• These changes initiate the production of numerous factors, cytokines, and chemokines by T-cells. (wikipedia.org)
  • Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
  • Fully activated immunostimulatory DCs express high levels of costimulatory molecules, produce pro-inflammatory cytokines, and stimulate T cell proliferation, whereas tolerogenic DCs express low levels of costimulatory molecules, produce immunomodulatory cytokines and impair T cell proliferation. (nih.gov)
  • Dendritic cells obtained from wt mice and infected in vitro with Ad vector containing AdrA wt, but not mut, had increased activation markers and produced large amounts of several immunostimulatory cytokines. (unav.edu)
  • This interaction is crucial to determine the isotype of Abs produced by B cells and the pattern of cytokines secreted by predominantly the T helper (Th) 2 cells such as Interleukin (IL)-4 [1]. (heraldopenaccess.us)
  • The pancreatic tumor does not respond to cytokines, immune checkpoint inhibitors, and adoptive cell therapy. (bookinghealth.com)
  • In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)
  • Monocyte-derived dendritic cell (DC)-based anti-cancer immunotherapy represents a promising treatment modality in these neoplasias. (muni.cz)
  • In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)
  • Background IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of immunostimulatory signals to patients with glioblastoma (GBM). (jefferson.edu)
  • Janssen Biotech acquired a worldwide license to Alligator Bioscience's Phase I immunotherapy ADC-1013 , an agonistic monoclonal antibody that targets CD40, an immuno-stimulatory receptor found on antigen-presenting cells, which can spur an increase in T cells attacking a tumor. (shu.edu)
  • But it can be boosted with a dendritic cell-based cancer immunotherapy, i.e. anti-tumor vaccine. (bookinghealth.com)
  • In contrast, the microenvironment of lung cancer, which responds well to immunotherapy, contains 80 times more dendritic cells. (bookinghealth.com)
  • We have an immunotherapy that's based on using the patient's own tumor cells as a source of antigen," said Mark Exley, an immunologist and chief scientific officer at Imvax. (drugdiscoverynews.com)
  • Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. (nature.com)
  • Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. (fda.gov)
  • plasmacytoid dendritic cells. (nih.gov)
  • Certain combinations of anti-cancer treatment resulted in a similar pattern of inadequate DC parameters, namely, a combination of temozolomide with irinotecan was associated with DCs showing poor maturation and decreased immunostimulatory features, and a combination of pazopanib, topotecan, and MTD-based cyclophosphamide was associated with poor monocyte differentiation and decreased DC immunostimulatory parameters. (muni.cz)
  • This study shows the novel selective inhibitory effect of GA on the production of DC-derived inflammatory mediators without affecting DC maturation or DC immunostimulatory potential. (aai.org)
  • Based on the source and maturation state, exosomes can be immunostimulatory or immunosuppressive in models of cancer, infection, tolerance, immune privilege, and arthritis. (socalflow.org)
  • We have modulated elements of the tumor microenvironment that are not cancer cells, reversing their role as accomplices in tumor growth to attackers that boost responses against the tumor," said Dr. Jose Conejo-Garcia, assistant professor of microbiology and immunology and of medicine, and a researcher at Dartmouth-Hitchcock's Norris Cotton Cancer Center, who led the research. (scienceblog.com)
  • In experiments on mice, the researchers found that the microenvironment of pancreatic tumors contains very few dendritic cells. (bookinghealth.com)
  • The endothelial cells appear swollen. (medscape.com)
  • Serum amyloid A medicates the inhibitory effect Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. (shen-nong.com)
  • We conclude that the DC-manufacturing yield and the immunostimulatory quality of anti-cancer DC-based vaccines generated from the monocytes of patients were not influenced by the monocyte isolation modality but were detrimentally affected by the specific combination of anti-cancer agents used prior to monocyte harvest. (muni.cz)
  • Let's talk about the administration of dendritic cells in pancreatic cancer, what problems they solve and the results of using dendritic cell vaccines in preclinical and clinical trials. (bookinghealth.com)
  • Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. (ox.ac.uk)
  • I. Expression on dendritic cells and other subsets of mouse leukocytes. (doximity.com)
  • Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (doximity.com)
  • In the T cell areas of lymphoid organs, mature effector DC not only present pathogen-derived peptides to T cells, but also adapt the class of immune response to the type of invading pathogen by driving the development of protective effector Th cell subsets. (aai.org)
  • Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. (biomedcentral.com)
  • We characterized the peripheral blood immune cell subsets and their expression of activation markers using three custom-designed Duraclone flow cytometric panels. (socalflow.org)
  • This injury appears to be a consequence of the host's immunological response to viral antigens that have penetrated the endothelium by means of the cells' own integrins. (medscape.com)
  • Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
  • Dendritic cells (DCs) are immune cells that recognize antigens (targets for attack) and show them to T-cells. (bookinghealth.com)
  • As a result, the T-cells know their enemy and begin to attack the antigens, in this case these are the antigens of pancreatic malignant neoplasms. (bookinghealth.com)
  • Apparently, this is due to the lack of stimulation of antitumor immunity during the mass decay of cancer cells and the release of antigens into the systemic bloodstream, as it happens with other tumors. (bookinghealth.com)
  • For DSc activation doctors use antigens of a patient's own tumor or lysate of allogeneic (donor) dendritic cells, which contains antigens common to different tumors. (bookinghealth.com)
  • Monocytes (a type of leukocytes) for dendritic cell production are harvested from the patient's blood by leukapheresis and are treated with tumor antigens. (bookinghealth.com)
  • For example, scientists have isolated patient dendritic cells, exposed them to antigens from the tumor, and reinfused the dendritic cells back into the patient. (drugdiscoverynews.com)
  • Instead, by triggering a patient's own tumor cells to release both immunostimulatory molecules and tumor-specific antigens within a biodiffusion chamber temporarily inserted in the patient's body, the researchers at Imvax turn the uniqueness of the tumor against itself. (drugdiscoverynews.com)
  • B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
  • CD80 is a member of the B7 family, which consists of molecules present at APCs and their receptors present on the T-cells. (wikipedia.org)
  • This mechanism ensures that costimulatory molecules for T-cells are present at the right time. (wikipedia.org)
  • Scientists have discovered that fucoidans are a source of necessary components of cell-surface molecules that facilitate cell-to-cell signaling, the core regulatory process responsible for everything from immunity and cardiovascular function to healthy cellular proliferation. (lifeextension.com)
  • The dendritic cells around ovarian cancer scoop up the nanocomplexes, composed of a polymer and small interfering RNA (siRNA) molecules to silence their immunosuppressive activity. (scienceblog.com)
  • Results IGV-001 causes oxidative and endoplasmic reticulum stress in GL261 cells, resulting in a cytotoxic response that enables the release of antigenic material and immunostimulatory, ICD-associated molecules including ATP and HMGB1 from BDCs. (jefferson.edu)
  • Exosomes can carry a broad variety of immunostimulatory molecules depending on the cell of origin and in vitro culture conditions. (exosome-rna.com)
  • Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
  • Rapid MYC-driven progressors exhibited a high number of activated/exhausted CD8(+) T cells with reduced immunosuppressive regulatory T (T-reg) cells, while late MYC acquisition in slow progressors was associated with lower CD8(+) T cell infiltration and more abundant T-reg cells. (unav.edu)
  • To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
  • Nanoparticle incorporation transforms them from an immunosuppressive to an immunostimulatory cell type at tumor locations, provoking anti-tumor responses and also directly killing tumor cells. (scienceblog.com)
  • DC vaccine quality was assessed in terms of DC yield, viability, immunophenotype, production of IL-12 and IL-10, and stimulation of allogenic donor T-cells and autologous T-cells in allo-MLR and auto-MLR, respectively. (muni.cz)
