• Dentre os microrganismos que causam as infecções destacamos a Cândida albicans que é um dos principais patógenos relacionados a infecções fúngicas prevalentes, juntamente a Cryptococcus neoformans e Aspergillus fumigatus. (unesp.br)
  • Candida albicans is one of the main pathogens related to prevalent fungal infections, along with Cryptococcus neoformans and Aspergillus fumigatus. (unesp.br)
  • The repertoires of Cryptococcus neoformans, Aspergillus fumigatus , and Aspergillus nidulans were found to exhibit the highest orthology to the human repertoire, and Saccharomyces cerevisiae one of the lowest. (biomedcentral.com)
  • Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae , whilst its repertoires exhibits greater orthology to that of humans. (biomedcentral.com)
  • Patients with immunosuppression are the most vulnerable to fungal meningitis. (wikidoc.org)
  • Fungal meningitis may uncommonly occur In patients with no underlying immunosuppression . (wikidoc.org)
  • In a 2016 study of patients with AIDS-associated cryptococcal meningitis, the addition of dexamethasone did not reduce mortality, was associated with more adverse events and disability, and resulted in slower clearance of Cryptococcus from the spinal fluid. (medscape.com)
  • Intracranial hypertension (ICH) is responsible for both early mortality and the auditory, visual, and cognitive sequelae of meningitis caused by Cryptococcus neoformans 1 1 Graybill JR, Sobel J, Saag M, van Der Horst C, Powderly W, Cloud G et al. (scielo.br)
  • Cryptococcus neoformans is an encapsulated yeast found in soil throughout the world, particularly in soil contaminated with pigeon guano ( 1 ). (cdc.gov)
  • We investigated an unusual cluster of 6 patients with Cryptococcus neoformans infection at a community hospital in Arkansas during April-December 2013, to determine source of infection. (cdc.gov)
  • But this immunosuppression is general, not specific, thus the patient is more susceptible to infection. (nanomedicine.com)
  • If infection occurs, immunosuppression must be suspended whereupon an implanted graft is usually lost due to rejection [ 371 ]. (nanomedicine.com)
  • An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression. (lookformedical.com)
  • In patients who are co-infected with HIV and C neoformans, the therapeutic goal may differ from that in patients with cryptococcal infection uncomplicated by HIV infection. (medscape.com)
  • For cryptococcal infections in patients with concomitant HIV infection who have a CD4 count of less than 200 cells/μL, the therapeutic goal is to control the acute infection, followed by life-long suppression of C neoformans . (medscape.com)
  • Immunocompromised hosts, regardless of underlying illness or factors leading to immunosuppression, commonly present diagnostic challenges in the face of severe infectious disease processes. (medscape.com)
  • Although the two newer triazoles, posaconazole and voriconazole, show in vitro activity against C neoformans, clinical data remain limited. (medscape.com)
  • These patients go through chemotherapy for cancer treatment and immunosuppression for transplants, that making them more vulnerable to these infections. (unesp.br)
  • Case Presentation: A 71-year-old female with metastatic thyroid cancer status-post (s/p) radioiodine ablation and total thyroidectomy on oral chemotherapy, chronic kidney disease stage IV s/p deceased donor kidney transplant in 2019 on oral immunosuppression, presented with weakness, gastrointestinal symptoms, and acute-on-chronic dysphagia. (shmabstracts.org)
  • HIV/ AIDS, malignancy, immunosuppression), altered microbiota, breached integumentary barriers ▪ Present in environment worldwide → immunocompetent, healthy individuals can be exposed without resulting in disease RISK FACTORS ▪ Immunosuppression (e.g. (osmosis.org)
  • In selected cases, susceptibility testing of the C. neoformans isolate may be beneficial to patient management, particularly if a comparison can be determined between baseline and sequential isolates. (algofinance.cz)
  • Non-modifiable factors associated with in-hospital mortality were older age, presence of immunosuppression, higher non-pulmonary sequential organ failure assessment scores, lower pulse oximetry readings, higher heart rates, and functional dependence. (ox.ac.uk)
  • Identify underlying mechanisms of brain tumor immunosuppression and evasion, with the goal to develop novel immunotherapies for brain cancer. (ucsf.edu)
