease significantly enhanced the immunosuppressive potential of MSCs. (biomedcentral.com)
Methods Serum levels of S100A8/A9 and S100A12 were measured by ELISA in paired samples of 100 SLE patients at time points of higher and lower disease activity. (lu.se)
Results Serum levels of S100A8/A9 and S100A12 were increased in SLE patients with high disease activity compared to paired samples at low disease activity (p = 0.01 and p = 0.008, respectively). (lu.se)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)

Systemic lupus erythematosus is characterized by the production of plethora of autoantibodies which potentially drive immune-complex related inflammation in various tissues and organs [ 1 ]. (hindawi.com)
In particular, immune modulating drugs have the potential to enhance the systemic anticancer immune effects induced by locoregional thermal ablation. (biomedcentral.com)

Centrifuge and aliquot serum into plastic vial. (mayocliniclabs.com)

Special EV surface protein patterns in serum have the potential as noninvasive biomarker candidates to distinguish several disease-related patterns ex vivo or in vivo. (nature.com)
1993. Malathion disposition in dermally and orally treated rats and its impact on the blood serum acetylcholine esterase and protein profile. (cdc.gov)

Regulatory T cells (Tregs) are important regulators of immune tolerance to self-antigens [ 14 , 15 ], and their impairment has been associated with the development of autoimmune diseases [ 16 , 17 ]. (hindawi.com)

Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)

We then tested whether the levels of three important cytokines (TNF-α, IFN-γ and IL-1β) in the serum, cortex and hypothalamus of these animals could be explained by the gregariousness phenotype and/or sex of the mice. (frontiersin.org)
We found main effects of gregariousness and sex on the serum levels of TNF-α, but not on IFN-γ or IL-1β. (frontiersin.org)
May slightly ↑serum digoxin levels. (unboundmedicine.com)
The ability of serum to support phagocytosis of NCs by PMNs was related to increased S100A8/A9 levels (p = 0.01). (lu.se)
Increased S100A8/A9 levels may reflect immune-pathological processes involving phagocytosis of immune complexes by PMNs. (lu.se)
Serum levels of hydrocortisol, IL-1β, IFN-gamma, and TNF-a, and salivary IgA were measured by enzyme-linked immunosorbent assay. (cdc.gov)

We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD(+)] and 803 without SSD [SSD(-)]) from the Données Informatisées et Validées en Transplantation data bank. (nih.gov)

Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. (wikipedia.org)

A serum biochemical profile and urinalysis may be performed to give clues as to possible causes of the anemia. (petplace.com)

This results in a large mass of aggregates of immune complexes deposited in various tissues, such as the internal elastic lamina of arteries and in perivascular regions. (medscape.com)

Furthermore, in limited surveys, seasonality (summer) and a temporal association between vaccination and onset of IMHA have been suggested, but since no specific vaccine has been implicated, it appears likely that vaccines enhance a smoldering immune process. (vin.com)

ACIP statements on individual vaccines or immune globulins should be consulted for more details on safety and efficacy and on the epidemiology of the diseases. (cdc.gov)

The immunosuppressive effects of steroid treatment vary, but many clinicians consider a dose equivalent to either 2 mg/kg of body weight or a total of 20 mg/day of prednisone as sufficiently immunosuppressive to raise concern about the safety of immunization with live-virus vaccines. (cdc.gov)
Patient-derived serum can be used as an iMSC priming strategy in iMSC-derived exosome treatment of RA. (biomedcentral.com)
Infections out of proportion to the degree of immunosuppressive treatment. (primaryimmune.org)

The classic syndrome is caused by immunization of the host by heterologous serum proteins. (medscape.com)

The final section contains summary tables on the use of vaccines and immune globulins, arranged by immunocompromising condition. (cdc.gov)

includes history, physical examination, and immune function testing. (msdmanuals.com)

The cause may also be unknown, as in idiopathic autoimmune hemolytic anemia, which accounts for one-half of all immune hemolytic anemias. (health.am)

Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)

Anatomy31

Organisms16

Diseases26

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes43

Information Science3

Health Care5

Receiving immunosuppressive therapy3

Antibodies14

Sickness15

Corticosteroids3

Therapy14

Dysfunction2

Therapies4

Immunity4

Suppress the immune1

Responses10

Antigen4

Inflammatory disease1

Clinical4

Antibody4

Agents6

System22

Diminish1

Liver4

Myopathy1

Response15

Transaminases2

Chronic2

Flow cytometry1

Reactions1

Assays2

Patients14

Systemic2

Vial1

Protein2

Tolerance1

Statins1

Levels6

Transplantation1

Potent1

Urinalysis1

Complexes1

Vaccine1

Efficacy1

Treatment3

Heterologous1

Vaccines1

Physical Examination1

Hemolytic anemias1

Checkpoint1