  • Baxalta, the biopharmaceutical spinoff of Baxter, entered into a $1.7 B deal with Precision BioSceinces for 6 CAR-T (Chimeric Antigen Receptor T-cell) projects, and Saronic Biotechnology announced positive data in preclinical studies of its autologous dendritic cell vaccine for hepatocellular carcinoma. (shu.edu)
  • Autologous (own) dendritic cells are used to treat pancreatic ductal adenocarcinoma. (bookinghealth.com)
  • Autologous cells are more commonly used. (bookinghealth.com)
  • As a result, human macrophages treated with a LILRB2 blocker are reprogrammed to increase the activation of autologous T cells in co-culture systems. (figshare.com)
  • CytoMed also engages in generating induced pluripotent stem cells (iPSCs) and developing them into cellular therapeutics using our proprietary technologies for our customers. (cytomed.sg)
  • These interactions result in an important costimulatory signal in the immunological synapse between antigen-presenting cells, B-cells, dendritic cells and T-cells that result in T and B-cell activation, proliferation and differentiation. (wikipedia.org)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
  • TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. (exeter.ac.uk)
  • Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
  • They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
  • Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
  • Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
  • Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)
  • B2 miceta-roglobulin knockout K562 cell-based artificial antigen presenting cells for ex vivo exp. (cytomed.sg)
  • Method For immunopharmacological screening campaigns, we built an artificial miniature immune system in which dendritic cells (DCs) derived from immature precursors present MHC (major histocompatibility complex) class I-restricted antigen to a T-cell hybridoma that then secretes interleukin-2 (IL-2). (bmj.com)
  • Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naive T cells, all characteristics of differentiated DCs. (stanford.edu)
  • and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)
  • B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)
  • Leveraging bulk and single cell RNA-sequencing datasets, as well as extensive immunophenotyping of human tumors, we found that LILRB2 is highly expressed on CD163+ CD11b+ cells in the TME and that LILRB2 expression correlates with CD163 expression across many tumor types. (figshare.com)
  • When they encapsulated both the rat glioblastoma tumor cells and the antisense IGF-IR RNA in a biodiffusion chamber and placed the chamber in the rat's abdomen for 24 hours, the rats that received the treatment lived three times longer than those that received no treatment, and their tumors never came back (5). (drugdiscoverynews.com)
  • Several recent experiments have suggested that the growth of some types of tumors is not only dependent on angiogenesis (i.e., mature endothelial-cell dependent generation of new blood vessels) but also is associated with vasculogenesis, which means endothelial progenitor cell (EPC) dependent generation of new blood vessels [2]. (alk-inhibitors.com)
  • When the major histocompatibility complex class II (MHC class II)-peptide complex on a dendritic cell interacts with the receptor on a T helper cell, CD80 is up-regulated, licensing the dendritic cell and allowing for interaction between the dendritic cell and CD 8+ T-cells via CD28. (wikipedia.org)
  • Thus, we studied the roles of Dectin-1, Dectin-2, and Toll-like receptor 4 (TLR4) in the hemocyanin activation of murine APCs, both in dendritic cells (DCs) and macrophages, using hemocyanins from Megathura crenulata (KLH), Concholepas concholepas (CCH) and Fissurella latimarginata (FLH). (exeter.ac.uk)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • The polymer interacts with a receptor that senses danger to activate cells that trigger an inflammatory immune response. (scienceblog.com)
  • IGV-001 consists of patient-derived GBM cells treated with an antisense oligodeoxynucleotide against insulin-like growth factor 1 receptor (IGF1R) and placed in proprietary biodiffusion chambers (BDCs). (jefferson.edu)
  • Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)
  • In contrast, astemizole acts as a histamine H1 receptor (H1R1) antagonist to activate T cells in a non-specific, DC-independent fashion. (bmj.com)