  • The majority of infections are believed to be due to Cryptococcus neoformans var. (unboundmedicine.com)
  • These patients go through chemotherapy for cancer treatment and immunosuppression for transplants, that making them more vulnerable to these infections. (unesp.br)
  • Cryptococcus neoformans is an infectious fungal pathogen known for causing serious central nervous system infections in immunocompromised individuals, specifically targeting their central nervous systems. (ablogwithadifference.com)
  • Cryptococcus neoformans is a dangerous fungal species with significant medical relevance due to its ability to cause serious infections in individuals with compromised immune systems. (ablogwithadifference.com)
  • [1] These individuals are prone to a wide variety of bacterial, viral, fungal and protozoal infections which include Toxoplasma gondii , Pneumocystis jirovecii (previously Pneumocystis carinii ), Cryptococcus neoformans , Mycobacterium avium , Mycobacterium tuberculosis , Cytomegalovirus, Herpes simplex viruses, Histoplasma capsulatum . (nih.gov)
  • Similar illnesses have also occurred in some HIV-uninfected patients following corticosteroid withdrawal, discontinuation of antitumor necrosis factor alpha therapy, recovery of neutropenia after cytotoxic chemotherapy, withdrawal of immunosuppression in transplant recipients infected with Cryptococcus neoformans , and engraftment of stem cell transplantation [ 8,15,16 ]. (medilib.ir)
  • PML has become of increasing concern in patients receiving aggressive immunosuppression for organ or stem cell transplantation or in patients treated with newer immunomodulatory agents, in particular natalizumab. (medlink.com)
  • Cryptococcal meningitis (C. neoformans var. (unboundmedicine.com)
  • TY - JOUR T1 - Cryptococcal meningitis (C. neoformans var. (unboundmedicine.com)
  • In immunocompromised hosts, these mechanisms fail allowing proliferation of C. neoformans in the lungs and subsequent dissemination to the CNS, causing meningitis/meningoencephalitis ( 6 , 8 ). (frontiersin.org)
  • Intracranial hypertension (ICH) is responsible for both early mortality and the auditory, visual, and cognitive sequelae of meningitis caused by Cryptococcus neoformans 1 1 Graybill JR, Sobel J, Saag M, van Der Horst C, Powderly W, Cloud G et al. (scielo.br)
  • The patients with CM were included if they had to meet one or more of the following criteria: (1) positive culture of cryptococcus from CSF, (2) positive CSF india ink testing, (3) positive CSF cryptococcal antigen testing, or (4) positive cerebral biopsy. (springer.com)
  • Convincing arguments indicate that acapsular C. neoformans strains either fail to cause disease or are severely impaired in disease progression. (medscape.com)
  • Molecular techniques may be used to speciate Cryptococcus from specimens that fail to culture. (wikipedia.org)
  • He subsequently developed bilateral pulmonary emboli, and ultimately succumbed to encephalitis and cryptococcemia in the context of being treated with high dose immunosuppression for the AIHA. (journalmc.org)
  • In fact, all clinically relevant strains of C. neoformans have a capsule that can be considered an invariant requirement of all wild-type pathogenic strains. (medscape.com)
  • [ 31 ] Indeed, Cryptococcus adaptation to the host mirrors the induction of the capsule. (medscape.com)
  • C. neoformans is unusual in that it is the only encapsulated human pathogen and the polysaccharide capsule is an absolute requirement for virulence. (grantome.com)
  • Cryptococcus neoformans is distinguished by its polysaccharide capsule, which surrounds each fungal cell and serves as a virulence factor. (ablogwithadifference.com)
  • and 2) the discovery that C. neoformans makes large amounts of oligosaccharides in culture that are raw materials for vaccine construction. (grantome.com)
  • We plan to take advantage of all that we have learned about antibody-mediated immunity against C. neoformans to develop a novel conjugate vaccine against a major human fungal pathogen. (grantome.com)
  • 17. Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. (nih.gov)
  • This case walks through that decision-making process and retrospectively serves as a reminder of the risks of high dose immunosuppression. (journalmc.org)
  • In addition, to coat the surface of C. neoformans , both GXM and GalXM are constitutively released into the extracellular environment in vitro and in vivo through secretory vesicles. (medscape.com)