  • Sequencing the B Cell Receptor Repertoires of Antibody-Deficient Individuals With and Without Infection Susceptibility. (resist-cluster.de)
  • Members of the leukocyte immunoglobulin-like receptor B (LILRB) family, including LILRB2 (ILT4), are known to transmit inhibitory signals in macrophages and other myeloid cells. (figshare.com)
  • They focused their attention on decades of research on the insulin-like growth factor I receptor (IGF-IR), which cancer cells overexpress to protect themselves from apoptosis (2). (drugdiscoverynews.com)
  • The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • Understanding the paradoxical importance of dendritic cells in immunity and tolerance will inform the development of successful cancer immunotherapies. (aacrjournals.org)
  • We now understand that adaptive immunity is the purview of a second set of leukocytes, T and B lymphocytes, which are responsible not only for antibody production but also for the generation of T cells that can directly identify and kill host cells infected by pathogens (e.g., viruses). (aacrjournals.org)
  • Ganoderma Lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. (shen-nong.com)
  • MultiVir's Ad-p53 Dendritic Cell Therapeutic Vaccine (Ad-p53-DCV) is an investigational immuno-stimulatory therapy designed to activate the immune system to attack tumor cells. (multivir.com)
  • CD80 interaction with CD28 also further stimulates dendritic cells, enhancing cytokine production, specifically IL-6, a pro-inflammatory molecule. (wikipedia.org)
  • Exosomes are cell-derived vesicles that are present in many and perhaps all biological fluids, including blood, urine, and cultured medium of cell cultures. (exosome-rna.com)
  • Exosomes contain various molecular constituents of their cell of origin, including proteins and RNA. (exosome-rna.com)
  • Exosomes released by dendritic cells are known to modulate cell-cell immunosignaling responses by containing MHCII and relevant adapter proteins that mediate docking and activation of acceptor cells. (socalflow.org)
  • Lung examination findings reveal an interstitial pneumonitis made up of edema fluid, mononuclear cells, and lymphocytes with polymorphonuclear leukocytes. (medscape.com)
  • To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-kappa B, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. (unav.edu)
  • The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
  • Astemizole induced the production of IL-2 and interferon-γ (IFN-γ) by CD4 + and CD8 + T cells both in vitro and in vivo. (bmj.com)
  • Laboratory and animal studies further reveal that fucoidans prevent certain infectious diseases, and block cancer cells from spreading and trigger their early death. (lifeextension.com)
  • Given their central role in controlling the immune response in patients with cancer, DCs are emerging as a critical cell type that must be considered as we come to understand basic cancer immunobiology. (aacrjournals.org)
  • Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
  • The Dartmouth work focuses on dendritic cells-an immune cell particularly abundant in the ovarian cancer environment. (scienceblog.com)
  • But we found that these dendritic cells that are commonly present in ovarian cancer were preferentially and avidly engulfing the nanoparticles. (scienceblog.com)
  • Dendritic cells are phagocytes-the soldiers of the immune system that gobble up bacteria and other pathogens, but ovarian cancer has co-opted them for its own use, he continued. (scienceblog.com)
  • Samples of human ovarian cancer cells show similar responses to nanoparticle stimulation, the researchers observed, suggesting feasibility in the clinical setting. (scienceblog.com)
  • Oncolytic viruses (OVs) are used to treat cancer, as they selectively replicate inside of and lyse tumor cells. (tcnj.edu)
  • Recent data demonstrate that the recruitment of dendritic cells to neoplastic lesions (and hence the priming of tumor-specific CD8 + T cells) is highly dependent on radiotherapy dose and fractionation through a mechanism that involves the accumulation of double-stranded DNA in the cytoplasm of cancer cells and consequent type I IFN release. (aacrjournals.org)
  • The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)
  • The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
  • Seek, See and Destroy ‒ iPSC-γδ NKT Cells Eliminate Cancer Cells! (cytomed.sg)
  • CXCR1 expression to improve anti-cancer efficacy of intravenously injected CAR-NK cells in mice w. (cytomed.sg)
  • Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T. (cytomed.sg)
  • In patients with cancer, high H1R1 expression correlated with low infiltration by TH1 cells, as well as with signs of T-cell exhaustion. (bmj.com)
  • In addition, dendritic cells are less functional in pancreatic cancer. (bookinghealth.com)
  • It is possible that dendritic cells will help to prevent recurrence and thus enable a complete cure of the cancer at an operable stage. (bookinghealth.com)
  • Different clinics use different approaches and it is still not known at what time, dose, course and intervals dendritic cell therapy for pancreatic cancer should be administered to achieve the best therapeutic results. (bookinghealth.com)
  • The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. (ox.ac.uk)
  • It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). (ox.ac.uk)
  • This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. (ox.ac.uk)
  • Using tiny chambers that release signals from a patient's own tumor, scientists trigger immune cells to mount a personalized attack against the cancer. (drugdiscoverynews.com)
  • Imvax's biodiffusion chambers (right) contain a cancer treatment that uses a person's own tumor cells to stimulate the immune system to fight the cancer. (drugdiscoverynews.com)
  • While the idea to use a cancer patient's tumor cells to fight against the tumor is not novel on its own, Exley added, "There are ways in which this is quite radically different, and that explains the substantially better looking clinical data that we've got as well as all the preclinical data we have that looks very positive. (drugdiscoverynews.com)
  • The challenge with this approach is, "you need to have a lot of [these cells] to reinfuse back into the body because eventually they die," said Corinne Ying Xuan Chua, a nanomedicine and cancer researcher at Houston Methodist Research Institute who is not associated with Imvax. (drugdiscoverynews.com)
  • Here, we show that the outcome of the manufacture of DC-based vaccine is highly variable in terms of both DC yield and DC immunostimulatory properties. (muni.cz)
  • A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
  • Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
  • High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. (stanford.edu)
  • It has long been appreciated that the innate and adaptive arms of the immune system must be coordinated, but it was not until the discovery of dendritic cells (DC) by Ralph Steinman at The Rockefeller University in the early 1980s that we truly understood conceptually how the immune system functions as a coherent unit. (aacrjournals.org)
  • In fact, in patients suffering from severe COVID-19, massive infiltration of proinflammatory immune cells, including activated macrophages, was detected in infected lung tissue. (nature.com)
  • The spleen in patients with HPS shows infiltration of immunocompetent cells within the red pulp and the periarteriolar sheaths. (medscape.com)
  • This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
  • STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
  • The inflammatory arthritides, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA), comprise autoimmune disorders characterised by chronic joint inflammation, immune cell infiltration to the synovium, fibroblast-like synoviocyte expansion and destruction of cartilage and bone. (biomedcentral.com)
  • A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
  • Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
  • Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. (stanford.edu)
  • Both ikarugamycin and astemizole improved the anticancer activity of the immunogenic chemotherapeutic agent oxaliplatin in a T cell-dependent fashion. (bmj.com)
  • Conclusions These findings underscore the potential utility of this screening system for the identification of immunostimulatory drugs with anticancer effects. (bmj.com)
  • Interaction of CD80 with CD28 triggers costimulatory signals and results in enhanced and sustained T-cell activation. (wikipedia.org)
  • CD80 is an essential component in dendritic cell licensing and cytotoxic T-cell activation. (wikipedia.org)
  • As mentioned above, this protein is crucial for immune cell activation in response to pathogens. (wikipedia.org)
  • This kind of pDC activation was dependent on direct integrin-mediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. (nature.com)
  • Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)
  • For dendritic cells derived from STING-deficient mice, no activation was detected. (unav.edu)
  • Dendritic cells (DC) 3 make up a family of highly specialized cells that upon activation by pathogens or their products mature into professional APC. (aai.org)
  • Recent research suggests that the cause is a deficiency of dendritic cell activation. (bookinghealth.com)
  • T-cells also increase the production of macrophage inflammatory proteins 1α and 1β (MIP‐α1 and MIP‐1β) and prevent apoptosis by induction of anti-apoptotic protein expression (e.g. (wikipedia.org)
  • m IGV-001 and h IGV-001 were analyzed for extracellular ATP and high mobility group box 1 (HMGB1) as indicators of immunogenic cell death (ICD), along with flow cytometric analysis of viability, surface calreticulin, and reactive oxygen species. (jefferson.edu)
  • CD80, CD86, and CD40) to become potent immunogenic APC for naive CD4 + Th cells ( 1 ). (aai.org)
  • Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. (ox.ac.uk)
  • The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. (ox.ac.uk)
  • DC exposed to GA induce effector IL-4-secreting Th2 cells and enhanced levels of the anti-inflammatory cytokine IL-10. (aai.org)
  • The anti-inflammatory effect of GA is mediated via DC as GA does not affect the polarization patterns of naive Th cells activated in an APC-free system. (aai.org)
  • DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization. (doximity.com)
  • Imvax scientists implant the biodiffusion chambers filled with the patient's own tumor cells and the IGF-IR antisense molecule into small incisions on either side of the abdomen for 48 hours. (drugdiscoverynews.com)
  • There may be some immunomodulatory effects via inhibition of elastase release from white blood cells. (probiotics.org)
  • Together, these results reveal that APC are essential for the GA-mediated shift in the Th cell profiles and indicate that DC are a prime target for the immunomodulatory effects of GA. (aai.org)
  • Here we describe a novel assay for monitoring prion uptake and trafficking by immune cells immediately following intraperitoneal inoculation by purifying and fluorescently labeling aggregated prion rods from infected brain material then monitoring their uptake and movement from the injection site and characterizing the cells mediating these events. (jove.com)
  • Andrews' and Craig Hooper's team at Thomas Jefferson University designed an antisense IGF-IR RNA molecule that inhibits glioblastoma tumor's IGF-IR and triggers tumor cell apoptosis in multiple rodent models (3,4). (drugdiscoverynews.com)
  • BDCs containing vehicle or m IGV-001 were implanted in the flanks of C57BL/6 albino female mice in preventative and therapeutic experiments, optionally in combination with a programmed cell death 1 (PD-1) blocker. (jefferson.edu)
  • Consistent with these observations, preventative IGV-001 limited tumor progression and extended overall survival in mice intracranially challenged with GL261 cells, a benefit that was associated with an increase in tumor-specific T cells with effector features. (jefferson.edu)
  • The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), then inducing a state of protective long-term immune memory. (bmj.com)
  • We will also describe our work in enabling single cell sequencing analysis, showing analysis of whole melanoma metastases to compare the T-cell gene expression programs of 19 patients and reveal similarities and differences in their exhaustion. (socalflow.org)
  • Finally, we discuss how single cell phenotyping and gene expression data can be integrated to map cellular phenotypes with 40+ proteins and 10,000 transcripts. (socalflow.org)
  • Overall, B-DCs demonstrated higher expression of CD86 and CD172α than L-DCs, but both cell types expressed high levels of MHC class II and CD44, as well as moderate amounts of CD163, CD204, and Bla36. (biomedcentral.com)
  • The NSCLC-eradicating effect of astemizole plus oxaliplatin was lost on depletion of either CD4 + or CD8 + T cells, as well as on neutralization of IFN-γ. (bmj.com)
  • An independent data monitoring committee (IDMC) has recommended the continuation of Argos' pivotal phase 3 ADAPT clinical trial of AGS-003 for the treatment of metastatic renal cell carcinoma (mRCC) based on results of the committee's second planned interim data analysis . (shu.edu)
  • Bioactivity of the general approach was also measured against hepatocellular carcinoma Hepa 1-6 cells. (jefferson.edu)